Stephan Harbarth

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc The estimated economic burden of genital herpes in the United States. An analysis using two costing approaches
    T D Szucs
    Division of Infectious Diseases, Children s Hospital, Boston, USA
    BMC Infect Dis 1:5. 2001
  2. ncbi request reprint Inappropriate initial antimicrobial therapy and its effect on survival in a clinical trial of immunomodulating therapy for severe sepsis
    Stephan Harbarth
    Divisions of Infectious Diseases, University of Geneva Hospitals, Geneva, Switzerland
    Am J Med 115:529-35. 2003
  3. ncbi request reprint Shortage of penicillin G: impact on antibiotic prescribing at a US tertiary care centre
    Stephan Harbarth
    Division of Infectious Diseases, University of Utah School of Medicine, Salt Lake City, UT, USA
    Int J Antimicrob Agents 21:484-7. 2003
  4. pmc Outpatient antibiotic use and prevalence of antibiotic-resistant pneumococci in France and Germany: a sociocultural perspective
    Stephan Harbarth
    University of Geneva Hospitals, Switzerland
    Emerg Infect Dis 8:1460-7. 2002
  5. ncbi request reprint Navigating the World Wide Web in search of resources on antimicrobial resistance
    Stephan Harbarth
    Division of Infectious Diseases, Geneva University Hospitals, Geneva, Switzerland
    Clin Infect Dis 43:72-8. 2006
  6. pmc Effects of antibiotics on nosocomial epidemiology of vancomycin-resistant enterococci
    Stephan Harbarth
    Division of Infectious Diseases, Children s Hospital, Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    Antimicrob Agents Chemother 46:1619-28. 2002
  7. ncbi request reprint Nosocomial transmission of antibiotic-resistant microorganisms
    S Harbarth
    Department of Infection Prevention and Control, Geneva University Hospitals, Geneva, Switzerland
    Curr Opin Infect Dis 14:437-42. 2001
  8. ncbi request reprint Parallel analysis of individual and aggregated data on antibiotic exposure and resistance in gram-negative bacilli
    S Harbarth
    Harvard Medical School, Boston, USA
    Clin Infect Dis 33:1462-8. 2001
  9. ncbi request reprint Antibiotic prophylaxis and the risk of Clostridium difficile-associated diarrhoea
    S Harbarth
    Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, USA
    J Hosp Infect 48:93-7. 2001
  10. doi request reprint A predictive model for identifying surgical patients at risk of methicillin-resistant Staphylococcus aureus carriage on admission
    Stephan Harbarth
    Infection Control Program, University of Geneva Hospitals and Medical Schools, Geneva, Switzerland
    J Am Coll Surg 207:683-9. 2008

Detail Information

Publications100

  1. pmc The estimated economic burden of genital herpes in the United States. An analysis using two costing approaches
    T D Szucs
    Division of Infectious Diseases, Children s Hospital, Boston, USA
    BMC Infect Dis 1:5. 2001
    ..Only limited data exist on the costs of genital herpes (GH) in the USA. We estimated the economic burden of GH in the USA using two different costing approaches...
  2. ncbi request reprint Inappropriate initial antimicrobial therapy and its effect on survival in a clinical trial of immunomodulating therapy for severe sepsis
    Stephan Harbarth
    Divisions of Infectious Diseases, University of Geneva Hospitals, Geneva, Switzerland
    Am J Med 115:529-35. 2003
    ..To examine the effect of inappropriate initial antimicrobial therapy on the prognosis of patients with sepsis who were enrolled in a clinical trial of an immunomodulating agent conducted in 108 hospitals in North America and Europe...
  3. ncbi request reprint Shortage of penicillin G: impact on antibiotic prescribing at a US tertiary care centre
    Stephan Harbarth
    Division of Infectious Diseases, University of Utah School of Medicine, Salt Lake City, UT, USA
    Int J Antimicrob Agents 21:484-7. 2003
    ..Shortage-triggered treatment changes had a negative effect on prescribing patterns, which may contribute to antibiotic resistance...
  4. pmc Outpatient antibiotic use and prevalence of antibiotic-resistant pneumococci in France and Germany: a sociocultural perspective
    Stephan Harbarth
    University of Geneva Hospitals, Switzerland
    Emerg Infect Dis 8:1460-7. 2002
    ..Understanding these determinants is crucial for the success of possible interventions. Finally, we emphasize the overarching importance of a sociocultural approach to preventing antibiotic resistance in the community...
  5. ncbi request reprint Navigating the World Wide Web in search of resources on antimicrobial resistance
    Stephan Harbarth
    Division of Infectious Diseases, Geneva University Hospitals, Geneva, Switzerland
    Clin Infect Dis 43:72-8. 2006
    ..We compiled a selection of Web sites that seemed to be useful as starting points for physicians, epidemiologists, researchers, or patients interested in this topic...
  6. pmc Effects of antibiotics on nosocomial epidemiology of vancomycin-resistant enterococci
    Stephan Harbarth
    Division of Infectious Diseases, Children s Hospital, Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    Antimicrob Agents Chemother 46:1619-28. 2002
  7. ncbi request reprint Nosocomial transmission of antibiotic-resistant microorganisms
    S Harbarth
    Department of Infection Prevention and Control, Geneva University Hospitals, Geneva, Switzerland
    Curr Opin Infect Dis 14:437-42. 2001
    ....
  8. ncbi request reprint Parallel analysis of individual and aggregated data on antibiotic exposure and resistance in gram-negative bacilli
    S Harbarth
    Harvard Medical School, Boston, USA
    Clin Infect Dis 33:1462-8. 2001
    ..Multicenter studies should include individual-patient-level data to elucidate more fully the relation between antibiotic exposure and resistance...
  9. ncbi request reprint Antibiotic prophylaxis and the risk of Clostridium difficile-associated diarrhoea
    S Harbarth
    Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, USA
    J Hosp Infect 48:93-7. 2001
    ..6; CI, 1.7-12.3). Our results did not confirm that extended prophylaxis after clean surgery increases the risk of CDAD, which remains an uncommon postoperative complication, associated even with short antibiotic exposure...
  10. doi request reprint A predictive model for identifying surgical patients at risk of methicillin-resistant Staphylococcus aureus carriage on admission
    Stephan Harbarth
    Infection Control Program, University of Geneva Hospitals and Medical Schools, Geneva, Switzerland
    J Am Coll Surg 207:683-9. 2008
    ..Indiscriminate application of these guidelines can result in a large number of unnecessary screening tests...
  11. pmc Use of oligoarrays for characterization of community-onset methicillin-resistant Staphylococcus aureus
    Thibaud Koessler
    Genomic Research Laboratory, Service of Infectious Diseases, University of Geneva Hospitals, CH 1211 Geneva 14, Switzerland
    J Clin Microbiol 44:1040-8. 2006
    ....
  12. doi request reprint Temporal effects of antibiotic use and hand rub consumption on the incidence of MRSA and Clostridium difficile
    Nathalie Vernaz
    Pharmacy Department, University of Geneva Hospitals and Medical School, Geneva, Switzerland
    J Antimicrob Chemother 62:601-7. 2008
    ..The aim of this study was to determine the temporal relation between the use of antibiotics and alcohol-based hand rubs (ABHRs) and the incidence of methicillin-resistant Staphylococcus aureus (MRSA) and Clostridium difficile...
  13. pmc Rapid Staphylococcus aureus agr type determination by a novel multiplex real-time quantitative PCR assay
    Patrice Francois
    Genomic Research Laboratory, University of Geneva Hospitals, Service of Infectious Diseases Genomic Research Laboratory, CH 1211 Geneva 14, Switzerland
    J Clin Microbiol 44:1892-5. 2006
    ..aureus agr type. This assay represents a rapid and affordable alternative to sequence-based strategies for assessing relevant epidemiological information...
  14. doi request reprint Rapid and high-throughput genotyping of Staphylococcus epidermidis isolates by automated multilocus variable-number of tandem repeats: a tool for real-time epidemiology
    Patrice Francois
    University of Geneva Hospitals, CH 1211 Geneva 14, Switzerland
    J Microbiol Methods 72:296-305. 2008
    ..This type of rapid and high-throughput methodology opens the possibility to rapidly assess long-term nosocomial transmission or to characterize infecting strains in the general procedure of routine laboratories, in real-time...
  15. pmc Methicillin-resistant Staphylococcus aureus, Geneva, Switzerland, 1993-2005
    Patrice Francois
    University of Geneva Hospitals, Geneva, Switzerland
    Emerg Infect Dis 14:304-7. 2008
    ..We demonstrated strain diversity, including clones rarely found in Europe. Local epidemiology of community-associated MRSA is diverse and is evolving by importation and transmission of new strains...
  16. ncbi request reprint Prevalence and prediction of previously unknown MRSA carriage on admission to a geriatric hospital
    Hugo Sax
    Infection Control Program, Geneva University Hospitals, Geneva, Switzerland
    Age Ageing 34:456-62. 2005
    ..to determine the prevalence and characteristics of previously unknown methicillin-resistant Staphylococcus aureus (MRSA) carriers at admission...
  17. ncbi request reprint Evaluating the probability of previously unknown carriage of MRSA at hospital admission
    Stephan Harbarth
    Infection Control Program and Division of Infectious Diseases, University of Geneva Hospitals, Geneva, Switzerland
    Am J Med 119:275.e15-23. 2006
    ..We determined the prevalence and risk profile of patients with previously unknown carriage of methicillin-resistant Staphylococcus aureus (MRSA) at hospital admission...
  18. pmc Evaluation of three molecular assays for rapid identification of methicillin-resistant Staphylococcus aureus
    Patrice Francois
    Department of Internal Medicine, Service of Infectious Diseases Genomic Research Laboratory, University of Geneva Hospitals, CH 1211 Geneva 14, Switzerland
    J Clin Microbiol 45:2011-3. 2007
    ..Our results suggest that users of orfX-staphylococcal cassette chromosome mec-based assays should repeatedly monitor the local epidemiology to minimize the risks of detection bias and the omission of emerging MRSA clones...
  19. doi request reprint Risk factors for methicillin-resistant Staphylococcus aureus surgical site infection
    Stephan Harbarth
    Infection Control Program, University of Geneva Hospitals and Medical School, Geneva, Switzerland
    Infect Control Hosp Epidemiol 29:890-3. 2008
    ..MRSA carriage on admission did not predict MRSA SSI...
  20. pmc Use of an automated multiple-locus, variable-number tandem repeat-based method for rapid and high-throughput genotyping of Staphylococcus aureus isolates
    Patrice Francois
    Genomic Research Laboratory, University of Geneva Hospitals, CH 1211 Geneva 14, Switzerland
    J Clin Microbiol 43:3346-55. 2005
    ..All steps of this new procedure were developed to ensure a rapid turnaround time and moderate cost. The results obtained suggest that this rapid approach is a valuable tool for the genotyping of S. aureus isolates in real time...
  21. pmc Evaluation of rapid screening and pre-emptive contact isolation for detecting and controlling methicillin-resistant Staphylococcus aureus in critical care: an interventional cohort study
    Stephan Harbarth
    Infection Control Program, Geneva University Hospitals, Geneva, Switzerland
    Crit Care 10:R25. 2006
    ....
  22. doi request reprint Universal screening for methicillin-resistant Staphylococcus aureus at hospital admission and nosocomial infection in surgical patients
    Stephan Harbarth
    Infection Control Program, University of Geneva Hospitals and Medical School, Geneva, Switzerland
    JAMA 299:1149-57. 2008
    ..Experts and policy makers have repeatedly called for universal screening at hospital admission to reduce nosocomial methicillin-resistant Staphylococcus aureus (MRSA) infection...
  23. doi request reprint Burden of bloodstream infection caused by extended-spectrum β-lactamase-producing enterobacteriaceae determined using multistate modeling at a Swiss University Hospital and a nationwide predictive model
    Andrew Stewardson
    Infection Control Program, University of Geneva Hospitals and Faculty of Medicine, Geneva, Switzerland
    Infect Control Hosp Epidemiol 34:133-43. 2013
    ..To obtain an unbiased estimate of the excess hospital length of stay (LOS) and cost attributable to extended-spectrum β-lactamase (ESBL) positivity in bloodstream infections (BSIs) due to Enterobacteriaceae...
  24. ncbi request reprint The impact of methicillin resistance in Staphylococcus aureus bacteremia on patient outcomes: mortality, length of stay, and hospital charges
    Sara E Cosgrove
    Division of Infectious Diseases, Johns Hopkins Medical Institutions, The Johns Hopkins Hospital, Baltimore, Maryland 21287, USA
    Infect Control Hosp Epidemiol 26:166-74. 2005
    ..To evaluate the impact of methicillin resistance in Staphylococcus aureus on mortality, length of hospitalization, and hospital charges...
  25. pmc Rapid identification of hospitalized patients at high risk for MRSA carriage
    R Scott Evans
    Department of Medical Informatics, LDS Hospital, Intermountain Healthcare, Salt Lake City, Utah, USA
    J Am Med Inform Assoc 15:506-12. 2008
    ..Previous MRSA colonization was the best predictor but other risk factors were needed to increase the sensitivity of the algorithm...
  26. doi request reprint Low risk despite high endemicity of methicillin-resistant Staphylococcus aureus infections following elective total joint arthroplasty: a 12-year experience
    Ilker Uckay
    Orthopedic Surgery Department, University of Geneva Hospitals, Geneva, Switzerland
    Ann Med 44:360-8. 2012
    ..3%) among all orthopedic patients. Conclusion. Institution-wide MRSA endemicity does not necessarily lead to a high MRSA infection risk after elective hip and knee arthroplasty...
  27. ncbi request reprint Antibiotic consumption, bacterial resistance and their correlation in a Swiss university hospital and its adult intensive care units
    Jutta M Loeffler
    Division of Infectious Diseases, Department of Internal Medicine, University Hospital of Geneva, Geneva, Switzerland
    Scand J Infect Dis 35:843-50. 2003
    ..for cephalosporin, in coagulase-negative staphylococci for gentamicin and in Streptococcus pneumoniae for penicillin...
  28. doi request reprint Pseudomonas aeruginosa outbreak in a pediatric intensive care unit linked to a humanitarian organization residential center
    Yves Longtin
    Infection Control Program, University of Geneva Hospitals and Faculty of Medicine, Geneva, Switzerland
    Pediatr Infect Dis J 29:233-7. 2010
    ..Between April 2006 and September 2008, we investigated an outbreak of P. aeruginosa infection occurring in a pediatric intensive care unit. We conducted epidemiologic and molecular investigations to identify the source of the outbreak...
  29. ncbi request reprint Acute respiratory distress syndrome after bacteremic sepsis does not increase mortality
    Philippe Eggimann
    Department of Medicine, Infection Control Program, University of Geneva Hospitals, 1211 Geneva 14, Switzerland
    Am J Respir Crit Care Med 167:1210-4. 2003
    ....
  30. pmc High prevalence of isolates with reduced glycopeptide susceptibility in persistent or recurrent bloodstream infections due to methicillin-resistant Staphylococcus aureus
    Ilker Uckay
    Service of Infectious Diseases, Infection Control Program, Geneva University Hospital and Medical School, Geneva, Switzerland
    Antimicrob Agents Chemother 56:1258-64. 2012
    ..0001). Detection of elevated teicoplanin MICs may help to predict a poor response to glycopeptide therapy in MRSA bacteremic patients...
  31. doi request reprint Should the methicillin-resistant Staphylococcus aureus carriage status be used as a guide to treatment for skin and soft tissue infections?
    Alexandra Reber
    Service of Infectious Diseases, Geneva University Hospitals and Medical School, Geneva, Switzerland
    J Infect 64:513-9. 2012
    ..Previous skin carriage of methicillin-resistant Staphylococcus aureus (MRSA) leads frequently to empiric antibiotic MRSA coverage for skin & soft tissue infections...
  32. pmc Community-associated methicillin-resistant Staphylococcus aureus, Switzerland
    Stephan Harbarth
    University of Geneva Hospitals, Geneva, Switzerland
    Emerg Infect Dis 11:962-5. 2005
    ..9/1,000 admissions. Although 5 CA-MRSA isolates contained Panton-Valentine leukocidin, only 1 patient had a previous skin infection. No easily modifiable risk factor for CA-MRSA was identified...
  33. doi request reprint Modelling the impact of antibiotic use on antibiotic-resistant Escherichia coli using population-based data from a large hospital and its surrounding community
    Nathalie Vernaz
    Pharmacy Department, University of Geneva Hospitals and Medical School, Geneva, Switzerland
    J Antimicrob Chemother 66:928-35. 2011
    ..To determine the temporal relationship between antibiotic use and incidence of antibiotic-resistant Escherichia coli in both the inpatient and outpatient setting of a large urban area...
  34. ncbi request reprint Does antibiotic selection impact patient outcome?
    Stephan Harbarth
    Infection Control Program and Division of Infectious Diseases, University of Geneva Hospitals, Geneva, CH 1211, Switzerland
    Clin Infect Dis 44:87-93. 2007
    ..Finally, better risk scores and laboratory tools are urgently needed to improve the adequacy of empirical antibiotic therapy and patient outcomes...
  35. ncbi request reprint Cost implications of successful hand hygiene promotion
    Didier Pittet
    Infection Control Program, University of Geneva Hospitals, Switzerland
    Infect Control Hosp Epidemiol 25:264-6. 2004
    ..The total cost of the hand hygiene promotion corresponded to less than 1% of the costs associated with nosocomial infections. Successful hand hygiene promotion is probably cost-saving...
  36. doi request reprint Methicillin-resistant Staphylococcus aureus control in the 21st century: beyond the acute care hospital
    Marta Banqué Navarro
    Infection Control Program, Geneva University Hospitals, Geneva, Switzerland
    Curr Opin Infect Dis 21:372-9. 2008
    ..To describe new trends in the epidemiology of methicillin-resistant Staphylococcus aureus in the community, among animals and in long-term care settings and to discuss potential infection control implications...
  37. pmc Epidemiology of methicillin-resistant Staphylococcus aureus carriage and MRSA surgical site infections in patients undergoing colorectal surgery: a cohort study in two centers
    Benedikt Huttner
    Infection Control Program, Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland
    Surg Infect (Larchmt) 13:401-5. 2012
    ..The aim of this retrospective cohort study was to describe the epidemiology of SSIs caused by MRSA after colorectal surgery in two tertiary-care centers, one in Geneva, Switzerland (G), and the other in Chicago, Illinois (C)...
  38. doi request reprint Impact of the French campaign to reduce inappropriate ambulatory antibiotic use on the prescription and consultation rates for respiratory tract infections
    Pierre Chahwakilian
    Infection Control Programme, University of Geneva Hospitals and Faculty of Medicine, Geneva, Switzerland
    J Antimicrob Chemother 66:2872-9. 2011
    ..To assess long-term trends in the volume of ambulatory antibiotic prescriptions and prescription and consultation rates for respiratory tract infections (RTIs) in France in relation to the yearly public antibiotic campaign since 2002...
  39. doi request reprint Use of benchmarking and public reporting for infection control in four high-income countries
    Thomas Haustein
    Infection Control Programme, Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland
    Lancet Infect Dis 11:471-81. 2011
    ..An opportunity now exists to learn from the different strategies that have been adopted...
  40. ncbi request reprint An outbreak of Pseudomonas aeruginosa pneumonia and bloodstream infection associated with intermittent otitis externa in a healthcare worker
    Anne Zawacki
    Children s Hospital, Boston, Massachusetts, USA
    Infect Control Hosp Epidemiol 25:1083-9. 2004
    ..To investigate an outbreak of Pseudomonas aeruginosa pneumonia and bloodstream infection among four neonates, determine risk factors for infection, and implement preventive strategies...
  41. doi request reprint Activity and impact on antibiotic use and costs of a dedicated infectious diseases consultant on a septic orthopaedic unit
    Ilker Uckay
    Orthopaedic Surgery Service, Geneva, Switzerland
    J Infect 58:205-12. 2009
    ..We investigated the daily clinical activity and the impact on antibiotic costs in the Septic Unit since 2000...
  42. doi request reprint Dissemination and sustainability of a hospital-wide hand hygiene program emphasizing positive reinforcement
    Jeanmarie Mayer
    Division of Epidemiology, University of Utah School of Medicine, Salt Lake City, Utah 84132, USA
    Infect Control Hosp Epidemiol 32:59-66. 2011
    ..To increase and sustain hospital-wide compliance with hand hygiene through a long-term ongoing multidimensional improvement program emphasizing behavioral factors...
  43. ncbi request reprint A simulation-based evaluation of methods to estimate the impact of an adverse event on hospital length of stay
    Matthew H Samore
    VA Salt Lake City Health Care System, Salt Lake City, Utah, USA
    Med Care 45:S108-15. 2007
    ..Conventional analytic methods were compared with inverse probability weighting (IPW)...
  44. pmc "Antibiotics are not automatic anymore"--the French national campaign to cut antibiotic overuse
    Benedikt Huttner
    Infection Control Program, University of Geneva Hospitals and Medical School, Geneva, Switzerland
    PLoS Med 6:e1000080. 2009
    Benedikt Huttner and Stephan Harbarth discuss the implications of a new study that examined the impact of a national campaign in France to reduce antibiotic overuse.
  45. ncbi request reprint Genotypic and phenotypic analysis of Clostridium difficile correlated with previous antibiotic exposure
    Matthew H Samore
    VA Salt Lake City Health Care System, and Division of Clinical Epidemiology, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT 84132, USA
    Microb Drug Resist 12:23-8. 2006
    ..Resistance of specific C. difficile strains to clindamycin and other antimicrobial agents may contribute to their hospital dissemination and explain, in part, the propensity of clindamycin to trigger nosocomial outbreaks...
  46. doi request reprint Infection prevention research in Europe: recent advances and future priorities
    Stephan Harbarth
    Infection Control Program, University of Geneva Hospitals and Faculty of Medicine, 4 rue Gabrielle Perret Gentil, Geneva, Switzerland
    Infect Control Hosp Epidemiol 31:S11-3. 2010
    ..This short overview highlights recent advances and future priorities in infection prevention research, including methodological challenges to be addressed...
  47. doi request reprint Characteristics and outcomes of public campaigns aimed at improving the use of antibiotics in outpatients in high-income countries
    Benedikt Huttner
    Infection Control Programme, Geneva University Hospitals and Medical School, Geneva, Switzerland
    Lancet Infect Dis 10:17-31. 2010
    ..Although the most effective interventions and potential adverse outcomes remain unclear, public campaigns can probably contribute to more careful use of antibiotics in outpatients, at least in high-prescribing countries...
  48. ncbi request reprint Prevention of primary bacteraemia
    Antoni Juan-Torres
    Division of Infectious Diseases, Geneva University Hospitals, Geneva, Switzerland
    Int J Antimicrob Agents 30:S80-7. 2007
    ....
  49. ncbi request reprint Effect of a comprehensive, multidisciplinary, educational program on the use of antibiotics in a geriatric university hospital
    Monika Lutters
    Department of Geriatrics, University Hospitals of Geneva, Geneva, Switzerland
    J Am Geriatr Soc 52:112-6. 2004
    ..To assess the effect of a comprehensive, educational antibiotic management program designed to improve antibiotic use and reduce treatment costs in elderly patients with suspected urinary or respiratory tract infection...
  50. ncbi request reprint Low apolipoprotein A-I level at intensive care unit admission and systemic inflammatory response syndrome exacerbation
    Catherine Chenaud
    Division of Surgical Intensive Care, Department of Anesthesiology, Pharmacology, and Surgical Intensive Care, University of Geneva Hospitals, Geneva, Switzerland
    Crit Care Med 32:632-7. 2004
    ..Examine whether a low serum level of apolipoprotein A-I at intensive care unit (ICU) admission is associated with a further increase of the number of systemic inflammatory response syndrome (SIRS) criteria...
  51. ncbi request reprint Bacteremic sepsis in intensive care: temporal trends in incidence, organ dysfunction, and prognosis
    Stephane Hugonnet
    Infection Control Program, Department of Internal Medicine, University of Geneva Hospitals, Switzerland
    Crit Care Med 31:390-4. 2003
    ..To determine whether changes have occurred at our center in the incidence, patterns of organ dysfunctions, prognostic factors, and case-fatality rate of bacteremic sepsis...
  52. ncbi request reprint Nursing resources: a major determinant of nosocomial infection?
    Stephane Hugonnet
    Infection Control Program, Department of Internal Medicine, University of Geneva Hospitals, Switzerland
    Curr Opin Infect Dis 17:329-33. 2004
    ..There is growing concern that changes in nurse workforce and hospital-restructuring interventions negatively impact on patient outcomes. This review focuses on the association between understaffing and health-care-associated infections...
  53. ncbi request reprint Epidemiology and prognostic determinants of bloodstream infections in surgical intensive care
    Stephan Harbarth
    Infection Control Program, University of Geneva Hospitals, 1211 Geneva 14, Switzerland
    Arch Surg 137:1353-9; discussion 1359. 2002
    ..A set of clinical variables available at the bedside can be used to predict outcome in critically ill patients with bloodstream infection (BSI)...
  54. ncbi request reprint A randomized clinical trial to compare fleroxacin-rifampicin with flucloxacillin or vancomycin for the treatment of staphylococcal infection
    Jacques Schrenzel
    Geneva University Hospitals, Geneva, Switzerland
    Clin Infect Dis 39:1285-92. 2004
    ..Oral combination therapy with fluoroquinolones plus rifampicin is a promising alternative to standard parenteral therapy for staphylococcal infections...
  55. pmc A novel multiplex real-time PCR assay for rapid typing of major staphylococcal cassette chromosome mec elements
    Patrice Francois
    Genomic Research Laboratory, University of Geneva Hospitals, CH 1211 Geneva 14, Switzerland
    J Clin Microbiol 42:3309-12. 2004
    ..This novel assay constitutes a valuable tool for evaluating the molecular epidemiology of MRSA and adjusting infection control strategies against MRSA...
  56. pmc Impact of outpatient antibiotic use on carriage of ampicillin-resistant Escherichia coli
    Matthew H Samore
    Division of Epidemiology, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT 84132, USA
    Antimicrob Agents Chemother 55:1135-41. 2011
    ..coli may promote population spread of resistant E. coli. Examining changes in both resistant and susceptible organisms in antibiotic-treated individuals and their close contacts improves understanding of antibiotic selection pressure...
  57. pmc Antimicrobial resistance determinants and future control
    Stephan Harbarth
    University of Geneva Hospitals, Geneva, Switzerland
    Emerg Infect Dis 11:794-801. 2005
    ..We describe determinants likely to influence the future epidemiology and health impact of antimicrobial-resistant infections. Understanding these factors will ultimately optimize preventive strategies for an unpredictable future...
  58. doi request reprint Hand hygiene practices and adherence determinants in surgical wards across Europe and Israel: a multicenter observational study
    Andie Lee
    Infection Control Program, University of Geneva Hospitals and Faculty of Medicine, Geneva, Switzerland
    Am J Infect Control 39:517-20. 2011
    ..Hand hygiene practices are influenced by numerous factors, and a tailored approach may be required to improve practices...
  59. ncbi request reprint Management of Gram-positive bacteraemia
    Ilker Uckay
    Division of Infectious Diseases, University of Geneva Hospitals, Geneva, Switzerland
    Curr Opin Infect Dis 20:561-7. 2007
    ..This paper reviews publications focusing exclusively on new findings related to Gram-positive bacteraemia in the published literature from July 2006 to June 2007...
  60. ncbi request reprint Prolonged antibiotic prophylaxis after cardiovascular surgery and its effect on surgical site infections and antimicrobial resistance
    S Harbarth
    Department of Epidemiology, Harvard School of Public Health, and Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    Circulation 101:2916-21. 2000
    ..Despite evidence supporting short antibiotic prophylaxis (ABP), it is still common practice to continue ABP for more than 48 hours after coronary artery bypass graft (CABG) surgery...
  61. ncbi request reprint Variation in antimicrobial utilization for febrile neutropenia in cancer patients. The CEMIC Study Group. Club d'Etudes des Maladies Infectieuses en Cancer
    S Harbarth
    Div of Infectious Diseases, Children s Hospital, Boston, MA 02115, USA
    Infection 28:375-8. 2000
    ..No previous study has compared hospitals with respect to the variation of antimicrobial utilization (AU) for cancer patients with febrile neutropenia (FNE)...
  62. ncbi request reprint Epidemiologic methods for the prevention of nosocomial infections
    S Harbarth
    Division of Infectious Diseases and Infection Control, Children s Hospital, Harvard Medical School, Boston, USA
    Int J Hyg Environ Health 203:153-7. 2000
    ..Based on the assumption that nosocomial infections have causal and preventive factors that can be identified through systematic investigation, epidemiologic methods add important knowledge to reduce hospital-acquired infections...
  63. ncbi request reprint Quantifying uncertainty: physicians' estimates of infection in critically ill neonates and children
    Joachim E Fischer
    Children s Hospital, University of Zurich, Zurich, Switzerland
    Clin Infect Dis 38:1383-90. 2004
    ..Physicians' prognoses regarding the presence of serious infection were remarkably precise. Studies investigating the value of new tests for diagnosis of sepsis should establish that they add incremental value to physicians' judgment...
  64. ncbi request reprint Clinical and economic outcomes of conventional amphotericin B-associated nephrotoxicity
    Stephan Harbarth
    Division of Infectious Diseases, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT 84132, USA
    Clin Infect Dis 35:e120-7. 2002
    ..CAB-associated NT was associated with increased mortality, but it did not impact the costs and length of hospital stay...
  65. doi request reprint Update on screening and clinical diagnosis of meticillin-resistant Staphylococcus aureus (MRSA)
    Stephan Harbarth
    Geneva University Hospitals and Medical School, Geneva, Switzerland
    Int J Antimicrob Agents 37:110-7. 2011
    ..This strategy is likely to be cost effective if linked to prompt institution of control measures...
  66. ncbi request reprint Interventional study to evaluate the impact of an alcohol-based hand gel in improving hand hygiene compliance
    Stephan Harbarth
    Infection Control Program, Children s Hospital, Boston, MA, USA
    Pediatr Infect Dis J 21:489-95. 2002
    ..To evaluate the effects of the introduction of an alcohol-based hand gel and multifaceted quality improvement (QI) interventions on hand hygiene (HH) compliance...
  67. ncbi request reprint Semmelweis' legacy: insights from an international survey among 265,000 students in 32 countries
    Stephan Harbarth
    Infection Control Program, Geneva University Hospitals, Geneva, Switzerland
    Int J Hyg Environ Health 207:481-5. 2004
    ..The present report describes the questions and student performance for this infection control exercise set and evaluates performance variability between countries...
  68. ncbi request reprint Control of a cluster of community-associated, methicillin-resistant Staphylococcus aureus in neonatology
    H Sax
    Infection Control Programme, University of Geneva Hospitals, Switzerland
    J Hosp Infect 63:93-100. 2006
    ..This spread among neonates and was subsequently transmitted to another mother and a sibling. This is the first report of a successfully controlled neonatology outbreak of genetically distinct PVL-producing CA-MRSA in Europe...
  69. ncbi request reprint Control of endemic methicillin-resistant Staphylococcus aureus--recent advances and future challenges
    S Harbarth
    Infection Control Program, University of Geneva Hospitals, Geneva, Switzerland
    Clin Microbiol Infect 12:1154-62. 2006
    ..This review summarises recent advances and studies that address these issues. Overall, it seems that there is no level of MRSA prevalence for which active control measures are no longer warranted...
  70. ncbi request reprint Should the development of new antibiotics be a public health priority?
    Stephan Harbarth
    Infection Control Program and Division of Infectious Diseases, University of Geneva Hospitals, Geneva, Switzerland
    Curr Opin Crit Care 13:554-6. 2007
  71. ncbi request reprint Control of multiply resistant cocci: do international comparisons help?
    S Harbarth
    Children s Hospital, and Harvard Medical School, Boston, USA
    Lancet Infect Dis 1:251-61. 2001
    ..Finally, we suggest that a macro-level perspective on antibiotic resistance can broaden the understanding of this worldwide calamity, and help prevent further dissemination of multiply resistant microorganisms...
  72. doi request reprint Risk factors for treatment failure in orthopedic device-related methicillin-resistant Staphylococcus aureus infection
    T Ferry
    Infectious Diseases Unit, Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland
    Eur J Clin Microbiol Infect Dis 29:171-80. 2010
    ..2-16.3; P = 0.025) were independent predictors of treatment failure after debridement. Therapy using a combination of antimicrobials should be considered for patients with MRSA ODRI, especially when implant removal is not feasible...
  73. ncbi request reprint Effectiveness of a hospital-wide programme to improve compliance with hand hygiene. Infection Control Programme
    D Pittet
    Department of Internal Medicine, University of Geneva Hospitals, and Institute of Social and Preventive Medicine, University of Geneva, Switzerland
    Lancet 356:1307-12. 2000
    ..We attempted to promote hand hygiene by implementing a hospital-wide programme, with special emphasis on bedside, alcohol-based hand disinfection. We measured nosocomial infections in parallel...
  74. doi request reprint Surveillance of extended-spectrum-beta-lactamase-producing Enterobacteriaceae in a Swiss Tertiary Care Hospital
    C Fankhauser
    Infection Control Programme, University of Geneva Hospitals, Geneva, Switzerland
    Swiss Med Wkly 139:747-51. 2009
    ....
  75. ncbi request reprint Are there patients with peritonitis who require empiric therapy for enterococcus?
    S Harbarth
    Infection Control Programme, Division of Infectious Diseases, University of Geneva Hospitals, 24 Rue Micheli du Crest, 1211 Geneva 14, Switzerland
    Eur J Clin Microbiol Infect Dis 23:73-7. 2004
    ..The ideal therapeutic regimen for these high-risk patients remains to be determined, but empirical therapy directed against enterococci should be considered...
  76. doi request reprint Procalcitonin levels during pregnancy, delivery and postpartum
    Céline Paccolat
    Department of Obstetrics and Gynecology, University of Geneva Hospitals and Faculty of Medicine, Geneva, Switzerland
    J Perinat Med 39:679-83. 2011
    ..To determine the normal value ranges of procalcitonin (PCT) in women with uncomplicated pregnancies...
  77. pmc Clostridium: transmission difficile?
    Stephan Harbarth
    Infection Control Program, University of Geneva Hospitals and Medical School, Geneva, Switzerland
    PLoS Med 9:e1001171. 2012
  78. pmc A call for action: the application of the international health regulations to the global threat of antimicrobial resistance
    Didier Wernli
    Division of International and Humanitarian Medicine, University of Geneva Hospitals and Faculty of Medicine, Geneva, Switzerland
    PLoS Med 8:e1001022. 2011
    ..Stephen Harbarth and colleagues argue that the International Health Regulations (IHR) should be applied to the global health threat of antimicrobial resistance...
  79. ncbi request reprint Variation in nosocomial infection prevalence according to patient care setting:a hospital-wide survey
    H Sax
    Infection Control Program, University of Geneva Hospitals, Geneva, Switzerland
    J Hosp Infect 48:27-32. 2001
    ..Prevalence studies are an easy surveillance tool that can be exploited further by analysing data according to hospital care settings to identify high-risk areas...
  80. ncbi request reprint The preventable proportion of nosocomial infections: an overview of published reports
    S Harbarth
    Infection Control Programme, Department of Internal Medicine, University of Geneva Hospitals, 24, Rue Micheli du Crest, CH 1211, Geneva 14, Switzerland
    J Hosp Infect 54:258-66; quiz 321. 2003
    ....
  81. doi request reprint Community-associated methicillin-resistant Staphylococcus aureus: risk factors for infection, and long-term follow-up
    Y Longtin
    University of Geneva Hospitals and Faculty of Medicine, Geneva, Switzerland
    Clin Microbiol Infect 15:552-9. 2009
    ..Further studies are needed to elucidate the role of migration as a factor contributing to the emergence of CA-MRSA in Europe...
  82. ncbi request reprint Lack of effect of combination antibiotic therapy on mortality in patients with pneumococcal sepsis
    S Harbarth
    Division of Infectious Diseases, University of Geneva Hospitals, Geneva, Switzerland
    Eur J Clin Microbiol Infect Dis 24:688-90. 2005
    ..Overall, in contrast to recently published reports, these results suggest that combination antibiotic therapy does not decrease mortality after severe pneumococcal sepsis...
  83. ncbi request reprint Multi-resistant infections in repatriated patients after natural disasters: lessons learned from the 2004 tsunami for hospital infection control
    I Uckay
    Infection Control Programme, University of Geneva Hospitals, Switzerland
    J Hosp Infect 68:1-8. 2008
    ..Infections may also become manifest after several weeks of hospitalisation. In case of life-threatening infection, antibiotic therapy should cover non-fermenting pathogens...
  84. ncbi request reprint Community-acquired methicillin-resistant Staphylococcus aureus in Switzerland: first surveillance report
    C Aramburu
    European Programme for Intervention Epidemiology Training, Geneva, Switzerland
    Euro Surveill 11:42-3. 2006
    ..Prevention and control of CA-MRSA infections represent a challenge for the future, requiring contact tracing, education and treatment of infected and colonised contacts...
  85. ncbi request reprint Is anti-tumor necrosis factor therapy associated with increased mortality in patients with severe sepsis caused by pneumonia?
    Stephan Harbarth
    J Infect Dis 189:1743. 2004
  86. pmc Antibiotic selection pressure and resistance in Streptococcus pneumoniae and Streptococcus pyogenes
    Werner C Albrich
    Emory University School of Medicine, Atlanta, Georgia, USA
    Emerg Infect Dis 10:514-7. 2004
    ..75; p < 0.001), as was macrolide use with MRSP (r = 0.88; p < 0.001) and MRGAS (r = 0.71; p = 0.004). Streptococcal resistance is directly associated with antibiotic selection pressure on a national level...
  87. pmc G-CSF and IL-8 for early diagnosis of sepsis in neonates and critically ill children - safety and cost effectiveness of a new laboratory prediction model: study protocol of a randomized controlled trial [ISRCTN91123847]
    Thomas Horisberger
    Department of Neonatology and Intensive Care, University Children s Hospital, Zurich, Switzerland
    Crit Care 8:R443-50. 2004
    ..Therefore, we will test the clinical efficacy of a previously validated diagnostic strategy to reduce antibiotic usage and nosocomial infection related morbidity...
  88. ncbi request reprint Effect of individual- and group-level antibiotic exposure on MRSA isolation: a multilevel analysis
    Arno Muller
    Service d Hygiène Hospitalière et d Épidémiologie Moléculaire, Centre Hospitalier Universitaire Jean Minjoz, 25030 Besancon, France
    J Antimicrob Chemother 58:878-81. 2006
    ..To observe the relative role of individual and group-level antimicrobial selective pressure on subsequent methicillin-resistant Staphylococcus aureus (MRSA) isolation in a university hospital...
  89. ncbi request reprint Use of procalcitonin to shorten antibiotic treatment duration in septic patients: a randomized trial
    Vandack Nobre
    Intensive Care, University Hospital of Geneva, 24, Micheli du Crest, 1211 Geneva 14, Switzerland
    Am J Respir Crit Care Med 177:498-505. 2008
    ..The duration of antibiotic therapy in critically ill patients with sepsis can result in antibiotic overuse, increasing the risk of developing bacterial resistance...
  90. pmc Mid-regional pro-adrenomedullin as a prognostic marker in sepsis: an observational study
    Mirjam Christ-Crain
    Department of Internal Medicine, University Hospital Basel, Petersgraben 4, 4031 Basel, Switzerland
    Crit Care 9:R816-24. 2005
    ..The aim of the present study was to evaluate the prognostic value of mid-regional pro-adrenomedullin (MR-proADM) levels in a cohort of medical intensive care patients and to compare it with other biomarkers and physiological scores...
  91. ncbi request reprint Procalcitonin guidance of antibiotic therapy in community-acquired pneumonia: a randomized trial
    Mirjam Christ-Crain
    Department of Internal Medicine, University Hospital, Basel, Switzerland
    Am J Respir Crit Care Med 174:84-93. 2006
    ..In patients with community-acquired pneumonia, guidelines recommend antibiotic treatment for 7 to 21 d. Procalcitonin is elevated in bacterial infections, and its dynamics have prognostic implications...
  92. ncbi request reprint Long-term reduction of vascular access-associated bloodstream infection
    Philippe Eggimann
    Ann Intern Med 142:875-6. 2005
  93. ncbi request reprint [The effect of antimicrobial use on emergence and selection of resistance]
    Stephan Harbarth
    Universitätsspitals Genf, Switzerland
    Anasthesiol Intensivmed Notfallmed Schmerzther 42:130-5. 2007
    ..Excessive antibiotic use has individual and ecologic effects that can alter clinical practice and increase treatment costs...
  94. pmc Diagnostic and prognostic accuracy of clinical and laboratory parameters in community-acquired pneumonia
    Beat Muller
    Departments of Internal Medicine, University Hospital, Petersgraben 4, CH 4031, Basel, Switzerland
    BMC Infect Dis 7:10. 2007
    ..This study aims to evaluate the diagnostic and prognostic accuracy of clinical signs and symptoms and laboratory biomarkers for CAP...
  95. ncbi request reprint Effect of design-related bias in studies of diagnostic tests for ventilator-associated pneumonia
    Sophie Michaud
    Medical Faculty of the University of Sherbrooke, Sherbrooke, Quebec, Canada
    Am J Respir Crit Care Med 166:1320-5. 2002
  96. pmc Ethics roundtable debate: A patient dies from an ICU-acquired infection related to methicillin-resistant Staphylococcus aureus--how do you defend your case and your team?
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Free University of Brussels, Belgium
    Crit Care 9:5-9. 2005
    ..The family decides to sue. We present how experts from four different countries assess the medicolegal issues involved in this case...
  97. doi request reprint Health-care workers: source, vector, or victim of MRSA?
    Werner C Albrich
    Respiratory and Meningeal Pathogens Research Unit, Chris Hani Baragwanath Hospital, University of the Witwatersrand, Johannesburg, South Africa
    Lancet Infect Dis 8:289-301. 2008
    ..We discuss advantages and disadvantages of screening and eradication policies for MRSA control and give recommendations for the management of colonised health-care workers in different settings...
  98. ncbi request reprint Control of nosocomial methicillin-resistant Staphylococcus aureus: where shall we send our hospital director next time?
    Stephan Harbarth
    Infect Control Hosp Epidemiol 24:314-6. 2003
  99. pmc The PIRO concept: R is for response
    Herwig Gerlach
    Department of Anaesthesiology and Intensive Care Medicine, Vivantes Klinikum Neukoelln, Germany
    Crit Care 7:256-9. 2003
  100. ncbi request reprint Diagnostic accuracy of G-CSF, IL-8, and IL-1ra in critically ill children with suspected infection
    Joachim E Fischer
    Department of Pediatrics, University Children s Hospital, Steinwiesstrasse 75, 8032 Zurich, Switzerland
    Intensive Care Med 28:1324-31. 2002
    ....