Susan E Hankinson

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. doi request reprint Circulating levels of sex steroids and prolactin in premenopausal women and risk of breast cancer
    Susan E Hankinson
    Harvard Medical School Channing Laboratory, Boston, MA, USA
    Adv Exp Med Biol 617:161-9. 2008
  2. pmc Reproductive aging-associated common genetic variants and the risk of breast cancer
    Chunyan He
    Department of Public Health, Indiana University School of Medicine, 980 West Walnut Street, R3 C241, Indianapolis, IN 46202, USA
    Breast Cancer Res 14:R54. 2012
  3. pmc Genetic polymorphisms of the GNRH1 and GNRHR genes and risk of breast cancer in the National Cancer Institute Breast and Prostate Cancer Cohort Consortium (BPC3)
    Federico Canzian
    German Cancer Research Center DKFZ, Heidelberg, Germany
    BMC Cancer 9:257. 2009
  4. pmc Towards an integrated model for breast cancer etiology: the lifelong interplay of genes, lifestyle, and hormones
    Susan E Hankinson
    Channing Laboratory, Department of Medicine, Harvard Medical School and Brigham and Women s Hospital, Boston, Massachusetts, USA
    Breast Cancer Res 6:213-8. 2004
  5. pmc Endogenous estrogen, testosterone and progesterone levels in relation to breast cancer risk
    Susan E Hankinson
    Channing Laboratory, Department of Medicine, 181 Longwood Avenue, Harvard Medical School, Brigham and Women s Hospital, MA 02115, USA
    J Steroid Biochem Mol Biol 106:24-30. 2007
  6. ncbi request reprint Endogenous hormones and risk of breast cancer in postmenopausal women
    Susan E Hankinson
    Channing Laboratory, Department of Medicine, Harvard Medical School and Brigham and Women s Hospital, Boston, MA 02115, USA
    Breast Dis 24:3-15. 2005
  7. pmc Circulating sex steroids and breast cancer risk in premenopausal women
    Susan E Hankinson
    Channing Laboratory, Department of Medicine, Harvard Medical School and Brigham and Women s Hospital, Boston, MA 02115, USA
    Horm Cancer 1:2-10. 2010
  8. pmc Coffee intake, variants in genes involved in caffeine metabolism, and the risk of epithelial ovarian cancer
    Joanne Kotsopoulos
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Cancer Causes Control 20:335-44. 2009
  9. ncbi request reprint Endogenous hormone levels, mammographic density, and subsequent risk of breast cancer in postmenopausal women
    Rulla M Tamimi
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Ave, Boston, MA 02115, USA
    J Natl Cancer Inst 99:1178-87. 2007
  10. ncbi request reprint No evidence of a role for PPARgamma Pro12Ala polymorphism in endometrial cancer susceptibility
    Randi A Paynter
    Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
    Pharmacogenetics 14:851-6. 2004

Collaborators

Detail Information

Publications126 found, 100 shown here

  1. doi request reprint Circulating levels of sex steroids and prolactin in premenopausal women and risk of breast cancer
    Susan E Hankinson
    Harvard Medical School Channing Laboratory, Boston, MA, USA
    Adv Exp Med Biol 617:161-9. 2008
  2. pmc Reproductive aging-associated common genetic variants and the risk of breast cancer
    Chunyan He
    Department of Public Health, Indiana University School of Medicine, 980 West Walnut Street, R3 C241, Indianapolis, IN 46202, USA
    Breast Cancer Res 14:R54. 2012
    ..Recent genome-wide association studies have identified several novel genetic loci associated with these two traits. However, the association between these loci and breast cancer risk is unknown...
  3. pmc Genetic polymorphisms of the GNRH1 and GNRHR genes and risk of breast cancer in the National Cancer Institute Breast and Prostate Cancer Cohort Consortium (BPC3)
    Federico Canzian
    German Cancer Research Center DKFZ, Heidelberg, Germany
    BMC Cancer 9:257. 2009
    ..We studied the association between breast cancer risk and polymorphisms in genes that code for GNRH1 and its receptor (GNRHR) in the large National Cancer Institute Breast and Prostate Cancer Cohort Consortium (NCI-BPC3)...
  4. pmc Towards an integrated model for breast cancer etiology: the lifelong interplay of genes, lifestyle, and hormones
    Susan E Hankinson
    Channing Laboratory, Department of Medicine, Harvard Medical School and Brigham and Women s Hospital, Boston, Massachusetts, USA
    Breast Cancer Res 6:213-8. 2004
    ..Further research is needed in many areas, but a few specific arenas are given particular mention...
  5. pmc Endogenous estrogen, testosterone and progesterone levels in relation to breast cancer risk
    Susan E Hankinson
    Channing Laboratory, Department of Medicine, 181 Longwood Avenue, Harvard Medical School, Brigham and Women s Hospital, MA 02115, USA
    J Steroid Biochem Mol Biol 106:24-30. 2007
    ..However, both positive and null associations have been observed with estrogens and progesterone and clearly more evaluation is needed...
  6. ncbi request reprint Endogenous hormones and risk of breast cancer in postmenopausal women
    Susan E Hankinson
    Channing Laboratory, Department of Medicine, Harvard Medical School and Brigham and Women s Hospital, Boston, MA 02115, USA
    Breast Dis 24:3-15. 2005
    ..In contrast, no important link has been found between circulating levels of IGF-I (and its binding protein, IGFBP-3) and breast cancer risk in postmenopausal women...
  7. pmc Circulating sex steroids and breast cancer risk in premenopausal women
    Susan E Hankinson
    Channing Laboratory, Department of Medicine, Harvard Medical School and Brigham and Women s Hospital, Boston, MA 02115, USA
    Horm Cancer 1:2-10. 2010
    ..In this review, we summarize current evidence and identify gaps and inconsistencies that need to be addressed in future studies of sex steroids and premenopausal breast cancer risk...
  8. pmc Coffee intake, variants in genes involved in caffeine metabolism, and the risk of epithelial ovarian cancer
    Joanne Kotsopoulos
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Cancer Causes Control 20:335-44. 2009
    ..Furthermore, we did not observe any clear gene-environment interactions between caffeine metabolizing genes and ovarian cancer. Future studies evaluating mechanisms by which coffee mediates this relationship are warranted...
  9. ncbi request reprint Endogenous hormone levels, mammographic density, and subsequent risk of breast cancer in postmenopausal women
    Rulla M Tamimi
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Ave, Boston, MA 02115, USA
    J Natl Cancer Inst 99:1178-87. 2007
    ..Whether mammographic density reflects levels of endogenous sex hormones is unclear. We examined whether these predictors are independently associated with breast cancer risk in a prospective study...
  10. ncbi request reprint No evidence of a role for PPARgamma Pro12Ala polymorphism in endometrial cancer susceptibility
    Randi A Paynter
    Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
    Pharmacogenetics 14:851-6. 2004
    ..Consistent with previous findings for breast cancer, these results suggest that the PPARgamma ProAla polymorphism does not play a major role in mediating circulating oestrogen levels or endometrial cancer susceptibility...
  11. pmc One-carbon metabolism factors and leukocyte telomere length
    Jason J Liu
    Departments of Epidemiology, Harvard School of Public Health, Boston, MA, USA
    Am J Clin Nutr 97:794-9. 2013
    ..Dietary and genetic factors involved in the one-carbon metabolism pathway may affect telomere length through DNA methylation and synthesis, but this has not been comprehensively investigated in epidemiologic studies...
  12. pmc Haplotypes of the estrogen receptor beta gene and breast cancer risk
    David G Cox
    Program in Molecular and Genetic Epidemiology, Epidemiology Department, Harvard School of Public Health, Boston, MA, USA
    Int J Cancer 122:387-92. 2008
    ..These data suggest that inherited variants in ESR2 (while possibly conferring a small increased risk of breast cancer) are not associated with appreciable (OR > 1.2) changes in breast cancer risk among Caucasian women...
  13. ncbi request reprint Prospective study of dietary fat and risk of cataract extraction among US women
    Minyi Lu
    Nutritional Epidemiology Program, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Am J Epidemiol 161:948-59. 2005
    ..89, 95% CI: 0.81, 0.98; p(trend) = 0.01). The authors' findings suggest that higher intake of long-chain omega-3 fatty acid (eicosapentaenoic acid and docosahexaenoic acid) and consumption of fish may modestly reduce the risk of cataract...
  14. ncbi request reprint Plasma sex hormone concentrations and subsequent risk of breast cancer among women using postmenopausal hormones
    Shelley S Tworoger
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Natl Cancer Inst 97:595-602. 2005
    ....
  15. ncbi request reprint Carbohydrate intake and glycemic index in relation to the odds of early cortical and nuclear lens opacities
    Chung Jung Chiu
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Am J Clin Nutr 81:1411-6. 2005
    ..Animal studies suggest a role for dietary carbohydrate in cataractogenesis. However, few published human studies have evaluated associations between carbohydrate nutrition and lens opacification...
  16. ncbi request reprint Polymorphisms in steroid hormone pathway genes and mammographic density
    Christopher A Haiman
    Department of Epidemiology, Harvard School of Public Health Boston, MA, USA
    Breast Cancer Res Treat 77:27-36. 2003
    ..However, our findings of differences in associations for UGT1A1 and AIB1 genotypes with breast density by menopausal status needs additional corroboration...
  17. ncbi request reprint Endogenous estrogen, androgen, and progesterone concentrations and breast cancer risk among postmenopausal women
    Stacey A Missmer
    Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    J Natl Cancer Inst 96:1856-65. 2004
    ..Nor has the relation between breast cancer risk and postmenopausal progesterone levels been investigated. We prospectively investigated these relations in a case-control study nested within the Nurses' Health Study...
  18. ncbi request reprint XRCC2 and XRCC3 polymorphisms are not associated with risk of colorectal adenoma
    Gregory J Tranah
    Department of Epidemiology, and Harvard Center for Cancer Prevention, Harvard School of Public Health, Boston, MA, USA
    Cancer Epidemiol Biomarkers Prev 13:1090-1. 2004
  19. pmc +331G/A variant in the progesterone receptor gene, postmenopausal hormone use and risk of breast cancer
    Joanne Kotsopoulos
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Int J Cancer 125:1685-91. 2009
    ..This finding adds to the evidence that the PR has an important etiologic role in breast cancer and should be evaluated in future studies...
  20. ncbi request reprint Interaction between a peroxisome proliferator-activated receptor gamma gene polymorphism and dietary fat intake in relation to body mass
    Asli Memisoglu
    Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Bldg II Rm 105, Boston, MA 02115, USA
    Hum Mol Genet 12:2923-9. 2003
    ..These data suggest that PPAR gamma genotype is an important factor in physiological responses to dietary fat in humans...
  21. pmc Common genetic variation in IGF1, IGFBP1 and IGFBP3 and ovarian cancer risk
    Kathryn L Terry
    Obstetrics and Gynecology Epidemiology Center, Department of Obstetrics and Gynecology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Carcinogenesis 30:2042-6. 2009
    ..Of particular interest was the IGFBP3 SNP rs2270628, which was associated with both increased IGF1 plasma levels and higher ovarian cancer risk...
  22. ncbi request reprint Endogenous steroid hormone concentrations and risk of breast cancer among premenopausal women
    A Heather Eliassen
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Ave, Boston, MA 02115, USA
    J Natl Cancer Inst 98:1406-15. 2006
    ..We prospectively evaluated associations between plasma sex hormone levels and breast cancer risk among premenopausal women in a case-control study nested within the Nurses' Health Study II...
  23. pmc Lycopene and other carotenoid intake in relation to risk of uterine leiomyomata
    Kathryn L Terry
    Channing Laboratory, The Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Am J Obstet Gynecol 198:37.e1-8. 2008
    ..Carotenoids have antioxidant properties and have been associated with reduced risks of some cancers. We hypothesized that carotenoid intake may reduce the risk of diagnosed uterine leiomyoma (UL)...
  24. ncbi request reprint Dairy products and ovarian cancer: a pooled analysis of 12 cohort studies
    Jeanine M Genkinger
    Department of Nutrition, Harvard School of Public Health, Room 339, Building 2, 665 Huntington Avenue, Boston, Massachusetts 02115, USA
    Cancer Epidemiol Biomarkers Prev 15:364-72. 2006
    ..Although case-control studies have reported conflicting results for dairy foods and lactose, several cohort studies have shown positive associations between skim milk, lactose, and ovarian cancer...
  25. ncbi request reprint Manganese superoxide dismutase polymorphism, plasma antioxidants, cigarette smoking, and risk of breast cancer
    Rulla M Tamimi
    Department ofEpidemiology, Harvard School of Public Health, Boston, MA, USA
    Cancer Epidemiol Biomarkers Prev 13:989-96. 2004
    ..41; 95% confidence interval 0.77-2.60; P for interaction = 0.03). These data suggest that the Ala allele of MnSOD may modify breast cancer risk among current smokers, but is not an independent risk factor for breast cancer...
  26. pmc A prospective study of dietary fat consumption and endometriosis risk
    Stacey A Missmer
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115 5804, USA
    Hum Reprod 25:1528-35. 2010
    ..Fish oil consumption has been associated with symptom improvement in studies of women with primary dysmenorrhea and with decreased endometriosis risk in autotransplantation animal studies...
  27. ncbi request reprint Dietary glycemic index and carbohydrate in relation to early age-related macular degeneration
    Chung Jung Chiu
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Am J Clin Nutr 83:880-6. 2006
    ..Several dietary factors have been linked to age-related maculopathy (ARM), the early form of age-related macular degeneration, and there is reason to think that dietary carbohydrate may play a role in the development of ARM...
  28. ncbi request reprint Reproducibility of plasma steroid hormones, prolactin, and insulin-like growth factor levels among premenopausal women over a 2- to 3-year period
    Stacey A Missmer
    Channing Laboratory, Brigham and Women s Hospital, 181 Longwood Avenue, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 15:972-8. 2006
    ..For estrone and estradiol, where ICCs were relatively low, it is important to use reproducibility data such as those to correct for measurement error in epidemiologic studies...
  29. pmc Plasma enterolactone and breast cancer risk in the Nurses' Health Study II
    Jing Xie
    Channing Division of Network Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Breast Cancer Res Treat 139:801-9. 2013
    ..This should be confirmed in future studies. ..
  30. pmc Circulating carotenoids and risk of breast cancer: pooled analysis of eight prospective studies
    A Heather Eliassen
    Channing Division of Network Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Ave, Boston, MA 02115, USA
    J Natl Cancer Inst 104:1905-16. 2012
    ..Most, but not all, past studies of circulating carotenoids and breast cancer have found an inverse association with at least one carotenoid, although the specific carotenoid has varied across studies...
  31. pmc Common genetic variation in IGF1, IGFBP-1, and IGFBP-3 in relation to mammographic density: a cross-sectional study
    Rulla M Tamimi
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Breast Cancer Res 9:R18. 2007
    ....
  32. ncbi request reprint Dietary fat consumption and primary open-angle glaucoma
    Jae H Kang
    Department of Epidemiology, Harvard School of Public Health, Channing Laboratory, 181 Longwood Avenue, Boston, MA 02115, USA
    Am J Clin Nutr 79:755-64. 2004
    ..Prostaglandin F(2alpha) analogues are effective intraocular-pressure-lowering drugs. Dietary fatty acids affect endogenous prostaglandin F(2alpha) concentrations and may thus influence intraocular pressure...
  33. ncbi request reprint The HRAS1 variable number of tandem repeats and risk of breast cancer
    Rulla M Tamimi
    Department of Epidemiology, Harvard School of Public Health, and Channing Laboratory, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Cancer Epidemiol Biomarkers Prev 12:1528-30. 2003
    ..These results suggest that there is no overall association between rare alleles of the HRAS1 VNTR and breast cancer...
  34. pmc Genetic variation in DNA repair pathway genes and premenopausal breast cancer risk
    Jiali Han
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, 181 Longwood Ave, Boston, MA 02115, USA
    Breast Cancer Res Treat 115:613-22. 2009
    ..We comprehensively evaluated genetic variants in DNA repair genes with premenopausal breast cancer risk...
  35. pmc Plasma dehydroepiandrosterone and risk of myocardial infarction in women
    John H Page
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Clin Chem 54:1190-6. 2008
    ..In this study we prospectively evaluated the relationships between plasma concentrations of dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEA-S) and subsequent myocardial infarction in women...
  36. ncbi request reprint Interaction between genetic variations in DNA repair genes and plasma folate on breast cancer risk
    Jiali Han
    Department of Nutrition, Harvard Center for Cancer Prevention, Harvard School of Public Health, Room 105, Building II, 665 Huntington Avenue, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 13:520-4. 2004
    ....
  37. ncbi request reprint Plasma vitamin B6 and the risk of colorectal cancer and adenoma in women
    Esther K Wei
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Natl Cancer Inst 97:684-92. 2005
    ..However, no previous epidemiologic studies have directly evaluated the association of plasma PLP with risk for colorectal neoplasia...
  38. pmc Variant ABO blood group alleles, secretor status, and risk of pancreatic cancer: results from the pancreatic cancer cohort consortium
    Brian M Wolpin
    Department of Medical Oncology, Dana Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 19:3140-9. 2010
    ..We hypothesized: 1) A(1) allele would confer greater risk than A(2) allele, 2) protective effect of the O allele would be equivalent for O01 and O02 variants, 3) secretor phenotype would modify the association with risk...
  39. ncbi request reprint Long-term nutrient intake and 5-year change in nuclear lens opacities
    Paul F Jacques
    Jean Mayer USDA Human Nutrition Research Center on Aging, School of Nutrition Science and Policy, Tufts University, Boston, Mass, USA
    Arch Ophthalmol 123:517-26. 2005
    ..To determine if usual nutrient intake is related to a 5-year change in the amount of lens nuclear opacification assessed by computer-assisted image analysis...
  40. ncbi request reprint A prospective study of trans fatty acids in erythrocytes and risk of coronary heart disease
    Qi Sun
    Department of Nutrition, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115, USA
    Circulation 115:1858-65. 2007
    ..We assessed the hypothesis that higher trans fatty acid contents in erythrocytes were associated with an elevated risk of CHD in a nested case-control study among US women...
  41. pmc Breast cancer susceptibility alleles and ovarian cancer risk in 2 study populations
    Margaret A Gates
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Int J Cancer 124:729-33. 2009
    ..16-1.18 per allele at the alpha=0.05 level in the pooled analysis. Our results do not provide strong support for an association between these breast cancer susceptibility alleles and epithelial ovarian cancer risk...
  42. ncbi request reprint A prospective study of plasma prolactin concentrations and risk of premenopausal and postmenopausal breast cancer
    Shelley S Tworoger
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Clin Oncol 25:1482-8. 2007
    ....
  43. ncbi request reprint Unopposed estrogen therapy and the risk of invasive breast cancer
    Wendy Y Chen
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Arch Intern Med 166:1027-32. 2006
    ..We sought to assess the relationship between longer-term use of unopposed estrogen and the risk of invasive breast cancer over an extended follow-up period...
  44. pmc The association of plasma androgen levels with breast, ovarian and endometrial cancer risk factors among postmenopausal women
    Kim N Danforth
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Int J Cancer 126:199-207. 2010
    ..Future studies are needed to clarify further which lifestyle factors modulate androgen levels...
  45. ncbi request reprint Incidence of laparoscopically confirmed endometriosis by demographic, anthropometric, and lifestyle factors
    Stacey A Missmer
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115 5804, USA
    Am J Epidemiol 160:784-96. 2004
    ....
  46. ncbi request reprint Body shape throughout life and correlations with IGFs and GH
    Eva S Schernhammer
    Channing Laboratory, Department of Medicine, Harvard Medical School, Brigham and Women s Hospital, 181 Longwood Avenue, Boston 02115, Massachusetts, USA
    Endocr Relat Cancer 14:721-32. 2007
    ..Our results suggest that childhood and adult body size may affect premenopausal breast cancer risk differently than birth weight, through associations with IGF and GH levels...
  47. ncbi request reprint Inflammatory markers and the risk of coronary heart disease in men and women
    Jennifer K Pai
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    N Engl J Med 351:2599-610. 2004
    ..The value of these inflammatory markers as independent predictors remains controversial...
  48. pmc Plasma vitamin D biomarkers and leukocyte telomere length
    Jason J Liu
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
    Am J Epidemiol 177:1411-7. 2013
    ..05). Higher plasma 25(OH)D levels may be associated with longer telomeres, and this association may be modified by calcium intake...
  49. pmc Urinary estrogens and estrogen metabolites and subsequent risk of breast cancer among premenopausal women
    A Heather Eliassen
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Cancer Res 72:696-706. 2012
    ..The inverse associations with parent estrogen metabolites and the parent estrogen metabolite/non-parent estrogen metabolite ratio suggest that women with higher urinary excretion of parent estrogens are at lower risk...
  50. pmc Talc use, variants of the GSTM1, GSTT1, and NAT2 genes, and risk of epithelial ovarian cancer
    Margaret A Gates
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 17:2436-44. 2008
    ..These results suggest that women with certain genetic variants may have a higher risk of ovarian cancer associated with genital talc use. Additional research is needed on these interactions and the underlying biological mechanisms...
  51. ncbi request reprint Relationship of plasma adiponectin with sex hormone and insulin-like growth factor levels
    Shelley S Tworoger
    Channing Laboratory, 181 Longwood Ave, 3rd Floor, Boston, MA 02115, USA
    Obesity (Silver Spring) 15:2217-24. 2007
    ....
  52. ncbi request reprint Dietary linolenic acid intake is positively associated with five-year change in eye lens nuclear density
    Minyi Lu
    Nutritional Epidemiology Program, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    J Am Coll Nutr 26:133-40. 2007
    ..The present study was designed to examine the associations between dietary fat and the change in nuclear lens opacification over five years...
  53. ncbi request reprint Physical activity and inactivity in relation to sex hormone, prolactin, and insulin-like growth factor concentrations in premenopausal women - exercise and premenopausal hormones
    Shelley S Tworoger
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Ave, 3rd Floor, Boston, MA 02115, USA
    Cancer Causes Control 18:743-52. 2007
    ..These cross-sectional results suggest that physical activity and inactivity have limited associations with premenopausal sex hormone and growth factor levels, except possibly luteal estrogens...
  54. pmc A profile of impaired insulin degradation in relation to late-life cognitive decline: a preliminary investigation
    Olivia I Okereke
    Division of Aging, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Int J Geriatr Psychiatry 24:177-82. 2009
    ..In preliminary analyses, we considered the relation of combined lower insulin secretion (c-peptide) and higher insulin--possibly a phenotype for impaired insulin degradation--to cognitive decline...
  55. ncbi request reprint Intake of zinc and antioxidant micronutrients and early age-related maculopathy lesions
    Martha Savaria Morris
    Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111, USA
    Ophthalmic Epidemiol 14:288-98. 2007
    ..Results of observational and intervention studies have been inconsistent...
  56. pmc Breast cancer susceptibility loci and mammographic density
    Rulla M Tamimi
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA, 02115, USA
    Breast Cancer Res 10:R66. 2008
    ....
  57. ncbi request reprint Endogenous sex hormones, breast cancer risk, and tamoxifen response: an ancillary study in the NSABP Breast Cancer Prevention Trial (P-1)
    Mary S Beattie
    Division of General Internal Medicine, Department of Medicine, University of California, San Francisco, CA, USA
    J Natl Cancer Inst 98:110-5. 2006
    ..The purpose of this study was to determine whether sex hormone levels were associated with breast cancer risk and with response to tamoxifen in a high-risk population...
  58. ncbi request reprint Leisure-time physical activity and reduced plasma levels of obesity-related inflammatory markers
    Tobias Pischon
    Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Obes Res 11:1055-64. 2003
    ..Furthermore, we examined the relationship between physical activity and insulin sensitivity (insulin, C-peptide, and hemoglobin A(1c) levels) and whether inflammatory markers mediate this association...
  59. ncbi request reprint Fructose, glycemic load, and quantity and quality of carbohydrate in relation to plasma C-peptide concentrations in US women
    Tianying Wu
    Department of Nutrition, Harvard School of Public Health, Boston, USA
    Am J Clin Nutr 80:1043-9. 2004
    ..However, associations between fructose and the quantity and quality of total carbohydrate intake in relation to C-peptide concentrations have not been adequately examined...
  60. ncbi request reprint Prospective study of the association between the proline to alanine codon 12 polymorphism in the PPARgamma gene and type 2 diabetes
    Asli Memisoglu
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Diabetes Care 26:2915-7. 2003
    ..To determine whether the Pro12Ala polymorphism in the PPARgamma gene was associated with risk of type 2 diabetes in the Nurses' Health Study...
  61. ncbi request reprint HSD17B1 gene polymorphisms and risk of endometrial and breast cancer
    Veronica Wendy Setiawan
    Department of Epidemiology, Harvard School of Public Health and Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Cancer Epidemiol Biomarkers Prev 13:213-9. 2004
    ..05) was suggested. These findings suggest that the HSD17B1 may be associated with circulating estradiol levels and interact with body mass index in postmenopausal breast cancer...
  62. ncbi request reprint Epidemiology of urinary melatonin in women and its relation to other hormones and night work
    Eva S Schernhammer
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 13:936-43. 2004
    ..There is little information, however, about the interrelationships of night work, urinary melatonin levels, and levels of plasma steroid hormones in women...
  63. ncbi request reprint Long-term intake of vitamins and carotenoids and odds of early age-related cortical and posterior subcapsular lens opacities
    Allen Taylor
    Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Am J Clin Nutr 75:540-9. 2002
    ..Proper nutrition appears to protect against cataracts. Few studies have related nutrition to the odds of developing cortical or posterior subcapsular (PSC) cataracts...
  64. ncbi request reprint Plasma androgen concentrations and risk of incident ovarian cancer
    Shelley S Tworoger
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Am J Epidemiol 167:211-8. 2008
    ..bottom, relative risks were 0.65 and 0.70, respectively). Overall, these results do not support a positive association between circulating androgen levels and ovarian cancer risk...
  65. pmc Polymorphisms in the vitamin D receptor and risk of ovarian cancer in four studies
    Shelley S Tworoger
    Channing Laboratory, Boston, MA 02115, USA
    Cancer Res 69:1885-91. 2009
    ..34-1.28), and among women with the Ff or ff genotype the OR was 0.71 (95% CI, 0.43-1.18). Our results of an association with the Fok1 VDR polymorphism further support a role of the vitamin D pathway in ovarian carcinogenesis...
  66. ncbi request reprint Homocysteine as a risk factor for coronary heart diseases and its association with inflammatory biomarkers, lipids and dietary factors
    Iris Shai
    Department of Nutrition, Harvard School of Public Health, Boston, MA, USA
    Atherosclerosis 177:375-81. 2004
    ..tHcy is an independent risk predictor of CHD and modestly associated with TNF-receptors. However, the inflammatory biomarkers measured could not explain its role in CHD...
  67. pmc Prospective study of lutein/zeaxanthin intake and risk of age-related macular degeneration
    Eunyoung Cho
    Department of Medicine, Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Am J Clin Nutr 87:1837-43. 2008
    ..The association between lutein/zeaxanthin intake and age-related macular degeneration (AMD) risk may differ by smoking status, vitamin C and E intakes, and body fatness...
  68. ncbi request reprint CYP19 (aromatase) haplotypes and endometrial cancer risk
    Randi A Paynter
    Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
    Int J Cancer 116:267-74. 2005
    ..Our data suggest that there is a high-frequency CYP19 haplotype related to higher estrogen to androgen ratios and increased risk of endometrial cancer and that this association may primarily pertain to postmenopausal women...
  69. pmc Risk factors for ductal and lobular breast cancer: results from the nurses' health study
    Joanne Kotsopoulos
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Breast Cancer Res 12:R106. 2010
    ....
  70. ncbi request reprint Lipoprotein (a) and coronary heart disease among women: beyond a cholesterol carrier?
    Iris Shai
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Eur Heart J 26:1633-9. 2005
    ..We assessed the role of Lp(a) in coronary heart diseases (CHD) by a recently developed assay that is not affected by the plasminogen-like Kringle-type-2 repeats...
  71. pmc Body size across the life course, mammographic density, and risk of breast cancer
    Holly R Harris
    Obstetrics and Gynecology Epidemiology Center, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Epidemiol 174:909-18. 2011
    ..Conversely, mammographic density does not appear to explain the inverse association between childhood and adolescent body fatness and breast cancer risk...
  72. ncbi request reprint A cross-sectional study of alcohol consumption patterns and biologic markers of glycemic control among 459 women
    Candyce H Kroenke
    Department of Epidemiology, Harvard School of Public Health, and Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Diabetes Care 26:1971-8. 2003
    ....
  73. pmc Physical activity's impact on the association of fat and fiber intake with survival after breast cancer
    Michelle D Holmes
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Epidemiol 170:1250-6. 2009
    ..40), P = 0.59. Results of simple models adjusted additionally for physical activity were similar to those for full multivariate models. Results show that physical activity strongly confounds the association between diet and survival...
  74. ncbi request reprint Plasma 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D and risk of incident ovarian cancer
    Shelley S Tworoger
    Channing Laboratory, Department of Medicine, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 16:783-8. 2007
    ..However, we observed significant associations in some subgroups, which should be evaluated further in other studies because increasing vitamin D intake is an easy preventive measure to adopt...
  75. ncbi request reprint Dietary fat intake and early age-related lens opacities
    Minyi Lu
    Nutritional Epidemiology Program and the Center for Ophthalmic Research, Department of Ophthalmology, Harvard Medical School and Brigham and Women s Hospital, Boston, MA, USA
    Am J Clin Nutr 81:773-9. 2005
    ..Dietary fat may affect lens cell membrane composition and function, which are related to age-related cataract...
  76. pmc A genome-wide association study identifies novel alleles associated with hair color and skin pigmentation
    Jiali Han
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, and Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS Genet 4:e1000074. 2008
    ..The signals detected in a region around the MC1R gene were explained by MC1R red hair color alleles. Our results suggest that the IRF4 and SLC24A4 loci are associated with human hair color and skin pigmentation...
  77. ncbi request reprint Nonnarcotic analgesic use and the risk of hypertension in US women
    Julien Dedier
    Section of General Internal Medicine Research Unit, Department of Medicine, Boston Medical Center, Mass, USA
    Hypertension 40:604-8; discussion 601-3. 2002
    ....
  78. pmc Body fatness at young ages and risk of breast cancer throughout life
    Heather J Baer
    Brigham and Women s Hospital, Boston, Massachusetts 02120, USA
    Am J Epidemiol 171:1183-94. 2010
    ..86 and RR = 0.92, respectively; P(heterogeneity) = 0.03). Body fatness at young ages has a strong and independent inverse relation to breast cancer risk throughout life...
  79. ncbi request reprint The androgen receptor CAG repeat polymorphism and risk of breast cancer in the Nurses' Health Study
    Christopher A Haiman
    Department of Epidemiology, Harvard Center for Cancer Prevention, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Cancer Res 62:1045-9. 2002
    ..However, these data suggest that longer AR [CAG](n) repeat alleles may increase breast cancer risk among women with a first-degree family history of breast cancer...
  80. ncbi request reprint Body iron stores and their determinants in healthy postmenopausal US women
    Jian meng Liu
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Am J Clin Nutr 78:1160-7. 2003
    ..Data on the determinants of body iron stores in middle-aged women are sparse...
  81. ncbi request reprint Associations between polymorphisms in the vitamin D receptor and breast cancer risk
    Wendy Y Chen
    Channing Laboratory, Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 14:2335-9. 2005
    ..Our results suggest that the VDR may be a mediator of breast cancer risk and could represent a target for cancer prevention efforts...
  82. ncbi request reprint Do breast-feeding and other reproductive factors influence future risk of rheumatoid arthritis? Results from the Nurses' Health Study
    Elizabeth W Karlson
    Brigham and Women s Hospital, Harvard Medical School, and Harvard School of Public Health, 75 Francis Street, Boston, MA 02115, USA
    Arthritis Rheum 50:3458-67. 2004
    ....
  83. pmc A prospective study of androgen levels, hormone-related genes and risk of rheumatoid arthritis
    Elizabeth W Karlson
    Division of Rheumatology, Immunology, and Allergy, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Arthritis Res Ther 11:R97. 2009
    ....
  84. pmc Endothelial nitric oxide synthase gene variants and primary open-angle glaucoma: interactions with sex and postmenopausal hormone use
    Jae Hee Kang
    Channing Laboratory, Department of Medicine, Harvard Medical School and Brigham and Women s Hospital, Boston, Massachusetts, USA
    Invest Ophthalmol Vis Sci 51:971-9. 2010
    ..To evaluate the association between the nitric oxide synthase gene (NOS3) variants and primary open-angle glaucoma (POAG)...
  85. ncbi request reprint Dietary fat intake and ovarian cancer in a cohort of US women
    Elizabeth R Bertone
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Am J Epidemiol 156:22-31. 2002
    ..Overall, results suggest no association between intake of any type of fat and ovarian cancer...
  86. ncbi request reprint Intake of dairy products, calcium, and vitamin d and risk of breast cancer
    Myung Hee Shin
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    J Natl Cancer Inst 94:1301-11. 2002
    ..We examined data from a large, long-term cohort study to evaluate whether high intake of dairy products, calcium, or vitamin D is associated with reduced risk of breast cancer...
  87. pmc Relationship between epidemiologic risk factors and hormone receptor expression in ovarian cancer: results from the Nurses' Health Study
    Jonathan L Hecht
    Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Cancer Epidemiol Biomarkers Prev 18:1624-30. 2009
    ..Reproductive and hormonal risk factors are associated with subgroups of ovarian cancer defined by histologic subtype or ERalpha and PR status. These finding support specific models of hormone mediated triggers of ovarian cancer...
  88. pmc Pancreatic cancer risk and ABO blood group alleles: results from the pancreatic cancer cohort consortium
    Brian M Wolpin
    Department of Medical Oncology, Dana Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA
    Cancer Res 70:1015-23. 2010
    ..68 (95% CI, 2.03-3.54) compared with nonsmokers of blood type O. We concluded that ABO genotypes were significantly associated with pancreatic cancer risk...
  89. ncbi request reprint Epoxide hydrolase polymorphisms, cigarette smoking and risk of colorectal adenoma in the Nurses' Health Study and the Health Professionals Follow-up Study
    Gregory J Tranah
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Carcinogenesis 25:1211-8. 2004
    ....
  90. ncbi request reprint Fruits and vegetables and ovarian cancer risk in a pooled analysis of 12 cohort studies
    Anita Koushik
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 14:2160-7. 2005
    ..Associations for total fruits and vegetables were similar for different histologic types. These results suggest that fruit and vegetable consumption in adulthood has no important association with the risk of ovarian cancer...
  91. ncbi request reprint Estrogen receptor beta (ESR2 ) polymorphisms and endometrial cancer (United States)
    Veronica Wendy Setiawan
    Channing Laboratory, Department of Epidemiology, Harvard School of Public Health 677 Huntington Avenue, Boston, MA 02115, USA
    Cancer Causes Control 15:627-33. 2004
    ..We validated and screened for variants in the ESR2 gene and examined whether they are associated with endometrial cancer risk...
  92. ncbi request reprint Insulin-like growth factors and ovarian cancer risk: a nested case-control study in three cohorts
    Shelley S Tworoger
    Channing Laboratory, Department of Medicine, Harvard School of Public Health, 3rd Floor, 181 Longwood Avenue, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 16:1691-5. 2007
    ..Overall, our results do not support a positive association between IGF-related proteins and ovarian cancer risk. (Cancer Epidemiol Biomarkers Prev 2007;16(8):1691-5)...
  93. ncbi request reprint Dietary patterns, the Alternate Healthy Eating Index and plasma sex hormone concentrations in postmenopausal women
    Teresa T Fung
    Department of Nutrition, Simmons College, Boston, MA 02115, USA
    Int J Cancer 121:803-9. 2007
    ..In contrast, the Western pattern was positively associated with estrogen levels and inversely with SHBG. However, these associations appeared to be largely accounted for by BMI...
  94. ncbi request reprint Nonsynonymous polymorphisms in genes in the one-carbon metabolism pathway and associations with colorectal cancer
    Anita Koushik
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 15:2408-17. 2006
    ..Our results corroborate previous findings for MTHFR Ala(222)Val and suggest that other genes involved in one-carbon metabolism, particularly those that affect DNA methylation, may be associated with colorectal cancer risk...
  95. pmc Mammographic density, plasma vitamin D levels and risk of breast cancer in postmenopausal women
    Angela K Green
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Int J Cancer 127:667-74. 2010
    ..Further research examining vitamin D, mammographic density and breast cancer risk is warranted...
  96. ncbi request reprint Combined estrogen and testosterone use and risk of breast cancer in postmenopausal women
    Rulla M Tamimi
    Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Arch Intern Med 166:1483-9. 2006
    ..Given the increasing trend in the use of hormone therapies containing androgens, we evaluated the relation between the use of estrogen and testosterone therapies and breast cancer...
  97. ncbi request reprint Weight status, abdominal adiposity, diabetes, and early age-related lens opacities
    Paul F Jacques
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging and Tufts University School of Nutrition Science and Policy, Tufts University, Boston, MA 02111, USA
    Am J Clin Nutr 78:400-5. 2003
    ..The association between weight status and the risk of lens opacities has received little attention...
  98. ncbi request reprint Comparison between plasma and erythrocyte fatty acid content as biomarkers of fatty acid intake in US women
    Qi Sun
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Am J Clin Nutr 86:74-81. 2007
    ..Erythrocyte fatty acids may be superior to plasma fatty acids for reflecting long-term fatty acid intake because of less sensitivity to recent intake and a slower turnover rate...
  99. ncbi request reprint No association between a single nucleotide polymorphism in CYP19 and breast cancer risk
    Christopher A Haiman
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Cancer Epidemiol Biomarkers Prev 11:215-6. 2002
  100. ncbi request reprint Intake of the major carotenoids and the risk of epithelial ovarian cancer in a pooled analysis of 10 cohort studies
    Anita Koushik
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Int J Cancer 119:2148-54. 2006
    ..These results suggest that consumption of the major carotenoids during adulthood does not play a major role in the incidence of ovarian cancer...
  101. pmc Energy balance, early life body size, and plasma prolactin levels in postmenopausal women
    Xuefen Su
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Ave, 3rd Floor, Boston, MA 02115, USA
    Cancer Causes Control 20:253-62. 2009
    ....