Jiali Han

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint No association between a stop codon polymorphism in RAD52 and breast cancer risk
    Jiali Han
    Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Cancer Epidemiol Biomarkers Prev 11:1138-9. 2002
  2. ncbi request reprint Interaction between genetic variations in DNA repair genes and plasma folate on breast cancer risk
    Jiali Han
    Department of Nutrition, Harvard Center for Cancer Prevention, Harvard School of Public Health, Room 105, Building II, 665 Huntington Avenue, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 13:520-4. 2004
  3. pmc Risk of a second primary cancer after non-melanoma skin cancer in white men and women: a prospective cohort study
    Fengju Song
    Department of Epidemiology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China
    PLoS Med 10:e1001433. 2013
  4. pmc ABO blood group and incidence of skin cancer
    Jing Xie
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
    PLoS ONE 5:e11972. 2010
  5. pmc Associations between rotating night shifts, sleep duration, and telomere length in women
    Geyu Liang
    Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 6:e23462. 2011
  6. pmc Pre-diagnostic plasma 25-hydroxyvitamin D levels and risk of non-melanoma skin cancer in women
    Geyu Liang
    Key Laboratory of Environmental Medicine Engineering of Ministry of Education, School of Public Health, Southeast University, Nanjing, China
    PLoS ONE 7:e35211. 2012
  7. pmc A prospective study of telomere length and the risk of skin cancer
    Jiali Han
    Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
    J Invest Dermatol 129:415-21. 2009
  8. pmc Genetic variation in DNA repair pathway genes and premenopausal breast cancer risk
    Jiali Han
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, 181 Longwood Ave, Boston, MA 02115, USA
    Breast Cancer Res Treat 115:613-22. 2009
  9. pmc A germline variant in the interferon regulatory factor 4 gene as a novel skin cancer risk locus
    Jiali Han
    Clinical Research Program, Department of Dermatology, Brigham and Women s Hospital, and Harvard Medical School, Boston, Massachusetts, USA
    Cancer Res 71:1533-9. 2011
  10. ncbi request reprint Melanocortin 1 receptor variants and skin cancer risk
    Jiali Han
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Int J Cancer 119:1976-84. 2006

Detail Information

Publications78

  1. ncbi request reprint No association between a stop codon polymorphism in RAD52 and breast cancer risk
    Jiali Han
    Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Cancer Epidemiol Biomarkers Prev 11:1138-9. 2002
  2. ncbi request reprint Interaction between genetic variations in DNA repair genes and plasma folate on breast cancer risk
    Jiali Han
    Department of Nutrition, Harvard Center for Cancer Prevention, Harvard School of Public Health, Room 105, Building II, 665 Huntington Avenue, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 13:520-4. 2004
    ....
  3. pmc Risk of a second primary cancer after non-melanoma skin cancer in white men and women: a prospective cohort study
    Fengju Song
    Department of Epidemiology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China
    PLoS Med 10:e1001433. 2013
    ..The purpose of this study is to prospectively examine the risk of primary cancer according to personal history of NMSC...
  4. pmc ABO blood group and incidence of skin cancer
    Jing Xie
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
    PLoS ONE 5:e11972. 2010
    ..Previous studies have examined the association between ABO blood group and the risk of some malignancies. However, no prospective cohort study to date has examined the association between ABO blood group and the risk of skin cancer...
  5. pmc Associations between rotating night shifts, sleep duration, and telomere length in women
    Geyu Liang
    Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 6:e23462. 2011
    ..Telomere length has been proposed as a marker of aging. However, our knowledge of lifestyle risk factors determining telomere length is limited...
  6. pmc Pre-diagnostic plasma 25-hydroxyvitamin D levels and risk of non-melanoma skin cancer in women
    Geyu Liang
    Key Laboratory of Environmental Medicine Engineering of Ministry of Education, School of Public Health, Southeast University, Nanjing, China
    PLoS ONE 7:e35211. 2012
    ..Recent reports have shown that vitamin D status was inversely associated with the risk of various cancers. However, few studies examined the association between vitamin D levels and risk of skin cancer...
  7. pmc A prospective study of telomere length and the risk of skin cancer
    Jiali Han
    Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
    J Invest Dermatol 129:415-21. 2009
    ..85 (95% CI, 0.94-3.62) (P, trend=0.09). The opposing associations observed should be interpreted with caution, and further research is needed to confirm these possible associations...
  8. pmc Genetic variation in DNA repair pathway genes and premenopausal breast cancer risk
    Jiali Han
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, 181 Longwood Ave, Boston, MA 02115, USA
    Breast Cancer Res Treat 115:613-22. 2009
    ..We comprehensively evaluated genetic variants in DNA repair genes with premenopausal breast cancer risk...
  9. pmc A germline variant in the interferon regulatory factor 4 gene as a novel skin cancer risk locus
    Jiali Han
    Clinical Research Program, Department of Dermatology, Brigham and Women s Hospital, and Harvard Medical School, Boston, Massachusetts, USA
    Cancer Res 71:1533-9. 2011
    ..6 × 10(-3)). Given that the T allele was shown previously to be associated with increased expression of IRF4 locus, further studies are warranted to elucidate the role of the IRF4 gene in human pigmentation and skin cancer development...
  10. ncbi request reprint Melanocortin 1 receptor variants and skin cancer risk
    Jiali Han
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Int J Cancer 119:1976-84. 2006
    ..004 and 0.05, respectively). These findings indicated that the effects of the MC1R variants on skin cancer risk were independent from self-reported phenotypic pigmentation...
  11. ncbi request reprint Manganese superoxide dismutase polymorphism and risk of skin cancer (United States)
    Jiali Han
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Ave, Boston, MA, 02115, USA
    Cancer Causes Control 18:79-89. 2007
    ..We assessed whether the functional V16A polymorphism in the MnSOD gene is associated with skin cancer risk...
  12. ncbi request reprint Polymorphisms in the MTHFR and VDR genes and skin cancer risk
    Jiali Han
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Carcinogenesis 28:390-7. 2007
    ..Due to a large number of comparisons and tests, the possible associations should be interpreted with caution and confirmed by other studies...
  13. ncbi request reprint Risk factors for skin cancers: a nested case-control study within the Nurses' Health Study
    Jiali Han
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Int J Epidemiol 35:1514-21. 2006
    ..Constitutional factors and sun exposure are associated with skin cancer risk. However, these relations are complex and differ according to skin cancer type...
  14. ncbi request reprint Polymorphisms in O6-methylguanine DNA methyltransferase and breast cancer risk
    Jiali Han
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Pharmacogenet Genomics 16:469-74. 2006
    ..We also evaluated the potential interactions between the two polymorphisms and estrogen-related risk factors and cigarette smoking on breast cancer risk...
  15. ncbi request reprint Polymorphisms in O6-methylguanine DNA methyltransferase and endometrial cancer risk
    Jiali Han
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School 181 Longwood Avenue, Boston, MA 02115, USA
    Carcinogenesis 27:2281-5. 2006
    ..41; 95%CI, 0.19-0.86). These data suggest that these two polymorphisms may influence endometrial cancer risk...
  16. ncbi request reprint Polymorphisms in DNA double-strand break repair genes and skin cancer risk
    Jiali Han
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, and Harvard Medical School, Boston, Massachusetts 02115, USA
    Cancer Res 64:3009-13. 2004
    ..05 for SCC, <0.0001 for BCC). The main effects of these genotypes were essentially null for melanoma risk. This study provides evidence to suggest the role of the DSB repair pathway in skin cancer development, especially for BCC...
  17. pmc Genetic variation in XRCC1, sun exposure, and risk of skin cancer
    J Han
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, and Harvard Medical School, 181 Longwood Ave, Boston, MA 02115, USA
    Br J Cancer 91:1604-9. 2004
    ..These two polymorphisms were not associated with BCC or melanoma risk. Our data suggest that the Arg194Trp and Arg399Gln polymorphisms may be differently associated with skin cancer risk according to exposure dose and skin cancer type...
  18. ncbi request reprint Genetic variation in XPD, sun exposure, and risk of skin cancer
    Jiali Han
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, Massachusetts 02115, USA
    Cancer Epidemiol Biomarkers Prev 14:1539-44. 2005
    ..03, 0.04, and 0.02 respectively). Similar interactions were also observed for the Asp312Asn. Our data suggest these two XPD nonsynonymous polymorphisms may be associated with skin cancer risk, especially for melanoma...
  19. ncbi request reprint Lack of associations of selected variants in genes involved in cell cycle and apoptosis with skin cancer risk
    Jiali Han
    Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 15:592-3. 2006
  20. pmc Genome-wide association studies identify several new loci associated with pigmentation traits and skin cancer risk in European Americans
    Mingfeng Zhang
    Clinical Research Program, Department of Dermatology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Hum Mol Genet 22:2948-59. 2013
    ..0 × 10(-8); P = 6.6 × 10(-7) in the discovery set and P = 3.0 × 10(-3) in the replication set) and rs8015138 upstream of GNG2 (P = 6.6 × 10(-8); P = 5.3 × 10(-7) in the discovery set and P = 0.01 in the replication set). ..
  21. pmc Genetic variants in pigmentation genes, pigmentary phenotypes, and risk of skin cancer in Caucasians
    Hongmei Nan
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Int J Cancer 125:909-17. 2009
    ..Our study provides evidence for the contribution of pigmentation genetic variants, in addition to the MC1R variants, to variation in human pigmentary phenotypes and possibly the development of skin cancer...
  22. pmc Genome-wide association study of tanning phenotype in a population of European ancestry
    Hongmei Nan
    Channing Laboratory, Department of Medicine, Harvard Medical School, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Invest Dermatol 129:2250-7. 2009
    ..Overall, these tanning ability-related loci are similar to the hair color-related loci previously reported in the GWAS of hair color...
  23. pmc Missense polymorphisms in matrix metalloproteinase genes and skin cancer risk
    Hongmei Nan
    Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 17:3551-7. 2008
    ..No associations were found for other SNPs with skin cancer risk. This study provides evidence for the contribution of the MMP9 Arg668Gln to SCC development...
  24. ncbi request reprint Polymorphisms in DNA double-strand break repair genes and breast cancer risk in the Nurses' Health Study
    Jiali Han
    Department of Nutrition, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
    Carcinogenesis 25:189-95. 2004
    ..The gene-environment interaction data suggest that the subtle effects of some of these variants on breast cancer risk may be magnified in the presence of certain exposures...
  25. pmc Genome-wide association study identifies novel alleles associated with risk of cutaneous basal cell carcinoma and squamous cell carcinoma
    Hongmei Nan
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Hum Mol Genet 20:3718-24. 2011
    ..21 (1.02-1.44); P= 0.03], were associated with an increased risk of SCC. These two variants were not associated with melanoma risk. We conclude that 6p25 and 13q32 are novel loci conferring susceptibility to non-melanoma skin cancer...
  26. pmc A genome-wide association study identifies novel alleles associated with hair color and skin pigmentation
    Jiali Han
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, and Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS Genet 4:e1000074. 2008
    ..The signals detected in a region around the MC1R gene were explained by MC1R red hair color alleles. Our results suggest that the IRF4 and SLC24A4 loci are associated with human hair color and skin pigmentation...
  27. pmc Obesity-related genetic variants, human pigmentation, and risk of melanoma
    Xin Li
    Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
    Hum Genet 132:793-801. 2013
    ..But none of them was associated with obesity or in linkage disequilibrium with obesity-related variants. FTO locus may confer variation in human pigmentation and risk of melanoma, which may be independent of its effect on obesity...
  28. ncbi request reprint Genetic variations in XRCC2 and XRCC3 are not associated with endometrial cancer risk
    Jiali Han
    Department of Nutrition and Harvard Center for Cancer Prevention, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Cancer Epidemiol Biomarkers Prev 13:330-1. 2004
  29. pmc Genome-wide association study identifies nidogen 1 (NID1) as a susceptibility locus to cutaneous nevi and melanoma risk
    Hongmei Nan
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Hum Mol Genet 20:2673-9. 2011
    ..5 × 10(-6)) and in primary melanoma (P = 4.6 × 10(-4)) compared with the normal skin...
  30. doi request reprint A genome-wide association study of severe teenage acne in European Americans
    Mingfeng Zhang
    Department of Dermatology, Clinical Research Program, Brigham and Women s Hospital, and Harvard Medical School, 181 Longwood Avenue, Boston, MA, 02115, USA
    Hum Genet 133:259-64. 2014
    ..01 (95 % confidence interval = 2.37-6.82). Upon further replication, our findings suggest new genetic basis of acne and may explain the association between acne and cancer risk observed in the epidemiological studies...
  31. pmc Use of tanning beds and incidence of skin cancer
    Mingfeng Zhang
    Brigham and Women s Hospital, Boston, MA, USA
    J Clin Oncol 30:1588-93. 2012
    ..We sought to evaluate the risk effect of tanning bed use on skin cancers among teenage and young adults. We also expected to determine whether a dose-response relationship was evident...
  32. pmc ASIP genetic variants and the number of non-melanoma skin cancers
    Wen Lin
    Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
    Cancer Causes Control 22:495-501. 2011
    ..32; 95% CI, 1.07-1.63). The OR increased to 1.45(1.18-1.78) for those with 2-4 NMSCs and 1.84(1.34-2.53) for those with at least five. The findings suggest that ASIP locus is associated with the number of NMSCs...
  33. ncbi request reprint A prospective study of XRCC1 haplotypes and their interaction with plasma carotenoids on breast cancer risk
    Jiali Han
    Department of Nutrition, Harvard Center for Cancer Prevention, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Cancer Res 63:8536-41. 2003
    ....
  34. pmc Interleukin and interleukin receptor gene polymorphisms and susceptibility to melanoma
    Fangyi Gu
    Department of aEpidemiology, Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Melanoma Res 18:330-5. 2008
    ..93 to 1.03. We did not find significant results for the SNPs in the other four genes. These data suggest the involvement of IL-6R in melanoma development. Further studies are needed to confirm these findings...
  35. ncbi request reprint The p53 codon 72 polymorphism, sunburns, and risk of skin cancer in US Caucasian women
    Jiali Han
    Department of Medicine, Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Carcinog 45:694-700. 2006
    ..This study suggests that the Arg72Pro polymorphism may play a role in skin carcinogenesis...
  36. pmc Shorter telomeres associate with a reduced risk of melanoma development
    Hongmei Nan
    Channing Laboratory, Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Cancer Res 71:6758-63. 2011
    ..43 (95% CI: 0.28-0.68; P(trend), 0.0003). Unlike findings for other tumors, shorter telomeres were significantly associated with a decreased risk of melanoma in this study, suggesting a unique role of telomeres in melanoma development...
  37. pmc Integrating pathway analysis and genetics of gene expression for genome-wide association study of basal cell carcinoma
    Mingfeng Zhang
    Clinical Research Program, Department of Dermatology, Harvard Medical School, Brigham and Women s Hospital, Boston, MA 02115, USA
    Hum Genet 131:615-23. 2012
    ..08). Based on the evidence of biological functions of the JAK-STAT pathway on oncogenesis, it is plausible that this pathway is involved in BCC pathogenesis...
  38. pmc A functional SNP in the MDM2 promoter, pigmentary phenotypes, and risk of skin cancer
    Hongmei Nan
    Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Harvard School of Public Health, 677 Huntington Ave, Boston, MA 02115, USA
    Cancer Causes Control 20:171-9. 2009
    ..05) than p53 Arg/Arg wild-type group (p, trend, 0.99; p, interaction, 0.07). These results provide evidence for the potential involvement of MDM2 SNP309 in pigmentary traits...
  39. pmc Genetic variants in telomere-maintaining genes and skin cancer risk
    Hongmei Nan
    Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
    Hum Genet 129:247-53. 2011
    ..05). We did not observe significant associations for SCC or BCC risk. Our study provides evidence for the contribution of genetic variants in the telomere-maintaining genes to melanoma susceptibility...
  40. ncbi request reprint Association of nut consumption with total and cause-specific mortality
    Ying Bao
    From the Channing Division of Network Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School Y B, F B H, E L G, M J S, W C W, C S F, the Departments of Epidemiology F B H, E L G, M J S, W C W and Nutrition F B H, E L G, M J S, W C W, Harvard School of Public Health, and the Department of Medical Oncology, Dana Farber Cancer Institute C S F all in Boston and the Department of Epidemiology, Richard M Fairbanks School of Public Health, and Melvin and Bren Simon Cancer Center, Indiana University, Indianapolis J H
    N Engl J Med 369:2001-11. 2013
    ..Increased nut consumption has been associated with a reduced risk of major chronic diseases, including cardiovascular disease and type 2 diabetes mellitus. However, the association between nut consumption and mortality remains unclear...
  41. pmc No association between Parkinson disease alleles and the risk of melanoma
    Shasha Meng
    Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
    Cancer Epidemiol Biomarkers Prev 21:243-5. 2012
    ..It has been hypothesized that these two diseases may share common genetic and environmental risk factors...
  42. pmc No association between telomere length in peripheral blood leukocytes and the risk of nonmelanoma skin cancer
    Geyu Liang
    Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 20:1043-5. 2011
    ..Recent reports have shown that telomere length was associated with the risk of various cancers, but the results have been inconsistent...
  43. pmc Exonuclease 1 (EXO1) gene variation and melanoma risk
    Fengju Song
    Department of Epidemiology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China
    DNA Repair (Amst) 11:304-9. 2012
    ..This study aimed to identify novel SNPs in the DNA repair-related genes associated with melanoma risk from a genome-wide association study (GWAS)...
  44. pmc Plasma vitamin D biomarkers and leukocyte telomere length
    Jason J Liu
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
    Am J Epidemiol 177:1411-7. 2013
    ..05). Higher plasma 25(OH)D levels may be associated with longer telomeres, and this association may be modified by calcium intake...
  45. pmc Smoking and risk of skin cancer: a prospective analysis and a meta-analysis
    Fengju Song
    Department of Epidemiology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China
    Int J Epidemiol 41:1694-705. 2012
    ..The association between smoking and the risk of skin cancer has not been well established...
  46. pmc Genetically determined ABCB5 functionality correlates with pigmentation phenotype and melanoma risk
    Jennifer Y Lin
    Department of Dermatology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Biochem Biophys Res Commun 436:536-42. 2013
    ..Moreover, they provide a first example that functional variation in a prospective cancer stem cell marker can be associated with disease risk for the corresponding malignancy. ..
  47. doi request reprint The association between physical activity and the risk of incident psoriasis
    Hillary C Frankel
    Department of Dermatology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Arch Dermatol 148:918-24. 2012
    ..To examine the association between total physical activity, walking, and vigorous exercise and the incidence of psoriasis in women...
  48. pmc Genetic variation in DNA repair pathway genes and melanoma risk
    Mingfeng Zhang
    Clinical Research Program, Department of Dermatology, Brigham and Women s Hospital, and Harvard Medical School, Boston, MA, USA
    DNA Repair (Amst) 10:111-6. 2011
    ..Further work on fine-mapping and on the functional characterization of this and linked SNPs in this region is required...
  49. pmc Physical activity, sedentary behavior, and leukocyte telomere length in women
    Mengmeng Du
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Am J Epidemiol 175:414-22. 2012
    ..Although associations were modest, these findings suggest that even moderate amounts of activity may be associated with longer telomeres, warranting further investigation in large prospective studies...
  50. pmc Genetic variants in FGFR2 and FGFR4 genes and skin cancer risk in the Nurses' Health Study
    Hongmei Nan
    Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    BMC Cancer 9:172. 2009
    ..Overexpression of the FGFR4 protein has been linked to cutaneous melanoma progression. Previous studies reported associations between genetic variants in the FGFR2 and FGFR4 genes and development of various cancers...
  51. pmc Comprehensive screen of genetic variation in DNA repair pathway genes and postmenopausal breast cancer risk
    Genevieve M Monsees
    Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115, USA
    Breast Cancer Res Treat 125:207-14. 2011
    ..85. Common variation alone in DNA repair genes plays at most a small role in determining postmenopausal breast cancer risk among women of European ancestry...
  52. pmc Smoking and risk of incident psoriasis among women and men in the United States: a combined analysis
    Wenqing Li
    Department of Dermatology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Am J Epidemiol 175:402-13. 2012
    ..0001). In this study, smoking was found to be an independent risk factor for psoriasis in both women and men. Psoriasis risk was particularly augmented for heavy smokers and persons with longer durations of smoking...
  53. pmc Rotating night shifts and risk of skin cancer in the nurses' health study
    Eva S Schernhammer
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School Boston, MA 02115, USA
    J Natl Cancer Inst 103:602-6. 2011
    ..005). Hair color, a surrogate for an individual's susceptibility to skin cancer, was a statistically significant effect modifier for the observed associations; darker-haired women had the lowest risk (P(interaction) = .02)...
  54. pmc Genetic determinants of hair color and Parkinson's disease risk
    Xiang Gao
    Department of Nutrition, Harvard University School of Public Health, Boston, MA, USA
    Ann Neurol 65:76-82. 2009
    ....
  55. pmc Genome-wide association study identifies novel loci predisposing to cutaneous melanoma
    Christopher I Amos
    Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Hum Mol Genet 20:5012-23. 2011
    ..3 rs7412746 (P = 6 × 10(-10)). Together, these data identified several candidate genes for additional studies to identify causal variants predisposing to increased risk for developing melanoma...
  56. pmc Personal history of prostate cancer and increased risk of incident melanoma in the United States
    Wen Qing Li
    Wen Qing Li and Alisa M Goldstein, National Cancer Institute, National Institutes of Health, Rockville, MD Wen Qing Li, Abrar A Qureshi, Jing Ma, Edward L Giovannucci, Meir J Stampfer, and Jiali Han, Brigham and Women s Hospital, Harvard Medical School Edward L Giovannucci and Meir J Stampfer, Harvard School of Public Health, Boston, MA Jiali Han, Richard M Fairbanks School of Public Health, Simon Cancer Center, Indiana University, Indianapolis, IN and Jiali Han, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China
    J Clin Oncol 31:4394-9. 2013
    ..These findings suggest a possible relationship between PCa and risk of melanoma. We prospectively evaluated this association among US men...
  57. doi request reprint Smoking and risk of incident psoriatic arthritis in US women
    Wenqing Li
    Department of Dermatology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Ann Rheum Dis 71:804-8. 2012
    ..Previous studies have found an association between smoking and psoriasis, but the association with PsA is unclear. The authors aimed to evaluate the association between smoking and the risk of incident PsA in a large cohort of women...
  58. pmc A prospective study of genetic polymorphism in MPO, antioxidant status, and breast cancer risk
    Chunyan He
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Breast Cancer Res Treat 113:585-94. 2009
    ..Further research is needed to confirm these possible associations...
  59. pmc PGC-1 coactivators regulate MITF and the tanning response
    Jonathan Shoag
    Cardiovascular Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
    Mol Cell 49:145-57. 2013
    ..These data identify PGC-1 coactivators as regulators of human tanning...
  60. doi request reprint Obesity and risk of incident psoriatic arthritis in US women
    Wenqing Li
    Department of Dermatology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Ann Rheum Dis 71:1267-72. 2012
    ..This study aimed to evaluate the association between obesity and the risk of incident PsA in a large cohort of women...
  61. doi request reprint Factors predictive of recurrence and death from cutaneous squamous cell carcinoma: a 10-year, single-institution cohort study
    Chrysalyne D Schmults
    Department of Dermatology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    JAMA Dermatol 149:541-7. 2013
    ..Although most cases of cutaneous squamous cell carcinoma (CSCC) are easily cured with surgery or ablation, a subset of these tumors recur, metastasize, and cause death. We conducted the largest study of CSCC outcomes since 1968...
  62. doi request reprint Current opportunities and challenges: genome-wide association studies on pigmentation and skin cancer
    Shasha Meng
    Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
    Pigment Cell Melanoma Res 25:612-7. 2012
    ..Furthermore, we summarize recent developments in post-GWAS activities such as meta-analysis, pathway analysis, and risk prediction...
  63. doi request reprint Geographical variation in residence and risk of multiple nonmelanoma skin cancers in US women and men
    Erin X Wei-Passanese
    Harvard Medical School, Boston, MA, USA
    Photochem Photobiol 88:483-9. 2012
    ..In conclusion, we found that consistent residence in medium- or high-UVR locations was significantly associated an incremental risk of ≥2 NMSCs later in life...
  64. pmc Psoriasis and risk of type 2 diabetes among women and men in the United States: a population-based cohort study
    Wenqing Li
    Department of Dermatology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Invest Dermatol 132:291-8. 2012
    ..In addition, the risk of T2D was much higher for those developing psoriasis at an early age. In conclusion, we found an association between psoriasis and the risk of T2D among individuals younger than 60 years...
  65. ncbi request reprint Heterogeneity in host risk factors for incident melanoma and non-melanoma skin cancer in a cohort of US women
    Abrar A Qureshi
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    J Epidemiol 21:197-203. 2011
    ..Melanoma, squamous cell carcinoma (SCC), and basal cell carcinoma (BCC) are 3 types of skin cancer that have distinct biologic characteristics and prognoses. We evaluated phenotypic differences in the risk of these cancers in US women...
  66. ncbi request reprint Genetic association and functional studies of major polymorphic variants of MGMT
    James M Bugni
    Biological Engineering Division, Biology Department, and Center for Environmental Health Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA
    DNA Repair (Amst) 6:1116-26. 2007
    ..Overall, the effects of polymorphic variation on protein function are subtle, and further investigation is required to provide a comprehensive mechanism that explains the observed associations of these variants with risk for cancer...
  67. pmc High phobic anxiety is related to lower leukocyte telomere length in women
    Olivia I Okereke
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 7:e40516. 2012
    ..Yet, little is known about relations of anxiety to telomeres. We examined whether a typically chronic form of anxiety--phobic anxiety--is related to telomere length...
  68. pmc Pathway analysis for genome-wide association study of basal cell carcinoma of the skin
    Mingfeng Zhang
    Department of Dermatology, Clinical Research Program, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 6:e22760. 2011
    ..Recently, a pathway-based approach has been developed to evaluate the cumulative contribution of the functionally related genes for genome-wide association studies (GWASs), which may help utilize GWAS data to a greater extent...
  69. pmc Genome-wide association study of relative telomere length
    Jennifer Prescott
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 6:e19635. 2011
    ..10, such as those for variants at the TERC locus. In general, common genetic variants associated with telomere length homeostasis have been difficult to detect. Potential biological and technical issues are discussed...
  70. pmc Family history of melanoma and Parkinson disease risk
    X Gao
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Neurology 73:1286-91. 2009
    ..If this was due to common genetic mechanisms, a positive family history of melanoma would be associated with an excessive PD risk, independent of environmental risk factors for PD...
  71. doi request reprint BOLD signal responses to controlled hypercapnia in human spinal cord
    J Cohen-Adad
    Unité de Neuroimagerie Fonctionnelle, Centre de Recherche, Institut Universitaire de Geriatrie de Montreal, Department of Physiology, Universite de Montreal, Montreal, Canada
    Neuroimage 50:1074-84. 2010
    ..Finely, we believe that the use of controlled global stimuli, such as hypercapnia, will help assess the effectiveness of new acquisition techniques...
  72. pmc Interaction between p53 codon 72 polymorphism and melanocortin 1 receptor variants on suntan response and cutaneous melanoma risk
    H Nan
    Department of Epidemiology, Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, 677 Huntington Ave, Boston, MA 02115, USA
    Br J Dermatol 159:314-21. 2008
    ..The common p53 codon 72 polymorphism alters the protein's transcriptional activity, which may influence the UV radiation-induced tanning response...
  73. doi request reprint Increased caffeine intake is associated with reduced risk of basal cell carcinoma of the skin
    Fengju Song
    Department of Dermatology, Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cancer Res 72:3282-9. 2012
    ..In contrast, caffeine intake was not found to be inversely associated with risks of SCC or melanoma. Our findings argue that caffeine intake in men and women is inversely associated with risk of BCC...
  74. doi request reprint Cutaneous squamous cell carcinoma: estimated incidence of disease, nodal metastasis, and deaths from disease in the United States, 2012
    Pritesh S Karia
    Department of Dermatology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02130, USA
    J Am Acad Dermatol 68:957-66. 2013
    ..However, CSCC has been excluded from national cancer registries. Thus the precise incidence of CSCC, along with metastases and deaths resulting from it, is unknown...
  75. pmc Alcohol intake and risk of incident psoriasis in US women: a prospective study
    Abrar A Qureshi
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Arch Dermatol 146:1364-9. 2010
    ..To evaluate the independent association between alcohol consumption and risk of developing psoriasis and to determine if this risk is associated with different types of alcoholic beverages...
  76. ncbi request reprint Ultraviolet radiation exposure and risk of non-Hodgkin's lymphoma
    Yawei Zhang
    Yale University School of Epidemiology and Public Health, New Haven, CT 06520 8034, USA
    Am J Epidemiol 165:1255-64. 2007
    ..0051). The risk appears to vary by non-Hodgkin's lymphoma subtypes. Further investigations of the role of ultraviolet radiation on the risk of non-Hodgkin's lymphoma are warranted...
  77. ncbi request reprint Comprehensive association testing of common genetic variation in DNA repair pathway genes in relationship with breast cancer risk in multiple populations
    Christopher A Haiman
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA
    Hum Mol Genet 17:825-34. 2008
    ..The methods utilized in this study, applied to multiple populations, provide a framework for testing in association studies in diverse populations...

Research Grants13

  1. Genetic Variants in Immunological Mediator Genes and Skin Cancer Risk
    Jiali Han; Fiscal Year: 2007
    ..This research will contribute to the scientific basis for identifying individuals at high-risk for skin cancer and providing individualized risk management strategies. ..
  2. Prospective Study of DNA Repair Gene Variants in Breast Cancer
    Jiali Han; Fiscal Year: 2009
    ..This innovative work is essential to advance this field, and it has substantial potential for application to other areas of cancer susceptibility. ..
  3. Cohort Study of Genetic Susceptibility to Cutaneous Malignant Melanoma
    Jiali Han; Fiscal Year: 2010
    ..This research will contribute to the scientific basis for identifying individuals at high risk for melanoma and providing individualized risk management strategies. ..
  4. Cohort Study of Genetic Susceptibility to Cutaneous Malignant Melanoma
    Jiali Han; Fiscal Year: 2009
    ..This research will contribute to the scientific basis for identifying individuals at high risk for melanoma and providing individualized risk management strategies. ..
  5. Cohort Study of Genetic Susceptibility to Cutaneous Malignant Melanoma
    Jiali Han; Fiscal Year: 2009
    ..This research will contribute to the scientific basis for identifying individuals at high risk for melanoma and providing individualized risk management strategies. ..
  6. Genetic Variants in Pigmentation Genes and Skin Cancer Risk
    Jiali Han; Fiscal Year: 2007
    ..This research will contribute to the scientific basis for identifying high-risk individuals for skin cancer and providing individualized risk management strategies. ..
  7. Prospective Study of DNA Repair Gene Variants in Breast Cancer
    Jiali Han; Fiscal Year: 2007
    ..This innovative work is essential to advance this field, and it has substantial potential for application to other areas of cancer susceptibility. ..
  8. Nucleotide Excision Repair Gene Variants and Skin Cancer
    Jiali Han; Fiscal Year: 2005
    ..abstract_text> ..