Pedram Hamrah

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Acute Herpetic Keratitis: What is the Role for Ganciclovir Ophthalmic Gel?
    Afsun Sahin
    Ocular Surface Imaging Center, Cornea and Refractive Surgery Service, Massachusetts Eye and Ear Infirmary, and Department of Ophthalmology, Harvard Medical School, Boston, MA Eskisehir Osmangazi University Medical School, Department of Ophthalmology, Eskisehir, Turkey
    Ophthalmol Eye Dis 4:23-34. 2012
  2. pmc Bilateral posterior ischemic optic neuropathy in a patient with severe diabetic ketoacidosis
    Albert E Smolyar
    Department of Ophthalmology and Visual Sciences, University of Louisville, Louisville, KY, USA
    Case Report Ophthalmol 2:91-4. 2011
  3. pmc Unilateral herpes zoster ophthalmicus results in bilateral corneal nerve alteration: an in vivo confocal microscopy study
    Pedram Hamrah
    Ocular Surface Imaging Center and Cornea and Refractive Surgery Service, Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts 02114, USA
    Ophthalmology 120:40-7. 2013
  4. pmc Cellular changes of the corneal epithelium and stroma in herpes simplex keratitis: an in vivo confocal microscopy study
    Pedram Hamrah
    Ocular Surface Imaging Center, Cornea Service, Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts 02114, USA
    Ophthalmology 119:1791-7. 2012
  5. ncbi request reprint Corneal antigen-presenting cells
    Pedram Hamrah
    Schepens Eye Research Institute, Massachusetts Eye and Ear Infirmary, and Department of Ophthalmology, Harvard Medical School, Boston, MA 02114, USA
    Chem Immunol Allergy 92:58-70. 2007
  6. pmc Corneal sensation and subbasal nerve alterations in patients with herpes simplex keratitis: an in vivo confocal microscopy study
    Pedram Hamrah
    Massachusetts Eye and Ear Infirmary, Cornea Service and Ocular Surface Imaging Center, Department of Ophthalmology, Harvard Medical School, Boston, Massachusett 02114, USA
    Ophthalmology 117:1930-6. 2010
  7. pmc Deletion of the chemokine receptor CCR1 prolongs corneal allograft survival
    Pedram Hamrah
    Laboratory of Immunology, Schepens Eye Research Institute, and the Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Boston, USA
    Invest Ophthalmol Vis Sci 48:1228-36. 2007
  8. pmc The chemokine receptor CCR7 mediates corneal antigen-presenting cell trafficking
    Yiping Jin
    Schepens Eye Research Institute and the Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, MA 02114, USA
    Mol Vis 13:626-34. 2007
  9. ncbi request reprint Alterations in corneal stromal dendritic cell phenotype and distribution in inflammation
    Pedram Hamrah
    Laboratory of Immunology, Schepens Eye Research Institute, and the Massachusetts Eye and Ear Infirmary, and the Department of Ophthalmology, Harvard Medical School, Boston, MA 02114, USA
    Arch Ophthalmol 121:1132-40. 2003
  10. pmc What is the value of incorporating tear osmolarity measurement in assessing patient response to therapy in dry eye disease?
    Francisco Amparo
    Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts
    Am J Ophthalmol 157:69-77.e2. 2014

Collaborators

Detail Information

Publications39

  1. pmc Acute Herpetic Keratitis: What is the Role for Ganciclovir Ophthalmic Gel?
    Afsun Sahin
    Ocular Surface Imaging Center, Cornea and Refractive Surgery Service, Massachusetts Eye and Ear Infirmary, and Department of Ophthalmology, Harvard Medical School, Boston, MA Eskisehir Osmangazi University Medical School, Department of Ophthalmology, Eskisehir, Turkey
    Ophthalmol Eye Dis 4:23-34. 2012
    ..In this paper, we have reviewed the pharmacology, efficacy, side effects, and the role of ganciclovir ophthalmic gel 0.15% in the treatment of acute herpetic keratitis...
  2. pmc Bilateral posterior ischemic optic neuropathy in a patient with severe diabetic ketoacidosis
    Albert E Smolyar
    Department of Ophthalmology and Visual Sciences, University of Louisville, Louisville, KY, USA
    Case Report Ophthalmol 2:91-4. 2011
    ..To report a case of bilateral posterior ischemic optic neuropathy (PION) in a patient with severe diabetic ketoacidosis (DKA)...
  3. pmc Unilateral herpes zoster ophthalmicus results in bilateral corneal nerve alteration: an in vivo confocal microscopy study
    Pedram Hamrah
    Ocular Surface Imaging Center and Cornea and Refractive Surgery Service, Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts 02114, USA
    Ophthalmology 120:40-7. 2013
    ..This study aimed to analyze bilateral corneal nerve changes in patients with HZO by in vivo confocal microscopy (IVCM) and their correlation with corneal sensation as a measure of nerve function...
  4. pmc Cellular changes of the corneal epithelium and stroma in herpes simplex keratitis: an in vivo confocal microscopy study
    Pedram Hamrah
    Ocular Surface Imaging Center, Cornea Service, Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts 02114, USA
    Ophthalmology 119:1791-7. 2012
    ..To analyze the morphologic features of corneal epithelial cells and keratocytes by in vivo confocal microscopy in patients with herpes simplex keratitis (HSK) as associated with corneal innervation...
  5. ncbi request reprint Corneal antigen-presenting cells
    Pedram Hamrah
    Schepens Eye Research Institute, Massachusetts Eye and Ear Infirmary, and Department of Ophthalmology, Harvard Medical School, Boston, MA 02114, USA
    Chem Immunol Allergy 92:58-70. 2007
    ..Additionally, one important aspect of immune privilege is likely the ocular 'imposition' of the immature phenotype on its resident bone marrow-derived cells...
  6. pmc Corneal sensation and subbasal nerve alterations in patients with herpes simplex keratitis: an in vivo confocal microscopy study
    Pedram Hamrah
    Massachusetts Eye and Ear Infirmary, Cornea Service and Ocular Surface Imaging Center, Department of Ophthalmology, Harvard Medical School, Boston, Massachusett 02114, USA
    Ophthalmology 117:1930-6. 2010
    ..To study and correlate corneal sensation in patients with herpes simplex keratitis (HSK) with density and morphologic features of subbasal corneal nerves by in vivo confocal microscopy (IVCM)...
  7. pmc Deletion of the chemokine receptor CCR1 prolongs corneal allograft survival
    Pedram Hamrah
    Laboratory of Immunology, Schepens Eye Research Institute, and the Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Boston, USA
    Invest Ophthalmol Vis Sci 48:1228-36. 2007
    ..The purpose of this study was to identify critical chemokine pathways involved in generating the alloimmune response to corneal transplants...
  8. pmc The chemokine receptor CCR7 mediates corneal antigen-presenting cell trafficking
    Yiping Jin
    Schepens Eye Research Institute and the Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, MA 02114, USA
    Mol Vis 13:626-34. 2007
    ..However, very little is known about the molecular regulation of this pathway. We investigated the expression and function of the chemokine receptor CCR7 in mediating corneal APC migration in inflammation...
  9. ncbi request reprint Alterations in corneal stromal dendritic cell phenotype and distribution in inflammation
    Pedram Hamrah
    Laboratory of Immunology, Schepens Eye Research Institute, and the Massachusetts Eye and Ear Infirmary, and the Department of Ophthalmology, Harvard Medical School, Boston, MA 02114, USA
    Arch Ophthalmol 121:1132-40. 2003
    ..The normal corneal stroma is endowed with large numbers of resident dendritic cells (DCs). The purpose of this study was to examine the phenotype and distribution of these cells in inflammation...
  10. pmc What is the value of incorporating tear osmolarity measurement in assessing patient response to therapy in dry eye disease?
    Francisco Amparo
    Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts
    Am J Ophthalmol 157:69-77.e2. 2014
    ..To evaluate the correlation between changes in tear osmolarity, symptoms, and corneal fluorescein staining in patients with dry eye disease (DED)...
  11. ncbi request reprint The corneal stroma is endowed with a significant number of resident dendritic cells
    Pedram Hamrah
    Laboratory of Immunology, Schepens Eye Research Institute, and the Department of Ophthalmology and Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts 02114, USA
    Invest Ophthalmol Vis Sci 44:581-9. 2003
    ..The purpose of this study was to examine the normal stroma for the presence of DCs and other bone marrow (BM)-derived cells...
  12. pmc Inflammation and the nervous system: the connection in the cornea in patients with infectious keratitis
    Andrea Cruzat
    Ocular Surface Imaging Center, Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts 02114, USA
    Invest Ophthalmol Vis Sci 52:5136-43. 2011
    ..To study the density and morphologic characteristics of epithelial dendritic cells, as correlated to subbasal corneal nerve alterations in acute infectious keratitis (IK) by in vivo confocal microscopy (IVCM)...
  13. pmc Nonvascular VEGF receptor 3 expression by corneal epithelium maintains avascularity and vision
    Claus Cursiefen
    Schepens Eye Research Institute, Harvard Medical School, 20 Staniford Street, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 103:11405-10. 2006
    ..VEGF receptor 3, normally present on lymphatic and proliferating blood vascular endothelium, is strongly constitutively expressed by corneal epithelium and is mechanistically responsible for suppressing inflammatory corneal angiogenesis...
  14. ncbi request reprint Novel characterization of MHC class II-negative population of resident corneal Langerhans cell-type dendritic cells
    Pedram Hamrah
    Laboratory of Immunology, Schepens Eye Research Institute and the Department of Ophthalmology, Harvard Medical School, 20 Staniford Street, Boston, MA 02114, USA
    Invest Ophthalmol Vis Sci 43:639-46. 2002
    ..The purpose of this study was to characterize the distribution and major histocompatibility complex (MHC) antigen expression of corneal LCs...
  15. ncbi request reprint Vascular endothelial growth factor receptor-3 mediates induction of corneal alloimmunity
    Lu Chen
    Laboratory of Immunology, Schepens Eye Research Institute and the Massachusetts Eye and Ear Infirmary and Department of Ophthalmology, Harvard Medical School, 20 Staniford Street, Boston, Massachusetts, USA
    Nat Med 10:813-5. 2004
    ..Regulating the function of VEGFR-3 may therefore be a mechanism for modulating adaptive immunity in the periphery...
  16. ncbi request reprint Early ocular chemokine gene expression and leukocyte infiltration after high-risk corneal transplantation
    Satoru Yamagami
    Schepens Eye Research Institute, Harvard Medical School, Boston, MA, USA
    Mol Vis 11:632-40. 2005
    ..To determine the differential gene expression of chemokine species and leukocyte infiltration of grafts in the early pre-rejection postoperative period after high-risk (HR) compared to normal-risk (NR) corneal transplantation...
  17. pmc Local treatment with alpha-melanocyte stimulating hormone reduces corneal allorejection
    Pedram Hamrah
    Schepens Eye Research Institute, Department of Ophthalmology, Harvard Medical School, Boston, MA 02114, USA
    Transplantation 88:180-7. 2009
    ..The purpose of this study was to determine the role of local therapy with alpha-MSH on corneal allograft survival, and the mechanisms by which it may influence graft outcome...
  18. ncbi request reprint Corneal immunity is mediated by heterogeneous population of antigen-presenting cells
    Pedram Hamrah
    Laboratory of Immunology, Schepens Eye Research Institute, and the Massachusetts Eye and Ear Infirmary and the Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Leukoc Biol 74:172-8. 2003
    ..These data revise the tenet that the cornea is immune-privileged as a result of lack of resident lymphoreticular cells and suggest that the cornea is capable of diverse cellular mechanisms for antigen presentation...
  19. ncbi request reprint CCR5 chemokine receptor mediates recruitment of MHC class II-positive Langerhans cells in the mouse corneal epithelium
    Satoru Yamagami
    Laboratory of Immunology, Schepens Eye Research Institute, Harvard Medical School, Boston, Massachusetts, USA
    Invest Ophthalmol Vis Sci 46:1201-7. 2005
    ....
  20. pmc Topical interleukin 1 receptor antagonist for treatment of dry eye disease: a randomized clinical trial
    Francisco Amparo
    Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA 02114, USA
    JAMA Ophthalmol 131:715-23. 2013
    ....
  21. pmc Novel expression of vascular endothelial growth factor receptor (VEGFR)-3 and VEGF-C on corneal dendritic cells
    Pedram Hamrah
    Laboratory of Immunology, Schepens Eye Research Institute and the Massachusetts Eye and Ear Infirmary and Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, USA
    Am J Pathol 163:57-68. 2003
    ..These data demonstrate, for the first time, the expression of VEGFR-3 and VEGF-C on tissue DC, which implicate a novel potential relationship between lymphangiogenesis and leukocyte trafficking in the eye...
  22. pmc Short-term topical bevacizumab in the treatment of stable corneal neovascularization
    Sheng Fu Cheng
    Cornea Service, Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, MA 02114, USA
    Am J Ophthalmol 154:940-948.e1. 2012
    ..To evaluate the safety and efficacy of topical bevacizumab in the treatment of corneal neovascularization...
  23. ncbi request reprint Expression of vascular endothelial growth factor receptor-3 (VEGFR-3) on monocytic bone marrow-derived cells in the conjunctiva
    Pedram Hamrah
    Laboratory of Immunology, Schepens Eye Research Institute, Harvard Medical School, 20 Staniford Street, Boston, MA 02114, USA
    Exp Eye Res 79:553-61. 2004
    ....
  24. ncbi request reprint Mechanisms of immunotherapeutic intervention by anti-CD154 (CD40L) antibody in high-risk corneal transplantation
    Ying Qian
    Department of Ophthalmology, The Schepens Eye Research Institute, Harvard Medical School, 20 Staniford Street, Boston, MA 02114, USA
    J Interferon Cytokine Res 22:1217-25. 2002
    ..In addition, anti-CD154 therapy suppresses ocular chemokine gene expression and leukocytic infiltration into allografts...
  25. pmc High-frequency topical cyclosporine 0.05% in the treatment of severe dry eye refractory to twice-daily regimen
    Mohammad H Dastjerdi
    Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, MA, USA
    Cornea 28:1091-6. 2009
    ..The purpose of this study was to report the efficacy of topical cyclosporine 0.05% at a frequency of 3 to 4 times daily in severe dry eye disease...
  26. pmc Bilateral nerve alterations in a unilateral experimental neurotrophic keratopathy model: a lateral conjunctival approach for trigeminal axotomy
    Takefumi Yamaguchi
    Schepens Eye Research Institute, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 8:e70908. 2013
    ..This model will allow investigating the effects of corneal nerve damage and serves as a new model for neurotrophic keratopathy...
  27. pmc Topical bevacizumab in the treatment of corneal neovascularization: results of a prospective, open-label, noncomparative study
    Mohammad H Dastjerdi
    Cornea and Refractive Surgery Service, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA
    Arch Ophthalmol 127:381-9. 2009
    ..To study the safety and efficacy of topical bevacizumab in the treatment of corneal neovascularization (NV)...
  28. pmc In vivo confocal microscopy of corneal nerves: analysis and clinical correlation
    Andrea Cruzat
    Ocular Surface Imaging Center, Cornea and Refractive Surgery Service, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA, USA
    Semin Ophthalmol 25:171-7. 2010
    ..The purpose of this review is to describe the principles, applications, and clinical correlation of IVCM in the study of corneal nerves in different ocular and systemic diseases...
  29. pmc Gene therapy in corneal transplantation
    Yureeda Qazi
    Cornea and Refractive Surgery Service, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA, USA and
    Semin Ophthalmol 28:287-300. 2013
    ..From efficient viral vectors to sustainable alternative splicing, we discuss the progress of gene therapy in promoting graft survival and postulate further avenues for gene-mediated prevention of allogeneic graft rejection...
  30. pmc In vivo imaging of corneal inflammation: new tools for clinical practice and research
    Dimosthenis Mantopoulos
    Cornea Service and Ocular Surface Imaging Center, Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, MA, USA
    Semin Ophthalmol 25:178-85. 2010
    ..To date, assessment of corneal inflammation, has only been possible by slit-lamp biomicroscopy. The purpose of this study is to review the current state of imaging technologies enabling in vivo imaging of inflammation in the cornea...
  31. pmc Clinically relevant biometry
    Afsun Sahin
    Ocular Surface Imaging Center, Cornea and Refractive Surgery Service, Massachusetts Eye and Ear Infirmary, and Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts 02114, USA
    Curr Opin Ophthalmol 23:47-53. 2012
    ..This article reviews recent advances in the field of clinical biometry and IOL power calculations...
  32. pmc Draining lymph nodes of corneal transplant hosts exhibit evidence for donor major histocompatibility complex (MHC) class II-positive dendritic cells derived from MHC class II-negative grafts
    Ying Liu
    The Laboratory of Immunology, Schepens Eye Research Institute, Harvard Medical School, Boston, MA 02114, USA
    J Exp Med 195:259-68. 2002
    ..These data refute the tenet that the cornea is immune privileged due to lack of resident lymphoreticular cells or due to antigenic sequestration from systemic immunity...
  33. pmc Image-guided evaluation and monitoring of treatment response in patients with dry eye disease
    Yureeda Qazi
    Ocular Surface Imaging Center, Cornea Service, Cornea and Refractive Surgery Service, Massachusetts Eye and Ear Infirmary, and Department of Ophthalmology, Harvard Medical School, 243 Charles Street, Boston, MA, 02114, USA
    Graefes Arch Clin Exp Ophthalmol 252:857-72. 2014
    ..Most of the currently available diagnostic tests demonstrate low correlation to patient symptoms and have low reproducibility...
  34. pmc Confocal microscopy of corneal dystrophies
    Anita N Shukla
    Ocular Surface Imaging Center, Cornea and Refractive Surgery Service, Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, MA 02114, USA
    Semin Ophthalmol 27:107-16. 2012
    ..The purpose of this review is to describe the principles, applications, and clinical correlation of IVCM in the study of corneal dystrophies...
  35. pmc Current state of in vivo confocal microscopy in management of microbial keratitis
    Radhika L Kumar
    Ocular Surface Imaging Center, Cornea and Refractive Surgey Service, Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, MA, USA
    Semin Ophthalmol 25:166-70. 2010
    ..The purpose of this study was to review the current literature on in vivo confocal microscopy of the cornea and to discuss the current clinical indications for its use in microbial keratitis...
  36. ncbi request reprint Vascular endothelial growth factor receptor-3 mediates induction of corneal alloimmunity. 2004
    Lu Chen
    Ocul Immunol Inflamm 15:275-8. 2007
  37. ncbi request reprint Expression of vascular endothelial growth factor receptor-3 (VEGFR-3) in the conjunctiva--a potential link between lymphangiogenesis and leukocyte trafficking on the ocular surface
    Pedram Hamrah
    Laboratory of Immunology, Schepens Eye Research Institute and the Department of Ophthalmology Harvard Medical School Boston, Massachusetts, USA
    Adv Exp Med Biol 506:851-60. 2002
  38. ncbi request reprint Role of immunity and inflammation in corneal and ocular surface disease associated with dry eye
    M Reza Dana
    Laboratory of Immunology Schepens Eye Research Institute and the Department of Ophthalmology Harvard Medical School Brigham and Women s Hospital Massachusetts Eye and Ear Infirmary Boston, Massachusetts, USA
    Adv Exp Med Biol 506:729-38. 2002