M Hammerschmidt

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi Mutations affecting morphogenesis during gastrulation and tail formation in the zebrafish, Danio rerio
    M Hammerschmidt
    Max Planck Institut fur Entwicklungsbiologie, Abteilung fur Genetik, Tubingen, Germany
    Development 123:143-51. 1996
  2. ncbi dino and mercedes, two genes regulating dorsal development in the zebrafish embryo
    M Hammerschmidt
    Max Planck Institut fur Entwicklungsbiologie, Abteilung fur Genetik, Tubingen, Germany
    Development 123:95-102. 1996
  3. ncbi Genes establishing dorsoventral pattern formation in the zebrafish embryo: the ventral specifying genes
    M C Mullins
    Max Planck Institut fur Entwicklungsbiologie, Tubingen, Germany
    Development 123:81-93. 1996
  4. ncbi Mutations affecting development of the midline and general body shape during zebrafish embryogenesis
    M Brand
    Max Planck Institut fur Entwicklungsbiologie, Tubingen, Germany
    Development 123:129-42. 1996
  5. ncbi Genes involved in forebrain development in the zebrafish, Danio rerio
    C P Heisenberg
    Max Planck Institut fur Entwicklungsbiologie, Tubingen, Germany
    Development 123:191-203. 1996
  6. ncbi Mutations affecting somite formation and patterning in the zebrafish, Danio rerio
    F J van Eeden
    MPI für Entwicklungsbiologie, Tubingen, Germany
    Development 123:153-64. 1996
  7. ncbi Genes controlling and mediating locomotion behavior of the zebrafish embryo and larva
    M Granato
    Max Planck Institut fur Entwicklungsbiologie, Abteilung Genetik, Tubingen, Germany
    Development 123:399-413. 1996
  8. ncbi Mutations affecting the formation of the notochord in the zebrafish, Danio rerio
    J Odenthal
    MPI für Entwicklungsbiologie, Tubingen, Germany
    Development 123:103-15. 1996
  9. ncbi Zebrafish pigmentation mutations and the processes of neural crest development
    R N Kelsh
    Max Planck Institut fur Entwicklungsbiologie, Abteilung Genetik, Tubingen, Germany
    Development 123:369-89. 1996
  10. ncbi Mutations affecting the cardiovascular system and other internal organs in zebrafish
    J N Chen
    Max Planck Institut fur Entwicklungsbiologie, Tubingen, Germany
    Development 123:293-302. 1996

Collaborators

Detail Information

Publications39

  1. ncbi Mutations affecting morphogenesis during gastrulation and tail formation in the zebrafish, Danio rerio
    M Hammerschmidt
    Max Planck Institut fur Entwicklungsbiologie, Abteilung fur Genetik, Tubingen, Germany
    Development 123:143-51. 1996
    ..Mutants in kugelig (kgg) do not form the yolk tube at the posterior side of the yolk sac...
  2. ncbi dino and mercedes, two genes regulating dorsal development in the zebrafish embryo
    M Hammerschmidt
    Max Planck Institut fur Entwicklungsbiologie, Abteilung fur Genetik, Tubingen, Germany
    Development 123:95-102. 1996
    ..Their function in the patterning of the ventrolateral mesoderm and the induction of the neuroectoderm is similar to the function of the Spemann organizer in the amphibian embryo...
  3. ncbi Genes establishing dorsoventral pattern formation in the zebrafish embryo: the ventral specifying genes
    M C Mullins
    Max Planck Institut fur Entwicklungsbiologie, Tubingen, Germany
    Development 123:81-93. 1996
    ..This pathway provides ventral positional information, counteracting the dorsalizing instructions of the organizer, which is localized in the dorsal shield...
  4. ncbi Mutations affecting development of the midline and general body shape during zebrafish embryogenesis
    M Brand
    Max Planck Institut fur Entwicklungsbiologie, Tubingen, Germany
    Development 123:129-42. 1996
    ..As a working hypothesis, we propose that midline-group genes may act to maintain proper structure and inductive function of zebrafish midline tissues...
  5. ncbi Genes involved in forebrain development in the zebrafish, Danio rerio
    C P Heisenberg
    Max Planck Institut fur Entwicklungsbiologie, Tubingen, Germany
    Development 123:191-203. 1996
    ..In an appendix to this study we list mutants showing alterations in the size of the eyes and abnormal differentiation of the lenses...
  6. ncbi Mutations affecting somite formation and patterning in the zebrafish, Danio rerio
    F J van Eeden
    MPI für Entwicklungsbiologie, Tubingen, Germany
    Development 123:153-64. 1996
    ....
  7. ncbi Genes controlling and mediating locomotion behavior of the zebrafish embryo and larva
    M Granato
    Max Planck Institut fur Entwicklungsbiologie, Abteilung Genetik, Tubingen, Germany
    Development 123:399-413. 1996
    ..Mutations in two genes, nevermind (nev) and macho (mao), affect axonal projection in the optic tectum, whereas axon formation and elongation of motorneurons are disrupted by mutations in the diwanka (diw) and the unplugged (unp) genes...
  8. ncbi Mutations affecting the formation of the notochord in the zebrafish, Danio rerio
    J Odenthal
    MPI für Entwicklungsbiologie, Tubingen, Germany
    Development 123:103-15. 1996
    ..In addition to the four mutants with defects in early notochord formation, we have isolated 84 mutants, defining at least 15 genes, with defects in later stages of notochord development. These are listed in an appendix to this study...
  9. ncbi Zebrafish pigmentation mutations and the processes of neural crest development
    R N Kelsh
    Max Planck Institut fur Entwicklungsbiologie, Abteilung Genetik, Tubingen, Germany
    Development 123:369-89. 1996
    ..In combination with the embryological advantages of zebrafish, these mutations should permit cellular and molecular dissection of many aspects of neural crest development...
  10. ncbi Mutations affecting the cardiovascular system and other internal organs in zebrafish
    J N Chen
    Max Planck Institut fur Entwicklungsbiologie, Tubingen, Germany
    Development 123:293-302. 1996
    ..The mutations presented here could serve as an entry point to the establishment of a genetic hierarchy underlying organogenesis...
  11. ncbi Mutations affecting neurogenesis and brain morphology in the zebrafish, Danio rerio
    Y J Jiang
    Max Planck Institut fur Entwicklungsbiologie, Tubingen, FRG
    Development 123:205-16. 1996
    ..atlantis (atl), big head (bid), wicked brain (win), scabland (sbd) and eisspalte (ele) mutants have different malformation of the brain folds. Some of them have transient phenotypes, and mutant individuals may grow up to adults...
  12. ncbi The zebrafish early arrest mutants
    D A Kane
    Max Planck Institut fur Entwicklungsbiologie, Abteilung fur Genetik, Tubingen, Germany
    Development 123:57-66. 1996
    ....
  13. ncbi Mutations affecting xanthophore pigmentation in the zebrafish, Danio rerio
    J Odenthal
    Max Planck Institut fur Entwicklungsbiologie, Tubingen, Germany
    Development 123:391-8. 1996
    ..These mutations may affect xanthophore pigment distribution within the cells or xanthophore cell shape. Mutations in seven genes affecting xanthophore pigmentation remain unclassified...
  14. ncbi Genetic analysis of fin formation in the zebrafish, Danio rerio
    F J van Eeden
    MPI für Entwicklungsbiologie, Tubingen, Germany
    Development 123:255-62. 1996
    ..Stein und bein (sub) has reduced dorsal and pelvic fins, whereas finless (fls) and wanda (wan) mutants affect all adult fins. Finally, mutations in four genes causing defects in embryonic skin formation will be briefly reported...
  15. ncbi Neural degeneration mutants in the zebrafish, Danio rerio
    M Furutani-Seiki
    Max Planck Institut fur Entwicklungsbiologie, Abteilung Genetik, Tubingen, Germany
    Development 123:229-39. 1996
    ..These results suggest that focal cell death may be a useful clue for the detection of early patterning defects of the vertebrate nervous system in regions devoid of visible landmarks...
  16. ncbi The identification of genes with unique and essential functions in the development of the zebrafish, Danio rerio
    P Haffter
    Max Planck Institut fur Entwicklungsbiologie, Abteilung Genetik, Tubingen, Germany
    Development 123:1-36. 1996
    ..Here we give an overview of the spectrum of mutant phenotypes obtained, and discuss the limits and the potentials of a genetic saturation screen in the zebrafish...
  17. ncbi Mutations in zebrafish genes affecting the formation of the boundary between midbrain and hindbrain
    M Brand
    Max Planck Institut fur Entwicklungsbiologie, Tubingen, Germany
    Development 123:179-90. 1996
    ..Our results confirm and extend a previous report, and show that at least one member of this conserved signalling pathway is required for formation of the boundary between midbrain and hindbrain in the zebrafish...
  18. ncbi Jaw and branchial arch mutants in zebrafish II: anterior arches and cartilage differentiation
    T Piotrowski
    Max Planck Institut fur Entwicklungsbiologie, Abteilung Genetik, Tubingen, Germany
    Development 123:345-56. 1996
    ..The mutants presented here may be valuable tools for elucidating the genetic mechanisms that underlie the development of the mandibular and the hyoid arches, as well as the process of cartilage differentiation...
  19. ncbi The zebrafish epiboly mutants
    D A Kane
    Max Planck Institut fur Entwicklungsbiologie, Abteilung fur Genetik, Tubingen, Germany
    Development 123:47-55. 1996
    ..Furthermore, the dominant zygotic-maternal effect phenotypes illustrate the maternal and zygotic interplay of genes that orchestrate the early cell movements of the zebrafish...
  20. ncbi Characterization of zebrafish mutants with defects in embryonic hematopoiesis
    D G Ransom
    Max Planck Institut für Entwickslungbiologie, Abteilung Genetik, Tubingen, Germany
    Development 123:311-9. 1996
    ..The analysis of these mutants provides a powerful approach towards defining the molecular mechanisms involved in vertebrate hematopoietic development...
  21. ncbi The expression of a zebrafish gene homologous to Drosophila snail suggests a conserved function in invertebrate and vertebrate gastrulation
    M Hammerschmidt
    Max Planck Institut fur Entwicklungsbiologie, Abteilung Genetik, Tubingen, Germany
    Development 119:1107-18. 1993
    ..Data obtained in studies with ectopic ntl expression support this model...
  22. ncbi Wnt5 is required for tail formation in the zebrafish embryo
    G J Rauch
    Max Planck Institut fur Entwicklungsbiologie, Tubingen, Germany
    Cold Spring Harb Symp Quant Biol 62:227-34. 1997
    ..The lack of a maternal effect phenotype in the progeny of these females suggests that no obvious function for the maternal wnt5 expression can be deduced...
  23. ncbi The molecular nature of zebrafish swirl: BMP2 function is essential during early dorsoventral patterning
    Y Kishimoto
    MPI für Entwicklungsbiologie, Tubingen, Germany
    Development 124:4457-66. 1997
    ..In addition zBMP2 has no maternal role in mesoderm induction. Our analysis shows that swirl/BMP2, unlike mouse BMP2 but like mouse BMP4, is required for early dorsoventral patterning of the zebrafish embryo...
  24. ncbi Expression of zebrafish goosecoid and no tail gene products in wild-type and mutant no tail embryos
    S Schulte-Merker
    Max Planck Institut fur Entwicklungsbiologie, Abteilung Genetik, Tubingen, Germany
    Development 120:843-52. 1994
    ..Studies with mutant embryos suggest that gsc is independent of ntl function in vivo...
  25. ncbi The type I serine/threonine kinase receptor Alk8/Lost-a-fin is required for Bmp2b/7 signal transduction during dorsoventral patterning of the zebrafish embryo
    H Bauer
    Hans Spemann Laboratory, Max Planck Institut fur Immunbiologie, Stuebeweg 51, D 79108 Freiburg, Germany
    Development 128:849-58. 2001
    ..Altogether, the data suggest that Alk8 acts as a Bmp2b/7 receptor upstream of Smad5...
  26. ncbi Cloning and characterization of zebrafish smad2, smad3 and smad4
    A Dick
    Max Planck Institut fur Immunbiologie, Stubeweg 51, D 79108, Freiburg, Germany
    Gene 246:69-80. 2000
    ..These data suggest that Smad2 acts as a mediator of Nodal signals during zebrafish midline signaling, while Smad3 might be involved in later steps of eye field separation...
  27. ncbi Morpholino phenocopies of the swirl, snailhouse, somitabun, minifin, silberblick, and pipetail mutations
    Z Lele
    Hans Spemann Laboratory, Max Planck Institut fur Immunbiologie, Freiburg, Germany
    Genesis 30:190-4. 2001
  28. ncbi Expression of BMP signalling pathway members in the developing zebrafish inner ear and lateral line
    C Mowbray
    Centre for Developmental Genetics, University of Sheffield School of Medicine and Biomedical Science, Firth Court, Western Bank, Sheffield S10 2TN, UK
    Mech Dev 108:179-84. 2001
    ..The conservation of bmp expression in cristae among different species adds weight to the growing evidence that BMPs are required for the development of the vertebrate ear...
  29. ncbi Zebrafish admp is required to restrict the size of the organizer and to promote posterior and ventral development
    Z Lele
    Max Planck Institut fur Immunbiologie, Stubeweg 51, Freiburg, Germany
    Dev Dyn 222:681-7. 2001
    ....
  30. ncbi Perp is required for tissue-specific cell survival during zebrafish development
    M Nowak
    Max Planck Institute for Immunobiology, Stuebeweg 51, 79108 Freiburg, Germany
    Cell Death Differ 12:52-64. 2005
    ..We conclude that, in contrast to its proapoptotic function in stressed cells, Perp plays an antiapoptotic role during normal zebrafish development to regulate tissue-specific cell survival...
  31. ncbi Smad1 and Smad5 have distinct roles during dorsoventral patterning of the zebrafish embryo
    A Dick
    Max Planck Institut fur Immunbiologie, Freiburg, Germany
    Dev Dyn 216:285-98. 1999
    ....
  32. ncbi The smad5 mutation somitabun blocks Bmp2b signaling during early dorsoventral patterning of the zebrafish embryo
    M Hild
    Hans Spemann Laboratory, Max Planck Institute of Immunobiology, Stuebeweg 51, D 79108 Freiburg, Germany de
    Development 126:2149-59. 1999
    ....
  33. ncbi Follistatin and noggin are excluded from the zebrafish organizer
    H Bauer
    Max Planck Institut fur Immunbiologie, Stubeweg 51, 79108 Freiburg, Germany
    Dev Biol 204:488-507. 1998
    ..It thus appears that many, but not all, aspects of early dorsoventral patterning are shared among different vertebrate species...
  34. ncbi Cloning and genetic mapping of zebrafish BMP-2
    K H Lee
    Department of Cardiology, Children s Hospital, Boston, Massachusetts, USA
    Dev Genet 23:97-103. 1998
    ....
  35. ncbi p53 deficiency rescues apoptosis and differentiation of multiple cell types in zebrafish flathead mutants deficient for zygotic DNA polymerase delta1
    N Plaster
    Georges Köhler Laboratory, Max Planck Institute of Immunobiology, Stuebeweg 51, 79108 Freiburg, Germany
    Cell Death Differ 13:223-35. 2006
    ..This indicates that under replication-compromised conditions, the p53 branch of the S-phase checkpoint is responsible for eliminating stalled cells that, given more time, would have otherwise finished their normal developmental program...
  36. ncbi Mutations affecting development of the zebrafish inner ear and lateral line
    T T Whitfield
    ICRF Developmental Biology Unit, Department of Zoology, Oxford, UK
    Development 123:241-54. 1996
    ..At least one mutant, dog-eared, shows defects in both the ear and another placodally derived sensory system, the lateral line, while hypersensitive mutants have additional trunk lateral line organs...
  37. ncbi A role for Indian hedgehog in extraembryonic endoderm differentiation in F9 cells and the early mouse embryo
    S Becker
    Department of Biology, Wesleyan University, Middletown, Connecticut 06559 0170, USA
    Dev Biol 187:298-310. 1997
    ..Taken together, these data suggest that Indian hedgehog is involved in mediating differentiation of extraembryonic endoderm during early mouse embryogenesis...
  38. ncbi The world according to hedgehog
    M Hammerschmidt
    Spemann Laboratories, Frieburg, Germany
    Trends Genet 13:14-21. 1997
    ..Here, we review recent experiments addressing the function of the various Hedgehog members during invertebrate and vertebrate development...
  39. ncbi Jaw and branchial arch mutants in zebrafish I: branchial arches
    T F Schilling
    Imperial Cancer Research Fund, London, UK
    Development 123:329-44. 1996
    ....