Research Topics
| MICHAEL HAMBLINSummaryAffiliation: Harvard University Country: USA Publications
Research Grants
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Detail Information
Publications
Low-level light stimulates excisional wound healing in miceTatiana N Demidova-Rice
Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Lasers Surg Med 39:706-15. 2007..Low levels of laser or non-coherent light, termed low-level light therapy (LLLT) have been reported to accelerate some phases of wound healing, but its clinical use remains controversial...- Animal models of skin disease for drug discoveryPinar Avci
Massachusetts General Hospital, Wellman Center for Photomedicine, 40 Blossom Street, Boston, MA 02114, USA 1 617 726 6182 1 617 726 8566
Expert Opin Drug Discov 8:331-55. 2013..Moving to the more consumer-oriented area of dermatology, there are models for studying the harmful effect of sunlight on the skin, and testing of sunscreens, and several different animal models of hair loss or alopecia... - Synthesis and characterization of positively charged pentacationic [60]fullerene monoadducts for antimicrobial photodynamic inactivationSammaiah Thota
Department of Chemistry, Institute of Nanoscience and Engineering Technology, University of Massachusetts, Lowell, MA 01854, USA
Molecules 17:5225-43. 2012..We demonstrated two plausible synthetic routes for the preparation of 1 and 2 with the product characterization via various spectroscopic methods... - Psychological benefits 2 and 4 weeks after a single treatment with near infrared light to the forehead: a pilot study of 10 patients with major depression and anxietyFredric Schiffer
The Department of Psychiatry, Harvard Medical School and the Developmental Biopsychiatry Research Program, McLean Hospital, 115 Mill Street Belmont, MA 02478 USA
Behav Brain Funct 5:46. 2009..abstract:.. - Pegylation of charged polymer-photosensitiser conjugates: effects on photodynamic efficacyM R Hamblin
Wellman Laboratories of Photomedicine, Massachusetts General Hospital, Boston, MA 02114, USA
Br J Cancer 89:937-43. 2003..These in vitro studies suggest that pegylation alters the phototoxicity of PS conjugates depending on the effect produced on the aggregation state... - Helicobacter pylori accumulates photoactive porphyrins and is killed by visible lightMichael R Hamblin
Wellman Center for Photomedicine, Massachusetts General Hospital, 40 Blossom Street, BAR314B, Boston, Massachusetts 02114 2698, USA
Antimicrob Agents Chemother 49:2822-7. 2005..Both virulent and drug-resistant strains are killed. The data suggest that phototherapy might be used to treat H. pylori infection in the human stomach... - Optical monitoring and treatment of potentially lethal wound infections in vivoMichael R Hamblin
Wellman Laboratories of Photomedicine, Massachusetts General Hospital, and Department of Dermatology, Harvard Medical School, Boston, Massachusetts 02114, USA
J Infect Dis 187:1717-25. 2003..PDT-treated wounds healed significantly faster than did silver nitrate-treated wounds, and this was not due to either inhibition of healing by silver nitrate or stimulation of healing by PDT... 
Polycationic photosensitizer conjugates: effects of chain length and Gram classification on the photodynamic inactivation of bacteriaMichael R Hamblin
Wellman Laboratories of Photomedicine, Massachusetts General Hospital and Department of Dermatology, Harvard Medical School, Boston, MA 02114 2698, USA
J Antimicrob Chemother 49:941-51. 2002..In this report we explore the relationship between the size of the polylysine chain and its effectiveness for mediating the killing of Gram-negative and Gram-positive bacteria...- Rapid control of wound infections by targeted photodynamic therapy monitored by in vivo bioluminescence imagingMichael R Hamblin
Wellman Laboratories of Photomedicine, Massachusetts General Hospital, Boston 02114 2698, USA
Photochem Photobiol 75:51-7. 2002..Our study points to the possible use of this methodology in the rapid control of wounds and other localized infections... - Photodynamic therapy: a new antimicrobial approach to infectious disease?Michael R Hamblin
Wellman Laboratories of Photomedicine, Massachusetts General Hospital, Boston, MA 02114, USA
Photochem Photobiol Sci 3:436-50. 2004.... - Scavenger-receptor targeted photodynamic therapyM R Hamblin
Wellman Laboratories of Photomedicine, Massachusetts General Hospital and Department of Dermatology, Harvard Medical School, Boston 02114, USA
Photochem Photobiol 72:533-40. 2000..These data show that scavenger receptor-targeted PDT gives a high degree of specificity toward macrophages and may have applications in the treatment of tumors and atherosclerosis... - Blue dye and red light, a dynamic combination for prophylaxis and treatment of cutaneous Candida albicans infections in miceTianhong Dai
Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Antimicrob Agents Chemother 55:5710-7. 2011..albicans burden in the infected mouse skin abrasion wounds. These data suggest that PDT is a viable approach for prophylaxis and treatment of cutaneous C. albicans infections... - Pegylation of a chlorin(e6) polymer conjugate increases tumor targeting of photosensitizerM R Hamblin
Wellman Laboratories of Photomedicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Cancer Res 61:7155-62. 2001..Taken together, these results suggest that pegylation of a polymer-photosensitizer conjugate improves tumor-targeting and may increase the efficacy of photodynamic therapy for ovarian cancer... - Cytoplasmic molecular delivery with shock waves: importance of impulseT Kodama
Wellman Laboratories of Photomedicine, Massachusetts General Hospital, and Department of Dermatology, Harvard Medical School, Boston, MA 02114, USA
Biophys J 79:1821-32. 2000.... - Macrophage-targeted photodynamic therapy: scavenger receptor expression and activation stateQ Liu
Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA 02114, USA
Int J Immunopathol Pharmacol 18:391-402. 2005..These data may have implications for the use of PDT to target physiologically undesirable macrophage subtypes implicated in disease, and on how manipulation of the activation status of the macrophage will influence the PDT effect... - Photodynamic tissue adhesion with chlorin(e6) protein conjugatesJ Khadem
The Retina Specialists of Boston, Harvard Medical School, 02114, USA
Invest Ophthalmol Vis Sci 40:3132-7. 1999..To test the hypothesis that a photodynamic laser-activated tissue solder would perform better in sealing scleral incisions when the photosensitizer was covalently linked to the protein than when it was noncovalently mixed... - Epidermal growth factor receptor-targeted immunophotodiagnosis and photoimmunotherapy of oral precancer in vivoN S Soukos
Wellman Laboratories of Photomedicine, Department of Dermatology, Massachusetts General Hospital, 50 Blossom Street, Boston, MA 02114, USA
Cancer Res 61:4490-6. 2001..Taken together, the results demonstrate the potential for development of immunophotodiagnosis as a diagnostic tool and as a method of monitoring response to therapy and that the EGFR may be an appropriate target in head and neck cancer... - In vivo fluorescence imaging of the transport of charged chlorin e6 conjugates in a rat orthotopic prostate tumourM R Hamblin
Wellman Laboratories of Photomedicine, Harvard Medical School, Massachusetts General Hospital, Boston 02114, USA
Br J Cancer 81:261-8. 1999..These results are consistent with differences in aggregation state between conjugates... - Biodistribution of charged 17.1A photoimmunoconjugates in a murine model of hepatic metastasis of colorectal cancerM R Hamblin
Wellman Laboratories of Photomedicine, Massachusetts General Hospital, Boston, MA 02114, USA
Br J Cancer 83:1544-51. 2000..Cationic species had a high uptake in the lungs compared to anionic species. The photoimmunoconjugates show an advantage over literature reports of other photosensitizers, which can result in tumour:normal liver ratios of less than 1... 
Biodistribution of charged F(ab')2 photoimmunoconjugates in a xenograft model of ovarian cancerL R Duska
Wellman Laboratories of Photomedicine, Harvard Medical School, Masssachusetts General Hospital, Boston 02114, USA
Br J Cancer 75:837-44. 1997..p. tumour. Positively charged PICs may have applications in the i.p. photoimmunotherapy of minimal residual ovarian cancer...- Targeted photodestruction of human colon cancer cells using charged 17.1A chlorin e6 immunoconjugatesM Del Governatore
Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
Br J Cancer 82:56-64. 2000..By contrast, 1 microM free c(e6) gave only a 35% reduction in colonies. These data suggest photoimmunoconjugates may have applications in photoimmunotherapy where destruction of colorectal cancer cells is required... - Macrophage-targeted photodynamic therapyT N Demidova
Wellman Center for Photomedicine, Mass. General Hospital, Boston, MA 02114, USA
Int J Immunopathol Pharmacol 17:117-26. 2004..The capability to selectively kill macrophages has applications in treating cancer and in the detection and therapy of vulnerable atherosclerotic plaque and possibly for autoimmune disease and some infections... - Photodynamic therapy targeted to pathogensT N Demidova
Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA 02114, USA
Int J Immunopathol Pharmacol 17:245-54. 2004..Not only were bacteria infecting wounds, burns, and abscesses killed, but mice were saved from death due to sepsis and wound healing was improved... - Synergistic combination of chitosan acetate with nanoparticle silver as a topical antimicrobial: efficacy against bacterial burn infectionsLiyi Huang
Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Antimicrob Agents Chemother 55:3432-8. 2011..These data suggest that a dressing combining chitosan acetate with silver leads to improved antimicrobial efficacy against fatal burn infections... - Drug discovery of antimicrobial photosensitizers using animal modelsSulbha K Sharma
Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA 02114, USA
Curr Pharm Des 17:1303-19. 2011..This range of animal models also represents a powerful aid in antimicrobial drug discovery... - Combination approaches to potentiate immune response after photodynamic therapy for cancerTyler G St Denis
Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA 02114, USA
Photochem Photobiol Sci 10:792-801. 2011..We believe that by understanding the methods employed by tumors to evade immune response and neutralizing them, more precise ways of potentiating PDT-induced immunity can be devised... - Topical antimicrobials for burn wound infectionsT Dai
Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA, USA
Recent Pat Antiinfect Drug Discov 5:124-51. 2010..This active area of research will continue to provide new topical antimicrobials for burns that will battle against growing multidrug resistance... - A green fluorescent protein-expressing murine tumour but not its wild-type counterpart is cured by photodynamic therapyA P Castano
BAR414, Wellman Center for Photomedicine, Massachusetts General Hospital, 40 Blossom Street, and Department of Dermatology, Harvard Medical School, Boston, MA 02114, USA
Br J Cancer 94:391-7. 2006..The presence of antibodies against EGFP in mouse serum suggests EGFP can act as a foreign antigen and PDT can then stimulate a long-term memory immune response... - Antimicrobial photodynamic therapy combined with conventional endodontic treatment to eliminate root canal biofilm infectionAguinaldo S Garcez
Center for Lasers and Applications, IPEN CNEN SP, Sao Paulo, SP, Brazil
Lasers Surg Med 39:59-66. 2007..To compare the effectiveness of antimicrobial photodynamic therapy (PDT), standard endodontic treatment and the combined treatment to eliminate bacterial biofilms present in infected root canals... - Macrophage-targeted photosensitizer conjugate delivered by intratumoral injectionFlorencia Anatelli
Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Mol Pharm 3:654-64. 2006..IT injection of nonconjugated PS gave lower tumor accumulation that did not correlate with macrophage content. IT injection of targeted macromolecular delivery systems is an underexplored area and worthy of further study... - A comparative in vitro photoinactivation study of clinical isolates of multidrug-resistant pathogensHi M Tang
Department of Health Technology and Informatics, Medical Laboratory Science Section, The Hong Kong Polytechnic University, Hung Hom, Hong Kong, SAR
J Infect Chemother 13:87-91. 2007..coli and E. coli (ATCC 25922). Our studied MRSA isolate responded better than S. aureus (ATCC 25923). Thus, pL-ce6-mediated PDI in other MRSA isolates deserves further investigation... - Susceptibility of Cryptococcus neoformans to photodynamic inactivation is associated with cell wall integrityBeth Burgwyn Fuchs
Infectious Diseases, Massachusetts General Hospital, Boston, MA 02144, USA
Antimicrob Agents Chemother 51:2929-36. 2007..These studies demonstrated that C. neoformans is sensitive to photodynamic therapy and illustrated the significance of cell wall integrity in microbial susceptibility to antimicrobial photodynamic inactivation... - Antimicrobial effects of photodynamic therapy on patients with necrotic pulps and periapical lesionAguinaldo Silva Garcez
Centro de Laser e Aplicações, IPEN CNEN SP, Sao Paulo, Brazil
J Endod 34:138-42. 2008..00006). Results suggest that the use of PDT added to endodontic treatment leads to an enhanced decrease of bacterial load and may be an appropriate approach for the treatment of oral infections... - Effect of chitosan acetate bandage on wound healing in infected and noninfected wounds in miceMarina Burkatovskaya
Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Wound Repair Regen 16:425-31. 2008..Chitosan acetate bandage reduced the number of inflammatory cells in the wound at days 2 and 4, and had an overall beneficial effect on wound healing especially during the early period where its antimicrobial effect is most important... - Inhibitors of bacterial multidrug efflux pumps potentiate antimicrobial photoinactivationGeorge P Tegos
Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Antimicrob Agents Chemother 52:3202-9. 2008..aureus. These data suggest that EPI could be used in combination with phenothiazinium salts and light to enhance their antimicrobial effect against localized infections... - Synthesis and properties of benzo[a]phenoxazinium chalcogen analogues as novel broad-spectrum antimicrobial photosensitizersJames W Foley
Rowland Institute at Harvard, Harvard University, Cambridge, Massachusetts 02142, USA
J Med Chem 49:5291-9. 2006..These data, taken with the findings of uptake and retention studies, suggest that the superior activity of selenium derivative 3 can be attributed to its much higher triplet quantum yield... - Bioconjugatable porphyrins bearing a compact swallowtail motif for water solubilityK Eszter Borbas
Department of Chemistry, North Carolina State University, Raleigh, North Carolina 27695-8204, USA
Bioconjug Chem 17:638-53. 2006..Taken together, this work enables preparation of useful quantities of water-soluble, bioconjugatable porphyrins in a compact architecture for applications in the life sciences... - Photodynamic inactivation of Bacillus spores, mediated by phenothiazinium dyesTatiana N Demidova
Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA 02114, USA
Appl Environ Microbiol 71:6918-25. 2005..The relatively mild conditions needed for spore killing could have applications for treating wounds contaminated by anthrax spores, for which conventional sporicides would have unacceptable tissue toxicity... - Monitoring photodynamic therapy of localized infections by bioluminescence imaging of genetically engineered bacteriaTatiana N Demidova
Wellman Center for Photomedicine, Massachusetts General Hospital, BAR414, 40 Blossom Street, Boston, MA, USA
J Photochem Photobiol B 81:15-25. 2005..Healing of the PDT treated wounds is not impaired and may actually be improved. This approach can allow many animal models of localized infections to be accurately monitored for efficacy of treatment by PDT... - Effect of cell-photosensitizer binding and cell density on microbial photoinactivationTatiana N Demidova
Massachusetts General Hospital, BAR314B, 40 Blossom Street, Boston, MA 02114-2698, USA
Antimicrob Agents Chemother 49:2329-35. 2005..coli>C. albicans, but C. albicans cells were 10 to 50 times bigger than the bacteria. We conclude that the number and mass of the cells compete both for available dye binding and for extracellularly generated reactive oxygen species... - Photodynamic therapy with fullerenesPawel Mroz
Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA, USA
Photochem Photobiol Sci 6:1139-49. 2007..The mechanism appears to involve superoxide anion as well as singlet oxygen, and under the right conditions fullerenes may have advantages over clinically applied photosensitizers for mediating photodynamic therapy of certain diseases... - Cationic fullerenes are effective and selective antimicrobial photosensitizersGeorge P Tegos
Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, 02114, USA
Chem Biol 12:1127-35. 2005..The high selectivity and efficacy exhibited by these photosensitizers encourage further testing for antimicrobial applications... - Effects of growth phase and extracellular slime on photodynamic inactivation of gram-positive pathogenic bacteriaFaten Gad
Wellman Laboratories of Photomedicine, Massachusetts General Hospital, BAR314B, 40 Blossom St, Boston, MA 02114-2698, USA
Antimicrob Agents Chemother 48:2173-8. 2004..These data suggest that slime production and stationary phase can be obstacles against PDI for gram-positive bacteria but that these obstacles can be overcome by using cationic PS... - Shock wave-mediated molecular delivery into cellsTetsuya Kodama
BAR314B, Wellman Laboratories of Photomedicine, Massachusetts General Hospital, Boston, MA 02114, USA
Biochim Biophys Acta 1542:186-94. 2002..Shock waves can deliver molecules of up to 2000000 molecular weight into the cytoplasm of cells without toxicity and may have applications in gene therapy... - Delivery of ribosome-inactivating protein toxin into cancer cells with shock wavesTetsuya Kodama
WEL224, Wellman Laboratories of Photomedicine, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
Cancer Lett 189:69-75. 2003..Higher toxicity was seen with the clonogenic assay compared to MTT assay. Shock waves may have applications in promoting cytoplasmic delivery of toxins into cancer cells after intratumoral injection... - Protease-stable polycationic photosensitizer conjugates between polyethyleneimine and chlorin(e6) for broad-spectrum antimicrobial photoinactivationGeorge P Tegos
Wellman Center for Photomedicine, Massachusetts General Hospital, and Department of Dermatology, Harvard Medical School, Boston, MA 02114-2698, USA
Antimicrob Agents Chemother 50:1402-10. 2006.... - Use of chitosan bandage to prevent fatal infections developing from highly contaminated wounds in miceMarina Burkatovskaya
Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA, USA
Biomaterials 27:4157-64. 2006..The data suggest that chitosan acetate rapidly kills bacteria in the wound before systemic invasion can take place, and is superior to alginate bandage and silver sulfadiazine that may both encourage bacterial growth in the short term... - Photosensitizer delivery to vulnerable atherosclerotic plaque: comparison of macrophage-targeted conjugate versus free chlorin(e6)Ahmed Tawakol
Massachusetts General Hospital, Cardiac Unit, Department of Medicine, and Harvard Medical School, Boston, Massachusetts, USA
J Biomed Opt 11:021008. 2006..The liver, spleen, lung, and gall bladder have the highest uptake in nontarget organs. Macrophage-targeted photosensitizer conjugates may have applications in both detecting and treating inflamed vulnerable plaque... - Helicobacter pylori in patients can be killed by visible lightRobert A Ganz
Sterilite LLC, Minnetonka, Minnesota, USA
Lasers Surg Med 36:260-5. 2005..CONCLUSION: Blue light phototherapy may represent a novel approach to eradication of H. pylori, particularly, in patients who have failed standard antibiotic treatment... - Photodynamic therapy for Staphylococcus aureus infected burn wounds in miceSaskia A G Lambrechts
Laser Center, Academic Medical Center, University of Amsterdam, The Netherlands
Photochem Photobiol Sci 4:503-9. 2005..Light alone or PDT both delayed the wound healing. These data suggest that PDT has the potential to rapidly reduce the bacterial load in infected burns. The treatment needs to be optimized to reduce wound damage and prevent recurrence... - Healing of perforating rat corneal incisions closed with photodynamic laser-activated tissue glueJohn Khadem
The Schepens Eye Research Institute, Harvard Medical School, Boston, MA, USA
Lasers Surg Med 35:304-11. 2004..CONCLUSIONS: These data demonstrate that photodynamic laser activated tissue glues can be used to effectively seal corneal incisions in living animals without thermal damage or undue inflammation... - Targeted photodynamic therapy of established soft-tissue infections in miceFaten Gad
Wellman Laboratories of Photomedicine, Masschusetts General Hospital, Boston 02114, USA
Photochem Photobiol Sci 3:451-8. 2004..PDT-treated infected legs healed better than legs with untreated infections. This data shows that PDT may have applications in drug-resistant soft-tissue infections... - Photodynamic therapy and anti-tumour immunityAna P Castano
Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, Massachusetts, USA
Nat Rev Cancer 6:535-45. 2006.... - Intravascular detection of inflamed atherosclerotic plaques using a fluorescent photosensitizer targeted to the scavenger receptorAhmed Tawakol
Department of Medicine Cardiac Unit, Massachusetts General Hospital, Boston, MA 02114, USA
Photochem Photobiol Sci 7:33-9. 2008..83, p < 0.001) and an inverse correlation between MA-ce6 uptake and smooth muscle cell staining (R = -0.74, p < 0.001). MA-ce6 may function as a molecular imaging agent to detect and/or photodynamically treat inflamed plaques... - Involvement of skeletal muscle gene regulatory network in susceptibility to wound infection following traumaYiorgos Apidianakis
Department of Surgery, Harvard Medical School and Massachusetts General Hospital, Boston, Massachusetts, United States of America
PLoS ONE 2:e1356. 2007..aeruginosa cells, could lead to novel therapies that prevent or treat deleterious and potentially fatal infections in severely injured individuals... - Phenothiazinium antimicrobial photosensitizers are substrates of bacterial multidrug resistance pumpsGeorge P Tegos
BAR414, Wellman Center for Photomedicine, Massachusetts General Hospital, 40 Blossom Street, Boston, Massachusetts 02114, USA
Antimicrob Agents Chemother 50:196-203. 2006..We propose that specific MDR inhibitors could be used in combination with phenothiazinium salts to enhance their photodestructive efficiency... - Functionalized fullerenes mediate photodynamic killing of cancer cells: Type I versus Type II photochemical mechanismPawel Mroz
Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA, USA
Free Radic Biol Med 43:711-9. 2007..We conclude that certain functionalized fullerenes have potential as novel PDT agents and phototoxicity may be mediated both by superoxide and by singlet oxygen... - Low-level laser therapy for zymosan-induced arthritis in rats: Importance of illumination timeAna P Castano
Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Lasers Surg Med 39:543-50. 2007..For all indications (including arthritis) the optimum optical parameters have been difficult to establish and so far are unknown... - Deficiency of mannose-binding lectin greatly increases susceptibility to postburn infection with Pseudomonas aeruginosaMette Møller-Kristensen
Laboratory of Developmental Immunology, Department of Pediatrics, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
J Immunol 176:1769-75. 2006..aeruginosa infection following burn injury and suggests that MBL deficiency in humans maybe a premorbid variable in the predisposition to infection in burn victims... - Photodynamic therapy plus low-dose cyclophosphamide generates antitumor immunity in a mouse modelAna P Castano
Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA 02114, USA
Proc Natl Acad Sci U S A 105:5495-500. 2008..Cured mice had tumor-specific T cells in spleens as determined by a (51)Cr release assay. We conclude that low-dose CY depletes T-regs and potentiates BPD-PDT, leading to tumor cures and memory immunity...
Research Grants
- Photodynamic Therapy of Localized InfectionsMichael R Hamblin; Fiscal Year: 2010..This application seeks to determine the optimum parameters for antimicrobial PDT and will look at new synergistic combination therapies. ..
- Photodynamic Therapy of Localized InfectionsMICHAEL HAMBLIN; Fiscal Year: 2009..This application seeks to determine the optimum parameters for antimicrobial PDT and will look at new synergistic combination therapies. ..
- Ultraviolet-C Therapy for OnychomycosisMICHAEL HAMBLIN; Fiscal Year: 2006....
- Photodynamic Therapy of Localized InfectionsMICHAEL HAMBLIN; Fiscal Year: 2006..abstract_text> ..
- Macrophage Targeted Photodynamic TherapyMICHAEL HAMBLIN; Fiscal Year: 2004....