MICHAEL HAMBLIN

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Rapid control of wound infections by targeted photodynamic therapy monitored by in vivo bioluminescence imaging
    Michael R Hamblin
    Wellman Laboratories of Photomedicine, Massachusetts General Hospital, Boston 02114 2698, USA
    Photochem Photobiol 75:51-7. 2002
  2. pmc Low-level light stimulates excisional wound healing in mice
    Tatiana N Demidova-Rice
    Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Lasers Surg Med 39:706-15. 2007
  3. pmc A green fluorescent protein-expressing murine tumour but not its wild-type counterpart is cured by photodynamic therapy
    A P Castano
    BAR414, Wellman Center for Photomedicine, Massachusetts General Hospital, 40 Blossom Street, and Department of Dermatology, Harvard Medical School, Boston, MA 02114, USA
    Br J Cancer 94:391-7. 2006
  4. ncbi request reprint Topical antimicrobials for burn infections - an update
    Mert Sevgi
    BAR414, 40 Blossom Street, Boston MA 02114, USA
    Recent Pat Antiinfect Drug Discov 8:161-97. 2013
  5. pmc Comparison of therapeutic effects between pulsed and continuous wave 810-nm wavelength laser irradiation for traumatic brain injury in mice
    Takahiro Ando
    Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, Massachusetts, United States of America
    PLoS ONE 6:e26212. 2011
  6. pmc Low-level laser therapy activates NF-kB via generation of reactive oxygen species in mouse embryonic fibroblasts
    Aaron C H Chen
    Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, Massachusetts, United States of America
    PLoS ONE 6:e22453. 2011
  7. pmc Photodynamic therapy of tumors can lead to development of systemic antigen-specific immune response
    Pawel Mroz
    Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, Massachusetts, United States of America
    PLoS ONE 5:e15194. 2010
  8. pmc Transcranial low-level laser therapy improves neurological performance in traumatic brain injury in mice: effect of treatment repetition regimen
    Weijun Xuan
    Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, Massachusetts, United States of America
    PLoS ONE 8:e53454. 2013
  9. doi request reprint Can biowarfare agents be defeated with light?
    Fatma Vatansever
    Wellman Center for Photomedicine Massachusetts General Hospital Boston MA USA Harvard Medical School Department of Dermatology Boston, MA USA
    Virulence 4:796-825. 2013
  10. pmc Antimicrobial photodynamic therapy to kill Gram-negative bacteria
    Felipe F Sperandio
    Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA 02114, USA
    Recent Pat Antiinfect Drug Discov 8:108-20. 2013

Research Grants

  1. Photodynamic Therapy of Localized Infections
    Michael R Hamblin; Fiscal Year: 2010
  2. Macrophage Targeted Photodynamic Therapy
    MICHAEL HAMBLIN; Fiscal Year: 2002
  3. Photodynamic Therapy of Localized Infections
    MICHAEL HAMBLIN; Fiscal Year: 2009
  4. Ultraviolet-C Therapy for Onychomycosis
    MICHAEL HAMBLIN; Fiscal Year: 2006
  5. Photodynamic Therapy of Localized Infections
    MICHAEL HAMBLIN; Fiscal Year: 2006
  6. Macrophage Targeted Photodynamic Therapy
    MICHAEL HAMBLIN; Fiscal Year: 2004
  7. Photodynamic Therapy of Localized Infections
    MICHAEL HAMBLIN; Fiscal Year: 2003
  8. Macrophage Targeted Photodynamic Therapy
    MICHAEL HAMBLIN; Fiscal Year: 2003

Collaborators

Detail Information

Publications67

  1. ncbi request reprint Rapid control of wound infections by targeted photodynamic therapy monitored by in vivo bioluminescence imaging
    Michael R Hamblin
    Wellman Laboratories of Photomedicine, Massachusetts General Hospital, Boston 02114 2698, USA
    Photochem Photobiol 75:51-7. 2002
    ..Our study points to the possible use of this methodology in the rapid control of wounds and other localized infections...
  2. pmc Low-level light stimulates excisional wound healing in mice
    Tatiana N Demidova-Rice
    Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Lasers Surg Med 39:706-15. 2007
    ..Low levels of laser or non-coherent light, termed low-level light therapy (LLLT) have been reported to accelerate some phases of wound healing, but its clinical use remains controversial...
  3. pmc A green fluorescent protein-expressing murine tumour but not its wild-type counterpart is cured by photodynamic therapy
    A P Castano
    BAR414, Wellman Center for Photomedicine, Massachusetts General Hospital, 40 Blossom Street, and Department of Dermatology, Harvard Medical School, Boston, MA 02114, USA
    Br J Cancer 94:391-7. 2006
    ..The presence of antibodies against EGFP in mouse serum suggests EGFP can act as a foreign antigen and PDT can then stimulate a long-term memory immune response...
  4. ncbi request reprint Topical antimicrobials for burn infections - an update
    Mert Sevgi
    BAR414, 40 Blossom Street, Boston MA 02114, USA
    Recent Pat Antiinfect Drug Discov 8:161-97. 2013
    ..Passive immunotherapy employs antibodies against pathogens and their virulence factors. Finally an interesting new area uses therapeutic microorganisms such as phages, probiotic bacteria and protozoa to combat infections. ..
  5. pmc Comparison of therapeutic effects between pulsed and continuous wave 810-nm wavelength laser irradiation for traumatic brain injury in mice
    Takahiro Ando
    Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, Massachusetts, United States of America
    PLoS ONE 6:e26212. 2011
    ..In the present study, we compared the therapeutic effect using 810-nm wavelength laser light in continuous and pulsed wave modes in a mouse model of TBI...
  6. pmc Low-level laser therapy activates NF-kB via generation of reactive oxygen species in mouse embryonic fibroblasts
    Aaron C H Chen
    Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, Massachusetts, United States of America
    PLoS ONE 6:e22453. 2011
    ..Despite over forty years of investigation on low-level light therapy (LLLT), the fundamental mechanisms underlying photobiomodulation at a cellular level remain unclear...
  7. pmc Photodynamic therapy of tumors can lead to development of systemic antigen-specific immune response
    Pawel Mroz
    Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, Massachusetts, United States of America
    PLoS ONE 5:e15194. 2010
    ..PDT has been shown to lead to local destruction of tumors as well as to induction of anti-tumor immune response...
  8. pmc Transcranial low-level laser therapy improves neurological performance in traumatic brain injury in mice: effect of treatment repetition regimen
    Weijun Xuan
    Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, Massachusetts, United States of America
    PLoS ONE 8:e53454. 2013
    ..There were more BrdU-positive cells in the lesion in 1- and 3-laser groups suggesting LLLT may increase neurogenesis. Transcranial NIR laser may provide benefit in cases of acute TBI provided the optimum treatment regimen is employed...
  9. doi request reprint Can biowarfare agents be defeated with light?
    Fatma Vatansever
    Wellman Center for Photomedicine Massachusetts General Hospital Boston MA USA Harvard Medical School Department of Dermatology Boston, MA USA
    Virulence 4:796-825. 2013
    ..Finally pulsed (femtosecond) high power lasers have been used to inactivate pathogens with some degree of selectivity. We have pointed to some of the ways light-based technology may be used to defeat biological warfare in the future. ..
  10. pmc Antimicrobial photodynamic therapy to kill Gram-negative bacteria
    Felipe F Sperandio
    Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA 02114, USA
    Recent Pat Antiinfect Drug Discov 8:108-20. 2013
    ..The present review also covers the different laboratory animal models normally used to treat Gram-negative bacterial infections with antimicrobial PDT...
  11. pmc Animal models of skin disease for drug discovery
    Pinar Avci
    Harvard Medical School, Massachusetts General Hospital, Wellman Center for Photomedicine, Department of Dermatology, Boston MA, USA
    Expert Opin Drug Discov 8:331-55. 2013
    ..Due to the distressing nature of many dermatological diseases, and the enormous consumer demand for products to reverse the effects of skin photodamage, aging, and hair loss, this is a very active field...
  12. pmc Synthesis and characterization of positively charged pentacationic [60]fullerene monoadducts for antimicrobial photodynamic inactivation
    Sammaiah Thota
    Department of Chemistry, Institute of Nanoscience and Engineering Technology, University of Massachusetts, Lowell, MA 01854, USA
    Molecules 17:5225-43. 2012
    ..We demonstrated two plausible synthetic routes for the preparation of 1 and 2 with the product characterization via various spectroscopic methods...
  13. pmc Psychological benefits 2 and 4 weeks after a single treatment with near infrared light to the forehead: a pilot study of 10 patients with major depression and anxiety
    Fredric Schiffer
    The Department of Psychiatry, Harvard Medical School and the Developmental Biopsychiatry Research Program, McLean Hospital, 115 Mill Street Belmont, MA 02478 USA
    Behav Brain Funct 5:46. 2009
    ..abstract:..
  14. pmc Photodynamic therapy: a new antimicrobial approach to infectious disease?
    Michael R Hamblin
    Wellman Laboratories of Photomedicine, Massachusetts General Hospital, Boston, MA 02114, USA
    Photochem Photobiol Sci 3:436-50. 2004
    ....
  15. pmc Pegylation of charged polymer-photosensitiser conjugates: effects on photodynamic efficacy
    M R Hamblin
    Wellman Laboratories of Photomedicine, Massachusetts General Hospital, Boston, MA 02114, USA
    Br J Cancer 89:937-43. 2003
    ..These in vitro studies suggest that pegylation alters the phototoxicity of PS conjugates depending on the effect produced on the aggregation state...
  16. pmc Blue dye and red light, a dynamic combination for prophylaxis and treatment of cutaneous Candida albicans infections in mice
    Tianhong Dai
    Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Antimicrob Agents Chemother 55:5710-7. 2011
    ..albicans burden in the infected mouse skin abrasion wounds. These data suggest that PDT is a viable approach for prophylaxis and treatment of cutaneous C. albicans infections...
  17. ncbi request reprint Polycationic photosensitizer conjugates: effects of chain length and Gram classification on the photodynamic inactivation of bacteria
    Michael R Hamblin
    Wellman Laboratories of Photomedicine, Massachusetts General Hospital and Department of Dermatology, Harvard Medical School, Boston, MA 02114 2698, USA
    J Antimicrob Chemother 49:941-51. 2002
    ..In this report we explore the relationship between the size of the polylysine chain and its effectiveness for mediating the killing of Gram-negative and Gram-positive bacteria...
  18. ncbi request reprint Scavenger-receptor targeted photodynamic therapy
    M R Hamblin
    Wellman Laboratories of Photomedicine, Massachusetts General Hospital and Department of Dermatology, Harvard Medical School, Boston 02114, USA
    Photochem Photobiol 72:533-40. 2000
    ..These data show that scavenger receptor-targeted PDT gives a high degree of specificity toward macrophages and may have applications in the treatment of tumors and atherosclerosis...
  19. pmc Helicobacter pylori accumulates photoactive porphyrins and is killed by visible light
    Michael R Hamblin
    Wellman Center for Photomedicine, Massachusetts General Hospital, 40 Blossom Street, BAR314B, Boston, Massachusetts 02114 2698, USA
    Antimicrob Agents Chemother 49:2822-7. 2005
    ..Both virulent and drug-resistant strains are killed. The data suggest that phototherapy might be used to treat H. pylori infection in the human stomach...
  20. pmc Optical monitoring and treatment of potentially lethal wound infections in vivo
    Michael R Hamblin
    Wellman Laboratories of Photomedicine, Massachusetts General Hospital, and Department of Dermatology, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Infect Dis 187:1717-25. 2003
    ..PDT-treated wounds healed significantly faster than did silver nitrate-treated wounds, and this was not due to either inhibition of healing by silver nitrate or stimulation of healing by PDT...
  21. ncbi request reprint Pegylation of a chlorin(e6) polymer conjugate increases tumor targeting of photosensitizer
    M R Hamblin
    Wellman Laboratories of Photomedicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Cancer Res 61:7155-62. 2001
    ..Taken together, these results suggest that pegylation of a polymer-photosensitizer conjugate improves tumor-targeting and may increase the efficacy of photodynamic therapy for ovarian cancer...
  22. pmc Cytoplasmic molecular delivery with shock waves: importance of impulse
    T Kodama
    Wellman Laboratories of Photomedicine, Massachusetts General Hospital, and Department of Dermatology, Harvard Medical School, Boston, MA 02114, USA
    Biophys J 79:1821-32. 2000
    ....
  23. ncbi request reprint Photodynamic tissue adhesion with chlorin(e6) protein conjugates
    J Khadem
    The Retina Specialists of Boston, Harvard Medical School, 02114, USA
    Invest Ophthalmol Vis Sci 40:3132-7. 1999
    ..To test the hypothesis that a photodynamic laser-activated tissue solder would perform better in sealing scleral incisions when the photosensitizer was covalently linked to the protein than when it was noncovalently mixed...
  24. pmc Macrophage-targeted photodynamic therapy: scavenger receptor expression and activation state
    Q Liu
    Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA 02114, USA
    Int J Immunopathol Pharmacol 18:391-402. 2005
    ..These data may have implications for the use of PDT to target physiologically undesirable macrophage subtypes implicated in disease, and on how manipulation of the activation status of the macrophage will influence the PDT effect...
  25. pmc Epidermal growth factor receptor-targeted immunophotodiagnosis and photoimmunotherapy of oral precancer in vivo
    N S Soukos
    Wellman Laboratories of Photomedicine, Department of Dermatology, Massachusetts General Hospital, 50 Blossom Street, Boston, MA 02114, USA
    Cancer Res 61:4490-6. 2001
    ..Taken together, the results demonstrate the potential for development of immunophotodiagnosis as a diagnostic tool and as a method of monitoring response to therapy and that the EGFR may be an appropriate target in head and neck cancer...
  26. pmc Biodistribution of charged 17.1A photoimmunoconjugates in a murine model of hepatic metastasis of colorectal cancer
    M R Hamblin
    Wellman Laboratories of Photomedicine, Massachusetts General Hospital, Boston, MA 02114, USA
    Br J Cancer 83:1544-51. 2000
    ..Cationic species had a high uptake in the lungs compared to anionic species. The photoimmunoconjugates show an advantage over literature reports of other photosensitizers, which can result in tumour:normal liver ratios of less than 1...
  27. pmc In vivo fluorescence imaging of the transport of charged chlorin e6 conjugates in a rat orthotopic prostate tumour
    M R Hamblin
    Wellman Laboratories of Photomedicine, Harvard Medical School, Massachusetts General Hospital, Boston 02114, USA
    Br J Cancer 81:261-8. 1999
    ..These results are consistent with differences in aggregation state between conjugates...
  28. pmc Biodistribution of charged F(ab')2 photoimmunoconjugates in a xenograft model of ovarian cancer
    L R Duska
    Wellman Laboratories of Photomedicine, Harvard Medical School, Masssachusetts General Hospital, Boston 02114, USA
    Br J Cancer 75:837-44. 1997
    ..p. tumour. Positively charged PICs may have applications in the i.p. photoimmunotherapy of minimal residual ovarian cancer...
  29. pmc Targeted photodestruction of human colon cancer cells using charged 17.1A chlorin e6 immunoconjugates
    M Del Governatore
    Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
    Br J Cancer 82:56-64. 2000
    ..By contrast, 1 microM free c(e6) gave only a 35% reduction in colonies. These data suggest photoimmunoconjugates may have applications in photoimmunotherapy where destruction of colorectal cancer cells is required...
  30. pmc Macrophage-targeted photodynamic therapy
    T N Demidova
    Wellman Center for Photomedicine, Mass General Hospital, Boston, MA 02114, USA
    Int J Immunopathol Pharmacol 17:117-26. 2004
    ..The capability to selectively kill macrophages has applications in treating cancer and in the detection and therapy of vulnerable atherosclerotic plaque and possibly for autoimmune disease and some infections...
  31. pmc Photodynamic therapy targeted to pathogens
    T N Demidova
    Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA 02114, USA
    Int J Immunopathol Pharmacol 17:245-54. 2004
    ..Not only were bacteria infecting wounds, burns, and abscesses killed, but mice were saved from death due to sepsis and wound healing was improved...
  32. pmc Synergistic combination of chitosan acetate with nanoparticle silver as a topical antimicrobial: efficacy against bacterial burn infections
    Liyi Huang
    Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Antimicrob Agents Chemother 55:3432-8. 2011
    ..These data suggest that a dressing combining chitosan acetate with silver leads to improved antimicrobial efficacy against fatal burn infections...
  33. pmc Drug discovery of antimicrobial photosensitizers using animal models
    Sulbha K Sharma
    Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA 02114, USA
    Curr Pharm Des 17:1303-19. 2011
    ..This range of animal models also represents a powerful aid in antimicrobial drug discovery...
  34. pmc Combination approaches to potentiate immune response after photodynamic therapy for cancer
    Tyler G St Denis
    Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA 02114, USA
    Photochem Photobiol Sci 10:792-801. 2011
    ..We believe that by understanding the methods employed by tumors to evade immune response and neutralizing them, more precise ways of potentiating PDT-induced immunity can be devised...
  35. pmc Topical antimicrobials for burn wound infections
    T Dai
    Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA, USA
    Recent Pat Antiinfect Drug Discov 5:124-51. 2010
    ..This active area of research will continue to provide new topical antimicrobials for burns that will battle against growing multidrug resistance...
  36. pmc Effect of cell-photosensitizer binding and cell density on microbial photoinactivation
    Tatiana N Demidova
    Massachusetts General Hospital, BAR314B, 40 Blossom Street, Boston, MA 02114 2698, USA
    Antimicrob Agents Chemother 49:2329-35. 2005
    ..coli>C. albicans, but C. albicans cells were 10 to 50 times bigger than the bacteria. We conclude that the number and mass of the cells compete both for available dye binding and for extracellularly generated reactive oxygen species...
  37. pmc Antimicrobial effects of photodynamic therapy on patients with necrotic pulps and periapical lesion
    Aguinaldo Silva Garcez
    Centro de Laser e Aplicações, IPEN CNEN SP, Sao Paulo, Brazil
    J Endod 34:138-42. 2008
    ..00006). Results suggest that the use of PDT added to endodontic treatment leads to an enhanced decrease of bacterial load and may be an appropriate approach for the treatment of oral infections...
  38. pmc Inhibitors of bacterial multidrug efflux pumps potentiate antimicrobial photoinactivation
    George P Tegos
    Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Antimicrob Agents Chemother 52:3202-9. 2008
    ..aureus. These data suggest that EPI could be used in combination with phenothiazinium salts and light to enhance their antimicrobial effect against localized infections...
  39. pmc Effect of chitosan acetate bandage on wound healing in infected and noninfected wounds in mice
    Marina Burkatovskaya
    Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Wound Repair Regen 16:425-31. 2008
    ..Chitosan acetate bandage reduced the number of inflammatory cells in the wound at days 2 and 4, and had an overall beneficial effect on wound healing especially during the early period where its antimicrobial effect is most important...
  40. pmc Cationic fullerenes are effective and selective antimicrobial photosensitizers
    George P Tegos
    Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, 02114, USA
    Chem Biol 12:1127-35. 2005
    ..The high selectivity and efficacy exhibited by these photosensitizers encourage further testing for antimicrobial applications...
  41. pmc Use of chitosan bandage to prevent fatal infections developing from highly contaminated wounds in mice
    Marina Burkatovskaya
    Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA, USA
    Biomaterials 27:4157-64. 2006
    ..The data suggest that chitosan acetate rapidly kills bacteria in the wound before systemic invasion can take place, and is superior to alginate bandage and silver sulfadiazine that may both encourage bacterial growth in the short term...
  42. pmc Effects of growth phase and extracellular slime on photodynamic inactivation of gram-positive pathogenic bacteria
    Faten Gad
    Wellman Laboratories of Photomedicine, Massachusetts General Hospital, BAR314B, 40 Blossom St, Boston, MA 02114 2698, USA
    Antimicrob Agents Chemother 48:2173-8. 2004
    ..These data suggest that slime production and stationary phase can be obstacles against PDI for gram-positive bacteria but that these obstacles can be overcome by using cationic PS...
  43. pmc Delivery of ribosome-inactivating protein toxin into cancer cells with shock waves
    Tetsuya Kodama
    WEL224, Wellman Laboratories of Photomedicine, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
    Cancer Lett 189:69-75. 2003
    ..Higher toxicity was seen with the clonogenic assay compared to MTT assay. Shock waves may have applications in promoting cytoplasmic delivery of toxins into cancer cells after intratumoral injection...
  44. ncbi request reprint Shock wave-mediated molecular delivery into cells
    Tetsuya Kodama
    BAR314B, Wellman Laboratories of Photomedicine, Massachusetts General Hospital, Boston, MA 02114, USA
    Biochim Biophys Acta 1542:186-94. 2002
    ..Shock waves can deliver molecules of up to 2000000 molecular weight into the cytoplasm of cells without toxicity and may have applications in gene therapy...
  45. pmc Photodynamic therapy with fullerenes
    Pawel Mroz
    Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA, USA
    Photochem Photobiol Sci 6:1139-49. 2007
    ..The mechanism appears to involve superoxide anion as well as singlet oxygen, and under the right conditions fullerenes may have advantages over clinically applied photosensitizers for mediating photodynamic therapy of certain diseases...
  46. pmc Synthesis and properties of benzo[a]phenoxazinium chalcogen analogues as novel broad-spectrum antimicrobial photosensitizers
    James W Foley
    Rowland Institute at Harvard, Harvard University, Cambridge, Massachusetts 02142, USA
    J Med Chem 49:5291-9. 2006
    ..These data, taken with the findings of uptake and retention studies, suggest that the superior activity of selenium derivative 3 can be attributed to its much higher triplet quantum yield...
  47. pmc Photosensitizer delivery to vulnerable atherosclerotic plaque: comparison of macrophage-targeted conjugate versus free chlorin(e6)
    Ahmed Tawakol
    Massachusetts General Hospital, Cardiac Unit, Department of Medicine, and Harvard Medical School, Boston, Massachusetts, USA
    J Biomed Opt 11:021008. 2006
    ..The liver, spleen, lung, and gall bladder have the highest uptake in nontarget organs. Macrophage-targeted photosensitizer conjugates may have applications in both detecting and treating inflamed vulnerable plaque...
  48. pmc Protease-stable polycationic photosensitizer conjugates between polyethyleneimine and chlorin(e6) for broad-spectrum antimicrobial photoinactivation
    George P Tegos
    Wellman Center for Photomedicine, Massachusetts General Hospital, and Department of Dermatology, Harvard Medical School, Boston, MA 02114 2698, USA
    Antimicrob Agents Chemother 50:1402-10. 2006
    ....
  49. pmc Antimicrobial photodynamic therapy combined with conventional endodontic treatment to eliminate root canal biofilm infection
    Aguinaldo S Garcez
    Center for Lasers and Applications, IPEN CNEN SP, Sao Paulo, SP, Brazil
    Lasers Surg Med 39:59-66. 2007
    ..To compare the effectiveness of antimicrobial photodynamic therapy (PDT), standard endodontic treatment and the combined treatment to eliminate bacterial biofilms present in infected root canals...
  50. pmc Macrophage-targeted photosensitizer conjugate delivered by intratumoral injection
    Florencia Anatelli
    Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Mol Pharm 3:654-64. 2006
    ..IT injection of nonconjugated PS gave lower tumor accumulation that did not correlate with macrophage content. IT injection of targeted macromolecular delivery systems is an underexplored area and worthy of further study...
  51. pmc A comparative in vitro photoinactivation study of clinical isolates of multidrug-resistant pathogens
    Hi M Tang
    Department of Health Technology and Informatics, Medical Laboratory Science Section, The Hong Kong Polytechnic University, Hung Hom, Hong Kong, SAR
    J Infect Chemother 13:87-91. 2007
    ..coli and E. coli (ATCC 25922). Our studied MRSA isolate responded better than S. aureus (ATCC 25923). Thus, pL-ce6-mediated PDI in other MRSA isolates deserves further investigation...
  52. pmc Susceptibility of Cryptococcus neoformans to photodynamic inactivation is associated with cell wall integrity
    Beth Burgwyn Fuchs
    Infectious Diseases, Massachusetts General Hospital, Boston, MA 02144, USA
    Antimicrob Agents Chemother 51:2929-36. 2007
    ..These studies demonstrated that C. neoformans is sensitive to photodynamic therapy and illustrated the significance of cell wall integrity in microbial susceptibility to antimicrobial photodynamic inactivation...
  53. pmc Monitoring photodynamic therapy of localized infections by bioluminescence imaging of genetically engineered bacteria
    Tatiana N Demidova
    Wellman Center for Photomedicine, Massachusetts General Hospital, BAR414, 40 Blossom Street, Boston, MA, USA
    J Photochem Photobiol B 81:15-25. 2005
    ..Healing of the PDT treated wounds is not impaired and may actually be improved. This approach can allow many animal models of localized infections to be accurately monitored for efficacy of treatment by PDT...
  54. pmc Photodynamic inactivation of Bacillus spores, mediated by phenothiazinium dyes
    Tatiana N Demidova
    Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA 02114, USA
    Appl Environ Microbiol 71:6918-25. 2005
    ..The relatively mild conditions needed for spore killing could have applications for treating wounds contaminated by anthrax spores, for which conventional sporicides would have unacceptable tissue toxicity...
  55. pmc Bioconjugatable porphyrins bearing a compact swallowtail motif for water solubility
    K Eszter Borbas
    Department of Chemistry, North Carolina State University, Raleigh, North Carolina 27695 8204, USA
    Bioconjug Chem 17:638-53. 2006
    ..Taken together, this work enables preparation of useful quantities of water-soluble, bioconjugatable porphyrins in a compact architecture for applications in the life sciences...
  56. pmc Targeted photodynamic therapy of established soft-tissue infections in mice
    Faten Gad
    Wellman Laboratories of Photomedicine, Masschusetts General Hospital, Boston 02114, USA
    Photochem Photobiol Sci 3:451-8. 2004
    ..PDT-treated infected legs healed better than legs with untreated infections. This data shows that PDT may have applications in drug-resistant soft-tissue infections...
  57. pmc Deficiency of mannose-binding lectin greatly increases susceptibility to postburn infection with Pseudomonas aeruginosa
    Mette Møller-Kristensen
    Laboratory of Developmental Immunology, Department of Pediatrics, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    J Immunol 176:1769-75. 2006
    ..aeruginosa infection following burn injury and suggests that MBL deficiency in humans maybe a premorbid variable in the predisposition to infection in burn victims...
  58. pmc Phenothiazinium antimicrobial photosensitizers are substrates of bacterial multidrug resistance pumps
    George P Tegos
    BAR414, Wellman Center for Photomedicine, Massachusetts General Hospital, 40 Blossom Street, Boston, Massachusetts 02114, USA
    Antimicrob Agents Chemother 50:196-203. 2006
    ..We propose that specific MDR inhibitors could be used in combination with phenothiazinium salts to enhance their photodestructive efficiency...
  59. pmc Photodynamic therapy for Staphylococcus aureus infected burn wounds in mice
    Saskia A G Lambrechts
    Laser Center, Academic Medical Center, University of Amsterdam, The Netherlands
    Photochem Photobiol Sci 4:503-9. 2005
    ..Light alone or PDT both delayed the wound healing. These data suggest that PDT has the potential to rapidly reduce the bacterial load in infected burns. The treatment needs to be optimized to reduce wound damage and prevent recurrence...
  60. pmc Photodynamic therapy and anti-tumour immunity
    Ana P Castano
    Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, Massachusetts, USA
    Nat Rev Cancer 6:535-45. 2006
    ....
  61. pmc Healing of perforating rat corneal incisions closed with photodynamic laser-activated tissue glue
    John Khadem
    The Schepens Eye Research Institute, Harvard Medical School, Boston, MA, USA
    Lasers Surg Med 35:304-11. 2004
    ..Laser-activated photodynamic biologic tissue glues may be useful for closing incisions in ophthalmology. We report on the use of two such preparations to close perforating corneal incisions in living rats...
  62. pmc Helicobacter pylori in patients can be killed by visible light
    Robert A Ganz
    Sterilite LLC, Minnetonka, Minnesota, USA
    Lasers Surg Med 36:260-5. 2005
    ..Novel antimicrobial approaches are sought due to the occurrence of antibiotic resistance and consequent treatment failure. We report here that H. pylori is susceptible to inactivation by blue light...
  63. pmc Photodynamic therapy plus low-dose cyclophosphamide generates antitumor immunity in a mouse model
    Ana P Castano
    Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 105:5495-500. 2008
    ..Cured mice had tumor-specific T cells in spleens as determined by a (51)Cr release assay. We conclude that low-dose CY depletes T-regs and potentiates BPD-PDT, leading to tumor cures and memory immunity...
  64. pmc Low-level laser therapy for zymosan-induced arthritis in rats: Importance of illumination time
    Ana P Castano
    Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Lasers Surg Med 39:543-50. 2007
    ..For all indications (including arthritis) the optimum optical parameters have been difficult to establish and so far are unknown...
  65. pmc Involvement of skeletal muscle gene regulatory network in susceptibility to wound infection following trauma
    Yiorgos Apidianakis
    Department of Surgery, Harvard Medical School and Massachusetts General Hospital, Boston, Massachusetts, United States of America
    PLoS ONE 2:e1356. 2007
    ..aeruginosa cells, could lead to novel therapies that prevent or treat deleterious and potentially fatal infections in severely injured individuals...
  66. pmc Functionalized fullerenes mediate photodynamic killing of cancer cells: Type I versus Type II photochemical mechanism
    Pawel Mroz
    Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA, USA
    Free Radic Biol Med 43:711-9. 2007
    ..We conclude that certain functionalized fullerenes have potential as novel PDT agents and phototoxicity may be mediated both by superoxide and by singlet oxygen...
  67. pmc Intravascular detection of inflamed atherosclerotic plaques using a fluorescent photosensitizer targeted to the scavenger receptor
    Ahmed Tawakol
    Department of Medicine Cardiac Unit, Massachusetts General Hospital, Boston, MA 02114, USA
    Photochem Photobiol Sci 7:33-9. 2008
    ..83, p < 0.001) and an inverse correlation between MA-ce6 uptake and smooth muscle cell staining (R = -0.74, p < 0.001). MA-ce6 may function as a molecular imaging agent to detect and/or photodynamically treat inflamed plaques...

Research Grants11

  1. Photodynamic Therapy of Localized Infections
    Michael R Hamblin; Fiscal Year: 2010
    ..This application seeks to determine the optimum parameters for antimicrobial PDT and will look at new synergistic combination therapies. ..
  2. Macrophage Targeted Photodynamic Therapy
    MICHAEL HAMBLIN; Fiscal Year: 2002
    ....
  3. Photodynamic Therapy of Localized Infections
    MICHAEL HAMBLIN; Fiscal Year: 2009
    ..This application seeks to determine the optimum parameters for antimicrobial PDT and will look at new synergistic combination therapies. ..
  4. Ultraviolet-C Therapy for Onychomycosis
    MICHAEL HAMBLIN; Fiscal Year: 2006
    ....
  5. Photodynamic Therapy of Localized Infections
    MICHAEL HAMBLIN; Fiscal Year: 2006
    ..abstract_text> ..
  6. Macrophage Targeted Photodynamic Therapy
    MICHAEL HAMBLIN; Fiscal Year: 2004
    ....
  7. Photodynamic Therapy of Localized Infections
    MICHAEL HAMBLIN; Fiscal Year: 2003
    ..abstract_text> ..
  8. Macrophage Targeted Photodynamic Therapy
    MICHAEL HAMBLIN; Fiscal Year: 2003
    ....