Kathleen J Haley

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Maternal smoking and the retinoid pathway in the developing lung
    Sara E Manoli
    Department of Medicine, Division of Pulmonary and Critical Care, Brigham and Women s Hospital, Boston, MA, USA
    Respir Res 13:42. 2012
  2. pmc RUNX transcription factors: association with pediatric asthma and modulated by maternal smoking
    Kathleen J Haley
    Brigham and Women s Hospital, Division of Pulmonary and Critical Care Medicine, PBB 3, 75 Francis St, Boston, Massachusetts 02115, USA
    Am J Physiol Lung Cell Mol Physiol 301:L693-701. 2011
  3. ncbi request reprint Ontogeny of the eotaxins in human lung
    Kathleen J Haley
    Brigham and Women s Hospital, Division of Pulmonary and Critical Care Medicine, 75 Francis Street, Boston, MA 02115, USA
    Am J Physiol Lung Cell Mol Physiol 294:L214-24. 2008
  4. pmc Induction of the plasminogen activator system by mechanical stimulation of human bronchial epithelial cells
    Eric K Chu
    Brigham and Women s Hospital, Department of Pulmonary and Critical Care Medicine, Harvard School of Public Health, Physiology Program and Children s Hospital Informatics Program, Boston, Massachusetts 02115, USA
    Am J Respir Cell Mol Biol 35:628-38. 2006
  5. ncbi request reprint Analysis of immunoglobulin and T-cell receptor gene deficiency in graft rejection by gene expression profiles
    Rachel A DeFina
    Laboratory of Molecular Immunology, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Transplantation 77:580-6. 2004
  6. ncbi request reprint Analysis of the major histocompatibility complex in graft rejection revisited by gene expression profiles
    Kenneth Christopher
    Laboratory of Molecular Immunology, Renal Division, Brigham and Women s Hospital, Boston, MA 02115, USA
    Transplantation 78:788-98. 2004
  7. ncbi request reprint Induction of early growth-response factor 1 by platelet-derived growth factor in human airway smooth muscle
    Josephine Hjoberg
    Physiology Program, Dept of Environmental Health, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115 6021, USA
    Am J Physiol Lung Cell Mol Physiol 286:L817-25. 2004
  8. ncbi request reprint Nitric oxide synthase-2 down-regulates surfactant protein-B expression and enhances endotoxin-induced lung injury in mice
    Rebecca M Baron
    Division of Pulmonary and Critical Care Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    FASEB J 18:1276-8. 2004
  9. ncbi request reprint Mechanotransduction through growth-factor shedding into the extracellular space
    Daniel J Tschumperlin
    Physiology Program, Department of Environmental Health, Harvard School of Public Health, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 429:83-6. 2004
  10. ncbi request reprint Constitutive and cytokine-induced expression of the ETS transcription factor ESE-3 in the lung
    Eric S Silverman
    Division of Pulmonary and Critical Care Medicine and Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston 02115, USA
    Am J Respir Cell Mol Biol 27:697-704. 2002

Collaborators

Detail Information

Publications20

  1. pmc Maternal smoking and the retinoid pathway in the developing lung
    Sara E Manoli
    Department of Medicine, Division of Pulmonary and Critical Care, Brigham and Women s Hospital, Boston, MA, USA
    Respir Res 13:42. 2012
    ..Thus, abnormalities in this pathway could mediate maternal smoking effects. We tested whether maternal smoking disrupts retinoic acid pathway expression and functioning in a murine model...
  2. pmc RUNX transcription factors: association with pediatric asthma and modulated by maternal smoking
    Kathleen J Haley
    Brigham and Women s Hospital, Division of Pulmonary and Critical Care Medicine, PBB 3, 75 Francis St, Boston, Massachusetts 02115, USA
    Am J Physiol Lung Cell Mol Physiol 301:L693-701. 2011
    ..We speculate that IUS exposure-altered expression of RUNX transcription factors increases the risk of asthma in children with IUS exposure...
  3. ncbi request reprint Ontogeny of the eotaxins in human lung
    Kathleen J Haley
    Brigham and Women s Hospital, Division of Pulmonary and Critical Care Medicine, 75 Francis Street, Boston, MA 02115, USA
    Am J Physiol Lung Cell Mol Physiol 294:L214-24. 2008
    ..We conclude that developing lung expresses the eotaxins and functional CCR3 receptor. CCL11 may promote airway epithelial proliferation in the developing lung...
  4. pmc Induction of the plasminogen activator system by mechanical stimulation of human bronchial epithelial cells
    Eric K Chu
    Brigham and Women s Hospital, Department of Pulmonary and Critical Care Medicine, Harvard School of Public Health, Physiology Program and Children s Hospital Informatics Program, Boston, Massachusetts 02115, USA
    Am J Respir Cell Mol Biol 35:628-38. 2006
    ..Together these observations suggest an integrated response of airway epithelial cells to mechanical stimulation, acting through the plasminogen-activating system to modify the airway microenvironment...
  5. ncbi request reprint Analysis of immunoglobulin and T-cell receptor gene deficiency in graft rejection by gene expression profiles
    Rachel A DeFina
    Laboratory of Molecular Immunology, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Transplantation 77:580-6. 2004
    ..Some members of the immunoglobulin superfamily (e.g., alphabeta T-cell receptors [TCR]) are known to be crucial for acute allograft rejection, but the role of other members remains poorly defined...
  6. ncbi request reprint Analysis of the major histocompatibility complex in graft rejection revisited by gene expression profiles
    Kenneth Christopher
    Laboratory of Molecular Immunology, Renal Division, Brigham and Women s Hospital, Boston, MA 02115, USA
    Transplantation 78:788-98. 2004
    ..The precise role of major histocompatibility complex (MHC) molecules in graft rejection remains incompletely understood. The important role of foreign peptides in the alloimmune response was recently recognized...
  7. ncbi request reprint Induction of early growth-response factor 1 by platelet-derived growth factor in human airway smooth muscle
    Josephine Hjoberg
    Physiology Program, Dept of Environmental Health, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115 6021, USA
    Am J Physiol Lung Cell Mol Physiol 286:L817-25. 2004
    ..Although EGR-1 is induced by PDGF in human airway smooth muscle cells in cell culture, the role of EGR-1 in airway remodeling and asthma remains to be established...
  8. ncbi request reprint Nitric oxide synthase-2 down-regulates surfactant protein-B expression and enhances endotoxin-induced lung injury in mice
    Rebecca M Baron
    Division of Pulmonary and Critical Care Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    FASEB J 18:1276-8. 2004
    ..This study demonstrates that expression of NOS2 in lung epithelial cells is critical for the development of lung injury and mediates surfactant dysfunction independent of NOS2 inflammatory cell expression and cytokine production...
  9. ncbi request reprint Mechanotransduction through growth-factor shedding into the extracellular space
    Daniel J Tschumperlin
    Physiology Program, Department of Environmental Health, Harvard School of Public Health, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 429:83-6. 2004
    ....
  10. ncbi request reprint Constitutive and cytokine-induced expression of the ETS transcription factor ESE-3 in the lung
    Eric S Silverman
    Division of Pulmonary and Critical Care Medicine and Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston 02115, USA
    Am J Respir Cell Mol Biol 27:697-704. 2002
    ..Overexpression of ESE-3 protein in 3T3 cells and human bronchial smooth muscle cells inhibits MMP-1 promoter activity, suggesting that ESE-3 may function as a transcriptional repressor...
  11. ncbi request reprint Analysis of cytokine functions in graft rejection by gene expression profiles
    Yurong Liang
    Laboratory of Molecular Immunology, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02215, USA
    Transplantation 76:1749-58. 2003
    ..Previous studies have suggested that IFNgamma can promote rejection and be important in tolerance induction...
  12. pmc Protectin D1 is generated in asthma and dampens airway inflammation and hyperresponsiveness
    Bruce D Levy
    Pulmonary and Critical Care Medicine, Department of Internal Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Immunol 178:496-502. 2007
    ..Together, these findings provide evidence for endogenous PD1 as a pivotal counterregulatory signal in allergic airway inflammation and point to new therapeutic strategies for modulating inflammation in asthmatic lung...
  13. ncbi request reprint Stage-specific effects of cAMP signaling during distal lung epithelial development
    Jingsong Xu
    Division of Pulmonary and Critical Care Medicine, Brigham and Women s Hospital at Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    J Biol Chem 281:38894-904. 2006
    ....
  14. ncbi request reprint Angiogenic growth factors in the pathophysiology of a murine model of acute lung injury
    Dimitrios Karmpaliotis
    Division of Pulmonary and Critical Care Medicine, Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02364, USA
    Am J Physiol Lung Cell Mol Physiol 283:L585-95. 2002
    ..These data suggest that changes in the balance between VEGF and Ang-1 and -4 after LPS exposure may modulate neutrophil influx, protein leakage, and alveolar flooding during early ALI...
  15. ncbi request reprint ABCA3 inactivation in mice causes respiratory failure, loss of pulmonary surfactant, and depletion of lung phosphatidylglycerol
    Michael L Fitzgerald
    Lipid Metabolism Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    J Lipid Res 48:621-32. 2007
    ..They also demonstrate the utility of the Abca3 null mouse as a model for a devastating human disease...
  16. ncbi request reprint Bronchial epithelial compression regulates MAP kinase signaling and HB-EGF-like growth factor expression
    Daniel J Tschumperlin
    Physiology Program, Department of Environmental Health, Harvard School of Public Health, Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Physiol Lung Cell Mol Physiol 282:L904-11. 2002
    ..These results demonstrate that compressive stress is a selective and potent activator of signal transduction and gene expression in bronchial epithelial cells...
  17. pmc The SERPINE2 gene is associated with chronic obstructive pulmonary disease
    Dawn L DeMeo
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Hum Genet 78:253-64. 2006
    ....
  18. ncbi request reprint Alterations in lung collectins in an adaptive allergic immune response
    Kathleen J Haley
    Respiratory Division, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Am J Physiol Lung Cell Mol Physiol 282:L573-84. 2002
    ..Our findings support a model in which surfactant apoproteins A and D are important to both innate immunity and adaptive immune responses to allergens...
  19. ncbi request reprint Effects of IL-13 on airway responses in the guinea pig
    Brian Morse
    Combined Program in Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Physiol Lung Cell Mol Physiol 282:L44-9. 2002
    ....
  20. ncbi request reprint Prolonged allograft survival in TNF receptor 1-deficient recipients is due to immunoregulatory effects, not to inhibition of direct antigraft cytotoxicity
    Charlotte M McKee
    Laboratory of Molecular Immunology, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    J Immunol 168:483-9. 2002
    ..These findings indicate that in our experimental system TNF-alpha and LTalpha exert profound immunoregulatory effects through TNF-R1...