Research Topics
Genomes and Genes | Kathleen J HaleySummaryAffiliation: Harvard University Country: USA Publications
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Publications
RUNX transcription factors: association with pediatric asthma and modulated by maternal smokingKathleen J Haley
Brigham and Women s Hospital, Division of Pulmonary and Critical Care Medicine, PBB 3, 75 Francis St, Boston, Massachusetts 02115, USA
Am J Physiol Lung Cell Mol Physiol 301:L693-701. 2011..We speculate that IUS exposure-altered expression of RUNX transcription factors increases the risk of asthma in children with IUS exposure...
Ontogeny of the eotaxins in human lungKathleen J Haley
Brigham and Women s Hospital, Division of Pulmonary and Critical Care Medicine, 75 Francis Street, Boston, MA 02115, USA
Am J Physiol Lung Cell Mol Physiol 294:L214-24. 2008..We conclude that developing lung expresses the eotaxins and functional CCR3 receptor. CCL11 may promote airway epithelial proliferation in the developing lung...- Induction of the plasminogen activator system by mechanical stimulation of human bronchial epithelial cellsEric K Chu
Brigham and Women s Hospital, Department of Pulmonary and Critical Care Medicine, Harvard School of Public Health, Physiology Program and Children s Hospital Informatics Program, Boston, Massachusetts 02115, USA
Am J Respir Cell Mol Biol 35:628-38. 2006..Together these observations suggest an integrated response of airway epithelial cells to mechanical stimulation, acting through the plasminogen-activating system to modify the airway microenvironment... - Analysis of immunoglobulin and T-cell receptor gene deficiency in graft rejection by gene expression profilesRachel A DeFina
Laboratory of Molecular Immunology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA
Transplantation 77:580-6. 2004..In addition, several genes are identified that are candidates as necessary for rejection. This has crucial implications for developing clinical therapies that target specific mechanisms for prolonging graft survival... - Analysis of the major histocompatibility complex in graft rejection revisited by gene expression profilesKenneth Christopher
Laboratory of Molecular Immunology, Renal Division, Brigham and Women s Hospital, Boston, MA 02115, USA
Transplantation 78:788-98. 2004..The precise role of major histocompatibility complex (MHC) molecules in graft rejection remains incompletely understood. The important role of foreign peptides in the alloimmune response was recently recognized... - Induction of early growth-response factor 1 by platelet-derived growth factor in human airway smooth muscleJosephine Hjoberg
Physiology Program, Dept of Environmental Health, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115 6021, USA
Am J Physiol Lung Cell Mol Physiol 286:L817-25. 2004..Although EGR-1 is induced by PDGF in human airway smooth muscle cells in cell culture, the role of EGR-1 in airway remodeling and asthma remains to be established... - Nitric oxide synthase-2 down-regulates surfactant protein-B expression and enhances endotoxin-induced lung injury in miceRebecca M Baron
Division of Pulmonary and Critical Care Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
FASEB J 18:1276-8. 2004..This study demonstrates that expression of NOS2 in lung epithelial cells is critical for the development of lung injury and mediates surfactant dysfunction independent of NOS2 inflammatory cell expression and cytokine production... - Mechanotransduction through growth-factor shedding into the extracellular spaceDaniel J Tschumperlin
Physiology Program, Department of Environmental Health, Harvard School of Public Health, Harvard Medical School, Boston, Massachusetts 02115, USA
Nature 429:83-6. 2004.... - Stage-specific effects of cAMP signaling during distal lung epithelial developmentJingsong Xu
Division of Pulmonary and Critical Care Medicine, Brigham and Women s Hospital at Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
J Biol Chem 281:38894-904. 2006.... - Angiogenic growth factors in the pathophysiology of a murine model of acute lung injuryDimitrios Karmpaliotis
Division of Pulmonary and Critical Care Medicine, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02364, USA
Am J Physiol Lung Cell Mol Physiol 283:L585-95. 2002..These data suggest that changes in the balance between VEGF and Ang-1 and -4 after LPS exposure may modulate neutrophil influx, protein leakage, and alveolar flooding during early ALI... - Protectin D1 is generated in asthma and dampens airway inflammation and hyperresponsivenessBruce D Levy
Pulmonary and Critical Care Medicine, Department of Internal Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
J Immunol 178:496-502. 2007..Together, these findings provide evidence for endogenous PD1 as a pivotal counterregulatory signal in allergic airway inflammation and point to new therapeutic strategies for modulating inflammation in asthmatic lung... - Analysis of cytokine functions in graft rejection by gene expression profilesYurong Liang
Laboratory of Molecular Immunology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02215, USA
Transplantation 76:1749-58. 2003..Thus, these genes become candidates for essential functions during rejection... - Maternal smoking and the retinoid pathway in the developing lungSara E Manoli
Department of Medicine, Division of Pulmonary and Critical Care, Brigham and Women s Hospital, Boston, MA, USA
Respir Res 13:42. 2012..Thus, abnormalities in this pathway could mediate maternal smoking effects. We tested whether maternal smoking disrupts retinoic acid pathway expression and functioning in a murine model... - Constitutive and cytokine-induced expression of the ETS transcription factor ESE-3 in the lungEric S Silverman
Division of Pulmonary and Critical Care Medicine and Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston 02115, USA
Am J Respir Cell Mol Biol 27:697-704. 2002..Overexpression of ESE-3 protein in 3T3 cells and human bronchial smooth muscle cells inhibits MMP-1 promoter activity, suggesting that ESE-3 may function as a transcriptional repressor... - ABCA3 inactivation in mice causes respiratory failure, loss of pulmonary surfactant, and depletion of lung phosphatidylglycerolMichael L Fitzgerald
Lipid Metabolism Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
J Lipid Res 48:621-32. 2007..They also demonstrate the utility of the Abca3 null mouse as a model for a devastating human disease... - Bronchial epithelial compression regulates MAP kinase signaling and HB-EGF-like growth factor expressionDaniel J Tschumperlin
Physiology Program, Department of Environmental Health, Harvard School of Public Health, Harvard Medical School, Boston, Massachusetts 02115, USA
Am J Physiol Lung Cell Mol Physiol 282:L904-11. 2002..These results demonstrate that compressive stress is a selective and potent activator of signal transduction and gene expression in bronchial epithelial cells... - The SERPINE2 gene is associated with chronic obstructive pulmonary diseaseDawn L DeMeo
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
Am J Hum Genet 78:253-64. 2006.... - Alterations in lung collectins in an adaptive allergic immune responseKathleen J Haley
Respiratory Division, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA
Am J Physiol Lung Cell Mol Physiol 282:L573-84. 2002..Our findings support a model in which surfactant apoproteins A and D are important to both innate immunity and adaptive immune responses to allergens... - Effects of IL-13 on airway responses in the guinea pigBrian Morse
Combined Program in Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
Am J Physiol Lung Cell Mol Physiol 282:L44-9. 2002.... - Prolonged allograft survival in TNF receptor 1-deficient recipients is due to immunoregulatory effects, not to inhibition of direct antigraft cytotoxicityCharlotte M McKee
Laboratory of Molecular Immunology, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
J Immunol 168:483-9. 2002..These findings indicate that in our experimental system TNF-alpha and LTalpha exert profound immunoregulatory effects through TNF-R1...