W Nicholas Haining

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Measuring T cell immunity to influenza vaccination in children after haemopoietic stem cell transplantation
    W Nicholas Haining
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Br J Haematol 127:322-5. 2004
  2. doi request reprint Integrating genomic signatures for immunologic discovery
    W Nicholas Haining
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Immunity 32:152-61. 2010
  3. pmc Identifying gnostic predictors of the vaccine response
    W Nicholas Haining
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA
    Curr Opin Immunol 24:332-6. 2012
  4. pmc The numerology of T cell functional diversity
    W Nicholas Haining
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Immunity 36:10-2. 2012
  5. pmc High-throughput gene expression profiling of memory differentiation in primary human T cells
    W Nicholas Haining
    Department of Pediatric Dana Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA
    BMC Immunol 9:44. 2008
  6. pmc Antigen-specific T-cell memory is preserved in children treated for acute lymphoblastic leukemia
    W Nicholas Haining
    Dana Farber Cancer Institute, 44 Binney St, Boston, MA 02115, USA
    Blood 106:1749-54. 2005
  7. ncbi request reprint Failure to define window of time for autologous tumor vaccination in patients with newly diagnosed or relapsed acute lymphoblastic leukemia
    W Nicholas Haining
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Exp Hematol 33:286-94. 2005
  8. pmc Deconvolving heterogeneity in the CD8+ T-cell response to HIV
    W Nicholas Haining
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA
    Curr Opin HIV AIDS 7:38-43. 2012
  9. pmc Identification of an evolutionarily conserved transcriptional signature of CD8 memory differentiation that is shared by T and B cells
    W Nicholas Haining
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    J Immunol 181:1859-68. 2008
  10. doi request reprint CpG oligodeoxynucleotides alter lymphocyte and dendritic cell trafficking in humans
    W Nicholas Haining
    Department of Hematology Oncology, Children s Hospital, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Clin Cancer Res 14:5626-34. 2008

Collaborators

Detail Information

Publications20

  1. pmc Measuring T cell immunity to influenza vaccination in children after haemopoietic stem cell transplantation
    W Nicholas Haining
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Br J Haematol 127:322-5. 2004
    ..This assay proved sufficiently sensitive to evaluate changes in T cell memory in immunocompromised individuals and could be used to better characterize post-HSCT immune reconstitution...
  2. doi request reprint Integrating genomic signatures for immunologic discovery
    W Nicholas Haining
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Immunity 32:152-61. 2010
    ....
  3. pmc Identifying gnostic predictors of the vaccine response
    W Nicholas Haining
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA
    Curr Opin Immunol 24:332-6. 2012
    ..The challenge for vaccinologists is therefore to use these tools to embed mechanistic insights into predictors of vaccine response...
  4. pmc The numerology of T cell functional diversity
    W Nicholas Haining
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Immunity 36:10-2. 2012
    ..In this issue of Immunity, Newell et al. (2012) use a new flow cytometry platform to show that the functional heterogeneity of the human T cell compartment is even greater than previously thought...
  5. pmc High-throughput gene expression profiling of memory differentiation in primary human T cells
    W Nicholas Haining
    Department of Pediatric Dana Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA
    BMC Immunol 9:44. 2008
    ....
  6. pmc Antigen-specific T-cell memory is preserved in children treated for acute lymphoblastic leukemia
    W Nicholas Haining
    Dana Farber Cancer Institute, 44 Binney St, Boston, MA 02115, USA
    Blood 106:1749-54. 2005
    ....
  7. ncbi request reprint Failure to define window of time for autologous tumor vaccination in patients with newly diagnosed or relapsed acute lymphoblastic leukemia
    W Nicholas Haining
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Exp Hematol 33:286-94. 2005
    ....
  8. pmc Deconvolving heterogeneity in the CD8+ T-cell response to HIV
    W Nicholas Haining
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA
    Curr Opin HIV AIDS 7:38-43. 2012
    ..This review will discuss the use of systems biology approaches to dissect the heterogeneity of the HIV-specific CD8+ T-cell response...
  9. pmc Identification of an evolutionarily conserved transcriptional signature of CD8 memory differentiation that is shared by T and B cells
    W Nicholas Haining
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    J Immunol 181:1859-68. 2008
    ..Thus, our data suggest that in addition to lineage-specific differentiation programs, T and B lymphocytes use a common transcriptional program during memory development that is disrupted in chronic viral infection...
  10. doi request reprint CpG oligodeoxynucleotides alter lymphocyte and dendritic cell trafficking in humans
    W Nicholas Haining
    Department of Hematology Oncology, Children s Hospital, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Clin Cancer Res 14:5626-34. 2008
    ..CpG-ODN also induce PDC to secrete chemokines that alter lymphocyte migration. Whether CpG-ODN TLR signals enhance antigen-specific immunity and/or trafficking in humans is unknown...
  11. doi request reprint Isolation of RNA and the synthesis and amplification of cDNA from antigen-specific T cells for genome-wide expression analysis
    R Anthony Barnitz
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA
    Methods Mol Biol 979:161-73. 2013
    ..This protocol is a useful tool for the study of genome-wide expression signatures from many of the subpopulations that are numerically small but important in immune responses and homeostasis...
  12. pmc Transcriptional analysis of HIV-specific CD8+ T cells shows that PD-1 inhibits T cell function by upregulating BATF
    Michael Quigley
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA
    Nat Med 16:1147-51. 2010
    ..Thus, inhibitory receptors can cause T cell exhaustion by upregulating genes--such as BATF--that inhibit T cell function. Such genes may provide new therapeutic opportunities to improve T cell immunity to HIV...
  13. pmc Antigen availability determines CD8⁺ T cell-dendritic cell interaction kinetics and memory fate decisions
    Sarah E Henrickson
    Division of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, USA
    Immunity 39:496-507. 2013
    ..Thus, T cells make fate decisions within hours after Ag exposure, resulting in long-term memory or abortive effector responses, correlating with T cell-DCs interaction kinetics...
  14. doi request reprint Compendium of Immune Signatures Identifies Conserved and Species-Specific Biology in Response to Inflammation
    Jernej Godec
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, USA
    Immunity 44:194-206. 2016
    ..ImmuneSigDB enables granular analysis of transcriptomic data to improve biological understanding of immune processes of the human and mouse immune systems. ..
  15. pmc Gene signatures related to B-cell proliferation predict influenza vaccine-induced antibody response
    Yan Tan
    Broad Institute of MIT and Harvard, Cambridge, MA, USA Bioinformatics Program, Boston University, Boston, MA, USA
    Eur J Immunol 44:285-95. 2014
    ..Our results demonstrate that gene set enrichment method can capture subtle transcriptional changes and may be a generally useful approach for developing and interpreting predictive models of the human immune response. ..
  16. ncbi request reprint Gene expression profiling identifies BAX-delta as a novel tumor antigen in acute lymphoblastic leukemia
    Sara Maia
    Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Cancer Res 65:10050-8. 2005
    ..This study suggests that (a) BAX-delta may serve as a widely expressed TAA in B-ALL and (b) gene expression profiling can be a generalizable tool to identify immunologic targets for cancer immunotherapy...
  17. ncbi request reprint pH-triggered microparticles for peptide vaccination
    W Nicholas Haining
    Department of Pediatric Oncology, Dana Farber Cancer Institute, and Division of Pediatric Hematology Oncology, Children s Hospital, Boston, MA 02115, USA
    J Immunol 173:2578-85. 2004
    ..Encapsulation of MHC I epitopes in pH-triggered microparticles increases Ag presentation and may improve CD8(+) T cell priming to peptide vaccines against viruses and cancer...
  18. pmc Inducible RNAi in vivo reveals that the transcription factor BATF is required to initiate but not maintain CD8+ T-cell effector differentiation
    Jernej Godec
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Boston, MA 02115 Department of Microbiology and Immunobiology, Harvard Medical School, and Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women s Hospital, Boston, MA 02115
    Proc Natl Acad Sci U S A 112:512-7. 2015
    ..This approach makes possible the study of gene function in vivo in unperturbed cells of hematopoietic origin that are refractory to viral transduction. ..
  19. pmc CD28 costimulation regulates genome-wide effects on alternative splicing
    Manish J Butte
    Department of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 7:e40032. 2012
    ..The effects of CD28 on alternative splicing provide a newly appreciated means by which CD28 can regulate T cell responses...
  20. pmc CD39 Expression Identifies Terminally Exhausted CD8+ T Cells
    Prakash K Gupta
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Boston, Massachusetts, United States of America Peter Medawar Building for Pathogen Research, University of Oxford, Oxford, United Kingdom
    PLoS Pathog 11:e1005177. 2015
    ..These findings provide a new marker of T cell exhaustion, and implicate the purinergic pathway in the regulation of T cell exhaustion. ..

Research Grants2

  1. Tumor Antigen Discovery in ALL by Expression Profiling
    WILLIAM HAINING; Fiscal Year: 2006
    ..This training will form the foundation of my career in translational research. ..
  2. Molecular Diagnosis of Defective Memory Differentiation in Tumor-Specific T Cells
    WILLIAM HAINING; Fiscal Year: 2008
    ..This will help identify the molecular basis for defective tumor-specific immunity, and provide a novel assay to predict immune response to cancer immunotherapy. [unreadable] [unreadable] [unreadable]..