W Nicholas Haining

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi Measuring T cell immunity to influenza vaccination in children after haemopoietic stem cell transplantation
    W Nicholas Haining
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Br J Haematol 127:322-5. 2004
  2. ncbi Integrating genomic signatures for immunologic discovery
    W Nicholas Haining
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Immunity 32:152-61. 2010
  3. ncbi Identifying gnostic predictors of the vaccine response
    W Nicholas Haining
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA
    Curr Opin Immunol 24:332-6. 2012
  4. ncbi The numerology of T cell functional diversity
    W Nicholas Haining
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Immunity 36:10-2. 2012
  5. ncbi Deconvolving heterogeneity in the CD8+ T-cell response to HIV
    W Nicholas Haining
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA
    Curr Opin HIV AIDS 7:38-43. 2012
  6. ncbi High-throughput gene expression profiling of memory differentiation in primary human T cells
    W Nicholas Haining
    Department of Pediatric Dana Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA
    BMC Immunol 9:44. 2008
  7. ncbi Antigen-specific T-cell memory is preserved in children treated for acute lymphoblastic leukemia
    W Nicholas Haining
    Dana Farber Cancer Institute, 44 Binney St, Boston, MA 02115, USA
    Blood 106:1749-54. 2005
  8. ncbi Failure to define window of time for autologous tumor vaccination in patients with newly diagnosed or relapsed acute lymphoblastic leukemia
    W Nicholas Haining
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Exp Hematol 33:286-94. 2005
  9. ncbi Identification of an evolutionarily conserved transcriptional signature of CD8 memory differentiation that is shared by T and B cells
    W Nicholas Haining
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    J Immunol 181:1859-68. 2008
  10. ncbi CpG oligodeoxynucleotides alter lymphocyte and dendritic cell trafficking in humans
    W Nicholas Haining
    Department of Hematology Oncology, Children s Hospital, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Clin Cancer Res 14:5626-34. 2008

Research Grants

  1. Tumor Antigen Discovery in ALL by Expression Profiling
    WILLIAM HAINING; Fiscal Year: 2006
  2. Molecular Diagnosis of Defective Memory Differentiation in Tumor-Specific T Cells
    WILLIAM HAINING; Fiscal Year: 2007
  3. Functional genomic analysis of the CD8 T cell response to HIV vaccines in
    MARGARET JULIANA MCELRATH; Fiscal Year: 2010

Collaborators

Detail Information

Publications15

  1. ncbi Measuring T cell immunity to influenza vaccination in children after haemopoietic stem cell transplantation
    W Nicholas Haining
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Br J Haematol 127:322-5. 2004
    ..This assay proved sufficiently sensitive to evaluate changes in T cell memory in immunocompromised individuals and could be used to better characterize post-HSCT immune reconstitution...
  2. ncbi Integrating genomic signatures for immunologic discovery
    W Nicholas Haining
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Immunity 32:152-61. 2010
    ....
  3. ncbi Identifying gnostic predictors of the vaccine response
    W Nicholas Haining
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA
    Curr Opin Immunol 24:332-6. 2012
    ..The challenge for vaccinologists is therefore to use these tools to embed mechanistic insights into predictors of vaccine response...
  4. ncbi The numerology of T cell functional diversity
    W Nicholas Haining
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Immunity 36:10-2. 2012
    ..In this issue of Immunity, Newell et al. (2012) use a new flow cytometry platform to show that the functional heterogeneity of the human T cell compartment is even greater than previously thought...
  5. ncbi Deconvolving heterogeneity in the CD8+ T-cell response to HIV
    W Nicholas Haining
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA
    Curr Opin HIV AIDS 7:38-43. 2012
    ..This review will discuss the use of systems biology approaches to dissect the heterogeneity of the HIV-specific CD8+ T-cell response...
  6. ncbi High-throughput gene expression profiling of memory differentiation in primary human T cells
    W Nicholas Haining
    Department of Pediatric Dana Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA
    BMC Immunol 9:44. 2008
    ....
  7. ncbi Antigen-specific T-cell memory is preserved in children treated for acute lymphoblastic leukemia
    W Nicholas Haining
    Dana Farber Cancer Institute, 44 Binney St, Boston, MA 02115, USA
    Blood 106:1749-54. 2005
    ....
  8. ncbi Failure to define window of time for autologous tumor vaccination in patients with newly diagnosed or relapsed acute lymphoblastic leukemia
    W Nicholas Haining
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Exp Hematol 33:286-94. 2005
    ....
  9. ncbi Identification of an evolutionarily conserved transcriptional signature of CD8 memory differentiation that is shared by T and B cells
    W Nicholas Haining
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    J Immunol 181:1859-68. 2008
    ..Thus, our data suggest that in addition to lineage-specific differentiation programs, T and B lymphocytes use a common transcriptional program during memory development that is disrupted in chronic viral infection...
  10. ncbi CpG oligodeoxynucleotides alter lymphocyte and dendritic cell trafficking in humans
    W Nicholas Haining
    Department of Hematology Oncology, Children s Hospital, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Clin Cancer Res 14:5626-34. 2008
    ..CpG-ODN also induce PDC to secrete chemokines that alter lymphocyte migration. Whether CpG-ODN TLR signals enhance antigen-specific immunity and/or trafficking in humans is unknown...
  11. ncbi Transcriptional analysis of HIV-specific CD8+ T cells shows that PD-1 inhibits T cell function by upregulating BATF
    Michael Quigley
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA
    Nat Med 16:1147-51. 2010
    ..Thus, inhibitory receptors can cause T cell exhaustion by upregulating genes--such as BATF--that inhibit T cell function. Such genes may provide new therapeutic opportunities to improve T cell immunity to HIV...
  12. ncbi Gene expression profiling identifies BAX-delta as a novel tumor antigen in acute lymphoblastic leukemia
    Sara Maia
    Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Cancer Res 65:10050-8. 2005
    ..This study suggests that (a) BAX-delta may serve as a widely expressed TAA in B-ALL and (b) gene expression profiling can be a generalizable tool to identify immunologic targets for cancer immunotherapy...
  13. ncbi pH-triggered microparticles for peptide vaccination
    W Nicholas Haining
    Department of Pediatric Oncology, Dana-Farber Cancer Institute, and Division of Pediatric Hematology/Oncology, Children's Hospital, Boston, MA 02115, USA
    J Immunol 173:2578-85. 2004
    ..Encapsulation of MHC I epitopes in pH-triggered microparticles increases Ag presentation and may improve CD8(+) T cell priming to peptide vaccines against viruses and cancer...
  14. ncbi Isolation of RNA and the synthesis and amplification of cDNA from antigen-specific T cells for genome-wide expression analysis
    R Anthony Barnitz
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA
    Methods Mol Biol 979:161-73. 2013
    ..This protocol is a useful tool for the study of genome-wide expression signatures from many of the subpopulations that are numerically small but important in immune responses and homeostasis...
  15. ncbi CD28 costimulation regulates genome-wide effects on alternative splicing
    Manish J Butte
    Department of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 7:e40032. 2012
    ..The effects of CD28 on alternative splicing provide a newly appreciated means by which CD28 can regulate T cell responses...

Research Grants4

  1. Tumor Antigen Discovery in ALL by Expression Profiling
    WILLIAM HAINING; Fiscal Year: 2006
    ..This training will form the foundation of my career in translational research. ..
  2. Molecular Diagnosis of Defective Memory Differentiation in Tumor-Specific T Cells
    WILLIAM HAINING; Fiscal Year: 2007
    ..This will help identify the molecular basis for defective tumor-specific immunity, and provide a novel assay to predict immune response to cancer immunotherapy. ..
  3. Functional genomic analysis of the CD8 T cell response to HIV vaccines in
    MARGARET JULIANA MCELRATH; Fiscal Year: 2010
    ..Information from this study will help identify new tests to evaluate how well vaccines work, and discover new ways to make a stronger immune response to HIV vaccines. ..