Marcia Haigis

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. doi request reprint The coordination of nuclear and mitochondrial communication during aging and calorie restriction
    Lydia W S Finley
    The Paul F Glenn Labs for the Biological Mechanisms of Aging, Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    Ageing Res Rev 8:173-88. 2009
  2. pmc Succinate dehydrogenase is a direct target of sirtuin 3 deacetylase activity
    Lydia W S Finley
    Department of Pathology, The Paul F Glenn Labs for the Biological Mechanisms of Aging, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 6:e23295. 2011
  3. pmc Mammalian sirtuins: biological insights and disease relevance
    Marcia C Haigis
    Glenn Laboratories for the Molecular Biology of Aging, Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Annu Rev Pathol 5:253-95. 2010
  4. pmc The aging stress response
    Marcia C Haigis
    Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    Mol Cell 40:333-44. 2010
  5. ncbi request reprint Role of sirtuins and calorie restriction in neuroprotection: implications in Alzheimer's and Parkinson's diseases
    Sarika Srivastava
    The Paul F Glenn Labs for the Biological Mechanisms of Aging, Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    Curr Pharm Des 17:3418-33. 2011
  6. pmc Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation
    David B Lombard
    Howard Hughes Medical Institute, The Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Mol Cell Biol 27:8807-14. 2007
  7. ncbi request reprint Sirtuins regulate key aspects of lipid metabolism
    David J Lomb
    Department of Pathology and Paul F Glenn Laboratories for the Biological Mechanisms of Aging, Harvard Medical School, Boston, MA 02115, USA
    Biochim Biophys Acta 1804:1652-7. 2010

Research Grants

  1. Regulation of mitochondrial metabolism by SIRT4
    Marcia Haigis; Fiscal Year: 2009
  2. Regulation of mitochondrial metabolism by SIRT4
    Marcia Haigis; Fiscal Year: 2010

Collaborators

Detail Information

Publications7

  1. doi request reprint The coordination of nuclear and mitochondrial communication during aging and calorie restriction
    Lydia W S Finley
    The Paul F Glenn Labs for the Biological Mechanisms of Aging, Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    Ageing Res Rev 8:173-88. 2009
    ..Greater understanding of the mechanisms by which mitochondria and the nucleus communicate will facilitate efforts to slow or reverse the mitochondrial dysfunction that occurs during aging...
  2. pmc Succinate dehydrogenase is a direct target of sirtuin 3 deacetylase activity
    Lydia W S Finley
    Department of Pathology, The Paul F Glenn Labs for the Biological Mechanisms of Aging, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 6:e23295. 2011
    ..SIRT3 is localized to mitochondria, where it deacetylates and activates a number of enzymes involved in fuel oxidation and energy production...
  3. pmc Mammalian sirtuins: biological insights and disease relevance
    Marcia C Haigis
    Glenn Laboratories for the Molecular Biology of Aging, Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Annu Rev Pathol 5:253-95. 2010
    ..This review summarizes and discusses the advances of the past decade and the challenges that will confront the field in the coming years...
  4. pmc The aging stress response
    Marcia C Haigis
    Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    Mol Cell 40:333-44. 2010
    ..The systems biology of stress response signaling thus provides a new approach to the understanding and potential treatment of age-related diseases...
  5. ncbi request reprint Role of sirtuins and calorie restriction in neuroprotection: implications in Alzheimer's and Parkinson's diseases
    Sarika Srivastava
    The Paul F Glenn Labs for the Biological Mechanisms of Aging, Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    Curr Pharm Des 17:3418-33. 2011
    ....
  6. pmc Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation
    David B Lombard
    Howard Hughes Medical Institute, The Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Mol Cell Biol 27:8807-14. 2007
    ..Overall, our results extend the recent finding of lysine acetylation of mitochondrial proteins and demonstrate that SIRT3 has evolved to control reversible lysine acetylation in this organelle...
  7. ncbi request reprint Sirtuins regulate key aspects of lipid metabolism
    David J Lomb
    Department of Pathology and Paul F Glenn Laboratories for the Biological Mechanisms of Aging, Harvard Medical School, Boston, MA 02115, USA
    Biochim Biophys Acta 1804:1652-7. 2010
    ..These findings suggest that sirtuins might provide important new targets for the treatment of obesity and related diseases. In this review, we discuss the major findings linking sirtuins with the regulation of lipid metabolism...

Research Grants2

  1. Regulation of mitochondrial metabolism by SIRT4
    Marcia Haigis; Fiscal Year: 2009
    ..These studies have the potential to lead to new treatments of diet and age-associated metabolic syndrome. ..
  2. Regulation of mitochondrial metabolism by SIRT4
    Marcia Haigis; Fiscal Year: 2010
    ..These studies have the potential to lead to new treatments of diet and age-associated metabolic syndrome. ..