D Haig

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc On the evolutionary stability of Mendelian segregation
    Francisco Ubeda
    Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Genetics 170:1345-57. 2005
  2. pmc Sexual conflict and the alternation of haploid and diploid generations
    David Haig
    Department of Organismic and Evolutionary Biology, Harvard University, 26 Oxford Street, Cambridge, MA 02138, USA
    Philos Trans R Soc Lond B Biol Sci 361:335-43. 2006
  3. pmc Filial mistletoes: the functional morphology of moss sporophytes
    David Haig
    Department of Organismic and Evolutionary Biology, Harvard University, 26 Oxford Street, Cambridge, MA 02138, USA
    Ann Bot 111:337-45. 2013
  4. doi request reprint Retroviruses and the placenta
    David Haig
    Department of Organismic and Evolutionary Biology, Harvard University, Cambridge MA 02138, USA
    Curr Biol 22:R609-13. 2012
  5. ncbi request reprint Meditations on birth weight: is it better to reduce the variance or increase the mean?
    David Haig
    Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA
    Epidemiology 14:490-2. 2003
  6. ncbi request reprint Placental growth hormone-related proteins and prolactin-related proteins
    D Haig
    Department of Organismic and Evolutionary Biology, Harvard University, 26 Oxford Street, Cambridge, MA 02138, USA
    Placenta 29:S36-41. 2008
  7. ncbi request reprint Evolutionary conflicts in pregnancy and calcium metabolism--a review
    D Haig
    Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA
    Placenta 25:S10-5. 2004
  8. ncbi request reprint The inexorable rise of gender and the decline of sex: social change in academic titles, 1945-2001
    David Haig
    Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Arch Sex Behav 33:87-96. 2004
  9. ncbi request reprint Self-imposed silence: parental antagonism and the evolution of X-chromosome inactivation
    David Haig
    Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Evolution 60:440-7. 2006
  10. ncbi request reprint Genomic imprinting and kinship: how good is the evidence?
    David Haig
    Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Annu Rev Genet 38:553-85. 2004

Collaborators

Detail Information

Publications48

  1. pmc On the evolutionary stability of Mendelian segregation
    Francisco Ubeda
    Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Genetics 170:1345-57. 2005
    ..Unlinked modifiers that alter the segregation ratio are unable to invade such a population. These results raise questions about the reasons for the ubiquity of Mendelian segregation...
  2. pmc Sexual conflict and the alternation of haploid and diploid generations
    David Haig
    Department of Organismic and Evolutionary Biology, Harvard University, 26 Oxford Street, Cambridge, MA 02138, USA
    Philos Trans R Soc Lond B Biol Sci 361:335-43. 2006
    ..Therefore, sexual conflict is predicted to be attenuated. Finally, we explore similarities among models of mate choice, offspring choice and segregation distortion...
  3. pmc Filial mistletoes: the functional morphology of moss sporophytes
    David Haig
    Department of Organismic and Evolutionary Biology, Harvard University, 26 Oxford Street, Cambridge, MA 02138, USA
    Ann Bot 111:337-45. 2013
    ....
  4. doi request reprint Retroviruses and the placenta
    David Haig
    Department of Organismic and Evolutionary Biology, Harvard University, Cambridge MA 02138, USA
    Curr Biol 22:R609-13. 2012
    ..The evolutionary interplay between retroviruses and host defenses may have contributed to the remarkable diversity of form among mammalian placentas and to mechanisms of genomic imprinting...
  5. ncbi request reprint Meditations on birth weight: is it better to reduce the variance or increase the mean?
    David Haig
    Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA
    Epidemiology 14:490-2. 2003
    ..In this model, risk would be reduced by decreasing the variance of the distribution of perturbations. The model is discussed in the context of the so-called "paradoxes of low birth weight."..
  6. ncbi request reprint Placental growth hormone-related proteins and prolactin-related proteins
    D Haig
    Department of Organismic and Evolutionary Biology, Harvard University, 26 Oxford Street, Cambridge, MA 02138, USA
    Placenta 29:S36-41. 2008
    ..In particular, placental hormones often evolve novel interactions with new receptors. The adaptive functions of some placental hormones may be revealed only under conditions of physiological stress...
  7. ncbi request reprint Evolutionary conflicts in pregnancy and calcium metabolism--a review
    D Haig
    Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA
    Placenta 25:S10-5. 2004
    ..Inactivation of the paternal copy of GNAS in proximal renal tubule is interpreted as a measure to maintain fetal bone mineralization in times of calcium stress at the expense of the maternal skeleton...
  8. ncbi request reprint The inexorable rise of gender and the decline of sex: social change in academic titles, 1945-2001
    David Haig
    Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Arch Sex Behav 33:87-96. 2004
    ..Since then, the use of gender has tended to expand to encompass the biological, and a sex/gender distinction is now only fitfully observed...
  9. ncbi request reprint Self-imposed silence: parental antagonism and the evolution of X-chromosome inactivation
    David Haig
    Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Evolution 60:440-7. 2006
    ..Once present, rXCI favors the evolution of locus-by-locus imprinting of X-linked loci, which creates an evolutionary dynamic in which different chromosomes compete to remain active...
  10. ncbi request reprint Genomic imprinting and kinship: how good is the evidence?
    David Haig
    Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Annu Rev Genet 38:553-85. 2004
    ..The diverse effects of imprinted genes on the development of white adipose tissue (WAT) have so far defied a unifying hypothesis in terms of the kinship theory...
  11. ncbi request reprint Intragenomic politics
    D Haig
    Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA
    Cytogenet Genome Res 113:68-74. 2006
    ....
  12. ncbi request reprint The complex history of distal human chromosome 1q
    David Haig
    Department of Organismic and Evolutionary Biology, Harvard University, 26 Oxford Street, Cambridge, MA 02138, USA
    Genomics 86:767-70. 2005
    ..Reconstruction of the history of distal human chromosome 1q is complicated by the "reuse" of breakpoints in different mammalian lineages and by coincidental shared synteny between humans and cats...
  13. doi request reprint Huddling: brown fat, genomic imprinting and the warm inner glow
    David Haig
    Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Curr Biol 18:R172-4. 2008
    ..Effects of imprinted genes on brown adipose tissue suggest that non-shivering thermogenesis is an arena for intragenomic conflict...
  14. ncbi request reprint Do imprinted genes have few and small introns?
    D Haig
    Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA
    Bioessays 18:351-3. 1996
    ..Similarly, small introns appear to be a property of chromosomal region rather than of imprinting status itself, because neighboring unimprinted genes also have small introns...
  15. pmc Colloquium papers: Transfers and transitions: parent-offspring conflict, genomic imprinting, and the evolution of human life history
    David Haig
    Department of Organismic and Evolutionary Biology, Harvard University, 26 Oxford Street, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 107:1731-5. 2010
    ....
  16. pmc Gestational drive and the green-bearded placenta
    D Haig
    Museum of Comparative Zoology, Harvard University, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 93:6547-51. 1996
    ..quot; Green-beard effects have many formal similarities to systems of meiotic drive and, like them, can be a source of intragenomic conflict...
  17. pmc Parental antagonism, relatedness asymmetries, and genomic imprinting
    D Haig
    Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA
    Proc Biol Sci 264:1657-62. 1997
    ..Parental antagonism favours the evolution of alleles that are expressed only when maternally derived or only when paternally derived (genomic imprinting)...
  18. ncbi request reprint Maternal-fetal interactions and MHC polymorphism
    D Haig
    Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA
    J Reprod Immunol 35:101-9. 1997
    ..If the artificial assumption of symmetrical selection is relaxed, the second class of model (gestational drive) could account for the otherwise inexplicable absence of MHC polymorphism in some species...
  19. pmc A brief history of human autosomes
    D Haig
    Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA
    Philos Trans R Soc Lond B Biol Sci 354:1447-70. 1999
    ....
  20. ncbi request reprint What is a marmoset?
    D Haig
    Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Am J Primatol 49:285-96. 1999
    ....
  21. pmc Genomic imprinting, sibling solidairity and the logic of collective action
    D Haig
    Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA
    Philos Trans R Soc Lond B Biol Sci 355:1593-7. 2000
    ..Maternally derived alleles are more willing than their paternally derived counterparts to contribute to public goods because they have a smaller effective group size...
  22. pmc Genomic imprinting and the evolutionary psychology of human kinship
    David Haig
    Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 108:10878-85. 2011
    ..Therefore, the innate dispositions of children toward parents and sibs are expected to be sensitive to cues of marital stability, and these dispositions may be subject to effects of imprinted genes...
  23. doi request reprint Genomic imprinting: an obsession with depilatory mice
    David Haig
    Department of Organismic and Evolutionary Biology, Harvard University, 26 Oxford Street, Cambridge, MA 02138, USA
    Curr Biol 21:R257-9. 2011
    ..Excessive grooming in mice has been promoted as a model of human obsessive-compulsive disorders. A recent paper adds Grb10 to the list of genes with effects on behavioral hair loss, with the added twist that this time the gene is imprinted...
  24. doi request reprint Games in tetrads: segregation, recombination, and meiotic drive
    David Haig
    Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Am Nat 176:404-13. 2010
    ..Recombinational responses to meiotic drive may contribute to sex differences in overall recombination and sex differences in the localization of chiasmata...
  25. pmc Sex-specific parent-of-origin allelic expression in the mouse brain
    Christopher Gregg
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Science 329:682-5. 2010
    ..Parent-of-origin effects thus provide new avenues for investigation of sexual dimorphism in brain function and disease...
  26. pmc Sex-specific meiotic drive and selection at an imprinted locus
    Francisco Ubeda
    Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Genetics 167:2083-95. 2004
    ..Multiple equilibria exist both with and without genomic imprinting, although they occurred in a greater proportion of parameter sets with genomic imprinting...
  27. pmc Genomic imprinting of two antagonistic loci
    J F Wilkins
    Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA
    Proc Biol Sci 268:1861-7. 2001
    ..We then discuss the consistency of these predictions with currently available comparative data on the insulin-like growth factor 2 insulin-like growth factor 2 receptor system of mammals...
  28. pmc Parental sex discrimination and intralocus sexual conflict
    Manus M Patten
    Department of Organismic and Evolutionary Biology, Harvard University, 26 Oxford Street, Cambridge, MA 02138, USA
    Biol Lett 5:667-70. 2009
    ..The model we present permits alternative interpretations of how the genes are expressed and how the fitness variation is assigned, which invites a theoretical comparison to models of both imprinted genes and sex allocation...
  29. doi request reprint Maintenance or loss of genetic variation under sexual and parental antagonism at a sex-linked locus
    Manus M Patten
    Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Evolution 63:2888-95. 2009
    ..Additionally, we find that the X chromosome is more favorable to the fixation of alleles that are beneficial when maternally derived...
  30. pmc High-resolution analysis of parent-of-origin allelic expression in the mouse brain
    Christopher Gregg
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Science 329:643-8. 2010
    ..Thus, parental expression bias emerges as a major mode of epigenetic regulation in the brain...
  31. ncbi request reprint Phylogeny of Agrodiaetus Hübner 1822 (Lepidoptera: Lycaenidae) inferred from mtDNA sequences of COI and COII and nuclear sequences of EF1-alpha: karyotype diversification and species radiation
    Nikolai P Kandul
    Department of Organismal and Evolutionary Biology, Harvard University, 26 Oxford Street, Cambridge, Massachusetts 02138, USA
    Syst Biol 53:278-98. 2004
    ..Rapid karyotype diversification may have played a significant role in the radiation of the genus Agrodiaetus...
  32. pmc Reciprocally imprinted genes and the response to selection on one sex
    Manus M Patten
    Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Genetics 179:1389-94. 2008
    ..The selective efficiency bias we identify between the two patterns of imprinting has implications for natural and livestock populations, which we discuss...
  33. doi request reprint Fitness variation due to sexual antagonism and linkage disequilibrium
    Manus M Patten
    Department of Organismic and Evolutionary Biology, Harvard University, 26 Oxford Street, Cambridge, Massachusetts 02138, USA
    Evolution 64:3638-42. 2010
    ..Our results uncover a unique contribution of conflicting selection pressures to the maintenance of variation, which simpler models that neglect genetic architecture overlook...
  34. ncbi request reprint Dividing the child
    Francisco Ubeda
    Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA
    Genetica 117:103-10. 2003
    ..s. Filius); between alleles of maternal and paternal origin within offspring (Matris v.s. Patris) and between mothers and the paternally derived alleles of offspring (Mater v.s. Patris)...
  35. pmc Parental modifiers, antisense transcripts and loss of imprinting
    Jon F Wilkins
    Program in Biophysics, Harvard University, Cambridge, MA 02138, USA
    Proc Biol Sci 269:1841-6. 2002
    ..Therefore, imprinting of demand-suppressing loci is predicted to be less evolutionarily stable than imprinting of demand-enhancing loci...
  36. pmc Flt1, pregnancy, and malaria: evolution of a complex interaction
    S Ananth Karumanchi
    Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 105:14243-4. 2008
  37. ncbi request reprint Inbreeding, maternal care and genomic imprinting
    Jon F Wilkins
    Program in Biophysics, Harvard University, Cambridge, MA 02138, USA
    J Theor Biol 221:559-64. 2003
    ..Just such an asymmetrical decrease in relatedness over time would be expected in a structured population in which patrilineal inbreeding is more common than matrilineal inbreeding...
  38. ncbi request reprint Phylogenetic analyses of the core antenna domain: investigating the origin of photosystem I
    Lucas J Mix
    Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA
    J Mol Evol 60:153-63. 2005
    ..A heterodimeric RC1 (=PSI) then arose within the cyanobacterial lineage. In this scenario, the current diversity of core antenna domains/proteins is explained without a need to invoke horizontal transfer...
  39. ncbi request reprint What good is genomic imprinting: the function of parent-specific gene expression
    Jon F Wilkins
    Society of Fellows, 7 Divinity Avenue, Harvard University, Cambridge, Massachusetts 02138, USA
    Nat Rev Genet 4:359-68. 2003
    ..However, the hypothesis is yet to provide a compelling explanation for many examples of imprinting...
  40. doi request reprint Sexual antagonism and the evolution of X chromosome inactivation
    Jan Engelstädter
    Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Evolution 62:2097-104. 2008
    ..The implications of our results are discussed in the light of empirical findings and a recently proposed alternative hypothesis for the evolution of X-inactivation...
  41. ncbi request reprint Prader-Willi syndrome and the evolution of human childhood
    David Haig
    Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Am J Hum Biol 15:320-9. 2003
    ..However, once a child was able to consume supplemental foods, maternal costs would have been reduced by children with increased, nonfastidious appetites...
  42. ncbi request reprint An earlier formulation of the genetic conflict hypothesis of genomic imprinting
    David Haig
    Nat Genet 38:271. 2006
  43. ncbi request reprint Behavioural genetics: Family matters
    David Haig
    Nature 421:491-2. 2003
  44. ncbi request reprint Reinforcement of pre-zygotic isolation and karyotype evolution in Agrodiaetus butterflies
    Vladimir A Lukhtanov
    Department of Entomology, St Petersburg State University, Universitetskaya nab 7 9, St Petersburg 199034, Russia
    Nature 436:385-9. 2005
    ..We find little evidence supporting sympatric speciation: rather, in Agrodiaetus, karyotypic changes accumulate gradually in allopatry, prompting reinforcement when karyotypically divergent races come into contact...
  45. ncbi request reprint Phenotypic heterogeneity is an evolutionarily conserved feature of the endothelium
    Kiichiro Yano
    Center for Vascular Biology Research and Division of Molecular and Vascular Medicine, Beth Israel Deaconess Medical Center, RW 663, 330 Brookline Ave, Department of Pathology, Harvard Medical School, Boston, MA 02215, USA
    Blood 109:613-5. 2007
    ..Together, these data suggest that structural, molecular, and functional heterogeneity of the endothelium evolved as an early feature of this cell lineage...
  46. ncbi request reprint Divergent mating systems and parental conflict as a barrier to hybridization in flowering plants
    Yaniv Brandvain
    College of the Atlantic, Bar Harbor, Maine 04609, USA
    Am Nat 166:330-8. 2005
    ..Many, but not all, of such reports support our hypothesis. Since parental conflicts can perturb fertilization and development, such conflicts may strengthen reproductive barriers between populations, contributing to speciation...
  47. ncbi request reprint Sostrup statement on low birthweight
    Melissa Adams
    Int J Epidemiol 32:884-5. 2003
  48. ncbi request reprint Angiogenic factors in the pathogenesis of preeclampsia
    Hai Tao Yuan
    Renal, Molecular, and Vascular Medicine Division, Departments of Medicine, Obstetrics and Gynecology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA
    Curr Top Dev Biol 71:297-312. 2005
    ....