Research Topics
| D HaigSummaryAffiliation: Harvard University Country: USA Publications
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Publications
On the evolutionary stability of Mendelian segregationFrancisco Ubeda
Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts 02138, USA
Genetics 170:1345-57. 2005..Unlinked modifiers that alter the segregation ratio are unable to invade such a population. These results raise questions about the reasons for the ubiquity of Mendelian segregation...- Sexual conflict and the alternation of haploid and diploid generationsDavid Haig
Department of Organismic and Evolutionary Biology, Harvard University, 26 Oxford Street, Cambridge, MA 02138, USA
Philos Trans R Soc Lond B Biol Sci 361:335-43. 2006..Therefore, sexual conflict is predicted to be attenuated. Finally, we explore similarities among models of mate choice, offspring choice and segregation distortion... 
Retroviruses and the placentaDavid Haig
Department of Organismic and Evolutionary Biology, Harvard University, Cambridge MA 02138, USA
Curr Biol 22:R609-13. 2012..The evolutionary interplay between retroviruses and host defenses may have contributed to the remarkable diversity of form among mammalian placentas and to mechanisms of genomic imprinting...
Placental growth hormone-related proteins and prolactin-related proteinsD Haig
Department of Organismic and Evolutionary Biology, Harvard University, 26 Oxford Street, Cambridge, MA 02138, USA
Placenta 29:S36-41. 2008..In particular, placental hormones often evolve novel interactions with new receptors. The adaptive functions of some placental hormones may be revealed only under conditions of physiological stress...- Meditations on birth weight: is it better to reduce the variance or increase the mean?David Haig
Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA
Epidemiology 14:490-2. 2003..In this model, risk would be reduced by decreasing the variance of the distribution of perturbations. The model is discussed in the context of the so-called "paradoxes of low birth weight.".. - Self-imposed silence: parental antagonism and the evolution of X-chromosome inactivationDavid Haig
Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts 02138, USA
Evolution 60:440-7. 2006..Once present, rXCI favors the evolution of locus-by-locus imprinting of X-linked loci, which creates an evolutionary dynamic in which different chromosomes compete to remain active... - Evolutionary conflicts in pregnancy and calcium metabolism--a reviewD Haig
Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA
Placenta 25:S10-5. 2004..Inactivation of the paternal copy of GNAS in proximal renal tubule is interpreted as a measure to maintain fetal bone mineralization in times of calcium stress at the expense of the maternal skeleton... - The inexorable rise of gender and the decline of sex: social change in academic titles, 1945-2001David Haig
Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts 02138, USA
Arch Sex Behav 33:87-96. 2004..Since then, the use of gender has tended to expand to encompass the biological, and a sex/gender distinction is now only fitfully observed... - Intragenomic politicsD Haig
Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA
Cytogenet Genome Res 113:68-74. 2006.... - Genomic imprinting and kinship: how good is the evidence?David Haig
Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts 02138, USA
Annu Rev Genet 38:553-85. 2004..The diverse effects of imprinted genes on the development of white adipose tissue (WAT) have so far defied a unifying hypothesis in terms of the kinship theory... - The complex history of distal human chromosome 1qDavid Haig
Department of Organismic and Evolutionary Biology, Harvard University, 26 Oxford Street, Cambridge, MA 02138, USA
Genomics 86:767-70. 2005..Reconstruction of the history of distal human chromosome 1q is complicated by the "reuse" of breakpoints in different mammalian lineages and by coincidental shared synteny between humans and cats... - Huddling: brown fat, genomic imprinting and the warm inner glowDavid Haig
Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts 02138, USA
Curr Biol 18:R172-4. 2008..Effects of imprinted genes on brown adipose tissue suggest that non-shivering thermogenesis is an arena for intragenomic conflict... - Do imprinted genes have few and small introns?D Haig
Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA
Bioessays 18:351-3. 1996..Similarly, small introns appear to be a property of chromosomal region rather than of imprinting status itself, because neighboring unimprinted genes also have small introns... - Colloquium papers: Transfers and transitions: parent-offspring conflict, genomic imprinting, and the evolution of human life historyDavid Haig
Department of Organismic and Evolutionary Biology, Harvard University, 26 Oxford Street, Cambridge, MA 02138, USA
Proc Natl Acad Sci U S A 107:1731-5. 2010.... - Gestational drive and the green-bearded placentaD Haig
Museum of Comparative Zoology, Harvard University, Cambridge, MA 02138, USA
Proc Natl Acad Sci U S A 93:6547-51. 1996..quot; Green-beard effects have many formal similarities to systems of meiotic drive and, like them, can be a source of intragenomic conflict... - Parental antagonism, relatedness asymmetries, and genomic imprintingD Haig
Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA
Proc Biol Sci 264:1657-62. 1997..Parental antagonism favours the evolution of alleles that are expressed only when maternally derived or only when paternally derived (genomic imprinting)... - Maternal-fetal interactions and MHC polymorphismD Haig
Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA
J Reprod Immunol 35:101-9. 1997..If the artificial assumption of symmetrical selection is relaxed, the second class of model (gestational drive) could account for the otherwise inexplicable absence of MHC polymorphism in some species... - A brief history of human autosomesD Haig
Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA
Philos Trans R Soc Lond B Biol Sci 354:1447-70. 1999.... - What is a marmoset?D Haig
Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts 02138, USA
Am J Primatol 49:285-96. 1999.... - Genomic imprinting, sibling solidairity and the logic of collective actionD Haig
Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA
Philos Trans R Soc Lond B Biol Sci 355:1593-7. 2000..Maternally derived alleles are more willing than their paternally derived counterparts to contribute to public goods because they have a smaller effective group size... - Genomic imprinting and the evolutionary psychology of human kinshipDavid Haig
Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA
Proc Natl Acad Sci U S A 108:10878-85. 2011..Therefore, the innate dispositions of children toward parents and sibs are expected to be sensitive to cues of marital stability, and these dispositions may be subject to effects of imprinted genes... - Genomic imprinting: an obsession with depilatory miceDavid Haig
Department of Organismic and Evolutionary Biology, Harvard University, 26 Oxford Street, Cambridge, MA 02138, USA
Curr Biol 21:R257-9. 2011..Excessive grooming in mice has been promoted as a model of human obsessive-compulsive disorders. A recent paper adds Grb10 to the list of genes with effects on behavioral hair loss, with the added twist that this time the gene is imprinted... - Games in tetrads: segregation, recombination, and meiotic driveDavid Haig
Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts 02138, USA
Am Nat 176:404-13. 2010..Recombinational responses to meiotic drive may contribute to sex differences in overall recombination and sex differences in the localization of chiasmata... - Sex-specific parent-of-origin allelic expression in the mouse brainChristopher Gregg
Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
Science 329:682-5. 2010..Parent-of-origin effects thus provide new avenues for investigation of sexual dimorphism in brain function and disease... - Sex-specific meiotic drive and selection at an imprinted locusFrancisco Ubeda
Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts 02138, USA
Genetics 167:2083-95. 2004..Multiple equilibria exist both with and without genomic imprinting, although they occurred in a greater proportion of parameter sets with genomic imprinting... - Genomic imprinting of two antagonistic lociJ F Wilkins
Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA
Proc Biol Sci 268:1861-7. 2001..We then discuss the consistency of these predictions with currently available comparative data on the insulin-like growth factor 2 insulin-like growth factor 2 receptor system of mammals... - Flt1, pregnancy, and malaria: evolution of a complex interactionS Ananth Karumanchi
Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
Proc Natl Acad Sci U S A 105:14243-4. 2008 - Parental sex discrimination and intralocus sexual conflictManus M Patten
Department of Organismic and Evolutionary Biology, Harvard University, 26 Oxford Street, Cambridge, MA 02138, USA
Biol Lett 5:667-70. 2009..The model we present permits alternative interpretations of how the genes are expressed and how the fitness variation is assigned, which invites a theoretical comparison to models of both imprinted genes and sex allocation... - Maintenance or loss of genetic variation under sexual and parental antagonism at a sex-linked locusManus M Patten
Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts 02138, USA
Evolution 63:2888-95. 2009..Additionally, we find that the X chromosome is more favorable to the fixation of alleles that are beneficial when maternally derived... - Dividing the childFrancisco Ubeda
Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA
Genetica 117:103-10. 2003..s. Filius); between alleles of maternal and paternal origin within offspring (Matris v.s. Patris) and between mothers and the paternally derived alleles of offspring (Mater v.s. Patris)... - High-resolution analysis of parent-of-origin allelic expression in the mouse brainChristopher Gregg
Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
Science 329:643-8. 2010..Thus, parental expression bias emerges as a major mode of epigenetic regulation in the brain... - Phylogeny of Agrodiaetus Hübner 1822 (Lepidoptera: Lycaenidae) inferred from mtDNA sequences of COI and COII and nuclear sequences of EF1-alpha: karyotype diversification and species radiationNikolai P Kandul
Department of Organismal and Evolutionary Biology, Harvard University, 26 Oxford Street, Cambridge, Massachusetts 02138, USA
Syst Biol 53:278-98. 2004..Rapid karyotype diversification may have played a significant role in the radiation of the genus Agrodiaetus... - Fitness variation due to sexual antagonism and linkage disequilibriumManus M Patten
Department of Organismic and Evolutionary Biology, Harvard University, 26 Oxford Street, Cambridge, Massachusetts 02138, USA
Evolution 64:3638-42. 2010..Our results uncover a unique contribution of conflicting selection pressures to the maintenance of variation, which simpler models that neglect genetic architecture overlook... - Parental modifiers, antisense transcripts and loss of imprintingJon F Wilkins
Program in Biophysics, Harvard University, Cambridge, MA 02138, USA
Proc Biol Sci 269:1841-6. 2002..Therefore, imprinting of demand-suppressing loci is predicted to be less evolutionarily stable than imprinting of demand-enhancing loci... - Reciprocally imprinted genes and the response to selection on one sexManus M Patten
Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts 02138, USA
Genetics 179:1389-94. 2008..The selective efficiency bias we identify between the two patterns of imprinting has implications for natural and livestock populations, which we discuss... - Inbreeding, maternal care and genomic imprintingJon F Wilkins
Program in Biophysics, Harvard University, Cambridge, MA 02138, USA
J Theor Biol 221:559-64. 2003..Just such an asymmetrical decrease in relatedness over time would be expected in a structured population in which patrilineal inbreeding is more common than matrilineal inbreeding... - What good is genomic imprinting: the function of parent-specific gene expressionJon F Wilkins
Society of Fellows, 7 Divinity Avenue, Harvard University, Cambridge, Massachusetts 02138, USA
Nat Rev Genet 4:359-68. 2003..However, the hypothesis is yet to provide a compelling explanation for many examples of imprinting... - Phylogenetic analyses of the core antenna domain: investigating the origin of photosystem ILucas J Mix
Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA
J Mol Evol 60:153-63. 2005..A heterodimeric RC1 (=PSI) then arose within the cyanobacterial lineage. In this scenario, the current diversity of core antenna domains/proteins is explained without a need to invoke horizontal transfer... - Sexual antagonism and the evolution of X chromosome inactivationJan Engelstädter
Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts 02138, USA
Evolution 62:2097-104. 2008..The implications of our results are discussed in the light of empirical findings and a recently proposed alternative hypothesis for the evolution of X-inactivation... - Prader-Willi syndrome and the evolution of human childhoodDavid Haig
Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts 02138, USA
Am J Hum Biol 15:320-9. 2003..However, once a child was able to consume supplemental foods, maternal costs would have been reduced by children with increased, nonfastidious appetites... - An earlier formulation of the genetic conflict hypothesis of genomic imprintingDavid Haig
Nat Genet 38:271. 2006 - Behavioural genetics: Family mattersDavid Haig
Nature 421:491-2. 2003 - Reinforcement of pre-zygotic isolation and karyotype evolution in Agrodiaetus butterfliesVladimir A Lukhtanov
Department of Entomology, St Petersburg State University, Universitetskaya nab. 7/9, St Petersburg 199034, Russia
Nature 436:385-9. 2005..We find little evidence supporting sympatric speciation: rather, in Agrodiaetus, karyotypic changes accumulate gradually in allopatry, prompting reinforcement when karyotypically divergent races come into contact... - Sostrup statement on low birthweightMelissa Adams
Int J Epidemiol 32:884-5. 2003 - Angiogenic factors in the pathogenesis of preeclampsiaHai-Tao Yuan
Renal, Molecular, and Vascular Medicine Division, Departments of Medicine, Obstetrics and Gynecology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA
Curr Top Dev Biol 71:297-312. 2005.... - Phenotypic heterogeneity is an evolutionarily conserved feature of the endotheliumKiichiro Yano
Center for Vascular Biology Research and Division of Molecular and Vascular Medicine, Beth Israel Deaconess Medical Center, RW 663, 330 Brookline Ave, Department of Pathology, Harvard Medical School, Boston, MA 02215, USA
Blood 109:613-5. 2007..Together, these data suggest that structural, molecular, and functional heterogeneity of the endothelium evolved as an early feature of this cell lineage... - Divergent mating systems and parental conflict as a barrier to hybridization in flowering plantsYaniv Brandvain
College of the Atlantic, Bar Harbor, Maine 04609, USA
Am Nat 166:330-8. 2005..Many, but not all, of such reports support our hypothesis. Since parental conflicts can perturb fertilization and development, such conflicts may strengthen reproductive barriers between populations, contributing to speciation...