Alejandro Gutierrez

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Pten mediates Myc oncogene dependence in a conditional zebrafish model of T cell acute lymphoblastic leukemia
    Alejandro Gutierrez
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    J Exp Med 208:1595-603. 2011
  2. pmc Aberrant AKT activation drives well-differentiated liposarcoma
    Alejandro Gutierrez
    Department of Pediatric Oncology, The Dana Farber Cancer Institute, MA 02215, USA
    Proc Natl Acad Sci U S A 108:16386-91. 2011
  3. pmc T-lymphoblastic lymphoma cells express high levels of BCL2, S1P1, and ICAM1, leading to a blockade of tumor cell intravasation
    Hui Feng
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Cancer Cell 18:353-66. 2010
  4. pmc Absence of biallelic TCRgamma deletion predicts early treatment failure in pediatric T-cell acute lymphoblastic leukemia
    Alejandro Gutierrez
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    J Clin Oncol 28:3816-23. 2010
  5. pmc Inactivation of LEF1 in T-cell acute lymphoblastic leukemia
    Alejandro Gutierrez
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Blood 115:2845-51. 2010
  6. pmc The TAL1 complex targets the FBXW7 tumor suppressor by activating miR-223 in human T cell acute lymphoblastic leukemia
    Marc R Mansour
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02216, USA
    J Exp Med 210:1545-57. 2013
  7. pmc Interconnecting molecular pathways in the pathogenesis and drug sensitivity of T-cell acute lymphoblastic leukemia
    Takaomi Sanda
    Departments of Pediatric Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA
    Blood 115:1735-45. 2010
  8. pmc The BCL11B tumor suppressor is mutated across the major molecular subtypes of T-cell acute lymphoblastic leukemia
    Alejandro Gutierrez
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Boston, MA, USA
    Blood 118:4169-73. 2011
  9. pmc Core transcriptional regulatory circuit controlled by the TAL1 complex in human T cell acute lymphoblastic leukemia
    Takaomi Sanda
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA
    Cancer Cell 22:209-21. 2012
  10. pmc TYK2-STAT1-BCL2 pathway dependence in T-cell acute lymphoblastic leukemia
    Takaomi Sanda
    Department of Pediatric Oncology, Children s Hospital, Boston, MA, USA
    Cancer Discov 3:564-77. 2013

Detail Information

Publications14

  1. pmc Pten mediates Myc oncogene dependence in a conditional zebrafish model of T cell acute lymphoblastic leukemia
    Alejandro Gutierrez
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    J Exp Med 208:1595-603. 2011
    ..Our findings indicate that Akt pathway activation is sufficient for tumor maintenance in this model, even after loss of survival signals driven by the MYC oncogene...
  2. pmc Aberrant AKT activation drives well-differentiated liposarcoma
    Alejandro Gutierrez
    Department of Pediatric Oncology, The Dana Farber Cancer Institute, MA 02215, USA
    Proc Natl Acad Sci U S A 108:16386-91. 2011
    ..Our findings are unique in providing an animal model to decipher the molecular pathogenesis of WDLPS, and implicate AKT as a previously unexplored therapeutic target in this chemoresistant sarcoma...
  3. pmc T-lymphoblastic lymphoma cells express high levels of BCL2, S1P1, and ICAM1, leading to a blockade of tumor cell intravasation
    Hui Feng
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Cancer Cell 18:353-66. 2010
    ..Thus, blockade of intravasation and hematologic dissemination in T-LBL is due to elevated S1P1 signaling, increased expression of ICAM1, and augmented homotypic cell-cell adhesion...
  4. pmc Absence of biallelic TCRgamma deletion predicts early treatment failure in pediatric T-cell acute lymphoblastic leukemia
    Alejandro Gutierrez
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    J Clin Oncol 28:3816-23. 2010
    ..To identify children with T-cell acute lymphoblastic leukemia (T-ALL) at high risk of induction chemotherapy failure by using DNA copy number analysis of leukemic cells collected at diagnosis...
  5. pmc Inactivation of LEF1 in T-cell acute lymphoblastic leukemia
    Alejandro Gutierrez
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Blood 115:2845-51. 2010
    ..Our findings suggest that LEF1 inactivation is an important step in the molecular pathogenesis of T-ALL in a subset of young children...
  6. pmc The TAL1 complex targets the FBXW7 tumor suppressor by activating miR-223 in human T cell acute lymphoblastic leukemia
    Marc R Mansour
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02216, USA
    J Exp Med 210:1545-57. 2013
    ..We conclude that TAL1-mediated up-regulation of miR-223 promotes the malignant phenotype in T-ALL through repression of the FBXW7 tumor suppressor. ..
  7. pmc Interconnecting molecular pathways in the pathogenesis and drug sensitivity of T-cell acute lymphoblastic leukemia
    Takaomi Sanda
    Departments of Pediatric Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA
    Blood 115:1735-45. 2010
    ....
  8. pmc The BCL11B tumor suppressor is mutated across the major molecular subtypes of T-cell acute lymphoblastic leukemia
    Alejandro Gutierrez
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Boston, MA, USA
    Blood 118:4169-73. 2011
    ..Our findings provide compelling evidence that BCL11B is a haploinsufficient tumor suppressor that collaborates with all major T-ALL oncogenic lesions in human thymocyte transformation...
  9. pmc Core transcriptional regulatory circuit controlled by the TAL1 complex in human T cell acute lymphoblastic leukemia
    Takaomi Sanda
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA
    Cancer Cell 22:209-21. 2012
    ..One of the critical downstream targets in this circuitry is the TRIB2 gene, which is oppositely regulated by TAL1 and E2A/HEB and is essential for the survival of T-ALL cells...
  10. pmc TYK2-STAT1-BCL2 pathway dependence in T-cell acute lymphoblastic leukemia
    Takaomi Sanda
    Department of Pediatric Oncology, Children s Hospital, Boston, MA, USA
    Cancer Discov 3:564-77. 2013
    ....
  11. ncbi request reprint Heat-shock induction of T-cell lymphoma/leukaemia in conditional Cre/lox-regulated transgenic zebrafish
    Hui Feng
    Pediatric Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Br J Haematol 138:169-75. 2007
    ..Heat-shock-regulated transgenic technology in zebrafish provides the missing link necessary to exploit the powerful genetic capacity of this organism to probe the multi-step molecular pathogenesis of leukaemia...
  12. pmc High frequency of PTEN, PI3K, and AKT abnormalities in T-cell acute lymphoblastic leukemia
    Alejandro Gutierrez
    Department of Pediatric Oncology, Dana Farber Cancer Institute, 44 Binney St, Boston, MA 02115, USA
    Blood 114:647-50. 2009
    ..These findings add significant support to the rationale for the development of therapies targeting the PTEN-PI3K-AKT pathway in T-ALL...
  13. doi request reprint Leukemia propagating cells akt up
    Alejandro Gutierrez
    Division of Hematology Oncology, Boston Children s Hospital, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA 02115, USA Electronic address
    Cancer Cell 25:263-5. 2014
    ..In this issue of Cancer Cell, Blackburn and colleagues report that Akt signaling regulates both leukemia-propagating potential and proliferation rate via distinct pathways in T-ALL. ..
  14. ncbi request reprint NOTCH and PI3K-AKT pathways intertwined
    Alejandro Gutierrez
    Department of Pediatric Oncology, Dana Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA
    Cancer Cell 12:411-3. 2007
    ..This novel observation suggests the need to simultaneously inhibit both pathways as a means to improve therapeutic efficacy in human T-ALL...