James Gusella

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint No post-genetics era in human disease research
    James Gusella
    Molecular Neurogenetics Unit, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    Nat Rev Genet 3:72-9. 2002
  2. ncbi request reprint Rescue of a human mRNA splicing defect by the plant cytokinin kinetin
    Susan A Slaugenhaupt
    Molecular Neurogenetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Hum Mol Genet 13:429-36. 2004
  3. pmc Lack of association of rare functional variants in TSC1/TSC2 genes with autism spectrum disorder
    Samira Bahl
    Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114, USA
    Mol Autism 4:5. 2013
  4. pmc A novel approach to investigate tissue-specific trinucleotide repeat instability
    Jong Min Lee
    Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA, USA
    BMC Syst Biol 4:29. 2010
  5. pmc The predominantly HEAT-like motif structure of huntingtin and its association and coincident nuclear entry with dorsal, an NF-kB/Rel/dorsal family transcription factor
    Hiroki Takano
    Molecular Neurogenetics Unit, Massachusetts General Hospital and Department of Genetics, Harvard Medical School, MGH East Building 149, 13th Street, Charlestown, Massachusetts 02129, USA
    BMC Neurosci 3:15. 2002
  6. pmc Reversal of a full-length mutant huntingtin neuronal cell phenotype by chemical inhibitors of polyglutamine-mediated aggregation
    Jin Wang
    Molecular Neurogenetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02129, USA
    BMC Neurosci 6:1. 2005
  7. pmc Genetic analysis of the GRIK2 modifier effect in Huntington's disease
    Wenqi Zeng
    Molecular Neurogenetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, 185 Cambridge Street, Boston, MA 02114, USA
    BMC Neurosci 7:62. 2006
  8. pmc Genome-wide significance for a modifier of age at neurological onset in Huntington's disease at 6q23-24: the HD MAPS study
    Jian Liang Li
    Department of Neurology, Boston University School of Medicine, Boston, MA, USA
    BMC Med Genet 7:71. 2006
  9. pmc Genomewide association study for onset age in Parkinson disease
    Jeanne C Latourelle
    Boston University School of Medicine, Boston, MA, USA
    BMC Med Genet 10:98. 2009
  10. pmc The Gly2019Ser mutation in LRRK2 is not fully penetrant in familial Parkinson's disease: the GenePD study
    Jeanne C Latourelle
    Department of Neurology, Boston University School of Medicine, Boston University, Boston, MA, USA
    BMC Med 6:32. 2008

Research Grants

  1. HUNTINGTON'S DISEASE CENTER WITHOUT WALLS
    James Gusella; Fiscal Year: 2007
  2. MECHANISM OF FAMILIAL DYSAUTONOMIA
    James Gusella; Fiscal Year: 2002
  3. MECHANISM OF FAMILIAL DYSAUTONOMIA
    James Gusella; Fiscal Year: 1999
  4. Vitamin D Hormone: Function and Mechanism of Action
    SYLVIA S CHRISTAKOS; Fiscal Year: 2010

Detail Information

Publications54

  1. ncbi request reprint No post-genetics era in human disease research
    James Gusella
    Molecular Neurogenetics Unit, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    Nat Rev Genet 3:72-9. 2002
    ..In the post-genomics era, genetics is fundamental to understanding disease at all stages of the pathogenic process...
  2. ncbi request reprint Rescue of a human mRNA splicing defect by the plant cytokinin kinetin
    Susan A Slaugenhaupt
    Molecular Neurogenetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Hum Mol Genet 13:429-36. 2004
    ..Further, kinetin should be explored as a treatment for increasing the level of normal IKAP in FD, and for other splicing disorders that may share a similar mechanism...
  3. pmc Lack of association of rare functional variants in TSC1/TSC2 genes with autism spectrum disorder
    Samira Bahl
    Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114, USA
    Mol Autism 4:5. 2013
    ....
  4. pmc A novel approach to investigate tissue-specific trinucleotide repeat instability
    Jong Min Lee
    Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA, USA
    BMC Syst Biol 4:29. 2010
    ..However progress in this area has been hampered by the lack of sensitive high-throughput instability quantification methods and global approaches to identify the underlying factors...
  5. pmc The predominantly HEAT-like motif structure of huntingtin and its association and coincident nuclear entry with dorsal, an NF-kB/Rel/dorsal family transcription factor
    Hiroki Takano
    Molecular Neurogenetics Unit, Massachusetts General Hospital and Department of Genetics, Harvard Medical School, MGH East Building 149, 13th Street, Charlestown, Massachusetts 02129, USA
    BMC Neurosci 3:15. 2002
    ....
  6. pmc Reversal of a full-length mutant huntingtin neuronal cell phenotype by chemical inhibitors of polyglutamine-mediated aggregation
    Jin Wang
    Molecular Neurogenetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02129, USA
    BMC Neurosci 6:1. 2005
    ....
  7. pmc Genetic analysis of the GRIK2 modifier effect in Huntington's disease
    Wenqi Zeng
    Molecular Neurogenetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, 185 Cambridge Street, Boston, MA 02114, USA
    BMC Neurosci 7:62. 2006
    ....
  8. pmc Genome-wide significance for a modifier of age at neurological onset in Huntington's disease at 6q23-24: the HD MAPS study
    Jian Liang Li
    Department of Neurology, Boston University School of Medicine, Boston, MA, USA
    BMC Med Genet 7:71. 2006
    ....
  9. pmc Genomewide association study for onset age in Parkinson disease
    Jeanne C Latourelle
    Boston University School of Medicine, Boston, MA, USA
    BMC Med Genet 10:98. 2009
    ..There have been previous genomewide association studies (GWAS) to identify genes influencing PD susceptibility, but this is the first to identify genes contributing to the variation in onset age...
  10. pmc The Gly2019Ser mutation in LRRK2 is not fully penetrant in familial Parkinson's disease: the GenePD study
    Jeanne C Latourelle
    Department of Neurology, Boston University School of Medicine, Boston University, Boston, MA, USA
    BMC Med 6:32. 2008
    ..Studies of the penetrance of LRRK2 mutations have produced a wide range of estimates, possibly due to differences in study design and recruitment, including in particular differences between samples of familial PD versus sporadic PD...
  11. ncbi request reprint Expanding the notion of disease in Huntington's disease
    James F Gusella
    Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, USA
    Biol Psychiatry 62:1340. 2007
  12. pmc Genomic profiling distinguishes familial multiple and sporadic multiple meningiomas
    Yiping Shen
    Molecular Neurogenetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA, 02114, USA
    BMC Med Genomics 2:42. 2009
    ....
  13. ncbi request reprint Huntington's disease: seeing the pathogenic process through a genetic lens
    James F Gusella
    Molecular Neurogenetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Richard B Simches Research Center, 185 Cambridge Street, Boston, MA 02114, USA
    Trends Biochem Sci 31:533-40. 2006
    ....
  14. ncbi request reprint Genetic criteria for Huntington's disease pathogenesis
    James F Gusella
    Center for Human Genetic Research, Massachusetts General Hospital, CPZN 5830, Boston, MA 02114, USA
    Brain Res Bull 72:78-82. 2007
    ....
  15. ncbi request reprint Merlin: the neurofibromatosis 2 tumor suppressor
    J F Gusella
    Molecular Neurogenetics Unit, Massachusetts General Hospital, Boston 02114, USA
    Biochim Biophys Acta 1423:M29-36. 1999
    ..Consequently, the disruptions due to merlin inactivation in the progression of malignant mesothelioma may represent a tumor suppressor role operating by a different pathway than that in schwannoma or meningioma...
  16. ncbi request reprint Huntingtin: a single bait hooks many species
    J F Gusella
    Molecular Neurogenetics Unit, Massachusetts General Hospital, Charlestown 02129, USA
    Curr Opin Neurobiol 8:425-30. 1998
    ..Recent protein trapping to identify huntingtin interactors now reveals that many different prey fall victim to huntingtin bait...
  17. pmc Huntington's disease: the case for genetic modifiers
    James F Gusella
    Molecular Neurogenetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA, 02114, USA
    Genome Med 1:80. 2009
    ....
  18. ncbi request reprint Molecular genetics: unmasking polyglutamine triggers in neurodegenerative disease
    J F Gusella
    Molecular Neurogenetics Unit, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    Nat Rev Neurosci 1:109-15. 2000
    ....
  19. pmc Prevalence of incompletely penetrant Huntington's disease alleles among individuals with major depressive disorder
    Roy H Perlis
    Center for Human Genetic Research and the Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02114, USA
    Am J Psychiatry 167:574-9. 2010
    ..However, the prevalence of HTT CAG repeat expansions among individuals diagnosed with major depressive disorder has not been established...
  20. ncbi request reprint Inactivation patterns of NF2 and DAL-1/4.1B (EPB41L3) in sporadic meningioma
    Fabio Nunes
    Department of Neurology, Massachusetts General Hospital, Building 149, 13th Street, Charlestown, MA 02129, USA
    Cancer Genet Cytogenet 162:135-9. 2005
    ..Furthermore, we found the majority of meningiomas developed monosomy rather than isodisomy at the NF2 and DAL-1/4.1B loci as the mechanism for LOH...
  21. pmc Screening for familial APP mutations in sporadic cerebral amyloid angiopathy
    Alessandro Biffi
    Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, United States of America
    PLoS ONE 5:e13949. 2010
    ..The majority of affected families harbor mutations in the Beta amyloid Peptide (Aβ) coding region of the gene for amyloid precursor protein (APP) or have duplications of chromosomal segments containing APP...
  22. pmc A genome-wide linkage and association scan reveals novel loci for autism
    Lauren A Weiss
    Center for Human Genetic Research, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Nature 461:802-8. 2009
    ..The linkage regions reported here provide targets for rare variation screening whereas the discovery of a single novel association demonstrates the action of common variants...
  23. pmc Association of a polymorphism near CREB1 with differential aversion processing in the insula of healthy participants
    Roy H Perlis
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Arch Gen Psychiatry 65:882-92. 2008
    ....
  24. pmc X-linked protocadherin 19 mutations cause female-limited epilepsy and cognitive impairment
    Leanne M Dibbens
    Department of Genetic Medicine, Level 9 Rieger Building, Women s and Children s Hospital, 72 King William Road, North Adelaide, South Australia 5006, Australia
    Nat Genet 40:776-81. 2008
    ..PCDH19 is expressed in developing brains of human and mouse and is the first member of the cadherin superfamily to be directly implicated in epilepsy or mental retardation...
  25. ncbi request reprint Early phenotypes that presage late-onset neurodegenerative disease allow testing of modifiers in Hdh CAG knock-in mice
    Vanessa C Wheeler
    Molecular Neurogenetics Unit and Molecular Neuropathology, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Hum Mol Genet 11:633-40. 2002
    ..Thus, potential HD therapies in man might be directed at different levels: preventing the disease-initiating mechanism or slowing the subsequent progression of pathogenesis...
  26. pmc Unbiased gene expression analysis implicates the huntingtin polyglutamine tract in extra-mitochondrial energy metabolism
    Jong Min Lee
    Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, United States of America
    PLoS Genet 3:e135. 2007
    ..Elucidation of this HD CAG-dependent pathway would spur efforts to achieve energy-based therapeutics in HD...
  27. pmc A humanized IKBKAP transgenic mouse models a tissue-specific human splicing defect
    Matthew M Hims
    Center for Human Genetic Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Genomics 90:389-96. 2007
    ..Last, these mice will permit direct studies of tissue-specific splicing and the identification of regulatory factors that play a role in complex gene expression...
  28. ncbi request reprint Familial dysautonomia
    Susan A Slaugenhaupt
    Harvard Institute of Human Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    Curr Opin Genet Dev 12:307-11. 2002
    ..IKAP, the IKBKAP-encoded protein, is a member of the recently identified human Elongator complex. The major FD mutation is a splice mutation that results in aberrant tissue-specific mRNA splicing...
  29. ncbi request reprint Therapeutic potential and mechanism of kinetin as a treatment for the human splicing disease familial dysautonomia
    Matthew M Hims
    Center for Human Genetic Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    J Mol Med (Berl) 85:149-61. 2007
    ..Lastly, we highlight the potential of kinetin for the treatment of other human splicing disorders by showing correction of a splicing defect in neurofibromatosis...
  30. ncbi request reprint Brain-derived neurotrophic factor does not influence age at neurologic onset of Huntington's disease
    Shotaro Kishikawa
    Molecular Neurogenetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, and Department of Neurology, Boston University School of Medicine, MA 02114, USA
    Neurobiol Dis 24:280-5. 2006
    ..These results indicate that BDNF does not influence significantly the mechanisms in HD pathogenesis that lead to neurologic onset...
  31. ncbi request reprint Identification of a presymptomatic molecular phenotype in Hdh CAG knock-in mice
    Elisa Fossale
    Molecular Neurogenetics Unit, Massachusetts General Hospital, Building 149, 13th Street, Charlestown, MA 02129, USA
    Hum Mol Genet 11:2233-41. 2002
    ..These findings, therefore, support a chronic impact of mutant huntingtin on an essential ribosomal regulatory gene to be investigated for its role very early in HD pathogenesis...
  32. ncbi request reprint Modified single-stranded oligonucleotides inhibit aggregate formation and toxicity induced by expanded polyglutamine
    Hetal Parekh-Olmedo
    Department of Biological Sciences, University of Delaware, Delaware Biotechnology Institute, Newark, DE 19711, USA
    J Mol Neurosci 24:257-67. 2004
    ..Our data provide the first evidence that short synthetic oligonucleotides inhibit a fundamental pathological pathway of HD and may provide the basis for a novel therapeutic approach...
  33. pmc Tissue-specific reduction in splicing efficiency of IKBKAP due to the major mutation associated with familial dysautonomia
    Math P Cuajungco
    Harvard Institute of Human Genetics, Harvard Medical School, Boston, MA, USA
    Am J Hum Genet 72:749-58. 2003
    ..Therefore, exploration of methods to increase the WT:MU IKBKAP transcript ratio in the nervous system offers a promising approach for developing an effective therapy for patients with FD...
  34. ncbi request reprint Candidate DNA replication initiation regions at human trinucleotide repeat disease loci
    Taurai Nenguke
    Program in Molecular and Computational Biology, University of Southern California, Los Angeles, CA 90089 1340, USA
    Hum Mol Genet 12:1021-8. 2003
    ..Comparison with experimental results from model systems suggests that a complex relationship may exist between instability and the proximity and/or orientation of the repeats with respect to an IR...
  35. ncbi request reprint Huntington's disease
    Marcy E MacDonald
    Molecular Neurogenetics Unit, Center for Human Genetics Research, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Neuromolecular Med 4:7-20. 2003
    ....
  36. ncbi request reprint Linkage of eye movement dysfunction to chromosome 6p in schizophrenia: additional evidence
    Steven Matthysse
    Psychology Research Laboratory, Mailman Research Center, McLean Hospital Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
    Am J Med Genet B Neuropsychiatr Genet 128:30-6. 2004
    ..1996, 1999]. We regard our results as independent evidence supporting the findings of Arolt et al. [1996, 1999] and also as support for the L.T. model as a way of combining the traits ETD and schizophrenia...
  37. ncbi request reprint The GPR54 gene as a regulator of puberty
    Stephanie B Seminara
    Reproductive Endocrine Unit, Massachusetts General Hospital, Boston, MA 02114, USA
    N Engl J Med 349:1614-27. 2003
    ..We conducted studies in humans and mice to identify the genetic factors that determine the onset of puberty...
  38. ncbi request reprint HD CAG repeat implicates a dominant property of huntingtin in mitochondrial energy metabolism
    Ihn Sik Seong
    Molecular Neurogenetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Richard B Simches Research Center, Boston, MA 02114, USA
    Hum Mol Genet 14:2871-80. 2005
    ..Moreover, the evidence that this polymorphism can determine energy status in the non-HD range suggests that it should be tested as a potential physiological modifier in both health and disease...
  39. pmc Mutations in CHD7, encoding a chromatin-remodeling protein, cause idiopathic hypogonadotropic hypogonadism and Kallmann syndrome
    Hyung Goo Kim
    Molecular Neurogenetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, and Department of Genetics, Harvard Medical School, Boston, MA 02114, USA
    Am J Hum Genet 83:511-9. 2008
    ..Our findings indicate that both normosmic IHH and KS are mild allelic variants of CHARGE syndrome and are caused by CHD7 mutations...
  40. pmc Evidence for a modifier of onset age in Huntington disease linked to the HD gene in 4p16
    Luc Djousse
    Evans Department of Medicine, Section of Preventive Medicine and Epidemiology, Boston University School of Medicine, Boston, Massachusetts, USA
    Neurogenetics 5:109-14. 2004
    ..Furthermore, the modifier may be present on both HD and normal chromosomes bearing the 3 allele of the MSX1 marker...
  41. pmc Human chromosome 7: DNA sequence and biology
    Stephen W Scherer
    Department of Genetics and Genomic Biology, The Hospital for Sick Children, Toronto, Ontario, Canada, M5G 1X8
    Science 300:767-72. 2003
    ..This approach enabled the discovery of candidate genes for developmental diseases including autism...
  42. pmc A genome scan for modifiers of age at onset in Huntington disease: The HD MAPS study
    Jian Liang Li
    Department of Neurology, Boston University School of Medicine, and Bioinformatics Program, School of Public Health, Boston University, Boston, MA, USA
    Am J Hum Genet 73:682-7. 2003
    ..Suggestive evidence for linkage was found at 4p16 (LOD=1.93), 6p21-23 (LOD=2.29), and 6q24-26 (LOD=2.28), which may be useful for investigation of genes that modify age at onset of HD...
  43. pmc Linkage analysis identifies a novel locus for restless legs syndrome on chromosome 2q in a South Tyrolean population isolate
    Irene Pichler
    Institute of Genetic Medicine, European Academy, Bolzano, Italy
    Am J Hum Genet 79:716-23. 2006
    ..1). These findings reemphasize the genetic heterogeneity of the disorder and strongly support the identification of a novel locus for RLS on chromosome 2q...
  44. ncbi request reprint Identification of the first non-Jewish mutation in familial Dysautonomia
    Maire Leyne
    Molecular Neurogenetics Unit, Massachusetts General Hospital, Charlestown, USA
    Am J Med Genet A 118:305-8. 2003
    ..In light of this fact, the diagnostic criteria for FD must be expanded. Furthermore, in order to ensure carrier identification in all ethnicities, this mutation must now be considered when screening for FD...
  45. ncbi request reprint The relationship between CAG repeat length and age of onset differs for Huntington's disease patients with juvenile onset or adult onset
    J Michael Andresen
    Massachusetts Institute of Technology, 77 Massachusetts Ave, Cambridge, MA 02139, USA
    Ann Hum Genet 71:295-301. 2007
    ..27, P= 2 x 10(-16)]. In both populations, the influence of each CAG repeat on age of onset appears to be stronger in the adult-onset range of CAG repeats than in the juvenile-onset range...
  46. ncbi request reprint Specific progressive cAMP reduction implicates energy deficit in presymptomatic Huntington's disease knock-in mice
    Silvia Gines
    Molecular Neurogenetics Unit, Massachusetts General Hospital, Building 149, 13th St, Charlestown, MA 02129, USA
    Hum Mol Genet 12:497-508. 2003
    ....
  47. ncbi request reprint Influence of heterozygosity for parkin mutation on onset age in familial Parkinson disease: the GenePD study
    Mei Sun
    Molecular Neurogenetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
    Arch Neurol 63:826-32. 2006
    ..The PARK2 gene at 6q26 encodes parkin, whose inactivation is implicated in an early-onset autosomal recessive form of Parkinson disease (PD)...
  48. pmc Disruption of ROBO2 is associated with urinary tract anomalies and confers risk of vesicoureteral reflux
    Weining Lu
    Genetics Division, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Am J Hum Genet 80:616-32. 2007
    ..Adult heterozygous and mosaic mutant mice with reduced Robo2 gene dosage also exhibit striking CAKUT-VUR phenotypes. Collectively, these results implicate the SLIT-ROBO signaling pathway in the pathogenesis of a subset of human VUR...
  49. pmc NFIA haploinsufficiency is associated with a CNS malformation syndrome and urinary tract defects
    Weining Lu
    Genetics Division, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS Genet 3:e80. 2007
    ....
  50. ncbi request reprint Is the disruption of an N-myristoyltransferase (NMT2) associated with hypoplastic testes?
    Fabiola Quintero-Rivera
    Massachusetts General Hospital, Center for Human Genetic Research, Boston, Massachusetts, USA
    Am J Med Genet A 143:1796-8. 2007
  51. pmc Biotin-responsive basal ganglia disease maps to 2q36.3 and is due to mutations in SLC19A3
    Wen Qi Zeng
    Molecular Neurogenetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Charlestown, MA 02129 2000, USA
    Am J Hum Genet 77:16-26. 2005
    ....
  52. pmc PARK3 influences age at onset in Parkinson disease: a genome scan in the GenePD study
    Anita L Destefano
    Department of Neurology, Boston University Schools of Medicine and of Public Health, Boston, MA 02118, USA
    Am J Hum Genet 70:1089-95. 2002
    ....
  53. ncbi request reprint The NF2 tumor suppressor Merlin and the ERM proteins interact with N-WASP and regulate its actin polymerization function
    Nitasha Manchanda
    Molecular Neurogenetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    J Biol Chem 280:12517-22. 2005
    ..This novel function of merlin and the ERMs illustrates a mechanism by which these proteins directly exert their effects on actin reorganization and also provides new insight into N-WASP regulation...
  54. doi request reprint Association between microdeletion and microduplication at 16p11.2 and autism
    Lauren A Weiss
    Autism Consortium, Boston, USA
    N Engl J Med 358:667-75. 2008
    ..Autism spectrum disorder is a heritable developmental disorder in which chromosomal abnormalities are thought to play a role...

Research Grants10

  1. HUNTINGTON'S DISEASE CENTER WITHOUT WALLS
    James Gusella; Fiscal Year: 2007
    ..which has made a major organizational and financial commitment to capitalize on basic science findings from academic studies such as those of this long-standing HD Center. ..
  2. MECHANISM OF FAMILIAL DYSAUTONOMIA
    James Gusella; Fiscal Year: 2002
    ....
  3. MECHANISM OF FAMILIAL DYSAUTONOMIA
    James Gusella; Fiscal Year: 1999
    ....
  4. Vitamin D Hormone: Function and Mechanism of Action
    SYLVIA S CHRISTAKOS; Fiscal Year: 2010
    ....