Research Topics
Genomes and GenesSpecies | Michael GurishSummaryAffiliation: Harvard University Country: USA Publications
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Publications
Intestinal mast cell progenitors require CD49dbeta7 (alpha4beta7 integrin) for tissue-specific homingM F Gurish
Department of Medicine, Harvard Medical School, Boston, MA 02115, USA
J Exp Med 194:1243-52. 2001....- Pulmonary CXCR2 regulates VCAM-1 and antigen-induced recruitment of mast cell progenitorsJenny Hallgren
Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital and Department of Medicine, Harvard Medical School, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 104:20478-83. 2007..Thus, these studies demonstrate a role for a chemokine receptor in regulating endothelial VCAM-1 expression, MCp migration, and the level of intraepithelial MC in the lung of aerosolized, antigen-challenged mice... 
Mast cells: ontogeny, homing, and recruitment of a unique innate effector cellMichael F Gurish
Division of Rheumatology, Immunology and Allergy, Department of Medicine, Brigham and Women s Hospital, MA 02115 6007, USA
J Allergy Clin Immunol 117:1285-91. 2006..These findings in mice await confirmation in human subjects...- CCR3 is required for tissue eosinophilia and larval cytotoxicity after infection with Trichinella spiralisMichael F Gurish
Division of Rheumatology, Allergy and Immunology, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
J Immunol 168:5730-6. 2002..spiralis, and defines the essential requirement for CCR3 in eosinophil, but not MC recruitment to tissues... - Genetic inversion in mast cell-deficient (Wsh) mice interrupts corin and manifests as hematopoietic and cardiac aberrancyPeter A Nigrovic
Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Boston, MA 02115, USA
Am J Pathol 173:1693-701. 2008..Studies performed using mast cell-deficient strains must consider the capacity of associated abnormalities to either expose or compensate for the missing mast cell lineage... - Mast cells contribute to initiation of autoantibody-mediated arthritis via IL-1Peter A Nigrovic
Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 104:2325-30. 2007..These findings illuminate a mechanism by which mast cells can participate in the pathogenesis of autoimmune inflammatory arthritis and provide insights of potential relevance to human rheumatoid arthritis... - Developmental checkpoints of the basophil/mast cell lineages in adult murine hematopoiesisYojiro Arinobu
Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 102:18105-10. 2005..Thus, circulating basophils and tissue mast cells share a common developmental stage at which their fate decision might be controlled principally by C/EBPalpha... - Mouse mast cell tryptase mMCP-6 is a critical link between adaptive and innate immunity in the chronic phase of Trichinella spiralis infectionKichul Shin
Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
J Immunol 180:4885-91. 2008.... - Pathways of murine mast cell development and trafficking: tracking the roots and routes of the mast cellJenny Hallgren
Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Boston, MA 02115, USA
Immunol Rev 217:8-18. 2007.... - Mast cell growth, differentiation, and deathMichael F Gurish
Department of Medicine, Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, USA
Clin Rev Allergy Immunol 22:107-18. 2002.... - Alpha-4 integrins and VCAM-1, but not MAdCAM-1, are essential for recruitment of mast cell progenitors to the inflamed lungJ Pablo Abonia
Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Smith Building, Room 624, 1 Jimmy Fund Way, Boston, MA 02115, USA
Blood 108:1588-94. 2006..Furthermore, the MCp is currently unique among inflammatory cells in its partial dependence on alpha4beta7 integrins for lung recruitment... - Mast cells: a cellular link between autoantibodies and inflammatory arthritisDavid M Lee
Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Science 297:1689-92. 2002..Thus, mast cells may function as a cellular link between autoantibodies, soluble mediators, and other effector populations in inflammatory arthritis... - Mast cell protease 5 mediates ischemia-reperfusion injury of mouse skeletal muscleJ Pablo Abonia
Department of Medicine, Brigham and Women s Hospital, and Harvard Medical School, Boston, MA 02115, USA
J Immunol 174:7285-91. 2005..We now report a cytotoxic activity associated with a MC-specific protease and demonstrate that mMCP-5 is critical for irreversible IR injury of skeletal muscle... - Constitutive homing of mast cell progenitors to the intestine depends on autologous expression of the chemokine receptor CXCR2J Pablo Abonia
Department of Pediatrics, Cincinnati Children s Medical Center, OH, USA
Blood 105:4308-13. 2005..Thus, the establishment and maintenance of MCps in the small intestine is a dynamic process that requires expression of the alpha4beta7 integrin and the alpha-chemokine receptor CXCR2... - IgE enhances parasite clearance and regulates mast cell responses in mice infected with Trichinella spiralisMichael F Gurish
Department of Medicine, Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital and Department of Medicine, Harvard Medical School, Boston, MA 02115, USA
J Immunol 172:1139-45. 2004..spiralis infection and participates in the response to larval stages of the parasite. Furthermore, our observations support a role for IgE in the regulation of MC homeostasis in vivo... - Lymphocyte-independent connective tissue mast cells populate murine synoviumKichul Shin
Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Arthritis Rheum 54:2863-71. 2006.... - Identification of eosinophil lineage-committed progenitors in the murine bone marrowHiromi Iwasaki
Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
J Exp Med 201:1891-7. 2005..The newly identified EoPs could be the cellular target in the treatment of a variety of disorders mediated by eosinophils... - Mast cells are an essential hematopoietic component for polyp developmentElias Gounaris
Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Proc Natl Acad Sci U S A 104:19977-82. 2007..Our data suggest that MC are an essential hematopoietic component for preneoplastic polyp development and are a novel target for therapeutic intervention... - Cooperative and antagonistic interplay between PU.1 and GATA-2 in the specification of myeloid cell fatesJonathan C Walsh
Department of Pharmacology and Physiological Sciences, The University of Chicago, IL 60637, USA
Immunity 17:665-76. 2002..Reexpression of GATA-2 in such progenitors enables the generation of mast cells. We propose a developmental model in which cooperative function or antagonistic crossregulation by PU.1 of GATA-2 promotes distinct myeloid cell fates...
Research Grants
- Mechanisms of Pulmonary Mast Cell Recruitment and MaturationMichael Gurish; Fiscal Year: 2010....
- Mechanisms of Pulmonary Mast Cell Recruitment and MaturationMichael Gurish; Fiscal Year: 2009....