Michael Gurish

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Intestinal mast cell progenitors require CD49dbeta7 (alpha4beta7 integrin) for tissue-specific homing
    M F Gurish
    Department of Medicine, Harvard Medical School, Boston, MA 02115, USA
    J Exp Med 194:1243-52. 2001
  2. pmc Pulmonary CXCR2 regulates VCAM-1 and antigen-induced recruitment of mast cell progenitors
    Jenny Hallgren
    Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital and Department of Medicine, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 104:20478-83. 2007
  3. ncbi request reprint Mast cells: ontogeny, homing, and recruitment of a unique innate effector cell
    Michael F Gurish
    Division of Rheumatology, Immunology and Allergy, Department of Medicine, Brigham and Women s Hospital, MA 02115 6007, USA
    J Allergy Clin Immunol 117:1285-91. 2006
  4. ncbi request reprint CCR3 is required for tissue eosinophilia and larval cytotoxicity after infection with Trichinella spiralis
    Michael F Gurish
    Division of Rheumatology, Allergy and Immunology, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Immunol 168:5730-6. 2002
  5. pmc Genetic inversion in mast cell-deficient (Wsh) mice interrupts corin and manifests as hematopoietic and cardiac aberrancy
    Peter A Nigrovic
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Pathol 173:1693-701. 2008
  6. pmc Mast cells contribute to initiation of autoantibody-mediated arthritis via IL-1
    Peter A Nigrovic
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 104:2325-30. 2007
  7. pmc Developmental checkpoints of the basophil/mast cell lineages in adult murine hematopoiesis
    Yojiro Arinobu
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 102:18105-10. 2005
  8. pmc Mouse mast cell tryptase mMCP-6 is a critical link between adaptive and innate immunity in the chronic phase of Trichinella spiralis infection
    Kichul Shin
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 180:4885-91. 2008
  9. ncbi request reprint Pathways of murine mast cell development and trafficking: tracking the roots and routes of the mast cell
    Jenny Hallgren
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Boston, MA 02115, USA
    Immunol Rev 217:8-18. 2007
  10. ncbi request reprint Mast cell growth, differentiation, and death
    Michael F Gurish
    Department of Medicine, Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Boston, MA, USA
    Clin Rev Allergy Immunol 22:107-18. 2002

Research Grants

Collaborators

Detail Information

Publications19

  1. pmc Intestinal mast cell progenitors require CD49dbeta7 (alpha4beta7 integrin) for tissue-specific homing
    M F Gurish
    Department of Medicine, Harvard Medical School, Boston, MA 02115, USA
    J Exp Med 194:1243-52. 2001
    ....
  2. pmc Pulmonary CXCR2 regulates VCAM-1 and antigen-induced recruitment of mast cell progenitors
    Jenny Hallgren
    Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital and Department of Medicine, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 104:20478-83. 2007
    ..Thus, these studies demonstrate a role for a chemokine receptor in regulating endothelial VCAM-1 expression, MCp migration, and the level of intraepithelial MC in the lung of aerosolized, antigen-challenged mice...
  3. ncbi request reprint Mast cells: ontogeny, homing, and recruitment of a unique innate effector cell
    Michael F Gurish
    Division of Rheumatology, Immunology and Allergy, Department of Medicine, Brigham and Women s Hospital, MA 02115 6007, USA
    J Allergy Clin Immunol 117:1285-91. 2006
    ..These findings in mice await confirmation in human subjects...
  4. ncbi request reprint CCR3 is required for tissue eosinophilia and larval cytotoxicity after infection with Trichinella spiralis
    Michael F Gurish
    Division of Rheumatology, Allergy and Immunology, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Immunol 168:5730-6. 2002
    ..spiralis, and defines the essential requirement for CCR3 in eosinophil, but not MC recruitment to tissues...
  5. pmc Genetic inversion in mast cell-deficient (Wsh) mice interrupts corin and manifests as hematopoietic and cardiac aberrancy
    Peter A Nigrovic
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Pathol 173:1693-701. 2008
    ..Studies performed using mast cell-deficient strains must consider the capacity of associated abnormalities to either expose or compensate for the missing mast cell lineage...
  6. pmc Mast cells contribute to initiation of autoantibody-mediated arthritis via IL-1
    Peter A Nigrovic
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 104:2325-30. 2007
    ..These findings illuminate a mechanism by which mast cells can participate in the pathogenesis of autoimmune inflammatory arthritis and provide insights of potential relevance to human rheumatoid arthritis...
  7. pmc Developmental checkpoints of the basophil/mast cell lineages in adult murine hematopoiesis
    Yojiro Arinobu
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 102:18105-10. 2005
    ..Thus, circulating basophils and tissue mast cells share a common developmental stage at which their fate decision might be controlled principally by C/EBPalpha...
  8. pmc Mouse mast cell tryptase mMCP-6 is a critical link between adaptive and innate immunity in the chronic phase of Trichinella spiralis infection
    Kichul Shin
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 180:4885-91. 2008
    ....
  9. ncbi request reprint Pathways of murine mast cell development and trafficking: tracking the roots and routes of the mast cell
    Jenny Hallgren
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Boston, MA 02115, USA
    Immunol Rev 217:8-18. 2007
    ....
  10. ncbi request reprint Mast cell growth, differentiation, and death
    Michael F Gurish
    Department of Medicine, Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Boston, MA, USA
    Clin Rev Allergy Immunol 22:107-18. 2002
    ....
  11. pmc Alpha-4 integrins and VCAM-1, but not MAdCAM-1, are essential for recruitment of mast cell progenitors to the inflamed lung
    J Pablo Abonia
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Smith Building, Room 624, 1 Jimmy Fund Way, Boston, MA 02115, USA
    Blood 108:1588-94. 2006
    ..Furthermore, the MCp is currently unique among inflammatory cells in its partial dependence on alpha4beta7 integrins for lung recruitment...
  12. ncbi request reprint Mast cells: a cellular link between autoantibodies and inflammatory arthritis
    David M Lee
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Science 297:1689-92. 2002
    ..Thus, mast cells may function as a cellular link between autoantibodies, soluble mediators, and other effector populations in inflammatory arthritis...
  13. pmc Mast cell protease 5 mediates ischemia-reperfusion injury of mouse skeletal muscle
    J Pablo Abonia
    Department of Medicine, Brigham and Women s Hospital, and Harvard Medical School, Boston, MA 02115, USA
    J Immunol 174:7285-91. 2005
    ..We now report a cytotoxic activity associated with a MC-specific protease and demonstrate that mMCP-5 is critical for irreversible IR injury of skeletal muscle...
  14. pmc Constitutive homing of mast cell progenitors to the intestine depends on autologous expression of the chemokine receptor CXCR2
    J Pablo Abonia
    Department of Pediatrics, Cincinnati Children s Medical Center, OH, USA
    Blood 105:4308-13. 2005
    ..Thus, the establishment and maintenance of MCps in the small intestine is a dynamic process that requires expression of the alpha4beta7 integrin and the alpha-chemokine receptor CXCR2...
  15. ncbi request reprint IgE enhances parasite clearance and regulates mast cell responses in mice infected with Trichinella spiralis
    Michael F Gurish
    Department of Medicine, Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital and Department of Medicine, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 172:1139-45. 2004
    ..spiralis infection and participates in the response to larval stages of the parasite. Furthermore, our observations support a role for IgE in the regulation of MC homeostasis in vivo...
  16. ncbi request reprint Lymphocyte-independent connective tissue mast cells populate murine synovium
    Kichul Shin
    Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Arthritis Rheum 54:2863-71. 2006
    ..We also examined the contribution of lymphocytes to synovial MC physiology...
  17. pmc Identification of eosinophil lineage-committed progenitors in the murine bone marrow
    Hiromi Iwasaki
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    J Exp Med 201:1891-7. 2005
    ..The newly identified EoPs could be the cellular target in the treatment of a variety of disorders mediated by eosinophils...
  18. pmc Mast cells are an essential hematopoietic component for polyp development
    Elias Gounaris
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 104:19977-82. 2007
    ..Our data suggest that MC are an essential hematopoietic component for preneoplastic polyp development and are a novel target for therapeutic intervention...
  19. ncbi request reprint Cooperative and antagonistic interplay between PU.1 and GATA-2 in the specification of myeloid cell fates
    Jonathan C Walsh
    Department of Pharmacology and Physiological Sciences, The University of Chicago, IL 60637, USA
    Immunity 17:665-76. 2002
    ..Reexpression of GATA-2 in such progenitors enables the generation of mast cells. We propose a developmental model in which cooperative function or antagonistic crossregulation by PU.1 of GATA-2 promotes distinct myeloid cell fates...

Research Grants2