V Gurewich

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Platelet associated u-PA up-regulates u-PA synthesis by endothelial cells
    L Camoin-Jau
    INSERM EMI 00 19, Laboratoire d Hematologie, Univ Mediterranee, UFR de Pharmacie and Hĵpital de la Conception, Marseille, France
    Thromb Haemost 88:517-23. 2002
  2. ncbi request reprint Thrombolysis vs. bleeding from hemostatic sites by a prourokinase mutant compared with tissue plasminogen activator
    V Gurewich
    Vascular Research Laboratory, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    J Thromb Haemost 4:1559-65. 2006
  3. doi request reprint Recombinant human C1-inhibitor prevents non-specific proteolysis by mutant pro-urokinase during optimal fibrinolysis
    Victor Gurewich
    Beth Israel Deaconess Medical Center, Harvard Medical School, Cambridge, MA 02138, USA
    Thromb Haemost 102:279-86. 2009
  4. ncbi request reprint A site-directed mutagenesis of pro-urokinase which substantially reduces its intrinsic activity
    J N Liu
    Vascular Research Laboratory, Deaconess Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA
    Biochemistry 35:14070-6. 1996
  5. ncbi request reprint C1-inhibitor prevents non-specific plasminogen activation by a prourokinase mutant without impeding fibrin-specific fibrinolysis
    R Pannell
    Vascular Research Laboratory, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    J Thromb Haemost 5:1047-54. 2007
  6. ncbi request reprint The kinetics of plasminogen activation by thrombin-cleaved pro-urokinase and promotion of its activity by fibrin fragment E-2 and by tissue plasminogen activator
    J N Liu
    Vascular Research Laboratory, New England Deaconess Hospital, Harvard Medical School, Boston, MA 02215
    Blood 81:980-7. 1993
  7. ncbi request reprint Demonstration of covalent binding of lipoprotein(a) [Lp(a)] to fibrin and endothelial cells
    J N Liu
    Vascular Research Laboratory, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Biochemistry 37:3949-54. 1998
  8. ncbi request reprint Fibrinolysis: an unfinished agenda
    V Gurewich
    Vascular Research Laboratory, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Blood Coagul Fibrinolysis 11:401-8. 2000

Collaborators

  • J N Liu
  • W Tang
  • R Pannell
  • L Camoin-Jau
  • W Kung
  • F Sabatier
  • F Anfosso
  • N Bardin
  • F Dignat-George
  • J Sampol

Detail Information

Publications8

  1. ncbi request reprint Platelet associated u-PA up-regulates u-PA synthesis by endothelial cells
    L Camoin-Jau
    INSERM EMI 00 19, Laboratoire d Hematologie, Univ Mediterranee, UFR de Pharmacie and Hĵpital de la Conception, Marseille, France
    Thromb Haemost 88:517-23. 2002
    ..This mechanism may represent a physiological control of platelet-mediated intravascular fibrin deposition...
  2. ncbi request reprint Thrombolysis vs. bleeding from hemostatic sites by a prourokinase mutant compared with tissue plasminogen activator
    V Gurewich
    Vascular Research Laboratory, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    J Thromb Haemost 4:1559-65. 2006
    ..This was a problem that seriously compromised proUK in clinical trials, as it precluded proUK-mediated fibrinolysis at therapeutic concentrations...
  3. doi request reprint Recombinant human C1-inhibitor prevents non-specific proteolysis by mutant pro-urokinase during optimal fibrinolysis
    Victor Gurewich
    Beth Israel Deaconess Medical Center, Harvard Medical School, Cambridge, MA 02138, USA
    Thromb Haemost 102:279-86. 2009
    ..The inhibition by C1I of non-specific but not fibrin-dependent plasminogen activation could not be duplicated by other serpins. The findings provide a potential means to optimize both the efficacy and safety of thrombolysis...
  4. ncbi request reprint A site-directed mutagenesis of pro-urokinase which substantially reduces its intrinsic activity
    J N Liu
    Vascular Research Laboratory, Deaconess Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA
    Biochemistry 35:14070-6. 1996
    ..This residue also appears to be important for the full expression of the enzymatic activity of urokinase...
  5. ncbi request reprint C1-inhibitor prevents non-specific plasminogen activation by a prourokinase mutant without impeding fibrin-specific fibrinolysis
    R Pannell
    Vascular Research Laboratory, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    J Thromb Haemost 5:1047-54. 2007
    ..Consistent with this, an unusual tcM5 complex with plasma C1-inhibitor was recently described in dog and human plasma. The effect of C1-inhibitor on fibrinolysis and fibrinogenolysis by M5 is the subject of this study...
  6. ncbi request reprint The kinetics of plasminogen activation by thrombin-cleaved pro-urokinase and promotion of its activity by fibrin fragment E-2 and by tissue plasminogen activator
    J N Liu
    Vascular Research Laboratory, New England Deaconess Hospital, Harvard Medical School, Boston, MA 02215
    Blood 81:980-7. 1993
    ..Thromb-UK has potential plasminogen-activating activity at surfaces where C-terminal lysines, functionally comparable to fragment E-2, are found...
  7. ncbi request reprint Demonstration of covalent binding of lipoprotein(a) [Lp(a)] to fibrin and endothelial cells
    J N Liu
    Vascular Research Laboratory, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Biochemistry 37:3949-54. 1998
    ..This property may contribute to the deposition of Lp(a) on endothelial surfaces and its colocalization with fibrin in atheromas...
  8. ncbi request reprint Fibrinolysis: an unfinished agenda
    V Gurewich
    Vascular Research Laboratory, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Blood Coagul Fibrinolysis 11:401-8. 2000
    ....