Research Topics
Genomes and Genes | SUZANNE Y GUENETTESummaryAffiliation: Harvard University Country: USA Publications
Research Grants
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Detail Information
Publications
FE65 as a link between VLDLR and APP to regulate their trafficking and processingSonya B Dumanis
Department of Neuroscience, Georgetown University Medical Center, 3970 Reservoir Road NW, Washington, DC 20057 1464, USA
Mol Neurodegener 7:9. 2012..In the present study, we tested whether FE65 can interact with another ApoE receptor, VLDLR, thereby altering its trafficking and processing, and whether FE65 can serve as a linker between APP and VLDLR...- Essential roles for the FE65 amyloid precursor protein-interacting proteins in brain developmentSuzanne Guenette
Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Charlestown, MA 02129 4404, USA
EMBO J 25:420-31. 2006..The defects observed in the double knockout may also involve the family of Ena/Vasp proteins, which participate in actin cytoskeleton remodeling and interact with the WW domains of FE65 proteins... 
Mechanisms of Abeta clearance and catabolismSUZANNE Y GUENETTE
Mass General Institute for Neurodegenerative Disease, Massachusetts General Hospital East, 114 16th St, Charlestown, MA 02129 4404, USA
Neuromolecular Med 4:147-60. 2003..This review will examine the data obtained from studies performed in knockout and transgenic mice on the proteases; the cells and the physiological mechanisms that play a part in the removal of Abeta from the brain...- Progress toward valid transgenic mouse models for Alzheimer's diseaseS Y Guenette
Department of Neurology, Massachusetts General Hospital, Charlestown 02129, USA
Neurobiol Aging 20:201-11. 1999..Crosses of APP transgenic mice with mice modified for known AD risk factors and "humanizing" the mouse may be necessary for complete replication of AD... - Astrocytes: a cellular player in Abeta clearance and degradationSUZANNE Y GUENETTE
Center for Aging Genetics and Neurodegeneration, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129 4404, USA
Trends Mol Med 9:279-80. 2003 - Low-density lipoprotein receptor-related protein levels and endocytic function are reduced by overexpression of the FE65 adaptor protein, FE65L1SUZANNE Y GUENETTE
Genetics and Aging Research Unit, Center for Aging Genetics and Neurodegeneration, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
J Neurochem 82:755-62. 2002..These data show that FE65L1 can differentially affect the metabolic fate of APP and LRP. In addition, these data suggest that the LRP decrease observed in FE65L1 overexpressing cells may in part contribute to altered APP processing... - A role for APP in motility and transcription?SUZANNE Y GUENETTE
Genetics and Aging Research Unit, Massachusetts General Hospital, Harvard Medical School, 114 16th Street, Charlestown, MA 02129 4404, USA
Trends Pharmacol Sci 23:203-5; discussion 205-6. 2002..Future studies are required to understand the full implications of these new findings and to determine whether therapeutic strategies for Alzheimer's disease should take these putative functions into account... - Evidence against association of the FE65 gene (APBB1) intron 13 polymorphism in Alzheimer's patientsS Y Guenette
Genetics and Aging Unit, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
Neurosci Lett 296:17-20. 2000..We conclude that the association of the FE65 intron 13 polymorphism with AD, if any, is smaller than previously reported... - Generation of the beta-amyloid peptide and the amyloid precursor protein C-terminal fragment gamma are potentiated by FE65L1Yang Chang
Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129 4404, USA
J Biol Chem 278:51100-7. 2003..Finally, although FE65L1 increases APP C-terminal domain production, it does not mediate the APP-dependent transcriptional activation observed with FE65... - FE65 proteins regulate NMDA receptor activation-induced amyloid precursor protein processingJaehong Suh
Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA
J Neurochem 119:377-88. 2011..Our results indicate that the FE65 proteins contribute to physiological APP processing and accumulation of APP metabolic products resulting from NMDAR activation... - HtrA2 regulates beta-amyloid precursor protein (APP) metabolism through endoplasmic reticulum-associated degradationHenri J Huttunen
Neurobiology of Disease Laboratory, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
J Biol Chem 282:28285-95. 2007..Based on these results we suggest a novel function for HtrA2 as a regulator of APP metabolism through ER-associated degradation...
Research Grants
- Biological Role of the FE65 Protein/APP InteractionsSuzanne Guenette; Fiscal Year: 2007..In addition, we will gain insight into the role of the FE65 proteins in cellular signaling events that are critical for brain function. ..
- ROLE OF HFE65 PROTEINS IN ALZHEIMER'S DISEASE.Suzanne Guenette; Fiscal Year: 2003..of hFE65L to LRP contribute to the extracellular pool of APPs and Abeta? Does the FE65L-APP interaction have an effect on intracellular Abeta42 production? Does FE65L act as an adaptor protein form a tripartite complex with APP and LRP? ..
- Biological Role of the FE65 Protein/APP InteractionsSuzanne Guenette; Fiscal Year: 2009..In addition, we will gain insight into the role of the FE65 proteins in cellular signaling events that are critical for brain function. ..