Haihua Gu

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Characterization of two SHP-2-associated binding proteins and potential substrates in hematopoietic cells
    H Gu
    Cancer Biology Program, Division of Hematology Oncology, Department of Medicine, Beth Israel Hospital and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 272:16421-30. 1997
  2. ncbi request reprint Cloning of p97/Gab2, the major SHP2-binding protein in hematopoietic cells, reveals a novel pathway for cytokine-induced gene activation
    H Gu
    Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Cell 2:729-40. 1998
  3. ncbi request reprint The scaffolding adapter Gab2, via Shp-2, regulates kit-evoked mast cell proliferation by activating the Rac/JNK pathway
    Min Yu
    Cancer Biology Program, Division of Hematology Oncology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 281:28615-26. 2006
  4. ncbi request reprint Scaffolding adapter Grb2-associated binder 2 requires Syk to transmit signals from FcepsilonRI
    Min Yu
    Cancer Biology Program, Division of Hematology Oncology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02115, USA
    J Immunol 176:2421-9. 2006
  5. ncbi request reprint Gab2 is phosphorylated on tyrosine upon interleukin-2/interleukin-15 stimulation in mycosis-fungoides-derived tumor T cells and associates inducibly with SHP-2 and Stat5a
    J L Brockdorff
    Institute for Medical Microbiology and Immunology, Harvard Medical School, Boston, Mass, USA
    Exp Clin Immunogenet 18:86-95. 2001
  6. ncbi request reprint A role for the scaffolding adapter GAB2 in breast cancer
    Mohamed Bentires-Alj
    Cancer Biology Program, Division of Hematology Oncology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, NRB 1030, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA
    Nat Med 12:114-21. 2006
  7. pmc Regulation of early events in integrin signaling by protein tyrosine phosphatase SHP-2
    E S Oh
    Cancer Biology Program, Division of Hematology Oncology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Mol Cell Biol 19:3205-15. 1999
  8. ncbi request reprint Divergent roles of SHP-2 in ERK activation by leptin receptors
    C Bjørbaek
    Department of Medicine, Division of Endocrinology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    J Biol Chem 276:4747-55. 2001
  9. pmc Activated STAT5 proteins induce activation of the PI 3-kinase/Akt and Ras/MAPK pathways via the Gab2 scaffolding adapter
    Remy Nyga
    INSERM E0351, Laboratoire d Immunologie, Faculte de Medecine, Université de Picardie Jule Verne, 3 rue des Louvels, 80036 Amiens, France
    Biochem J 390:359-66. 2005
  10. ncbi request reprint Critical role for Gab2 in transformation by BCR/ABL
    Martin Sattler
    Dana Farber Cancer Institute, Department of Adult Oncology, Harvard Medical School, 44 Binney Street, Boston, Massachusetts 02115, USA
    Cancer Cell 1:479-92. 2002

Research Grants

Collaborators

Detail Information

Publications19

  1. ncbi request reprint Characterization of two SHP-2-associated binding proteins and potential substrates in hematopoietic cells
    H Gu
    Cancer Biology Program, Division of Hematology Oncology, Department of Medicine, Beth Israel Hospital and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 272:16421-30. 1997
    ..Our results indicate that SHP-2 forms at least two separate complexes in hematopoietic cells and point to new potential SHP-2 targets...
  2. ncbi request reprint Cloning of p97/Gab2, the major SHP2-binding protein in hematopoietic cells, reveals a novel pathway for cytokine-induced gene activation
    H Gu
    Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Cell 2:729-40. 1998
    ..Our results identify p97 as an important regulator of receptor signaling that controls a novel pathway to immediate-early gene activation and suggest multiple functions for SHP2 in cytokine receptor signaling...
  3. ncbi request reprint The scaffolding adapter Gab2, via Shp-2, regulates kit-evoked mast cell proliferation by activating the Rac/JNK pathway
    Min Yu
    Cancer Biology Program, Division of Hematology Oncology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 281:28615-26. 2006
    ..Our data show that Gab2 via Shp-2 is critical for transmitting signals from Kit Tyr(567) to activate the Rac/JNK pathway controlling mast cell proliferation, which likely contributes to mast cell development in specific tissues...
  4. ncbi request reprint Scaffolding adapter Grb2-associated binder 2 requires Syk to transmit signals from FcepsilonRI
    Min Yu
    Cancer Biology Program, Division of Hematology Oncology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02115, USA
    J Immunol 176:2421-9. 2006
    ....
  5. ncbi request reprint Gab2 is phosphorylated on tyrosine upon interleukin-2/interleukin-15 stimulation in mycosis-fungoides-derived tumor T cells and associates inducibly with SHP-2 and Stat5a
    J L Brockdorff
    Institute for Medical Microbiology and Immunology, Harvard Medical School, Boston, Mass, USA
    Exp Clin Immunogenet 18:86-95. 2001
    ..Thus, although Gab2 seems to function normally in MF T cells compared to normal T cells, Gab2 itself might be abnormally regulated by an Src family kinase...
  6. ncbi request reprint A role for the scaffolding adapter GAB2 in breast cancer
    Mohamed Bentires-Alj
    Cancer Biology Program, Division of Hematology Oncology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, NRB 1030, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA
    Nat Med 12:114-21. 2006
    ..Agents that target GAB2 or GAB2-dependent pathways may be useful for treating breast tumors that overexpress GAB2 or HER2 or both...
  7. pmc Regulation of early events in integrin signaling by protein tyrosine phosphatase SHP-2
    E S Oh
    Cancer Biology Program, Division of Hematology Oncology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Mol Cell Biol 19:3205-15. 1999
    ....
  8. ncbi request reprint Divergent roles of SHP-2 in ERK activation by leptin receptors
    C Bjørbaek
    Department of Medicine, Division of Endocrinology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    J Biol Chem 276:4747-55. 2001
    ..SHP-2 is thus a positive regulator of ERK by leptin receptors, and both the adaptor function and the phosphatase activity of SHP-2 are critical for this regulation...
  9. pmc Activated STAT5 proteins induce activation of the PI 3-kinase/Akt and Ras/MAPK pathways via the Gab2 scaffolding adapter
    Remy Nyga
    INSERM E0351, Laboratoire d Immunologie, Faculte de Medecine, Université de Picardie Jule Verne, 3 rue des Louvels, 80036 Amiens, France
    Biochem J 390:359-66. 2005
    ..Taken together, our results indicate that Gab2 is required for caSTAT5-induced cell proliferation by regulating both the PI3K/Akt and the Ras/MAPK pathways...
  10. ncbi request reprint Critical role for Gab2 in transformation by BCR/ABL
    Martin Sattler
    Dana Farber Cancer Institute, Department of Adult Oncology, Harvard Medical School, 44 Binney Street, Boston, Massachusetts 02115, USA
    Cancer Cell 1:479-92. 2002
    ..Our results identify Gab2 and its associated proteins as key determinants of the lineage and severity of BCR/ABL transformation...
  11. ncbi request reprint The 'Shp'ing news: SH2 domain-containing tyrosine phosphatases in cell signaling
    Benjamin G Neel
    Cancer Biology Program Division of Hematology Oncology Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA
    Trends Biochem Sci 28:284-93. 2003
    ..Despite these efforts, however, the key targets of each Shp have remained elusive. Identifying these substrates remains a major challenge for future research...
  12. pmc New role for Shc in activation of the phosphatidylinositol 3-kinase/Akt pathway
    H Gu
    Cancer Biology Program, Division of Hematology Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, and Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Cell Biol 20:7109-20. 2000
    ..Our results suggest that cytokine receptors lacking direct PI-3K binding sites activate Akt via a Shc/Grb2/Gab2/PI-3K pathway, thereby regulating cell survival and/or proliferation...
  13. pmc Identification of major binding proteins and substrates for the SH2-containing protein tyrosine phosphatase SHP-1 in macrophages
    J F Timms
    Cancer Biology Program, Division of Hematology Oncology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Mol Cell Biol 18:3838-50. 1998
    ..Our data suggest that BIT and PIR-B recruit multiple signaling molecules to receptor complexes, where they are regulated by SHP-1 and/or SHP-2...
  14. ncbi request reprint Essential role for Gab2 in the allergic response
    H Gu
    Cancer Biology Program, Division of Hematology and Oncology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Nature 412:186-90. 2001
    ..Gab2 and/or its associated signalling molecules may be new targets for developing drugs to treat allergy...
  15. pmc Critical role for scaffolding adapter Gab2 in Fc gamma R-mediated phagocytosis
    Haihua Gu
    Harvard Institutes of Medicine, 77 Ave Louis Pasteur, HIM 1047 Boston, MA 02115, USA
    J Cell Biol 161:1151-61. 2003
    ..Because PI3K activity is required for FcgammaR-mediated phagocytosis, our results indicate that Gab2 acts as a key component of FcgammaR-mediated phagocytosis, most likely by amplifying PI3K signaling in the nascent phagosome...
  16. ncbi request reprint The docking protein Gab2 is overexpressed and estrogen regulated in human breast cancer
    Roger J Daly
    Cancer Research Program, Garvan Institute of Medical Research, St Vincent s Hospital, Sydney, NSW 2010, Australia
    Oncogene 21:5175-81. 2002
    ..Gab2 therefore represents a novel link between steroid and growth factor signaling in breast cancer, and when overexpressed, may modulate the sensitivity of breast cancer cells to these important growth regulators...
  17. ncbi request reprint The "Gab" in signal transduction
    Haihua Gu
    Cancer Biology Program, Division of Hematology Oncology, Dept of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Ave, Boston, MA 02215, USA
    Trends Cell Biol 13:122-30. 2003
    ..Here, we review the structure, mechanism of action and function of these interesting molecules in normal biology and disease...
  18. ncbi request reprint Scaffolding protein Gab2 mediates fibroblast transformation by the SEA tyrosine kinase
    Irene Ischenko
    Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, NY 11794 5222, USA
    Oncogene 22:6311-8. 2003
    ..Using mutant forms of Gab2, we show that activation of the PI3K-Akt pathway via Gab2 is required for V-SEA-induced transformation. However, efficient fibroblast transformation also requires the SHP2 interaction site on Gab2...
  19. pmc Enhanced pulmonary arteriopathy in simian immunodeficiency virus-infected macaques exposed to morphine
    Leslie Spikes
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA
    Am J Respir Crit Care Med 185:1235-43. 2012
    ..Conclusions: Our findings suggest that SIV/HIV protein(s) and morphine interact to cause the proliferation of apoptosis-resistant endothelial cells leading to angio-obliteration...

Research Grants1

  1. Role of Gab2 in Mast Cell Function and Ontogeny
    Haihua Gu; Fiscal Year: 2006
    ..abstract_text> ..