Staci A Gruber

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Altered regional blood volume in chronic cannabis smokers
    Jennifer T Sneider
    Cognitive Neuroimaging Laboratory, Brain Imaging Center, McLean Hospital, Belmont, MA 02478, USA
    Exp Clin Psychopharmacol 14:422-8. 2006
  2. ncbi request reprint Neuropsychological consequences of opiate use
    Staci A Gruber
    Cognitive Neuroimaging Laboratory, McLean Hospital Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
    Neuropsychol Rev 17:299-315. 2007
  3. pmc Differences in regional blood volume during a 28-day period of abstinence in chronic cannabis smokers
    Jennifer T Sneider
    Cognitive Neuroimaging Laboratory, Brain Imaging Center, McLean Hospital, Belmont, MA 02478, United States
    Eur Neuropsychopharmacol 18:612-9. 2008
  4. pmc Altered affective response in marijuana smokers: an FMRI study
    Staci A Gruber
    Cognitive Neuroimaging Laboratory, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
    Drug Alcohol Depend 105:139-53. 2009
  5. pmc Why so impulsive? White matter alterations are associated with impulsivity in chronic marijuana smokers
    Staci A Gruber
    Cognitive and Clinical Neuroimaging Core, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
    Exp Clin Psychopharmacol 19:231-42. 2011
  6. doi request reprint Worth the wait: effects of age of onset of marijuana use on white matter and impulsivity
    Staci A Gruber
    Cognitive and Clinical Neuroimaging Core, McLean Imaging Center, McLean Hospital, 115 Mill St, Belmont, MA, 02478, USA
    Psychopharmacology (Berl) 231:1455-65. 2014
  7. pmc Age of onset of marijuana use and executive function
    Staci A Gruber
    Cognitive and Clinical Neuroimaging Core, Brain Imaging Center, McLean Hospital, Belmont, MA 02478, USA
    Psychol Addict Behav 26:496-506. 2012
  8. pmc Age of onset of marijuana use impacts inhibitory processing
    Staci A Gruber
    Cognitive and Clinical Neuroimaging Core, Brain Imaging Center, McLean Hospital, 115 Mill St, Belmont, MA 02478, USA
    Neurosci Lett 511:89-94. 2012
  9. pmc Neuropsychological performance predicts clinical recovery in bipolar patients
    Staci A Gruber
    Cognitive Neuroimaging Laboratory, Brain Imaging Center, McLean Hospital, Harvard Medical School, Belmont, MA 02478, USA
    J Affect Disord 105:253-60. 2008
  10. ncbi request reprint Methadone maintenance improves cognitive performance after two months of treatment
    Staci A Gruber
    Cognitive Neuroimaging Laboratory, McLean Hospital, Belmont, MA 02478, USA
    Exp Clin Psychopharmacol 14:157-64. 2006

Research Grants

Detail Information

Publications33

  1. ncbi request reprint Altered regional blood volume in chronic cannabis smokers
    Jennifer T Sneider
    Cognitive Neuroimaging Laboratory, Brain Imaging Center, McLean Hospital, Belmont, MA 02478, USA
    Exp Clin Psychopharmacol 14:422-8. 2006
    ..It would be of interest to extend the investigation beyond 6-36 hr of abstinence from cannabis to determine whether increased CBV values persist for several weeks or eventually normalize...
  2. ncbi request reprint Neuropsychological consequences of opiate use
    Staci A Gruber
    Cognitive Neuroimaging Laboratory, McLean Hospital Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
    Neuropsychol Rev 17:299-315. 2007
    ..Factors that contribute to addiction and recovery are also discussed, as it is difficult to disentangle the effects of opiate use on cognitive performance from other factors that may affect neurobehavioral measures...
  3. pmc Differences in regional blood volume during a 28-day period of abstinence in chronic cannabis smokers
    Jennifer T Sneider
    Cognitive Neuroimaging Laboratory, Brain Imaging Center, McLean Hospital, Belmont, MA 02478, United States
    Eur Neuropsychopharmacol 18:612-9. 2008
    ..These findings suggest that while CBV levels begin to normalize with continued abstinence from cannabis, specifically in frontal areas, other temporal and cerebellar brain regions show slower CBV decreases...
  4. pmc Altered affective response in marijuana smokers: an FMRI study
    Staci A Gruber
    Cognitive Neuroimaging Laboratory, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
    Drug Alcohol Depend 105:139-53. 2009
    ....
  5. pmc Why so impulsive? White matter alterations are associated with impulsivity in chronic marijuana smokers
    Staci A Gruber
    Cognitive and Clinical Neuroimaging Core, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
    Exp Clin Psychopharmacol 19:231-42. 2011
    ..Early MJ use may result in reduced FA and increased diffusivity, which may be associated with increased impulsivity, and ultimately contribute to the initiation of MJ use or the inability to discontinue use...
  6. doi request reprint Worth the wait: effects of age of onset of marijuana use on white matter and impulsivity
    Staci A Gruber
    Cognitive and Clinical Neuroimaging Core, McLean Imaging Center, McLean Hospital, 115 Mill St, Belmont, MA, 02478, USA
    Psychopharmacology (Berl) 231:1455-65. 2014
    ..In particular, MJ use has been shown to be associated with alterations in frontal white matter microstructure, which may be related to reports of increased levels of impulsivity in this population...
  7. pmc Age of onset of marijuana use and executive function
    Staci A Gruber
    Cognitive and Clinical Neuroimaging Core, Brain Imaging Center, McLean Hospital, Belmont, MA 02478, USA
    Psychol Addict Behav 26:496-506. 2012
    ..Exposure to MJ during a period of neurodevelopmental vulnerability, such as adolescence, may result in altered brain development and enduring neuropsychological changes...
  8. pmc Age of onset of marijuana use impacts inhibitory processing
    Staci A Gruber
    Cognitive and Clinical Neuroimaging Core, Brain Imaging Center, McLean Hospital, 115 Mill St, Belmont, MA 02478, USA
    Neurosci Lett 511:89-94. 2012
    ..Further investigation is warranted, as early exposure to MJ may result in reorganization of critical brain regions...
  9. pmc Neuropsychological performance predicts clinical recovery in bipolar patients
    Staci A Gruber
    Cognitive Neuroimaging Laboratory, Brain Imaging Center, McLean Hospital, Harvard Medical School, Belmont, MA 02478, USA
    J Affect Disord 105:253-60. 2008
    ..Although a number of investigations have reported cognitive deficits in patients with bipolar disorder, relatively few have focused on the relationship between these impairments and clinical outcome...
  10. ncbi request reprint Methadone maintenance improves cognitive performance after two months of treatment
    Staci A Gruber
    Cognitive Neuroimaging Laboratory, McLean Hospital, Belmont, MA 02478, USA
    Exp Clin Psychopharmacol 14:157-64. 2006
    ..Results suggest that opiate-dependent subjects exhibit significant improvement in cognitive function after MM treatment. Future investigations are needed to confirm these findings...
  11. ncbi request reprint Decreased activation of the anterior cingulate in bipolar patients: an fMRI study
    Staci A Gruber
    Cognitive Neuroimaging Laboratory, Brain Imaging Center, McLean Hospital, 115 Mill Street NIC 148 Belmont, MA 02478, USA
    J Affect Disord 82:191-201. 2004
    ..To date, studies that have examined ACC function in bipolar patients have not differentiated subregions within this area, nor have they examined changes in these subregions in relation with DLPFC activation...
  12. pmc Depressed mood and lateralized prefrontal activity during a Stroop task in adolescent children
    William D S Killgore
    Cognitive Neuroimaging Laboratory, McLean Hospital, Harvard Medical School, Belmont, MA 02478, USA
    Neurosci Lett 416:43-8. 2007
    ..When interpreted from a compensatory recruitment perspective, findings suggest that affective lateralization in adolescents is consistent with that seen in adulthood...
  13. pmc Abnormal corticostriatal activity during fear perception in bipolar disorder
    William D S Killgore
    Cognitive Neuroimaging Laboratory, McLean Hospital, Harvard Medical School, Belmont, Massachusetts 02478, USA
    Neuroreport 19:1523-7. 2008
    ..early) stage of the task, bipolar patients failed to show normal task-related activity in these regions. Results suggest that bipolar disorder may involve corticostriatal dysfunction...
  14. ncbi request reprint Recognition of happy facial affect in panic disorder: an fMRI study
    Srinivasan S Pillay
    Brain Imaging Center, McLean Hospital, 115 Mill Street, Belmont, MA 02478, United States
    J Anxiety Disord 21:381-93. 2007
    ....
  15. doi request reprint Amygdala volume and verbal memory performance in schizophrenia and bipolar disorder
    William D S Killgore
    Department of Psychiatry, Neuroimaging Center, McLean Hospital, Harvard Medical School, Belmont, MA, USA
    Cogn Behav Neurol 22:28-37. 2009
    ..To clarify the relationship between amygdala-hippocampal volume and cognitive performance in schizophrenia and bipolar disorder...
  16. ncbi request reprint fMRI of fearful facial affect recognition in panic disorder: the cingulate gyrus-amygdala connection
    Srinivasan S Pillay
    Brain Imaging Center, McLean Hospital, 115 Mill Street, Belmont, MA 02478, United States
    J Affect Disord 94:173-81. 2006
    ..This study investigated cingulate cortex (CC) and amygdala response to fearful facial affect recognition in patients with panic disorder (PD) as measured by BOLD fMRI during the presentation of static facial images...
  17. ncbi request reprint Stroop performance in normal control subjects: an fMRI study
    Staci A Gruber
    Cognitive Neuroimaging Laboratory, Brain Imaging Center, Harvard Medical School, McLean Hospital, 115 Mill Street, Belmont, Massachusetts 02478 9106, USA
    Neuroimage 16:349-60. 2002
    ..This study extends previous findings by demonstrating that in healthy adults, a subdivision of the cingulate cortex is specifically associated with the cognitive demands present in the interference condition...
  18. ncbi request reprint White matter abnormalities observed in bipolar disorder: a diffusion tensor imaging study
    Deborah A Yurgelun-Todd
    Department of Psychiatry, Harvard Medical School, Boston, MA, USA
    Bipolar Disord 9:504-12. 2007
    ..The objective of the present study was to examine white matter tract integrity, using diffusion tensor imaging (DTI), in bipolar patients and healthy comparison subjects...
  19. ncbi request reprint Reduced amygdala volumes in first-episode bipolar disorder and correlation with cerebral white matter
    Isabelle M Rosso
    Brain Imaging Center, McLean Hospital, Belmont, Massachusetts 02478, USA
    Biol Psychiatry 61:743-9. 2007
    ..It is unclear whether amygdala abnormalities are present early in the course of illness and/or are the consequence of disease progression...
  20. ncbi request reprint Neuroimaging of marijuana smokers during inhibitory processing: a pilot investigation
    Staci A Gruber
    Cognitive Neuroimaging Laboratory, Brain Imaging Center, McLean Hospital, Department of Psychiatry, Harvard Medical School, Belmont, MA 02478, USA
    Brain Res Cogn Brain Res 23:107-18. 2005
    ....
  21. doi request reprint Increased amygdala fMRI activation after secretin administration
    Deborah A Yurgelun-Todd
    Neuroimaging Laboratory, McLean Hospital Harvard Medical School, Belmont, MA 02478 9106, USA
    Exp Clin Psychopharmacol 16:191-8. 2008
    ..The presence of increased activation of the amygdala during the viewing of fearful faces is consistent with findings from animal studies and suggests a mechanism by which secretin may modulate social behavior...
  22. ncbi request reprint Sex differences in the relationship between white matter microstructure and impulsivity in adolescents
    Marisa M Silveri
    Cognitive Neuroimaging and Neuropsychology Laboratory, McLean Hospital, Belmont, MA 02478, USA
    Magn Reson Imaging 24:833-41. 2006
    ..These data further suggest a neurobiological mechanism underlying some of the emotional and cognitive changes commonly observed in males versus females during the adolescent period...
  23. pmc Differential activation patterns of occipital and prefrontal cortices during motion processing: evidence from normal and schizophrenic brains
    Yue Chen
    McLean Hospital, Department of Psychiatry, Harvard Medical School, Belmont, Massachusetts 02478, USA
    Cogn Affect Behav Neurosci 8:293-303. 2008
    ..Furthermore, this result provides evidence that in the context of broadly distributed cortical dysfunction, the usual functional specificity of the cortex becomes modified, even across the domains of sensory and cognitive processing...
  24. ncbi request reprint Functional magnetic resonance imaging studies of schizophrenic patients during word production: effects of D-cycloserine
    Deborah A Yurgelun-Todd
    Cognitive Neuroimaging Laboratory, Brain Imaging Center, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
    Psychiatry Res 138:23-31. 2005
    ..These results suggest that the addition of D-cycloserine to conventional neuroleptics may improve negative symptoms through enhanced temporal lobe function...
  25. ncbi request reprint "Age of onset of marijuana use and executive function": Correction to Gruber et al. (2011)
    Staci A Gruber
    Cognitive and Clinical Neuroimaging Core, Brain Imaging Center, McLean Hospital
    Psychol Addict Behav 26:506. 2012
    ..Exposure to MJ during a period of neurodevelopmental vulnerability, such as adolescence, may result in altered brain development and enduring neuropsychological changes. (PsycINFO Database Record (c) 2012 APA, all rights reserved)...
  26. ncbi request reprint Spatial working memory in heavy cannabis users: a functional magnetic resonance imaging study
    Gen Kanayama
    Cognitive Neuroimaging Laboratory, Brain Imaging Center, McLean Hospital Harvard Medical School, 115 Mill St, Belmont, MA 02478, USA
    Psychopharmacology (Berl) 176:239-47. 2004
    ..Many neuropsychological studies have documented deficits in working memory among recent heavy cannabis users. However, little is known about the effects of cannabis on brain activity...
  27. ncbi request reprint Activation in dorsolateral prefrontal cortex in response to maternal criticism and praise in recovered depressed and healthy control participants
    Jill M Hooley
    Department of Psychology, Harvard University, Cambridge, Massacusetts 02138, USA
    Biol Psychiatry 57:809-12. 2005
    ..Functional magnetic resonance imaging (fMRI) was used to assess focal activation changes in DLPFC in response to a novel psychosocial challenge stimulus developed from the expressed emotion construct...
  28. doi request reprint Neural processing of emotional overinvolvement in borderline personality disorder
    Jill M Hooley
    Department of Psychology, Harvard University, Cambridge, MA 02138, USA
    J Clin Psychiatry 71:1017-24. 2010
    ..Specifically, we tested the hypothesis that, unlike healthy controls or people with other psychiatric problems, people with BPD process EOI as an approach-related stimulus...
  29. doi request reprint Cortico-limbic response to personally challenging emotional stimuli after complete recovery from depression
    Jill M Hooley
    Department of Psychology, Harvard University, Cambridge, MA 02138, USA
    Psychiatry Res 171:106-19. 2009
    ..Criticism may be a risk factor for relapse because it activates the amygdala and perturbs the affective circuitry that underlies depression...
  30. doi request reprint Altered affective processing in bipolar disorder: an fMRI study
    Kelly A Sagar
    Cognitive and Clinical Neuroimaging Core, Brain Imaging Center, McLean Hospital, Belmont, MA 02478, USA
    J Affect Disord 150:1192-6. 2013
    ..However, results remain largely inconsistent across studies. The aim of the current study was to further examine affective processing in patients with bipolar disorder...
  31. ncbi request reprint Functional magnetic resonance imaging in schizophrenia: cortical response to motor stimulation
    Jadwiga Rogowska
    Cognitive Neuroimaging Laboratory, Brain Imaging Center, McLean Hospital Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
    Psychiatry Res 130:227-43. 2004
    ..In BA4, this reduction is significant for right (P=0.007) and left (P=0.003) finger tapping. Similar results were obtained for BA6. Further analyses are necessary to evaluate the activation in other motor system regions...
  32. ncbi request reprint Cerebellar blood volume in bipolar patients correlates with medication
    Russell T Loeber
    Cognitive Neuroimaging Laboratory, McLean Hospital Brain Imaging Center, Boston, MA 02178, USA
    Biol Psychiatry 51:370-6. 2002
    ..Having previously found differences in cerebellar blood volume in patients with bipolar disorder compared to healthy control subjects, this study examined whether some variability in the patient population may be an effect of medication...
  33. ncbi request reprint Frontal lobe GABA levels in cocaine dependence: a two-dimensional, J-resolved magnetic resonance spectroscopy study
    Yong Ke
    Brain Imaging Center, McLean Hospital, 115 Mill St, Belmont, MA 02478, USA
    Psychiatry Res 130:283-93. 2004
    ..However, cocaine-dependent subjects without an alcohol disorder (N=12) also had lower GABA levels (1.04 mM/kg) than the comparison subjects (t [d.f.=30]=2.09, P=0.045), suggesting that cocaine dependence alone can decrease GABA levels...

Research Grants3

  1. Frontal Neural Mechanisms and Risk for Substance Abuse
    Staci Gruber; Fiscal Year: 2003
    ..Additionally, findings from this project will provide the foundation for future grant applications aimed at examining the role of the prefrontal cortex in substance abuse. ..
  2. Marijuana and Mood: Frontal Predictors of Behavior
    Staci Gruber; Fiscal Year: 2007
    ....