Research Topics
| Jan GrimmSummaryAffiliation: Harvard University Country: USA Publications
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Detail Information
Publications
Influence of thrombus age on the mechanical thrombectomy efficacy of the amplatz thrombectomy device in vitroJan Grimm
Klinik für Diagnostische Radiologie, Christian Albrechts Universitat zu Kiel, A Heller Strasse 9, 24105 Kiel, Germany
Cardiovasc Intervent Radiol 26:265-8. 2003..To determine the efficacy of thrombectomy for the Amplatz Thrombectomy Device (ATD) according to the age of the thrombus...- Hemolytic effect of deformed intra-arterial stents and stent grafts in vitroJan Grimm
Klinik für Diagnostische Radiologie der Christian Albrecht Universität CAU zu Kiel, A Heller Strasse 9, 24105 Kiel, Germany
Eur Radiol 13:1333-8. 2003..The stent grafts did not perform better than the stents. Differences in the design of a prosthesis and in the degree of stent deformation seem to have an influence on the hemolysis caused... - Comparison of various cerebral protection devices used for carotid artery stent placement: an in vitro experimentStefan Muller-Hulsbeck
Department of Radiology, University Hospital, Arnold Heller Strasse 9, 24105 Kiel, Germany
J Vasc Interv Radiol 14:613-20. 2003..To compare the effectiveness of five basic cerebral protection devices designed for carotid angioplasty in an in-vitro bench-top model... - Endovascular placement of self-expanding nitinol coil stents for the treatment of femoropopliteal obstructive diseaseThomas Jahnke
Department of Diagnostic Radiology, University Hospital, Christian Albrechts Universitat Kiel, Arnold Heller Strasse 9, 24105 Kiel, Germany
J Vasc Interv Radiol 13:257-66. 2002..To report on a prospective two-center study to evaluate safety and effectiveness of a self-expanding nitinol coil stent in patients with femoropopliteal obstructive disease... - Comparison and modification of two cerebral protection devices used for carotid angioplasty: in vitro experimentStefan Muller-Hulsbeck
Department of Radiology, University Hospital, Arnold Heller Strasse 9, 24105 Kiel, Germany
Radiology 225:289-94. 2002..However, embolization into the external carotid artery was more frequent with use of the GuideWire, as compared with that with use of the Angioguard... - In vitro effectiveness of mechanical thrombectomy devices for large vessel diameter and low-pressure fluid dynamic applicationsStefan Muller-Hulsbeck
Department of Radiology, University Hospital, Arnold Heller Strasse 9, 24105 Kiel, Germany
J Vasc Interv Radiol 13:831-9. 2002.... 
In vivo imaging of T cell delivery to tumors after adoptive transfer therapyMikael J Pittet
Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Simches Research Building, 185 Cambridge Street, Boston, MA 02114, USA
Proc Natl Acad Sci U S A 104:12457-61. 2007....- Tracking the recruitment of diabetogenic CD8+ T-cells to the pancreas in real timeAnna Moore
MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Building 149, 13th Street, Room 2301, Charlestown, MA 02129, USA
Diabetes 53:1459-66. 2004..This study demonstrates the feasibility of visualizing the presence of ongoing autoimmune responses noninvasively... - Magnetic resonance imaging of the pancreas and pancreatic tumors in a mouse orthotopic model of human cancerJan Grimm
Center for Molecular Imaging Research, Department of Radiology, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA
Int J Cancer 106:806-11. 2003..MR serves as a noninvasive high-resolution image modality to monitor murine pancreas as well as size, growth and even areas of heterogeneity in orthotopic pancreatic tumors... - A spatially and temporally restricted mouse model of soft tissue sarcomaDavid G Kirsch
Center for Cancer Research, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA
Nat Med 13:992-7. 2007..Therefore, the intrinsic pathway of apoptosis seems sufficient to mediate p53 tumor suppression in an epithelial cancer, but not in this model of soft tissue sarcoma... - Experience on endothelial cell adhesion on vascular stents and stent-grafts: first in vitro resultsStefan Muller-Hulsbeck
Department of Radiology, Hospital of Radiotherapy, Kiel, Germany
Invest Radiol 37:314-20. 2002..To evaluate endothelial cell (EC) attachment on different stents and stent-grafts combined with different coating materials... - Restoration of p53 function leads to tumour regression in vivoAndrea Ventura
Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA
Nature 445:661-5. 2007..These results support efforts to treat human cancers by way of pharmacological reactivation of p53... - Oligomerization of CXCL10 is necessary for endothelial cell presentation and in vivo activityGabriele S V Campanella
Division of Rheumatology, Allergy, and Immunology, Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
J Immunol 177:6991-8. 2006..We therefore propose that oligomerization of IP-10 is required for presentation on endothelial cells and subsequent transendothelial migration, an essential step for lymphocyte recruitment in vivo... - Deglycosylated anti-amyloid-beta antibodies eliminate cognitive deficits and reduce parenchymal amyloid with minimal vascular consequences in aged amyloid precursor protein transgenic miceDonna M Wilcock
Department of Pharmacology and Molecular Therapeutics, University of South Florida, Tampa, Florida 33612, USA
J Neurosci 26:5340-6. 2006.... - Metabolic biotinylation of cell surface receptors for in vivo imagingBakhos A Tannous
Center for Molecular Imaging Research, Massachusetts General Hospital-East, Building 149, 13th Street, Charlestown, Massachusetts 02129, USA
Nat Methods 3:391-6. 2006..This BAP-TM allows noninvasive real-time imaging of any cell type transduced to express this reporter protein in culture or in vivo... - Volumetric tomography of fluorescent proteins through small animals in vivoGiannis Zacharakis
Laboratory for Bio-optics and Molecular Imaging, Center for Molecular Imaging Research, Harvard Medical School, Charlestown, MA 02129, USA
Proc Natl Acad Sci U S A 102:18252-7. 2005..This technology can significantly improve imaging capacity over the current state of the art and should find wide in vivo imaging applications in drug discovery, immunology, and cancer research... - Tomographic fluorescence mapping of tumor targetsXavier Montet
Center for Molecular Imaging Research, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
Cancer Res 65:6330-6. 2005..FMT measurements can be done serially, with short imaging times and within the same live animal. The described method should be valuable for rapidly profiling biological phenomena in vivo... - The neuronal scaffold protein Shank3 mediates signaling and biological function of the receptor tyrosine kinase Ret in epithelial cellsGunnar Schuetz
MaxDelbrück Center for Molecular Medicine, Berlin, Germany
J Cell Biol 167:945-52. 2004..These results demonstrate that the Shank3 adaptor protein can mediate cellular signaling, and provide a molecular mechanism for the biological divergence between the Ret9 and Ret51 isoform... - Profiling of microdissected gastric epithelial cells reveals a cell type-specific response to Helicobacter pylori infectionAnne Mueller
Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA
Gastroenterology 127:1446-62. 2004..We have explored the transcriptional response of the epithelium globally by applying a whole-genome approach to a murine model of infection... - In vitro comparison of four cerebral protection filters for preventing human plaque embolization during carotid interventionsStefan Muller-Hulsbeck
Department of Radiology, University Hospital, Kiel, Germany
J Endovasc Ther 9:793-802. 2002..To evaluate in an in vitro bench-top model the efficacy of 4 filtration devices designed for cerebral protection during carotid angioplasty... - Novel nanosensors for rapid analysis of telomerase activityJan Grimm
Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
Cancer Res 64:639-43. 2004..Together, these studies establish and validate a novel and powerful tool for rapidly sensing telomerase activity and provide the rationale for developing analogous magnetic nanoparticles for in vivo sensing... - Distinct gene expression profiles characterize the histopathological stages of disease in Helicobacter-induced mucosa-associated lymphoid tissue lymphomaAnne Mueller
Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305-5402, USA
Proc Natl Acad Sci U S A 100:1292-7. 2003..Finally, we found that the transition to destructive lymphoepithelial lesions and malignant lymphoma is marked by an increase in transcription of a single gene encoding calgranulin AMrp-8... - Noninvasive in vivo imaging of monocyte trafficking to atherosclerotic lesionsMoritz F Kircher
Center for Molecular Imaging Research, Massachusetts General Hospital and Harvard Medical School, Charlestown, Mass, USA
Circulation 117:388-95. 2008..We sought to establish a noninvasive technique to determine monocyte trafficking to atherosclerotic lesions in live animals...