Rebecca J Greenwald

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi CTLA-4 regulates cell cycle progression during a primary immune response
    Rebecca J Greenwald
    Immunology Research Division, Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215, USA
    Eur J Immunol 32:366-73. 2002
  2. ncbi Negative co-receptors on lymphocytes
    Rebecca J Greenwald
    Immunology Research Division, Department of Pathology, Brigham and Women s Hospital, 221 Longwood Avenue, Boston, MA 02115, USA
    Curr Opin Immunol 14:391-6. 2002
  3. ncbi The B7 family revisited
    Rebecca J Greenwald
    Department of Pathology, Harvard Medical School and Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Annu Rev Immunol 23:515-48. 2005
  4. ncbi PD-L1 and PD-L2 have distinct roles in regulating host immunity to cutaneous leishmaniasis
    Spencer C Liang
    Department of Pathology, Harvard Medical School and Brigham and Women s Hospital, Boston, MA 02115, USA
    Eur J Immunol 36:58-64. 2006
  5. ncbi Cutting edge: CTLA-4 (CD152) differentially regulates mitogen-activated protein kinases (extracellular signal-regulated kinase and c-Jun N-terminal kinase) in CD4+ T cells from receptor/ligand-deficient mice
    Helga Schneider
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Boston, MA 02115, USA
    J Immunol 169:3475-9. 2002
  6. ncbi Rap1-GTP is a negative regulator of Th cell function and promotes the generation of CD4+CD103+ regulatory T cells in vivo
    Lequn Li
    Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School and Brigham and Women's Hospital, Boston, MA 02115, USA
    J Immunol 175:3133-9. 2005
  7. ncbi Deletion of a conserved Il4 silencer impairs T helper type 1-mediated immunity
    K Mark Ansel
    Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Immunol 5:1251-9. 2004
  8. ncbi The threshold pattern of calcineurin-dependent gene expression is altered by loss of the endogenous inhibitor calcipressin
    Sandra Ryeom
    Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nat Immunol 4:874-81. 2003
  9. ncbi T helper differentiation in resistant and susceptible B7-deficient mice infected with Leishmania major
    Julia A Brown
    Department of Pathology, Immunology Research Division, Brigham and Women's Hospital, Boston, MA, USA
    Eur J Immunol 32:1764-72. 2002
  10. ncbi E mu-BRD2 transgenic mice develop B-cell lymphoma and leukemia
    Rebecca J Greenwald
    Department of Pathology, Immunology Research Division, Brigham and Women s Hospital, Harvard Medcial School, Boston, MA, USA
    Blood 103:1475-84. 2004

Collaborators

Detail Information

Publications12

  1. ncbi CTLA-4 regulates cell cycle progression during a primary immune response
    Rebecca J Greenwald
    Immunology Research Division, Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215, USA
    Eur J Immunol 32:366-73. 2002
    ..Re-expression of the cell cycle inhibitor p27(kip1) is delayed in the absence of CTLA-4. These studies demonstrate that the B7 : CTLA-4 pathway exerts its major effects on T cell immune responses via regulation of the cell cycle...
  2. ncbi Negative co-receptors on lymphocytes
    Rebecca J Greenwald
    Immunology Research Division, Department of Pathology, Brigham and Women s Hospital, 221 Longwood Avenue, Boston, MA 02115, USA
    Curr Opin Immunol 14:391-6. 2002
    ..Recent studies indicate that ICOS exerts distinct effects at different phases of an immune response: ICOS can inhibit as well as stimulate T cell responses...
  3. ncbi The B7 family revisited
    Rebecca J Greenwald
    Department of Pathology, Harvard Medical School and Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Annu Rev Immunol 23:515-48. 2005
    ..In this review, we revisit the roles of the B7:CD28 family members in regulating immune responses, and we discuss their therapeutic potential...
  4. ncbi PD-L1 and PD-L2 have distinct roles in regulating host immunity to cutaneous leishmaniasis
    Spencer C Liang
    Department of Pathology, Harvard Medical School and Brigham and Women s Hospital, Boston, MA 02115, USA
    Eur J Immunol 36:58-64. 2006
    ..Taken together, our results demonstrate that PD-L1 and PD-L2 have distinct roles in regulating the immune response to L. mexicana...
  5. ncbi Cutting edge: CTLA-4 (CD152) differentially regulates mitogen-activated protein kinases (extracellular signal-regulated kinase and c-Jun N-terminal kinase) in CD4+ T cells from receptor/ligand-deficient mice
    Helga Schneider
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Boston, MA 02115, USA
    J Immunol 169:3475-9. 2002
    ..Our findings demonstrate that CTLA-4 cosignaling is more complex than previously appreciated, with an ability to differentially regulate members of the MAPK family in T cells...
  6. ncbi Rap1-GTP is a negative regulator of Th cell function and promotes the generation of CD4+CD103+ regulatory T cells in vivo
    Lequn Li
    Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School and Brigham and Women's Hospital, Boston, MA 02115, USA
    J Immunol 175:3133-9. 2005
    ....
  7. ncbi Deletion of a conserved Il4 silencer impairs T helper type 1-mediated immunity
    K Mark Ansel
    Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Immunol 5:1251-9. 2004
    ....
  8. ncbi The threshold pattern of calcineurin-dependent gene expression is altered by loss of the endogenous inhibitor calcipressin
    Sandra Ryeom
    Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nat Immunol 4:874-81. 2003
    ..Thus, calcipressins modulate the pattern of calcineurin-dependent transcription, and may influence calcineurin activity beyond calcium to integrate a broad array of signals into the cellular response...
  9. ncbi T helper differentiation in resistant and susceptible B7-deficient mice infected with Leishmania major
    Julia A Brown
    Department of Pathology, Immunology Research Division, Brigham and Women's Hospital, Boston, MA, USA
    Eur J Immunol 32:1764-72. 2002
    ..major, whereas BALB/c B7-1-deficient mice remain as susceptible as wild-type BALB/c mice. Differential expression of B7-1 and B7-2 can explain the distinct roles observed for these B7 costimulators in L. major infection...
  10. ncbi E mu-BRD2 transgenic mice develop B-cell lymphoma and leukemia
    Rebecca J Greenwald
    Department of Pathology, Immunology Research Division, Brigham and Women s Hospital, Harvard Medcial School, Boston, MA, USA
    Blood 103:1475-84. 2004
    ..This report is the first to describe a transgenic mouse model for constitutive expression of a protein with more than one bromodomain...
  11. ncbi An autoimmune disease-associated CTLA-4 splice variant lacking the B7 binding domain signals negatively in T cells
    Lalitha Vijayakrishnan
    Center for Neurologic Diseases, Department of Neurology, Boston, MA 02115 USA
    Immunity 20:563-75. 2004
    ..These data suggest that increased expression and negative signaling delivered by the liCTLA-4 may regulate development of T cell-mediated autoimmune diseases...
  12. ncbi Development of autoimmunity in mice lacking DNA topoisomerase 3beta
    Kelvin Y Kwan
    Department of Molecular and Cellular Biology, Harvard University, 7 Divinity Avenue, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 104:9242-7. 2007
    ....