Genomes and Genes
Rebecca J Greenwald
Affiliation: Harvard University
- CTLA-4 regulates cell cycle progression during a primary immune responseRebecca J Greenwald
Immunology Research Division, Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215, USA
Eur J Immunol 32:366-73. 2002..Re-expression of the cell cycle inhibitor p27(kip1) is delayed in the absence of CTLA-4. These studies demonstrate that the B7 : CTLA-4 pathway exerts its major effects on T cell immune responses via regulation of the cell cycle...
- Negative co-receptors on lymphocytesRebecca J Greenwald
Immunology Research Division, Department of Pathology, Brigham and Women s Hospital, 221 Longwood Avenue, Boston, MA 02115, USA
Curr Opin Immunol 14:391-6. 2002..Recent studies indicate that ICOS exerts distinct effects at different phases of an immune response: ICOS can inhibit as well as stimulate T cell responses...
- The B7 family revisitedRebecca J Greenwald
Department of Pathology, Harvard Medical School and Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
Annu Rev Immunol 23:515-48. 2005..In this review, we revisit the roles of the B7:CD28 family members in regulating immune responses, and we discuss their therapeutic potential...
- PD-L1 and PD-L2 have distinct roles in regulating host immunity to cutaneous leishmaniasisSpencer C Liang
Department of Pathology, Harvard Medical School and Brigham and Women s Hospital, Boston, MA 02115, USA
Eur J Immunol 36:58-64. 2006..Taken together, our results demonstrate that PD-L1 and PD-L2 have distinct roles in regulating the immune response to L. mexicana...
- Cutting edge: CTLA-4 (CD152) differentially regulates mitogen-activated protein kinases (extracellular signal-regulated kinase and c-Jun N-terminal kinase) in CD4+ T cells from receptor/ligand-deficient miceHelga Schneider
Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Boston, MA 02115, USA
J Immunol 169:3475-9. 2002..Our findings demonstrate that CTLA-4 cosignaling is more complex than previously appreciated, with an ability to differentially regulate members of the MAPK family in T cells...
- Rap1-GTP is a negative regulator of Th cell function and promotes the generation of CD4+CD103+ regulatory T cells in vivoLequn Li
Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School and Brigham and Women s Hospital, Boston, MA 02115, USA
J Immunol 175:3133-9. 2005....
- Deletion of a conserved Il4 silencer impairs T helper type 1-mediated immunityK Mark Ansel
Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
Nat Immunol 5:1251-9. 2004....
- The threshold pattern of calcineurin-dependent gene expression is altered by loss of the endogenous inhibitor calcipressinSandra Ryeom
Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, Massachusetts 02115, USA
Nat Immunol 4:874-81. 2003..Thus, calcipressins modulate the pattern of calcineurin-dependent transcription, and may influence calcineurin activity beyond calcium to integrate a broad array of signals into the cellular response...
- T helper differentiation in resistant and susceptible B7-deficient mice infected with Leishmania majorJulia A Brown
Department of Pathology, Immunology Research Division, Brigham and Women s Hospital, Boston, MA, USA
Eur J Immunol 32:1764-72. 2002..major, whereas BALB/c B7-1-deficient mice remain as susceptible as wild-type BALB/c mice. Differential expression of B7-1 and B7-2 can explain the distinct roles observed for these B7 costimulators in L. major infection...
- E mu-BRD2 transgenic mice develop B-cell lymphoma and leukemiaRebecca J Greenwald
Department of Pathology, Immunology Research Division, Brigham and Women s Hospital, Harvard Medcial School, Boston, MA, USA
Blood 103:1475-84. 2004..This report is the first to describe a transgenic mouse model for constitutive expression of a protein with more than one bromodomain...
- An autoimmune disease-associated CTLA-4 splice variant lacking the B7 binding domain signals negatively in T cellsLalitha Vijayakrishnan
Center for Neurologic Diseases, Department of Neurology, Boston, MA 02115 USA
Immunity 20:563-75. 2004..These data suggest that increased expression and negative signaling delivered by the liCTLA-4 may regulate development of T cell-mediated autoimmune diseases...
- Development of autoimmunity in mice lacking DNA topoisomerase 3betaKelvin Y Kwan
Department of Molecular and Cellular Biology, Harvard University, 7 Divinity Avenue, Cambridge, MA 02138, USA
Proc Natl Acad Sci U S A 104:9242-7. 2007....