S M Greenberg

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Is "compassionate use" compassionate?: rFVIIa for intracerebral hemorrhage
    Steven M Greenberg
    Neurology 67:934-5. 2006
  2. ncbi request reprint Diagnosis of cerebral amyloid angiopathy. Sensitivity and specificity of cortical biopsy
    S M Greenberg
    Department of Neurology, Massachusetts General Hospital, Boston 02114, USA
    Stroke 28:1418-22. 1997
  3. ncbi request reprint Donepezil therapy in clinical practice: a randomized crossover study
    S M Greenberg
    Department of Neurology, Partners HealthCare Inc of Massachusetts General Hospital, Boston 02114, USA
    Arch Neurol 57:94-9. 2000
  4. ncbi request reprint Plasma beta-amyloid peptide, transforming growth factor-beta 1, and risk for cerebral amyloid angiopathy
    S M Greenberg
    Massachusetts General Hospital, Boston 02114, USA
    Ann N Y Acad Sci 903:144-9. 2000
  5. ncbi request reprint Hemorrhage burden predicts recurrent intracerebral hemorrhage after lobar hemorrhage
    Steven M Greenberg
    Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, Mass 02114, USA
    Stroke 35:1415-20. 2004
  6. ncbi request reprint Cerebral amyloid angiopathy and vessel dysfunction
    Steven M Greenberg
    Department of Neurology, Massachusetts General Hospital, Boston, Mass 02114, USA
    Cerebrovasc Dis 13:42-7. 2002
  7. ncbi request reprint Hemorrhagic stroke associated with the Iowa amyloid precursor protein mutation
    S M Greenberg
    Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Neurology 60:1020-2. 2003
  8. ncbi request reprint Outcome markers for clinical trials in cerebral amyloid angiopathy
    S M Greenberg
    Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
    Amyloid 8:56-60. 2001
  9. ncbi request reprint Plasma beta-amyloid and white matter lesions in AD, MCI, and cerebral amyloid angiopathy
    M E Gurol
    Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA
    Neurology 66:23-9. 2006
  10. pmc Genetic variation at CR1 increases risk of cerebral amyloid angiopathy
    A Biffi
    Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA, USA
    Neurology 78:334-41. 2012

Collaborators

Detail Information

Publications65

  1. ncbi request reprint Is "compassionate use" compassionate?: rFVIIa for intracerebral hemorrhage
    Steven M Greenberg
    Neurology 67:934-5. 2006
  2. ncbi request reprint Diagnosis of cerebral amyloid angiopathy. Sensitivity and specificity of cortical biopsy
    S M Greenberg
    Department of Neurology, Massachusetts General Hospital, Boston 02114, USA
    Stroke 28:1418-22. 1997
    ..We therefore attempted to estimate the sensitivity and specificity of cortical biopsy for diagnosis of CAA as the cause of intracerebral hemorrhage...
  3. ncbi request reprint Donepezil therapy in clinical practice: a randomized crossover study
    S M Greenberg
    Department of Neurology, Partners HealthCare Inc of Massachusetts General Hospital, Boston 02114, USA
    Arch Neurol 57:94-9. 2000
    ..To determine the efficacy of donepezil hydrochloride for the treatment of Alzheimer disease in patients drawn from clinical practice...
  4. ncbi request reprint Plasma beta-amyloid peptide, transforming growth factor-beta 1, and risk for cerebral amyloid angiopathy
    S M Greenberg
    Massachusetts General Hospital, Boston 02114, USA
    Ann N Y Acad Sci 903:144-9. 2000
    ..While the data do not exclude important roles for these molecules as risks for CAA, they indicate that plasma measurements are not useful in its diagnosis...
  5. ncbi request reprint Hemorrhage burden predicts recurrent intracerebral hemorrhage after lobar hemorrhage
    Steven M Greenberg
    Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, Mass 02114, USA
    Stroke 35:1415-20. 2004
    ..We sought to determine whether hemorrhages detected at the time of lobar ICH predict the major clinical complications of CAA: recurrent ICH or decline in cognition and function...
  6. ncbi request reprint Cerebral amyloid angiopathy and vessel dysfunction
    Steven M Greenberg
    Department of Neurology, Massachusetts General Hospital, Boston, Mass 02114, USA
    Cerebrovasc Dis 13:42-7. 2002
    ..Future studies will seek to define the clinical importance of vascular beta-amyloid as a potential target for drug therapy in dementia...
  7. ncbi request reprint Hemorrhagic stroke associated with the Iowa amyloid precursor protein mutation
    S M Greenberg
    Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Neurology 60:1020-2. 2003
    ..These data point to other genetic or environmental factors that may determine the occurrence of symptomatic hemorrhage in amyloid angiopathy...
  8. ncbi request reprint Outcome markers for clinical trials in cerebral amyloid angiopathy
    S M Greenberg
    Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
    Amyloid 8:56-60. 2001
    ..This analysis suggests that radiographic detection of small hemorrhages may be an efficient surrogate endpoint for pilot trials of promising therapeutic approaches to cerebral amyloid angiopathy...
  9. ncbi request reprint Plasma beta-amyloid and white matter lesions in AD, MCI, and cerebral amyloid angiopathy
    M E Gurol
    Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA
    Neurology 66:23-9. 2006
    ..Recent studies suggest a role for circulating beta-amyloid peptide in microvascular dysfunction and white matter disease...
  10. pmc Genetic variation at CR1 increases risk of cerebral amyloid angiopathy
    A Biffi
    Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA, USA
    Neurology 78:334-41. 2012
    ....
  11. ncbi request reprint Contrast extravasation on CT angiography predicts hematoma expansion in intracerebral hemorrhage
    J N Goldstein
    Department of Emergency Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
    Neurology 68:889-94. 2007
    ..However, only a minority arrive within this time frame. Therefore, alternative markers for expansion risk are needed...
  12. pmc Plasma Abeta, homocysteine, and cognition: the Vitamin Intervention for Stroke Prevention (VISP) trial
    A Viswanathan
    Hemorrhagic Stroke Research Program, Massachusetts General Hospital Stroke Research Center, 175 Cambridge Street, Suite 300, Boston, MA 02114, USA
    Neurology 72:268-72. 2009
    ....
  13. pmc Warfarin-related intraventricular hemorrhage: imaging and outcome
    A Biffi
    Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA, USA
    Neurology 77:1840-6. 2011
    ..We investigated whether OAT also influences risk of development of intraventricular hemorrhage (IVH), the volume of IVH and IVH expansion, and whether IVH is a substantive mediator of the overall effect of OAT on ICH outcome...
  14. pmc Silent ischemic infarcts are associated with hemorrhage burden in cerebral amyloid angiopathy
    W T Kimberly
    Hemorrhagic Stroke Research Program, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Neurology 72:1230-5. 2009
    ..We examined the prevalence and associated risk factors for infarcts detected by diffusion-weighted imaging (DWI)...
  15. pmc White matter hyperintensity volume is increased in small vessel stroke subtypes
    N S Rost
    J Philip Kistler Stroke Research Center, Center for Human Genetics Research, Massachusetts General Hospital, 175 Cambridge St, Suite 300, Boston, MA 02114, USA
    Neurology 75:1670-7. 2010
    ..Therefore, we hypothesized that WMH would be most severe in patients with lacunar stroke and intracerebral hemorrhage (ICH), 2 types of stroke in which cerebral small vessel (SV) changes are pathophysiologically relevant...
  16. ncbi request reprint Course of cerebral amyloid angiopathy-related inflammation
    C Kinnecom
    Hemorrhagic Stroke Research Program, Department of Neurology, Massachusetts General Hospital, Boston, MA, USA
    Neurology 68:1411-6. 2007
    ..A subset of patients with cerebral amyloid angiopathy (CAA) present with cognitive symptoms, seizures, headaches, T2-hyperintense MRI lesions, and neuropathologic evidence of CAA-associated vascular inflammation...
  17. pmc MR imaging detection of cerebral microbleeds: effect of susceptibility-weighted imaging, section thickness, and field strength
    R N K Nandigam
    Hemorrhagic Stroke Research Program, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    AJNR Am J Neuroradiol 30:338-43. 2009
    ....
  18. ncbi request reprint The effects of AbetaPP mutations and APOE polymorphisms on cerebral amyloid angiopathy
    G W Rebeck
    Alzheimer Research Unit, Massachusetts General Hospital, Charlestown 02129, USA
    Amyloid 8:43-7. 2001
    ..We suggest that the initial deposition of Abeta occurs in the absence of apoE, and that the process of Abeta deposit growth or stabilization is apoE-dependent...
  19. ncbi request reprint Quantitation of apoE domains in Alzheimer disease brain suggests a role for apoE in Abeta aggregation
    H S Cho
    Alzheimer Research Unit, Massachusetts General Hospital, Boston 02129, USA
    J Neuropathol Exp Neurol 60:342-9. 2001
    ..Furthermore, the presence of the apoE receptor binding domain in the center of amyloid deposits could affect surrounding cells via chronic interactions with cell surface apoE receptors...
  20. ncbi request reprint Warfarin, hematoma expansion, and outcome of intracerebral hemorrhage
    J J Flibotte
    Stroke Service and Neurology Clinical Trials Unit, Massachusetts General Hospital, Boston, MA 02114, USA
    Neurology 63:1059-64. 2004
    ..Warfarin increases mortality of intracerebral hemorrhage (ICH). The authors investigated whether this effect reflects increased baseline ICH volume at presentation or increased ICH expansion...
  21. ncbi request reprint Antiplatelet use after intracerebral hemorrhage
    A Viswanathan
    Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA
    Neurology 66:206-9. 2006
    ..Survivors of intracerebral hemorrhage are at risk for recurrent intracerebral hemorrhage and ischemic cardiovascular and cerebrovascular disease...
  22. pmc Statin use and outcome after intracerebral hemorrhage: case-control study and meta-analysis
    A Biffi
    Center for Human Genetic Research, Massachusetts General Hospital, 185 Cambridge Street, CPZN 6818, Boston, MA 02114, USA
    Neurology 76:1581-8. 2011
    ..We therefore performed a meta-analysis of all available evidence, including unpublished data from our own institution, to determine whether statin exposure is protective for patients who develop ICH...
  23. ncbi request reprint White matter lesions, cognition, and recurrent hemorrhage in lobar intracerebral hemorrhage
    E E Smith
    Department of Neurology, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA
    Neurology 63:1606-12. 2004
    ..The authors investigated the relationships between white matter lesions, cognitive impairment, and risk of recurrent hemorrhage in a prospectively identified cohort of patients with lobar intracerebral hemorrhage (ICH)...
  24. ncbi request reprint Lack of independent associations of apolipoprotein E promoter and intron 1 polymorphisms with Alzheimer's disease
    G W Rebeck
    Alzheimer Research Unit, Massachusetts General Hospital, Charlestown 02129, USA
    Neurosci Lett 272:155-8. 1999
    ..Controlling for these linkages, we found no independent association between the -219 polymorphism and AD or CAA. Thus, our studies do not support independent associations between AD and either the IE-1 or the -219 polymorphisms...
  25. ncbi request reprint Association of homocysteine with plasma amyloid beta protein in aging and neurodegenerative disease
    M C Irizarry
    The Massachusetts Alzheimer Disease Research Center, Massachusetts General Hospital, Boston, MA, USA
    Neurology 65:1402-8. 2005
    ..tHcy may potentiate neurotoxic and vasculopathic processes, including amyloid beta protein (Abeta) metabolism, implicated in neurodegenerative diseases...
  26. pmc Impaired visual evoked flow velocity response in cerebral amyloid angiopathy
    E E Smith
    Harvard Medical School, 175 Cambridge Street, Suite 300, Massachusetts General Hospital, Boston, MA 02114, USA
    Neurology 71:1424-30. 2008
    ..Animal models of cerebral amyloid angiopathy (CAA) exhibit abnormal vascular reactivity. We determined whether vascular reactivity, measured by transcranial Doppler ultrasound (TCD), is reduced in humans with CAA...
  27. ncbi request reprint Leukoaraiosis is associated with warfarin-related hemorrhage following ischemic stroke
    E E Smith
    Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Neurology 59:193-7. 2002
    ..This study investigates radiographic and clinical characteristics of patients with warfarin-related ICH following ischemic stroke...
  28. ncbi request reprint Warfarin-associated hemorrhage and cerebral amyloid angiopathy: a genetic and pathologic study
    J Rosand
    Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
    Neurology 55:947-51. 2000
    ..The pathogenesis of this often-fatal complication remains obscure. Cerebral amyloid angiopathy (CAA) is a major cause of spontaneous lobar hemorrhage in the elderly and is associated with specific alleles of the APOE gene...
  29. ncbi request reprint Clinical diagnosis of cerebral amyloid angiopathy: validation of the Boston criteria
    K A Knudsen
    Clinical Trials Unit, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, USA
    Neurology 56:537-9. 2001
    ..All 13 individuals were confirmed neuropathologically as having CAA. This small pathologic series indicates that the diagnosis of probable CAA can be made during life with high accuracy...
  30. pmc Prior antiplatelet therapy and outcome following intracerebral hemorrhage: a systematic review
    B B Thompson
    Department of Neurology, Brown University, Providence, RI, USA
    Neurology 75:1333-42. 2010
    ..We performed a systematic review and meta-analysis to address the hypothesis that pre-ICH APT use is associated with mortality and poor functional outcome following ICH...
  31. ncbi request reprint Prevalence and effects of lobar microhemorrhages in early-stage dementia
    Alireza Atri
    Department of Neurology, Massachusetts General Hospital, Boston, MA, USA
    Neurodegener Dis 2:305-12. 2005
    ..The prevalence and effects of LMH detectable by gradient echo MRI (GE-MRI) in early-stage dementia are unknown...
  32. ncbi request reprint Current pharmacotherapy for Alzheimer's disease
    A Lleo
    Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Annu Rev Med 57:513-33. 2006
    ....
  33. ncbi request reprint White matter alterations in cerebral amyloid angiopathy measured by diffusion tensor imaging
    David H Salat
    Massachusetts General Hospital Massachusetts Institute of Technology Harvard Medical School, Athinoula A Martinos Center for Biomedical Imaging, Charlestown, Mass 02129 2060, USA
    Stroke 37:1759-64. 2006
    ..We used diffusion tensor imaging to evaluate the anatomic distribution of white matter degeneration in participants diagnosed with advanced CAA...
  34. pmc Tissue microstructural changes are independently associated with cognitive impairment in cerebral amyloid angiopathy
    Anand Viswanathan
    Hemorrhagic Stroke Research Program, Massachusetts General Hospital, Stroke Research Center, 175 Cambridge Street, Suite 300, Boston, MA 02114, USA
    Stroke 39:1988-92. 2008
    ..We hypothesized that higher global mean apparent diffusion coefficient (mean ADC), reflecting a higher amount of chronic tissue disruption caused by CAA, would be independently associated with CAA-related cognitive impairment...
  35. ncbi request reprint Imaging of amyloid burden and distribution in cerebral amyloid angiopathy
    Keith A Johnson
    Department of Radiology, Massachusetts General Hospital, Boston, MA 02114, USA
    Ann Neurol 62:229-34. 2007
    ....
  36. ncbi request reprint Beyond hypertension: unraveling the causes of intracerebral hemorrhage
    Jonathan Rosand
    Stroke 33:1195-6. 2002
  37. ncbi request reprint Abeta species, including IsoAsp23 Abeta, in Iowa-type familial cerebral amyloid angiopathy
    Youngah Shin
    Alzheimer Research Unit, Massachusetts General Hospital, 114 16th St, Charlestown 02129, USA
    Acta Neuropathol 105:252-8. 2003
    ..These data suggest that alteration of Abeta Asn23 to isoAsp may be an important determinant in the deposition of Abeta in cerebral blood vessels...
  38. pmc Spatial distribution of white-matter hyperintensities in Alzheimer disease, cerebral amyloid angiopathy, and healthy aging
    Christopher M Holland
    Center for Neurological Imaging, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Stroke 39:1127-33. 2008
    ..We sought to determine whether the spatial distribution of WMHs discriminates between different disease groups and healthy aging individuals and whether these distributions are related to local cerebral perfusion patterns...
  39. doi request reprint Effect of statins on intracerebral hemorrhage outcome and recurrence
    Emilie FitzMaurice
    Stroke 39:2151-4. 2008
    ..We investigated (1) whether statin use before ICH was associated with functional independence at 90 days, and (2) whether survivors exposed to statins after ICH had an increased risk of recurrence...
  40. doi request reprint Magnetic resonance imaging white matter hyperintensities and brain volume in the prediction of mild cognitive impairment and dementia
    Eric E Smith
    Neurology Clinical Trials Unit, Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Arch Neurol 65:94-100. 2008
    ..To determine whether magnetic resonance imaging (MRI) white matter hyperintensities (WMH), whole-brain atrophy, and cardiovascular risk factors predict the development of cognitive decline and dementia...
  41. doi request reprint The genetic architecture of intracerebral hemorrhage
    Natalia S Rost
    Department of Neurology, and Hemorrhagic Stroke Research Program, Massachusetts General Hospital, 185 Cambridge Street, Boston MA 02114, USA
    Stroke 39:2166-73. 2008
    ..This review focuses on evidence for a genetic contribution to ICH, delineates approaches to genetic studies of ICH, and explores foundations for their future applications...
  42. doi request reprint Statins, low cholesterol, and hemorrhagic stroke: an uncertain triangle
    Bradley S Jacobs
    Neurology 70:2355-6. 2008
  43. doi request reprint Prediction of functional outcome in patients with primary intracerebral hemorrhage: the FUNC score
    Natalia S Rost
    Massachusetts General Hospital, Center for Human Genetic Research, Boston, MA 02114, USA
    Stroke 39:2304-9. 2008
    ..We developed an acute clinical score to predict likelihood of functional independence...
  44. ncbi request reprint Vascular changes in Iowa-type hereditary cerebral amyloid angiopathy
    Youngah Shin
    Department of Neurology, Alzheimer Research Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Ann N Y Acad Sci 977:245-51. 2002
    ..The observed changes in the Iowa brain suggest pathophysiologic mechanisms for vascular dysfunction in CAA and possible approaches to treatment of CAA-related cognitive impairment...
  45. ncbi request reprint Dynamic single-section CT demonstrates reduced cerebral blood flow in acute intracerebral hemorrhage
    Jonathan Rosand
    Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts, USA
    Cerebrovasc Dis 14:214-20. 2002
    ..A gradient of hypoperfusion appears to extend at least 4 mm beyond the hematoma edge and may be time dependent. Whether reduced CBF is associated with perihematoma ischemia requires additional study...
  46. ncbi request reprint Cerebral amyloid angiopathy and dementia: two amyloids are worse than one
    Steven M Greenberg
    Neurology 58:1587-8. 2002
  47. ncbi request reprint Contrast extravasation on CT angiography predicts hematoma expansion in intracerebral hemorrhage
    Yasuo Murai
    Neurology 69:617; author reply 617. 2007
  48. ncbi request reprint Early edema in warfarin-related intracerebral hemorrhage
    Joshua M Levine
    Department of Neurology, 3 W Gates Building, Hospital of the University of Pennsylvania, 3400 Spruce St, Philadelphia, PA 19104, USA
    Neurocrit Care 7:58-63. 2007
    ..A leading theory proposes that early PHE results from activation of the clotting cascade. We sought to test this theory by examining the relationship between early PHE and warfarin use in ICH patients...
  49. ncbi request reprint Age-dependent cerebrovascular dysfunction in a transgenic mouse model of cerebral amyloid angiopathy
    Hwa Kyoung Shin
    Stroke and Neurovascular Regulation Laboratory, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Brain 130:2310-9. 2007
    ..These responses do not differ from controls when studied non-invasively prior to vascular Abeta deposition, thus challenging the view that elevated soluble Abeta levels are sufficient to cause cerebrovascular dysfunction...
  50. ncbi request reprint Spatial clustering of hemorrhages in probable cerebral amyloid angiopathy
    Jonathan Rosand
    Vascular and Critical Care Neurology, Massachusetts General Hospital, Boston, MA 02114, USA
    Ann Neurol 58:459-62. 2005
    ..These data suggest that regional differences within the brain play a role in the development of CAA-related hemorrhage...
  51. ncbi request reprint Hemorrhagic stroke
    Eric E Smith
    Vascular and Critical Care Neurology, Massachusetts General Hospital, Boston, MA 02114, USA
    Neuroimaging Clin N Am 15:259-72, ix. 2005
    ..New evidence suggests that MR imaging alone may be adequate to identify hemorrhagic stroke in the acute setting, and that MR imaging is superior to CT for identification of chronic microbleeds and hemorrhagic conversion of infarction...
  52. ncbi request reprint Amyloid angiopathy-related vascular cognitive impairment
    Steven M Greenberg
    Neurology Clinical Trials Unit and Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, Mass 02114, USA
    Stroke 35:2616-9. 2004
    ..These data highlight the importance of elucidating the effects of vascular amyloid on cerebrovascular function and of developing therapeutic strategies for this potentially widespread form of microvascular cognitive impairment...
  53. ncbi request reprint Treatment and prevention of primary intracerebral hemorrhage
    Amytis Towfighi
    Vascular and Critical Care Neurology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Semin Neurol 25:445-52. 2005
    ....
  54. ncbi request reprint The effect of warfarin and intensity of anticoagulation on outcome of intracerebral hemorrhage
    Jonathan Rosand
    Neurology Clinical Trials Unit, Department of Neurology, Massachusetts General Hospital, 15 Parkman Street, Boston, MA 02114, USA
    Arch Intern Med 164:880-4. 2004
    ..We studied the determinants of ICH outcome to quantify the independent effect of warfarin...
  55. ncbi request reprint Kinetics of cerebral amyloid angiopathy progression in a transgenic mouse model of Alzheimer disease
    Elissa M Robbins
    MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    J Neurosci 26:365-71. 2006
    ..35% of total available vessel area per day (95% confidence interval, 0.3-0.4%). The consistent rate of disease progression implies that this model is amenable to investigations of therapeutic interventions...
  56. ncbi request reprint Clinical manifestations of cerebral amyloid angiopathy-related inflammation
    Jessica A Eng
    Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Ann Neurol 55:250-6. 2004
    ..These data add to evidence that inflammation against A beta can cause vascular dysfunction, a potential mechanism for the toxic response recently observed in clinical trials of A beta immunization...
  57. ncbi request reprint Can patients be anticoagulated after intracerebral hemorrhage? A decision analysis
    Mark H Eckman
    Division of General Internal Medicine and the Center for Clinical Effectiveness, University of Cincinnati, Cincinnati, OH, USA
    Stroke 34:1710-6. 2003
    ....
  58. ncbi request reprint Reply
    Jonathan Rosand
    Ann Neurol 59:432. 2006
  59. ncbi request reprint Small vessels, big problems
    Steven M Greenberg
    Neurology Clinical Trials Unit, Massachusetts General Hospital, Boston, USA
    N Engl J Med 354:1451-3. 2006
  60. ncbi request reprint The cerebral beta-amyloid angiopathies: hereditary and sporadic
    Sandy X Zhang-Nunes
    Neurology Clinical Trials Unit and MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Boston 02114, USA
    Brain Pathol 16:30-9. 2006
    ....
  61. ncbi request reprint Characterization of amyloid deposition in the APPswe/PS1dE9 mouse model of Alzheimer disease
    Monica Garcia-Alloza
    Alzheimer Research Unit, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, 114 16th Street, Charlestown, MA 02129, USA
    Neurobiol Dis 24:516-24. 2006
    ....
  62. ncbi request reprint A phase 2 study of tramiprosate for cerebral amyloid angiopathy
    Steven M Greenberg
    Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Alzheimer Dis Assoc Disord 20:269-74. 2006
    ..Tramiprosate (3-amino-1-propanesulfonic acid) is a candidate molecule shown in preclinical studies to reduce CAA in a transgenic mouse model...
  63. ncbi request reprint Antibody-mediated clearance of amyloid-beta peptide from cerebral amyloid angiopathy revealed by quantitative in vivo imaging
    Claudia M Prada
    Department of Neurology Alzheimer Research Unit, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    J Neurosci 27:1973-80. 2007
    ..This quantitative in vivo imaging approach directly demonstrates that CAA in a transgenic mouse model can be cleared with an optimized immunotherapy...
  64. ncbi request reprint Clinical diagnosis of cerebral amyloid angiopathy: validation of the Boston criteria
    Eric E Smith
    Neurology Clinical Trials Unit, Wang 836, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
    Curr Atheroscler Rep 5:260-6. 2003
    ..These criteria will be crucial for disease classification for future clinical studies...
  65. ncbi request reprint Progression of cerebral amyloid angiopathy in transgenic mouse models of Alzheimer disease
    Sarah B Domnitz
    Alzheimer Research Unit, Massachusetts General Institute for Neurodegenerative Disease, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    J Neuropathol Exp Neurol 64:588-94. 2005
    ..This approach should lead to more informed analysis of the consequences of evolving therapeutic options for AD on this related form of vascular pathology...