E M Gravallese

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi Pathogenesis of bone erosions in rheumatoid arthritis
    S R Goldring
    Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
    Curr Opin Rheumatol 12:195-9. 2000
  2. ncbi TRANCE/RANKL knockout mice are protected from bone erosion in a serum transfer model of arthritis
    A R Pettit
    Beth Israel Deaconess Medical Center, New England Baptist Bone and Joint Institute, Harvard Institutes of Medicine, Boston, Massachusetts 02115, USA
    Am J Pathol 159:1689-99. 2001
  3. ncbi The role played by cell-substrate interactions in the pathogenesis of osteoclast-mediated peri-implant osteolysis
    Zhenxin Shen
    New England Baptist Bone and Joint Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    Arthritis Res Ther 8:R70. 2006
  4. ncbi Bone destruction in arthritis
    E M Gravallese
    Department of Medicine, Beth Israel Deaconess Medical Center, New England Baptist Bone and Joint Institute, Harvard Institutes of Medicine, 4 Blackfan Circle, Room 241, Boston, MA 02115, USA
    Ann Rheum Dis 61:ii84-6. 2002
  5. ncbi The role of TNF-receptor family members and other TRAF-dependent receptors in bone resorption
    E M Gravallese
    Beth Israel Deaconess Medical Center, New England Baptist Bone and Joint Institute, Harvard Institutes of Medicine, Harvard Medical School, Boston, MA 02115, USA
    Arthritis Res 3:6-12. 2001
  6. ncbi Plasma cell differentiation requires the transcription factor XBP-1
    A M Reimold
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Nature 412:300-7. 2001
  7. ncbi Angiopoietin-1 is expressed in the synovium of patients with rheumatoid arthritis and is induced by tumour necrosis factor alpha
    E M Gravallese
    Beth Israel Deaconess Medical Center, Department of Medicine, New England Baptist Bone and Joint Institute, Harvard Institutes of Medicine, 4 Blackfan Circle, Boston, MA 02115, USA
    Ann Rheum Dis 62:100-7. 2003
  8. ncbi The nuclear factor of activated T cells (NFAT) transcription factor NFATp (NFATc2) is a repressor of chondrogenesis
    A M Ranger
    Department of Immunology, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    J Exp Med 191:9-22. 2000
  9. ncbi RANKL protein is expressed at the pannus-bone interface at sites of articular bone erosion in rheumatoid arthritis
    A R Pettit
    Institute for Molecular Bioscience, University of Queensland, Brisbane, QLD 4072, Australia
    Rheumatology (Oxford) 45:1068-76. 2006
  10. ncbi In situ hybridization studies suggest a role for the basic region-leucine zipper protein hXBP-1 in exocrine gland and skeletal development during mouse embryogenesis
    I M Clauss
    Department of Cancer Biology, Harvard School of Public Health, Boston, Massachusetts 02115
    Dev Dyn 197:146-56. 1993

Collaborators

Detail Information

Publications10

  1. ncbi Pathogenesis of bone erosions in rheumatoid arthritis
    S R Goldring
    Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
    Curr Opin Rheumatol 12:195-9. 2000
    ..This paper reviews the cellular mechanisms and factors implicated in bone erosions in rheumatoid arthritis, and discusses the possible therapeutic strategies suggested by these findings...
  2. ncbi TRANCE/RANKL knockout mice are protected from bone erosion in a serum transfer model of arthritis
    A R Pettit
    Beth Israel Deaconess Medical Center, New England Baptist Bone and Joint Institute, Harvard Institutes of Medicine, Boston, Massachusetts 02115, USA
    Am J Pathol 159:1689-99. 2001
    ..These results confirm the central role of osteoclasts in the pathogenesis of bone erosion in arthritis and demonstrate distinct mechanisms of cartilage destruction and bone erosion in this animal model of arthritis...
  3. ncbi The role played by cell-substrate interactions in the pathogenesis of osteoclast-mediated peri-implant osteolysis
    Zhenxin Shen
    New England Baptist Bone and Joint Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    Arthritis Res Ther 8:R70. 2006
    ..We speculate that, in addition to the role of cytokines and growth factors, the substrate with which these cells interact plays a critical role in their differential phenotypic and functional properties...
  4. ncbi Bone destruction in arthritis
    E M Gravallese
    Department of Medicine, Beth Israel Deaconess Medical Center, New England Baptist Bone and Joint Institute, Harvard Institutes of Medicine, 4 Blackfan Circle, Room 241, Boston, MA 02115, USA
    Ann Rheum Dis 61:ii84-6. 2002
    ....
  5. ncbi The role of TNF-receptor family members and other TRAF-dependent receptors in bone resorption
    E M Gravallese
    Beth Israel Deaconess Medical Center, New England Baptist Bone and Joint Institute, Harvard Institutes of Medicine, Harvard Medical School, Boston, MA 02115, USA
    Arthritis Res 3:6-12. 2001
    ....
  6. ncbi Plasma cell differentiation requires the transcription factor XBP-1
    A M Reimold
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Nature 412:300-7. 2001
    ..XBP-1 is the only transcription factor known to be selectively and specifically required for the terminal differentiation of B lymphocytes to plasma cells...
  7. ncbi Angiopoietin-1 is expressed in the synovium of patients with rheumatoid arthritis and is induced by tumour necrosis factor alpha
    E M Gravallese
    Beth Israel Deaconess Medical Center, Department of Medicine, New England Baptist Bone and Joint Institute, Harvard Institutes of Medicine, 4 Blackfan Circle, Boston, MA 02115, USA
    Ann Rheum Dis 62:100-7. 2003
    ..CONCLUSIONS: Ang-1 mRNA and protein are expressed in the synovium of patients with RA, and are up regulated in synovial fibroblasts by TNF alpha. Ang-1 may therefore be an important regulator of angiogenesis in inflammatory arthritis...
  8. ncbi The nuclear factor of activated T cells (NFAT) transcription factor NFATp (NFATc2) is a repressor of chondrogenesis
    A M Ranger
    Department of Immunology, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    J Exp Med 191:9-22. 2000
    ..Thus, NFATp is a repressor of cartilage cell growth and differentiation and also has the properties of a tumor suppressor...
  9. ncbi RANKL protein is expressed at the pannus-bone interface at sites of articular bone erosion in rheumatoid arthritis
    A R Pettit
    Institute for Molecular Bioscience, University of Queensland, Brisbane, QLD 4072, Australia
    Rheumatology (Oxford) 45:1068-76. 2006
    ..These data provide further evidence implicating RANKL in the pathogenesis of arthritis-induced joint destruction...
  10. ncbi In situ hybridization studies suggest a role for the basic region-leucine zipper protein hXBP-1 in exocrine gland and skeletal development during mouse embryogenesis
    I M Clauss
    Department of Cancer Biology, Harvard School of Public Health, Boston, Massachusetts 02115
    Dev Dyn 197:146-56. 1993
    ..It is intriguing that the promoter regions of several such genes contain potential hXBP-1 binding sites...