Research Topics
| PHILIPPE ADAM GRANDJEANSummaryAffiliation: Harvard University Country: USA Publications
Research Grants
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Detail Information
Publications
Implications of the precautionary principle for primary prevention and researchPhilippe Grandjean
Institute of Public Health, University of Southern Denmark, Odense, Denmark
Annu Rev Public Health 25:199-223. 2004..From this perspective, current research is afflicted by important biases and insufficient focus on major environmental health problems...
Elimination half-lives of polychlorinated biphenyl congeners in childrenPhilippe Grandjean
Institute of Public Health, University of Southern Denmark, Winsløwparken 17, DK 5000 Odense, Denmark
Environ Sci Technol 42:6991-6. 2008..The longest half-lives correspond to elimination of the parent PCB solely with a daily fat excretion rate of 1-2 g, whereas shorter half-lives assume metabolic break-down...- Late insights into early origins of diseasePhilippe Grandjean
Department of Environmental Medicine, University of Southern Denmark, Odense, Denmark
Basic Clin Pharmacol Toxicol 102:94-9. 2008..Additional emphasis should be placed on the question: what could be known, given our study opportunities and methodologies? Our late insights into the early disease origins may then benefit science and prevention... 
Serum vaccine antibody concentrations in children exposed to perfluorinated compoundsPhilippe Grandjean
Department of Environmental Health, Harvard School of Public Health, 401 Park Dr, EOME 3E 110, Boston, MA 02215, USA
JAMA 307:391-7. 2012..They cause immune suppression in a rodent model at serum concentrations similar to those occurring in the US population, but adverse health effects of PFC exposure are poorly understood...- Seven deadly sins of environmental epidemiology and the virtues of precautionPhilippe Grandjean
Department of Environmental Medicine, University of Southern Denmark, Odense, Denmark
Epidemiology 19:158-62. 2008.... - Implications of the Precautionary Principle for public health practice and researchPhilippe Grandjean
Institute of Public Health, University of Southern Denmark, Odense, Denmark
Int J Occup Med Environ Health 17:5-7. 2004 - The delayed appearance of a mercurial warningPhilippe Grandjean
Department of Environmental Medicine, University of Southern Denmark, Odense, Denmark
Epidemiology 19:10-1. 2008..The delayed release of the 1971 results therefore reminds us as epidemiologists of our obligation, even in the presence of scientific uncertainty, to call attention to preventable risks... - Developmental arsenic neurotoxicity in retrospectPhilippe Grandjean
Department of Environmental Medicine, University of Southern Denmark, Odense, Denmark
Epidemiology 18:25-6. 2007 - Developmental neurotoxicity of industrial chemicalsP Grandjean
Institute of Public Health, University of Southern Denmark, Odense, Denmark
Lancet 368:2167-78. 2006..New, precautionary approaches that recognise the unique vulnerability of the developing brain are needed for testing and control of chemicals... - Cardiac autonomic activity in methylmercury neurotoxicity: 14-year follow-up of a Faroese birth cohortPhilippe Grandjean
Institute of Public Health, University of Southern Denmark, Odense, Denmark
J Pediatr 144:169-76. 2004..To determine whether heart function in childhood is affected by exposure to methylmercury (MeHg) from seafood... - Pesticide exposure and stunting as independent predictors of neurobehavioral deficits in Ecuadorian school childrenPhilippe Grandjean
Institute of Public Health, University of Southern Denmark, Odense, Denmark
Pediatrics 117:e546-56. 2006..To examine possible effects on blood pressure, neurological function, and neurobehavioral tests in school-aged children with and without prenatal pesticide exposure in an area where stunting is common... - Marine food pollutants as a risk factor for hypoinsulinemia and type 2 diabetesPhilippe Grandjean
Institute of Public Health, University of Southern Denmark, Odense, Denmark
Epidemiology 22:410-7. 2011..This concern was examined in a cross-sectional study of elderly subjects from a fishing population with elevated contaminant exposures from seafood species high in the food chain... - Methylmercury and brain development: imprecision and underestimation of developmental neurotoxicity in humansPhilippe Grandjean
Harvard School of Public Health, Boston, MA, USA
Mt Sinai J Med 78:107-18. 2011..The experience obtained with methylmercury should therefore be taken into account when evaluating the evidence for other substances suspected of being neurotoxic... - Allergy and sensitization during childhood associated with prenatal and lactational exposure to marine pollutantsPhilippe Grandjean
Institute of Public Health, University of Southern Denmark, Odense, Denmark
Environ Health Perspect 118:1429-33. 2010.... - Adverse effects of methylmercury: environmental health research implicationsPhilippe Grandjean
Department of Environmental Medicine, University of Southern Denmark, Odense, Denmark
Environ Health Perspect 118:1137-45. 2010.... - Umbilical cord mercury concentration as biomarker of prenatal exposure to methylmercuryPhilippe Grandjean
Institute of Public Health, University of Southern Denmark, Odense, Denmark
Environ Health Perspect 113:905-8. 2005..Cord mercury analysis can therefore be used as a valid measure of prenatal methylmercury exposure, but appropriate adjustment for the imprecision should be considered... - Effects of breast feeding on neuropsychological development in a community with methylmercury exposure from seafoodTina Kold Jensen
Department of Environmental Medicine, Institute of Public Health, University of Southern Denmark, Odense C, Denmark
J Expo Anal Environ Epidemiol 15:423-30. 2005..Although the advantage may be less, Faroese women can still safely breastfeed their children... - Separation of risks and benefits of seafood intakeEsben Budtz Jørgensen
Department of Biostatistics, Institute of Public Health, University of Copenhagen, Copenhagen, Denmark
Environ Health Perspect 115:323-7. 2007..In resolving this conundrum, most epidemiologic studies provide little guidance because they address either nutrient benefits or mercury toxicity, not both... - Arachidonic acid status during pregnancy is associated with polychlorinated biphenyl exposurePhilippe Grandjean
Institute of Public Health, University of Southern Denmark, Odense
Am J Clin Nutr 77:715-9. 2003..However, the nutritional benefits could be limited by polychlorinated biphenyl (PCB) contamination. In particular, inhibition of desaturase activities by PCBs may affect the maintenance of arachidonic acid (AA) status during development... - Assessment of xenoestrogenic exposure by a biomarker approach: application of the E-Screen bioassay to determine estrogenic response of serum extractsThomas Høj Rasmussen
Department of Environmental Medicine, Institute of Public Health, University of Southern Denmark, Odense, Denmark
Environ Health 2:12. 2003..Thus, analysis of mixtures allows evaluation of combined effects of chemicals each present at low concentrations... - Underestimation of risk due to exposure misclassificationPhilippe Grandjean
Institute of Public Health, University of Southern Denmark, Odense, Denmark
Int J Occup Med Environ Health 17:131-6. 2004..When exposure measurement errors are overlooked or underestimated, decisions based on the precautionary principle will not appropriately reflect the degree of precaution that was intended... - Attenuated growth of breast-fed children exposed to increased concentrations of methylmercury and polychlorinated biphenylsPhilippe Grandjean
Department of Environmental Health, Boston University Schools of Medicine and Public Health, Boston, Massachusetts, USA
FASEB J 17:699-701. 2003..Thus, in communities with increased contaminant exposures, risks associated with lactational transfer of toxicants to the infant must be considered when judging the benefits of prolonged breast-feeding... - Total imprecision of exposure biomarkers: implications for calculating exposure limitsPhilippe Grandjean
Institute of Public Health, University of Southern Denmark, Odense, Denmark
Am J Ind Med 50:712-9. 2007..Unrecognized imprecision leads to underestimation of the true toxicity of the exposure. We have assessed the total imprecision of exposure biomarkers and the implications for calculation of exposure limits... - Negative confounding in the evaluation of toxicity: the case of methylmercury in fish and seafoodAnna L Choi
Department of Environmental Health, Harvard School of Public Health, Boston, MA 02215, USA
Crit Rev Toxicol 38:877-93. 2008..Attention should also be paid to the occurrence of negative confounding in other connections... - Neurotoxic risk caused by stable and variable exposure to methylmercury from seafoodPhilippe Grandjean
Institute of Public Health, University of Southern Denmark, Odense, Denmark
Ambul Pediatr 3:18-23. 2003..To examine whether the dose-effect relationship for developmental mercury neurotoxicity is affected by variable mercury exposure during pregnancy... - Methylmercury exposure and adverse cardiovascular effects in Faroese whaling menAnna L Choi
Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02215, USA
Environ Health Perspect 117:367-72. 2009..Methylmercury (MeHg), a worldwide contaminant found in fish and seafood, has been linked to an increased risk of cardiovascular mortality... - Neurodevelopmental toxicity risks due to occupational exposure to industrial chemicals during pregnancyJordi Julvez
Department of Environmental Health, Harvard School of Public Health, Landmark Building 3E 110, 401 Park Drive, Boston, MA 02215, USA
Ind Health 47:459-68. 2009..Due to the vulnerability of the brain during early development, a precautionary approach to neurodevelopmental toxicity needs to be applied in occupational health... - Methylmercury toxicity and functional programmingPhilippe Grandjean
Department of Environmental Health, Harvard School of Public Health, Landmark Center, 3 110E, 401 Park Drive, Boston, MA 02215, USA
Reprod Toxicol 23:414-20. 2007..PRINCIPAL CONCLUSIONS: The lasting functional changes caused by neurodevelopmental methylmercury toxicity fit into the pattern of functional programming, with effects opposite to those linked to beneficial stimuli... - Direct assessment of cumulative aryl hydrocarbon receptor agonist activity in sera from experimentally exposed mice and environmentally exposed humansJennifer J Schlezinger
Department of Environmental Health, Boston University School of Public Health, Boston, Massachusetts 02118, USA
Environ Health Perspect 118:693-8. 2010..However, assessment of the significance of human exposures is hampered by an incomplete understanding of how complex mixtures affect AhR activation/inactivation... - Xeno-oestrogenic activity in serum as marker of occupational pesticide exposureHelle Raun Andersen
Institute of Public Health, Department of Environmental Medicine, University of Southern Denmark, Odense, Denmark
Occup Environ Med 64:708-14. 2007..An increasing number of currently used pesticides are reported to possess oestrogen-like properties or to disturb the endocrine system in other ways... - Polychlorinated biphenyl (PCB) induction of CYP3A4 enzyme activity in healthy Faroese adultsMaria Skaalum Petersen
Institute of Public Health, Environmental Medicine, University of Southern Denmark, Winsløvparken 17, 5000 Odense C, Denmark
Toxicol Appl Pharmacol 224:202-6. 2007.... - Selenium as a potential protective factor against mercury developmental neurotoxicityAnna L Choi
Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA
Environ Res 107:45-52. 2008..Additional research is needed to determine the identity of the nutrients responsible for the beneficial effects... - High latitude and marine diet: vitamin D status in elderly FaroeseChristine Dalgård
Department of Environmental Health, Institute of Public Health, University of Southern Denmark, JB Winslowsvej 17, 2nd Floor, 5000 Odense C, Denmark
Br J Nutr 104:914-8. 2010..Thus, even in a population with a high intake of marine food, the northern latitude causes a low vitamin D status. Efforts to improve vitamin D status in this population are warranted... - Impact of dietary exposure to food contaminants on the risk of Parkinson's diseaseMaria Skaalum Petersen
Institute of Public Health, Environmental Medicine, University of Southern Denmark, Winslowparken 17, Odense C, Denmark
Neurotoxicology 29:584-90. 2008..Increased intake of whale meat and blubber in adult life was significantly associated with PD, thus suggesting a positive association between previous exposure to marine food contaminants and development of PD... - Caffeine N3-demethylation (CYP1A2) in a population with an increased exposure to polychlorinated biphenylsMaria Skaalum Petersen
Institute of Public Health, Department of Environmental Medicine, University of Southern Denmark, Winslovparken 17, 5000 Odense C, Denmark
Eur J Clin Pharmacol 62:1041-8. 2006..Further, to investigate the effect of sex, smoking, and oral contraceptive use on the CYP1A2 activity... - Spermaturia and serum hormone concentrations at the age of puberty in boys prenatally exposed to polychlorinated biphenylsNanette M Mol
Institute of Public Health, University of Southern Denmark, Odense, Denmark
Eur J Endocrinol 146:357-63. 2002..Despite the wide range of exposure to PCB, the findings did not reveal any definite associations with the development of puberty. However, because of the limited size of the cohort, small effects cannot be excluded... - Potential developmental neurotoxicity of pesticides used in EuropeMarina Bjørling-Poulsen
Department of Environmental Medicine, University of Southern Denmark, Winslowparken 17, 5000 Odense, Denmark
Environ Health 7:50. 2008..While awaiting more definite evidence, existing uncertainties should be considered in light of the need for precautionary action to protect brain development... - Implications of the Precautionary Principle in research and policy-makingPhilippe Grandjean
Institute of Public Health, University of Southern Denmark, Odense C, Denmark
Am J Ind Med 45:382-5. 2004..Research approaches should be developed and strengthened to counteract innate ideological biases and to support our confidence in applying the PP for decision-making in the public policy arena... - Impaired reproductive development in sons of women occupationally exposed to pesticides during pregnancyHelle R Andersen
Institute of Public Health, Department of Environmental Medicine, University of Southern Denmark, Odense, Denmark
Environ Health Perspect 116:566-72. 2008..The aim of this prospective study was to investigate whether occupational pesticide exposure during pregnancy causes adverse effects on the reproductive development in the male infants... - Criteria for skin notation in different countriesJesper B Nielsen
Institute of Public Health, University of Southern Denmark, DK 5000 Odense C, Denmark
Am J Ind Med 45:275-80. 2004..However, risk is not a qualitative term, but needs a quantitative measure to be useful for prevention. For this reason, some countries have developed alternative criteria for assigning skin notations to industrial chemicals... - Increased prenatal exposure to methylmercury does not affect the risk of Parkinson's diseaseMaria Skaalum Petersen
Institute of Public Health, Environmental Medicine, University of Southern Denmark, Winslowparken 17, Odense C, Denmark
Neurotoxicology 29:591-5. 2008.... - Genetic predisposition to Parkinson's disease: CYP2D6 and HFE in the Faroe IslandsJónrit Halling
Clinical Pharmacology, Institute of Public Health, University of Southern Denmark, Winslowparken, Odense C, Denmark
Pharmacogenet Genomics 18:209-12. 2008..To investigate whether the genetic variants of CYP2D6 and HFE are more frequent in Parkinson's disease (PD) patients compared with controls in a population where the prevalence of these variants and PD are increased... - Non-precautionary aspects of toxicologyPhilippe Grandjean
Institute of Public Health, University of Southern Denmark, Winslowparken 17, DK 5000 Odense C, Denmark
Toxicol Appl Pharmacol 207:652-7. 2005.... - Concentrations of polybrominated diphenyl ethers, polychlonnated biphenyls, and polychlorobiphenylols in serum from pregnant Faroese women and their children 7 years laterBritta Fängström
Department of Environmental Chemistry, Stockholm University, SE 106 91 Stockholm, Sweden
Environ Sci Technol 39:9457-63. 2005..The PBDE concentrations were similar in both mothers and their children. The main persistent organic pollutant concentrations in the children are most probably due to other environmental exposure than maternal transfer... - Developmental origins of environmentally induced disease and dysfunction International Conference on Foetal Programming and Developmental Toxicity, Tórshavn, Faroe Islands, 20-24 May, 2007Philippe Grandjean
Basic Clin Pharmacol Toxicol 102:71-2. 2008 - [Environmental epidemiology research leads to a decrease of the exposure limit for mercury]Pal Weihe
Faerøernes Sygehusvaesen, afdeling for arbejdsmedicin og folkesundhed, Syddansk Universitet, Institut for Sundhedstjenesteforskning, og Københavns Universitet, Institut for Folkesundhedsvidenskab, Biostatistisk Afdeling
Ugeskr Laeger 165:107-11. 2003..An increase in blood pressure was also associated with the prenatal exposure level. The exposure limit for mercury has therefore been decreased... - In utero and early-life conditions and adult health and diseasePhilippe Grandjean
N Engl J Med 359:1523; author reply 1524. 2008 - Delayed brainstem auditory evoked potential latencies in 14-year-old children exposed to methylmercuryKatsuyuki Murata
Division of Environmental Health Sciences, Akita University School of Medicine, Akita, Japan
J Pediatr 144:177-83. 2004..A change in vulnerability to MeHg toxicity is suggested by the apparent sensitivity of the peak III-V component to recent MeHg exposure... - Prenatal methylmercury exposure in the SeychellesNiels Keiding
Lancet 362:664-5; author reply 665. 2003 - Estimation of health effects of prenatal methylmercury exposure using structural equation modelsEsben Budtz-Jørgensen
Department of Biostatistics, University of Copenhagen, Blegdamsvej 3, DK 2200 Copenhagen, Denmark
Environ Health 1:2. 2002..This approach was used in a large epidemiological data set from a prospective study of developmental methyl-mercury toxicity... - Hydroxylated PCB metabolites and PCBs in serum from pregnant Faroese womenBritta Fängström
Department of Environmental Chemistry, Stockholm University, Stockholm, Sweden
Environ Health Perspect 110:895-9. 2002..More than 25 additional OH-PCBs were indicated. This study confirms the presence of high concentrations of organohalogen substances in populations or areas far removed from their sources... - Benchmark dose calculations for methylmercury-associated delays on evoked potential latencies in two cohorts of childrenKatsuyuki Murata
Department of Hygiene, Akita University School of Medicine, Japan
Risk Anal 22:465-74. 2002..The benchmark results using evoked potential latencies are in close agreement with results based on neuropsychological test performance... - Neurobehavioral performance of Inuit children with increased prenatal exposure to methylmercuryPal Weihe
Department of Occupational and Public Health, The Faroese Hospital System, Torshavn, Foroe Islands
Int J Circumpolar Health 61:41-9. 2002..The data from the present study therefore appears in accordance with other evidence that prenatal or early postnatal exposures to methylmercury may cause subtle neurobehavioral deficits... - Association between mercury concentrations in blood and hair in methylmercury-exposed subjects at different agesEsben Budtz-Jørgensen
Institute of Clinical Research, Odense University Hospital, DK 5000 Odense, Denmark
Environ Res 95:385-93. 2004..Although practical for field studies and monitoring purposes, hair-mercury concentration results, therefore, need to be calibrated and interpreted in regard to each specific study setting... - The faroes statement: human health effects of developmental exposure to chemicals in our environmentPhilippe Grandjean
Basic Clin Pharmacol Toxicol 102:73-5. 2008 - The Declaration of Brescia on prevention of the neurotoxicity of metals June 18, 2006Philip Landrigan
Am J Ind Med 50:709-11. 2007 - Serum polychlorinated biphenyl and organochlorine insecticide concentrations in a Faroese birth cohortDana B Barr
Centers for Disease Control and Prevention, 4770 Buford Highway, Mailstop F17, Atlanta, GA 30341, USA
Chemosphere 62:1167-82. 2006.... - A retrospective study of PBDEs and PCBs in human milk from the Faroe IslandsBritta Fängström
Department of Environmental Chemistry, Stockholm University, SE 106 91 Stockholm, Sweden
Environ Health 4:12. 2005..Polychlorobiphenylols (OH-PCBs), the dominating class of PCB metabolites, some of which are known to be strongly retained in human blood, were also included in the assessment... - The Declaration of Brescia on Prevention of the Neurotoxicity of Metals Brescia, Italia 17-18 June 2006Philip Landrigan
Med Lav 97:811-4. 2006 - Impact of prenatal methylmercury exposure on neurobehavioral function at age 14 yearsFrodi Debes
Faroese Hospital System, , Faroe Islands, Denmark
Neurotoxicol Teratol 28:363-75. 2006..These findings are supported by independent assessment of neurophysiological outcomes. The effects on brain function associated with prenatal methylmercury exposure therefore appear to be multi-focal and permanent... - Polybrominated diphenyl ethers and traditional organochlorine pollutants in fulmars (Fulmarus glacialis) from the Faroe IslandsBritta Fängström
Department of Environmental Chemistry, Stockholm University, SE 106 91 Stockholm, Sweden
Chemosphere 60:836-43. 2005..e. 590-5700 ng/gl.w. for CB-153. Hence humans are also exposed to PCBs at a reasonable degree via intake of fulmar and/or fulmar egg and not only via pilot whale blubber... - Neurophysiological evidence of methylmercury neurotoxicityKatsuyuki Murata
Department of Environmental Health Sciences, Akita University School of Medicine, Akita, Japan
Am J Ind Med 50:765-71. 2007..The objectives of this article were to present an overview of neurophysiological findings involved in methylmercury neurotoxicity and to examine the usefulness of those measures... - Effects of exposure imprecision on estimation of the benchmark doseEsben Budtz-Jørgensen
Department of Biostatistics, University of Copenhagen, Denmark
Risk Anal 24:1689-96. 2004..Methods that allow this adjustment are described and illustrated in data from an epidemiological study on the health effects of prenatal mercury exposure... - Measuring mercury concentrationPhilippe Grandjean
Epidemiology 16:133. 2005 - Confounder selection in environmental epidemiology: assessment of health effects of prenatal mercury exposureEsben Budtz-Jørgensen
Department of Biostatistics, University of Copenhagen, and Faroese Hospital System, Torshavn, Faroe Islands
Ann Epidemiol 17:27-35. 2007..Whereas standard analysis usually is conducted as if the confounders were known a priori, selection uncertainty also must be taken into account... - Effects of developmental co-exposure to methylmercury and 2,2',4,4',5,5'-hexachlorobiphenyl (PCB153) on cholinergic muscarinic receptors in rat brainTeresa Coccini
Toxicology Division, Institute of Pavia, IRCCS Salvatore Maugeri Foundation, Pavia, Italy
Neurotoxicology 27:468-77. 2006..MR changes were detected in both immature and adult animals and the interaction of MeHg and PCB153 at the level of these receptors occurred in a non-additive manner... - Long-term consequences of arsenic poisoning during infancy due to contaminated milk powderMiwako Dakeishi
Department of Environmental Health Sciences, Akita University School of Medicine, 1 1 1 Hondo, Akita 010 8543 Japan
Environ Health 5:31. 2006..Along with more recent epidemiological studies of children with environmental arsenic exposures, the data amply demonstrate the need to consider neurotoxicity as a key concern in risk assessment of inorganic arsenic exposure... - [Semi-truths about semiconductors]Philippe Grandjean
Syddansk Universitet, Institut for Sundhedstjenesteforskning
Ugeskr Laeger 164:3868-9. 2002 - Re: Implementation of WHO Guidelines on Disclosure of Interest by members of WHO Expert PanelsOlav Axelson
Int J Occup Environ Health 8:271-3. 2002 - Comparison of polychlorinated biphenyl levels across studies of human neurodevelopmentMatthew P Longnecker
Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
Environ Health Perspect 111:65-70. 2003..S. studies or recent Dutch, German, and northern Québec studies. Our results will facilitate a direct comparison of the findings on PCBs and neurodevelopment when they are published for all 10 studies... - Contaminants in fish oilPhilippe Grandjean
Am J Clin Nutr 82:1354; author reply 1354-5. 2005 - Correction for "Delayed brainstem auditory evoked potential latencies in 14-year-old children exposed to methylmercury" by Murata et alKatsuyuki Murata
J Pediatr 149:583-4. 2006 - Consequences of exposure measurement error for confounder identification in environmental epidemiologyEsben Budtz-Jørgensen
Department of Biostatistics, University of Copenhagen, Blegdamsvej 3, DK 2200 Copenhagen N, Denmark
Stat Med 22:3089-100. 2003..These difficulties in statistical model development are illustrated by examples from a epidemiological study performed in the Faroe Islands to investigate the adverse health effects of prenatal mercury exposure... - Application of hair-mercury analysis to determine the impact of a seafood advisoryPal Weihe
Faroese Hospital System, Sigmundargøta 5, P O Box 14, FO 110 Tórshavn, Faroe Islands
Environ Res 97:200-7. 2005.... - Extended follow-up of cancer incidence in fluoride-exposed workersPhilippe Grandjean
J Natl Cancer Inst 96:802-3. 2004 - Breastfeeding and the weanling's dilemmaPhilippe Grandjean
Am J Public Health 94:1075; author reply 1075-6. 2004
Research Grants
- MERCURY-ASSOCIATED NEUROBEHAVIORAL DEFICIT IN CHILDRENPhilippe Grandjean; Fiscal Year: 2009....
- Health Effects of Lifetime Exposure to Food ContaminantsPhilippe Grandjean; Fiscal Year: 2009..The results may therefore provide new information that could very likely have an impact on the preventive efforts and standard-setting of the EPA and other regulatory agencies in the U.S and elsewhere. ..
- Three-generation Human Study of Reproductive Effects of Marine Food ContaminantsPHILIPPE ADAM GRANDJEAN; Fiscal Year: 2010..Current evidence already suggests that these pathologies may already affect many populations, and the present proposal aims at identifying whether persistent organochlorine pollutants contribute to these abnormalities. ..
- Health Effects of Lifetime Exposure to Food ContaminantsPhilippe Grandjean; Fiscal Year: 2007..The results may therefore provide new information that could very likely have an impact on the preventive efforts and standard-setting of the EPA and other regulatory agencies in the U.S and elsewhere. ..
- Three-generation Human Study of Reproductive Effects of Marine Food ContaminantsPhilippe Grandjean; Fiscal Year: 2007..Current evidence already suggests that these pathologies may already affect many populations, and the present proposal aims at identifying whether persistent organochlorine pollutants contribute to these abnormalities. ..
- Epidemiology of Immunotoxicant Exposure in ChildrenPhilippe Grandjean; Fiscal Year: 2007..These results are expected to extend substantially the current documentation for PCB risk assessment. ..
- Effects of perinatal endocrine disrupters in childrenPhilippe Grandjean; Fiscal Year: 2004..Modern statistical methods will be used to determine whether these outcome variables are associated with estrogen, thyroid, or Ah receptor abnormalities and specific contaminant exposures prenatally or postnatally. ..
- MERCURY-ASSOCIATED NEUROBEHAVIORAL DEFICIT IN CHILDRENPHILIPPE ADAM GRANDJEAN; Fiscal Year: 2010....