PHILIPPE ADAM GRANDJEAN

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Partition of environmental chemicals between maternal and fetal blood and tissues
    Larry L Needham
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Environ Sci Technol 45:1121-6. 2011
  2. pmc Neurobehavioral deficits and increased blood pressure in school-age children prenatally exposed to pesticides
    Raul Harari
    Corporacion para el Desarrollo de la Produccion y el Medio Ambiente Laboral, Quito, Ecuador
    Environ Health Perspect 118:890-6. 2010
  3. pmc Serum concentrations of antibodies against vaccine toxoids in children exposed perinatally to immunotoxicants
    Carsten Heilmann
    Paediatric Clinic II, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    Environ Health Perspect 118:1434-8. 2010
  4. ncbi request reprint Neurobehavioural effects of developmental toxicity
    Philippe Grandjean
    Department of Environmental Medicine, University of Southern Denmark, Odense, Denmark Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA Electronic address
    Lancet Neurol 13:330-8. 2014
  5. pmc Seven deadly sins of environmental epidemiology and the virtues of precaution
    Philippe Grandjean
    Department of Environmental Medicine, University of Southern Denmark, Odense, Denmark
    Epidemiology 19:158-62. 2008
  6. pmc Elimination half-lives of polychlorinated biphenyl congeners in children
    Philippe Grandjean
    Institute of Public Health, University of Southern Denmark, Winsløwparken 17, DK 5000 Odense, Denmark
    Environ Sci Technol 42:6991-6. 2008
  7. ncbi request reprint Implications of the Precautionary Principle for public health practice and research
    Philippe Grandjean
    Institute of Public Health, University of Southern Denmark, Odense, Denmark
    Int J Occup Med Environ Health 17:5-7. 2004
  8. ncbi request reprint The delayed appearance of a mercurial warning
    Philippe Grandjean
    Department of Environmental Medicine, University of Southern Denmark, Odense, Denmark
    Epidemiology 19:10-1. 2008
  9. ncbi request reprint Implications of the precautionary principle for primary prevention and research
    Philippe Grandjean
    Institute of Public Health, University of Southern Denmark, Odense, Denmark
    Annu Rev Public Health 25:199-223. 2004
  10. pmc Marine food pollutants as a risk factor for hypoinsulinemia and type 2 diabetes
    Philippe Grandjean
    Institute of Public Health, University of Southern Denmark, Odense, Denmark
    Epidemiology 22:410-7. 2011

Detail Information

Publications81

  1. pmc Partition of environmental chemicals between maternal and fetal blood and tissues
    Larry L Needham
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Environ Sci Technol 45:1121-6. 2011
    ..Although the environmental chemicals examined pass through the placenta and are excreted into milk, partitions between maternal and fetal samples are not uniform...
  2. pmc Neurobehavioral deficits and increased blood pressure in school-age children prenatally exposed to pesticides
    Raul Harari
    Corporacion para el Desarrollo de la Produccion y el Medio Ambiente Laboral, Quito, Ecuador
    Environ Health Perspect 118:890-6. 2010
    ..The long-term neurotoxicity risks caused by prenatal exposures to pesticides are unclear, but a previous pilot study of Ecuadorian school children suggested that blood pressure and visuospatial processing may be vulnerable...
  3. pmc Serum concentrations of antibodies against vaccine toxoids in children exposed perinatally to immunotoxicants
    Carsten Heilmann
    Paediatric Clinic II, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    Environ Health Perspect 118:1434-8. 2010
    ..In this study we applied serum concentrations of specific antibodies against childhood vaccines as sentinels of immunotoxicity...
  4. ncbi request reprint Neurobehavioural effects of developmental toxicity
    Philippe Grandjean
    Department of Environmental Medicine, University of Southern Denmark, Odense, Denmark Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA Electronic address
    Lancet Neurol 13:330-8. 2014
    ..To coordinate these efforts and to accelerate translation of science into prevention, we propose the urgent formation of a new international clearinghouse. ..
  5. pmc Seven deadly sins of environmental epidemiology and the virtues of precaution
    Philippe Grandjean
    Department of Environmental Medicine, University of Southern Denmark, Odense, Denmark
    Epidemiology 19:158-62. 2008
    ....
  6. pmc Elimination half-lives of polychlorinated biphenyl congeners in children
    Philippe Grandjean
    Institute of Public Health, University of Southern Denmark, Winsløwparken 17, DK 5000 Odense, Denmark
    Environ Sci Technol 42:6991-6. 2008
    ..The longest half-lives correspond to elimination of the parent PCB solely with a daily fat excretion rate of 1-2 g, whereas shorter half-lives assume metabolic break-down...
  7. ncbi request reprint Implications of the Precautionary Principle for public health practice and research
    Philippe Grandjean
    Institute of Public Health, University of Southern Denmark, Odense, Denmark
    Int J Occup Med Environ Health 17:5-7. 2004
  8. ncbi request reprint The delayed appearance of a mercurial warning
    Philippe Grandjean
    Department of Environmental Medicine, University of Southern Denmark, Odense, Denmark
    Epidemiology 19:10-1. 2008
    ..The delayed release of the 1971 results therefore reminds us as epidemiologists of our obligation, even in the presence of scientific uncertainty, to call attention to preventable risks...
  9. ncbi request reprint Implications of the precautionary principle for primary prevention and research
    Philippe Grandjean
    Institute of Public Health, University of Southern Denmark, Odense, Denmark
    Annu Rev Public Health 25:199-223. 2004
    ..From this perspective, current research is afflicted by important biases and insufficient focus on major environmental health problems...
  10. pmc Marine food pollutants as a risk factor for hypoinsulinemia and type 2 diabetes
    Philippe Grandjean
    Institute of Public Health, University of Southern Denmark, Odense, Denmark
    Epidemiology 22:410-7. 2011
    ..This concern was examined in a cross-sectional study of elderly subjects from a fishing population with elevated contaminant exposures from seafood species high in the food chain...
  11. ncbi request reprint Pesticide exposure and stunting as independent predictors of neurobehavioral deficits in Ecuadorian school children
    Philippe Grandjean
    Institute of Public Health, University of Southern Denmark, Odense, Denmark
    Pediatrics 117:e546-56. 2006
    ..To examine possible effects on blood pressure, neurological function, and neurobehavioral tests in school-aged children with and without prenatal pesticide exposure in an area where stunting is common...
  12. pmc Late insights into early origins of disease
    Philippe Grandjean
    Department of Environmental Medicine, University of Southern Denmark, Odense, Denmark
    Basic Clin Pharmacol Toxicol 102:94-9. 2008
    ..Additional emphasis should be placed on the question: what could be known, given our study opportunities and methodologies? Our late insights into the early disease origins may then benefit science and prevention...
  13. pmc Allergy and sensitization during childhood associated with prenatal and lactational exposure to marine pollutants
    Philippe Grandjean
    Institute of Public Health, University of Southern Denmark, Odense, Denmark
    Environ Health Perspect 118:1429-33. 2010
    ....
  14. ncbi request reprint Cardiac autonomic activity in methylmercury neurotoxicity: 14-year follow-up of a Faroese birth cohort
    Philippe Grandjean
    Institute of Public Health, University of Southern Denmark, Odense, Denmark
    J Pediatr 144:169-76. 2004
    ..To determine whether heart function in childhood is affected by exposure to methylmercury (MeHg) from seafood...
  15. ncbi request reprint Developmental neurotoxicity of industrial chemicals
    P Grandjean
    Institute of Public Health, University of Southern Denmark, Odense, Denmark
    Lancet 368:2167-78. 2006
    ..New, precautionary approaches that recognise the unique vulnerability of the developing brain are needed for testing and control of chemicals...
  16. doi request reprint Serum vaccine antibody concentrations in children exposed to perfluorinated compounds
    Philippe Grandjean
    Department of Environmental Health, Harvard School of Public Health, 401 Park Dr, EOME 3E 110, Boston, MA 02215, USA
    JAMA 307:391-7. 2012
    ..They cause immune suppression in a rodent model at serum concentrations similar to those occurring in the US population, but adverse health effects of PFC exposure are poorly understood...
  17. pmc Adverse effects of methylmercury: environmental health research implications
    Philippe Grandjean
    Department of Environmental Medicine, University of Southern Denmark, Odense, Denmark
    Environ Health Perspect 118:1137-45. 2010
    ....
  18. pmc Methylmercury and brain development: imprecision and underestimation of developmental neurotoxicity in humans
    Philippe Grandjean
    Harvard School of Public Health, Boston, MA, USA
    Mt Sinai J Med 78:107-18. 2011
    ..The experience obtained with methylmercury should therefore be taken into account when evaluating the evidence for other substances suspected of being neurotoxic...
  19. ncbi request reprint Developmental arsenic neurotoxicity in retrospect
    Philippe Grandjean
    Department of Environmental Medicine, University of Southern Denmark, Odense, Denmark
    Epidemiology 18:25-6. 2007
  20. pmc Umbilical cord mercury concentration as biomarker of prenatal exposure to methylmercury
    Philippe Grandjean
    Institute of Public Health, University of Southern Denmark, Odense, Denmark
    Environ Health Perspect 113:905-8. 2005
    ..Cord mercury analysis can therefore be used as a valid measure of prenatal methylmercury exposure, but appropriate adjustment for the imprecision should be considered...
  21. ncbi request reprint Effects of breast feeding on neuropsychological development in a community with methylmercury exposure from seafood
    Tina Kold Jensen
    Department of Environmental Medicine, Institute of Public Health, University of Southern Denmark, Odense C, Denmark
    J Expo Anal Environ Epidemiol 15:423-30. 2005
    ..Although the advantage may be less, Faroese women can still safely breastfeed their children...
  22. pmc Separation of risks and benefits of seafood intake
    Esben Budtz-Jørgensen
    Department of Biostatistics, Institute of Public Health, University of Copenhagen, Copenhagen, Denmark
    Environ Health Perspect 115:323-7. 2007
    ..In resolving this conundrum, most epidemiologic studies provide little guidance because they address either nutrient benefits or mercury toxicity, not both...
  23. ncbi request reprint Arachidonic acid status during pregnancy is associated with polychlorinated biphenyl exposure
    Philippe Grandjean
    Institute of Public Health, University of Southern Denmark, Odense
    Am J Clin Nutr 77:715-9. 2003
    ..However, the nutritional benefits could be limited by polychlorinated biphenyl (PCB) contamination. In particular, inhibition of desaturase activities by PCBs may affect the maintenance of arachidonic acid (AA) status during development...
  24. ncbi request reprint Underestimation of risk due to exposure misclassification
    Philippe Grandjean
    Institute of Public Health, University of Southern Denmark, Odense, Denmark
    Int J Occup Med Environ Health 17:131-6. 2004
    ..When exposure measurement errors are overlooked or underestimated, decisions based on the precautionary principle will not appropriately reflect the degree of precaution that was intended...
  25. pmc Assessment of xenoestrogenic exposure by a biomarker approach: application of the E-Screen bioassay to determine estrogenic response of serum extracts
    Thomas Høj Rasmussen
    Department of Environmental Medicine, Institute of Public Health, University of Southern Denmark, Odense, Denmark
    Environ Health 2:12. 2003
    ..Thus, analysis of mixtures allows evaluation of combined effects of chemicals each present at low concentrations...
  26. pmc Total imprecision of exposure biomarkers: implications for calculating exposure limits
    Philippe Grandjean
    Institute of Public Health, University of Southern Denmark, Odense, Denmark
    Am J Ind Med 50:712-9. 2007
    ..Unrecognized imprecision leads to underestimation of the true toxicity of the exposure. We have assessed the total imprecision of exposure biomarkers and the implications for calculation of exposure limits...
  27. ncbi request reprint Attenuated growth of breast-fed children exposed to increased concentrations of methylmercury and polychlorinated biphenyls
    Philippe Grandjean
    Department of Environmental Health, Boston University Schools of Medicine and Public Health, Boston, Massachusetts, USA
    FASEB J 17:699-701. 2003
    ..Thus, in communities with increased contaminant exposures, risks associated with lactational transfer of toxicants to the infant must be considered when judging the benefits of prolonged breast-feeding...
  28. ncbi request reprint Neurodevelopmental toxicity risks due to occupational exposure to industrial chemicals during pregnancy
    Jordi Julvez
    Department of Environmental Health, Harvard School of Public Health, Landmark Building 3E 110, 401 Park Drive, Boston, MA 02215, USA
    Ind Health 47:459-68. 2009
    ..Due to the vulnerability of the brain during early development, a precautionary approach to neurodevelopmental toxicity needs to be applied in occupational health...
  29. pmc Xeno-oestrogenic activity in serum as marker of occupational pesticide exposure
    Helle Raun Andersen
    Institute of Public Health, Department of Environmental Medicine, University of Southern Denmark, Odense, Denmark
    Occup Environ Med 64:708-14. 2007
    ..An increasing number of currently used pesticides are reported to possess oestrogen-like properties or to disturb the endocrine system in other ways...
  30. pmc Direct assessment of cumulative aryl hydrocarbon receptor agonist activity in sera from experimentally exposed mice and environmentally exposed humans
    Jennifer J Schlezinger
    Department of Environmental Health, Boston University School of Public Health, Boston, Massachusetts 02118, USA
    Environ Health Perspect 118:693-8. 2010
    ..However, assessment of the significance of human exposures is hampered by an incomplete understanding of how complex mixtures affect AhR activation/inactivation...
  31. ncbi request reprint Polychlorinated biphenyl (PCB) induction of CYP3A4 enzyme activity in healthy Faroese adults
    Maria Skaalum Petersen
    Institute of Public Health, Environmental Medicine, University of Southern Denmark, Winsløvparken 17, 5000 Odense C, Denmark
    Toxicol Appl Pharmacol 224:202-6. 2007
    ....
  32. pmc Selenium as a potential protective factor against mercury developmental neurotoxicity
    Anna L Choi
    Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA
    Environ Res 107:45-52. 2008
    ..Additional research is needed to determine the identity of the nutrients responsible for the beneficial effects...
  33. pmc Methylmercury exposure and adverse cardiovascular effects in Faroese whaling men
    Anna L Choi
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02215, USA
    Environ Health Perspect 117:367-72. 2009
    ..Methylmercury (MeHg), a worldwide contaminant found in fish and seafood, has been linked to an increased risk of cardiovascular mortality...
  34. pmc Negative confounding in the evaluation of toxicity: the case of methylmercury in fish and seafood
    Anna L Choi
    Department of Environmental Health, Harvard School of Public Health, Boston, MA 02215, USA
    Crit Rev Toxicol 38:877-93. 2008
    ..Attention should also be paid to the occurrence of negative confounding in other connections...
  35. ncbi request reprint Neurotoxic risk caused by stable and variable exposure to methylmercury from seafood
    Philippe Grandjean
    Institute of Public Health, University of Southern Denmark, Odense, Denmark
    Ambul Pediatr 3:18-23. 2003
    ..To examine whether the dose-effect relationship for developmental mercury neurotoxicity is affected by variable mercury exposure during pregnancy...
  36. ncbi request reprint Methylmercury toxicity and functional programming
    Philippe Grandjean
    Department of Environmental Health, Harvard School of Public Health, Landmark Center, 3 110E, 401 Park Drive, Boston, MA 02215, USA
    Reprod Toxicol 23:414-20. 2007
    ..This notion is considered from epidemiological evidence using developmental methylmercury neurotoxicity as an example...
  37. doi request reprint High latitude and marine diet: vitamin D status in elderly Faroese
    Christine Dalgård
    Department of Environmental Health, Institute of Public Health, University of Southern Denmark, JB Winslowsvej 17, 2nd Floor, 5000 Odense C, Denmark
    Br J Nutr 104:914-8. 2010
    ..Thus, even in a population with a high intake of marine food, the northern latitude causes a low vitamin D status. Efforts to improve vitamin D status in this population are warranted...
  38. pmc Potential developmental neurotoxicity of pesticides used in Europe
    Marina Bjørling-Poulsen
    Department of Environmental Medicine, University of Southern Denmark, Winslowparken 17, 5000 Odense, Denmark
    Environ Health 7:50. 2008
    ..While awaiting more definite evidence, existing uncertainties should be considered in light of the need for precautionary action to protect brain development...
  39. doi request reprint Impact of dietary exposure to food contaminants on the risk of Parkinson's disease
    Maria Skaalum Petersen
    Institute of Public Health, Environmental Medicine, University of Southern Denmark, Winslowparken 17, Odense C, Denmark
    Neurotoxicology 29:584-90. 2008
    ..Increased intake of whale meat and blubber in adult life was significantly associated with PD, thus suggesting a positive association between previous exposure to marine food contaminants and development of PD...
  40. ncbi request reprint Caffeine N3-demethylation (CYP1A2) in a population with an increased exposure to polychlorinated biphenyls
    Maria Skaalum Petersen
    Institute of Public Health, Department of Environmental Medicine, University of Southern Denmark, Winslovparken 17, 5000 Odense C, Denmark
    Eur J Clin Pharmacol 62:1041-8. 2006
    ..Further, to investigate the effect of sex, smoking, and oral contraceptive use on the CYP1A2 activity...
  41. ncbi request reprint Spermaturia and serum hormone concentrations at the age of puberty in boys prenatally exposed to polychlorinated biphenyls
    Nanette M Mol
    Institute of Public Health, University of Southern Denmark, Odense, Denmark
    Eur J Endocrinol 146:357-63. 2002
    ..To determine whether prenatal exposure to polychlorinated biphenyls (PCBs) with possible hormone-disrupting effects is capable of affecting sexual differentiation in boys at the age of puberty...
  42. ncbi request reprint Implications of the Precautionary Principle in research and policy-making
    Philippe Grandjean
    Institute of Public Health, University of Southern Denmark, Odense C, Denmark
    Am J Ind Med 45:382-5. 2004
    ..Research approaches should be developed and strengthened to counteract innate ideological biases and to support our confidence in applying the PP for decision-making in the public policy arena...
  43. pmc Impaired reproductive development in sons of women occupationally exposed to pesticides during pregnancy
    Helle R Andersen
    Institute of Public Health, Department of Environmental Medicine, University of Southern Denmark, Odense, Denmark
    Environ Health Perspect 116:566-72. 2008
    ..The aim of this prospective study was to investigate whether occupational pesticide exposure during pregnancy causes adverse effects on the reproductive development in the male infants...
  44. doi request reprint Increased prenatal exposure to methylmercury does not affect the risk of Parkinson's disease
    Maria Skaalum Petersen
    Institute of Public Health, Environmental Medicine, University of Southern Denmark, Winslowparken 17, Odense C, Denmark
    Neurotoxicology 29:591-5. 2008
    ....
  45. ncbi request reprint Criteria for skin notation in different countries
    Jesper B Nielsen
    Institute of Public Health, University of Southern Denmark, DK 5000 Odense C, Denmark
    Am J Ind Med 45:275-80. 2004
    ..However, risk is not a qualitative term, but needs a quantitative measure to be useful for prevention. For this reason, some countries have developed alternative criteria for assigning skin notations to industrial chemicals...
  46. ncbi request reprint Non-precautionary aspects of toxicology
    Philippe Grandjean
    Institute of Public Health, University of Southern Denmark, Winslowparken 17, DK 5000 Odense C, Denmark
    Toxicol Appl Pharmacol 207:652-7. 2005
    ....
  47. doi request reprint Genetic predisposition to Parkinson's disease: CYP2D6 and HFE in the Faroe Islands
    Jónrit Halling
    Clinical Pharmacology, Institute of Public Health, University of Southern Denmark, Winslowparken, Odense C, Denmark
    Pharmacogenet Genomics 18:209-12. 2008
    ..To investigate whether the genetic variants of CYP2D6 and HFE are more frequent in Parkinson's disease (PD) patients compared with controls in a population where the prevalence of these variants and PD are increased...
  48. ncbi request reprint Prenatal methylmercury exposure in the Seychelles
    Niels Keiding
    Lancet 362:664-5; author reply 665. 2003
  49. pmc Long-term consequences of arsenic poisoning during infancy due to contaminated milk powder
    Miwako Dakeishi
    Department of Environmental Health Sciences, Akita University School of Medicine, 1 1 1 Hondo, Akita 010 8543 Japan
    Environ Health 5:31. 2006
    ..Along with more recent epidemiological studies of children with environmental arsenic exposures, the data amply demonstrate the need to consider neurotoxicity as a key concern in risk assessment of inorganic arsenic exposure...
  50. ncbi request reprint Neurobehavioral performance of Inuit children with increased prenatal exposure to methylmercury
    Pal Weihe
    Department of Occupational and Public Health, The Faroese Hospital System, Torshavn, Foroe Islands
    Int J Circumpolar Health 61:41-9. 2002
    ..The data from the present study therefore appears in accordance with other evidence that prenatal or early postnatal exposures to methylmercury may cause subtle neurobehavioral deficits...
  51. doi request reprint In utero and early-life conditions and adult health and disease
    Philippe Grandjean
    N Engl J Med 359:1523; author reply 1524. 2008
  52. ncbi request reprint Benchmark dose calculations for methylmercury-associated delays on evoked potential latencies in two cohorts of children
    Katsuyuki Murata
    Department of Hygiene, Akita University School of Medicine, Japan
    Risk Anal 22:465-74. 2002
    ..The benchmark results using evoked potential latencies are in close agreement with results based on neuropsychological test performance...
  53. ncbi request reprint Association between mercury concentrations in blood and hair in methylmercury-exposed subjects at different ages
    Esben Budtz-Jørgensen
    Institute of Clinical Research, Odense University Hospital, DK 5000 Odense, Denmark
    Environ Res 95:385-93. 2004
    ..Although practical for field studies and monitoring purposes, hair-mercury concentration results, therefore, need to be calibrated and interpreted in regard to each specific study setting...
  54. pmc Hydroxylated PCB metabolites and PCBs in serum from pregnant Faroese women
    Britta Fängström
    Department of Environmental Chemistry, Stockholm University, Stockholm, Sweden
    Environ Health Perspect 110:895-9. 2002
    ..More than 25 additional OH-PCBs were indicated. This study confirms the presence of high concentrations of organohalogen substances in populations or areas far removed from their sources...
  55. pmc Estimation of health effects of prenatal methylmercury exposure using structural equation models
    Esben Budtz-Jørgensen
    Department of Biostatistics, University of Copenhagen, Blegdamsvej 3, DK 2200 Copenhagen, Denmark
    Environ Health 1:2. 2002
    ..This approach was used in a large epidemiological data set from a prospective study of developmental methyl-mercury toxicity...
  56. ncbi request reprint [Environmental epidemiology research leads to a decrease of the exposure limit for mercury]
    Pal Weihe
    Faerøernes Sygehusvaesen, afdeling for arbejdsmedicin og folkesundhed, Syddansk Universitet, Institut for Sundhedstjenesteforskning, og Københavns Universitet, Institut for Folkesundhedsvidenskab, Biostatistisk Afdeling
    Ugeskr Laeger 165:107-11. 2003
    ..An increase in blood pressure was also associated with the prenatal exposure level. The exposure limit for mercury has therefore been decreased...
  57. ncbi request reprint The Declaration of Brescia on prevention of the neurotoxicity of metals June 18, 2006
    Philip Landrigan
    Am J Ind Med 50:709-11. 2007
  58. ncbi request reprint Delayed brainstem auditory evoked potential latencies in 14-year-old children exposed to methylmercury
    Katsuyuki Murata
    Division of Environmental Health Sciences, Akita University School of Medicine, Akita, Japan
    J Pediatr 144:177-83. 2004
    ..To determine possible exposure-associated delays in auditory brainstem evoked potential latencies as an objective measure of neurobehavioral toxicity in 14-year-old children with developmental exposure to methylmercury (MeHg) from seafood...
  59. ncbi request reprint Measuring mercury concentration
    Philippe Grandjean
    Epidemiology 16:133. 2005
  60. ncbi request reprint Confounder selection in environmental epidemiology: assessment of health effects of prenatal mercury exposure
    Esben Budtz-Jørgensen
    Department of Biostatistics, University of Copenhagen, and Faroese Hospital System, Torshavn, Faroe Islands
    Ann Epidemiol 17:27-35. 2007
    ..Whereas standard analysis usually is conducted as if the confounders were known a priori, selection uncertainty also must be taken into account...
  61. pmc Impact of prenatal methylmercury exposure on neurobehavioral function at age 14 years
    Frodi Debes
    Faroese Hospital System, FR 100 Tórshavn, Faroe Islands, Denmark
    Neurotoxicol Teratol 28:363-75. 2006
    ..These findings are supported by independent assessment of neurophysiological outcomes. The effects on brain function associated with prenatal methylmercury exposure therefore appear to be multi-focal and permanent...
  62. ncbi request reprint The Declaration of Brescia on Prevention of the Neurotoxicity of Metals Brescia, Italia 17-18 June 2006
    Philip Landrigan
    Med Lav 97:811-4. 2006
  63. ncbi request reprint Concentrations of polybrominated diphenyl ethers, polychlonnated biphenyls, and polychlorobiphenylols in serum from pregnant Faroese women and their children 7 years later
    Britta Fängström
    Department of Environmental Chemistry, Stockholm University, SE 106 91 Stockholm, Sweden
    Environ Sci Technol 39:9457-63. 2005
    ..The PBDE concentrations were similar in both mothers and their children. The main persistent organic pollutant concentrations in the children are most probably due to other environmental exposure than maternal transfer...
  64. ncbi request reprint Effects of developmental co-exposure to methylmercury and 2,2',4,4',5,5'-hexachlorobiphenyl (PCB153) on cholinergic muscarinic receptors in rat brain
    Teresa Coccini
    Toxicology Division, Institute of Pavia, IRCCS Salvatore Maugeri Foundation, Pavia, Italy
    Neurotoxicology 27:468-77. 2006
    ..MR changes were detected in both immature and adult animals and the interaction of MeHg and PCB153 at the level of these receptors occurred in a non-additive manner...
  65. ncbi request reprint Neurophysiological evidence of methylmercury neurotoxicity
    Katsuyuki Murata
    Department of Environmental Health Sciences, Akita University School of Medicine, Akita, Japan
    Am J Ind Med 50:765-71. 2007
    ..The objectives of this article were to present an overview of neurophysiological findings involved in methylmercury neurotoxicity and to examine the usefulness of those measures...
  66. ncbi request reprint Polybrominated diphenyl ethers and traditional organochlorine pollutants in fulmars (Fulmarus glacialis) from the Faroe Islands
    Britta Fängström
    Department of Environmental Chemistry, Stockholm University, SE 106 91 Stockholm, Sweden
    Chemosphere 60:836-43. 2005
    ..e. 590-5700 ng/gl.w. for CB-153. Hence humans are also exposed to PCBs at a reasonable degree via intake of fulmar and/or fulmar egg and not only via pilot whale blubber...
  67. doi request reprint Developmental origins of environmentally induced disease and dysfunction International Conference on Foetal Programming and Developmental Toxicity, Tórshavn, Faroe Islands, 20-24 May, 2007
    Philippe Grandjean
    Basic Clin Pharmacol Toxicol 102:71-2. 2008
  68. ncbi request reprint Serum polychlorinated biphenyl and organochlorine insecticide concentrations in a Faroese birth cohort
    Dana B Barr
    Centers for Disease Control and Prevention, 4770 Buford Highway, Mailstop F17, Atlanta, GA 30341, USA
    Chemosphere 62:1167-82. 2006
    ....
  69. pmc A retrospective study of PBDEs and PCBs in human milk from the Faroe Islands
    Britta Fängström
    Department of Environmental Chemistry, Stockholm University, SE 106 91 Stockholm, Sweden
    Environ Health 4:12. 2005
    ..Polychlorobiphenylols (OH-PCBs), the dominating class of PCB metabolites, some of which are known to be strongly retained in human blood, were also included in the assessment...
  70. ncbi request reprint Effects of exposure imprecision on estimation of the benchmark dose
    Esben Budtz-Jørgensen
    Department of Biostatistics, University of Copenhagen, Denmark
    Risk Anal 24:1689-96. 2004
    ..Methods that allow this adjustment are described and illustrated in data from an epidemiological study on the health effects of prenatal mercury exposure...
  71. doi request reprint The faroes statement: human health effects of developmental exposure to chemicals in our environment
    Philippe Grandjean
    Basic Clin Pharmacol Toxicol 102:73-5. 2008
  72. ncbi request reprint Correction for "Delayed brainstem auditory evoked potential latencies in 14-year-old children exposed to methylmercury" by Murata et al
    Katsuyuki Murata
    J Pediatr 149:583-4. 2006
  73. ncbi request reprint Application of hair-mercury analysis to determine the impact of a seafood advisory
    Pal Weihe
    Faroese Hospital System, Sigmundargøta 5, P O Box 14, FO 110 Tórshavn, Faroe Islands
    Environ Res 97:200-7. 2005
    ....
  74. ncbi request reprint [Semi-truths about semiconductors]
    Philippe Grandjean
    Syddansk Universitet, Institut for Sundhedstjenesteforskning
    Ugeskr Laeger 164:3868-9. 2002
  75. ncbi request reprint Re: Implementation of WHO Guidelines on Disclosure of Interest by members of WHO Expert Panels
    Olav Axelson
    Int J Occup Environ Health 8:271-3. 2002
  76. ncbi request reprint Contaminants in fish oil
    Philippe Grandjean
    Am J Clin Nutr 82:1354; author reply 1354-5. 2005
  77. pmc Comparison of polychlorinated biphenyl levels across studies of human neurodevelopment
    Matthew P Longnecker
    Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Environ Health Perspect 111:65-70. 2003
    ..S. studies or recent Dutch, German, and northern Québec studies. Our results will facilitate a direct comparison of the findings on PCBs and neurodevelopment when they are published for all 10 studies...
  78. ncbi request reprint Extended follow-up of cancer incidence in fluoride-exposed workers
    Philippe Grandjean
    J Natl Cancer Inst 96:802-3. 2004
  79. ncbi request reprint Consequences of exposure measurement error for confounder identification in environmental epidemiology
    Esben Budtz-Jørgensen
    Department of Biostatistics, University of Copenhagen, Blegdamsvej 3, DK 2200 Copenhagen N, Denmark
    Stat Med 22:3089-100. 2003
    ..These difficulties in statistical model development are illustrated by examples from a epidemiological study performed in the Faroe Islands to investigate the adverse health effects of prenatal mercury exposure...
  80. pmc Breastfeeding and the weanling's dilemma
    Philippe Grandjean
    Am J Public Health 94:1075; author reply 1075-6. 2004

Research Grants21

  1. MERCURY-ASSOCIATED NEUROBEHAVIORAL DEFICIT IN CHILDREN
    PHILIPPE ADAM GRANDJEAN; Fiscal Year: 2010
    ....
  2. Three-generation Human Study of Reproductive Effects of Marine Food Contaminants
    PHILIPPE ADAM GRANDJEAN; Fiscal Year: 2010
    ..Current evidence already suggests that these pathologies may already affect many populations, and the present proposal aims at identifying whether persistent organochlorine pollutants contribute to these abnormalities. ..
  3. Health Effects of Lifetime Exposure to Food Contaminants
    Philippe Grandjean; Fiscal Year: 2009
    ..The results may therefore provide new information that could very likely have an impact on the preventive efforts and standard-setting of the EPA and other regulatory agencies in the U.S and elsewhere. ..
  4. Three-generation Human Study of Reproductive Effects of Marine Food Contaminants
    Philippe Grandjean; Fiscal Year: 2009
    ..Current evidence already suggests that these pathologies may already affect many populations, and the present proposal aims at identifying whether persistent organochlorine pollutants contribute to these abnormalities. ..
  5. Three-generation Human Study of Reproductive Effects of Marine Food Contaminants
    Philippe Grandjean; Fiscal Year: 2007
    ..Current evidence already suggests that these pathologies may already affect many populations, and the present proposal aims at identifying whether persistent organochlorine pollutants contribute to these abnormalities. ..
  6. Epidemiology of Immunotoxicant Exposure in Children
    Philippe Grandjean; Fiscal Year: 2007
    ..These results are expected to extend substantially the current documentation for PCB risk assessment. ..
  7. Three-generation Human Study of Reproductive Effects of Marine Food Contaminants
    Philippe Grandjean; Fiscal Year: 2006
    ..Current evidence already suggests that these pathologies may already affect many populations, and the present proposal aims at identifying whether persistent organochlorine pollutants contribute to these abnormalities. ..
  8. Epidemiology of Immunotoxicant Exposure in Children
    Philippe Grandjean; Fiscal Year: 2005
    ..These results are expected to extend substantially the current documentation for PCB risk assessment. ..
  9. Effects of perinatal endocrine disrupters in children
    Philippe Grandjean; Fiscal Year: 2004
    ..Modern statistical methods will be used to determine whether these outcome variables are associated with estrogen, thyroid, or Ah receptor abnormalities and specific contaminant exposures prenatally or postnatally. ..
  10. Epidemiology of Immunotoxicant Exposure in Children
    Philippe Grandjean; Fiscal Year: 2004
    ..These results are expected to extend substantially the current documentation for PCB risk assessment. ..
  11. Effects of perinatal endocrine disrupters in children
    Philippe Grandjean; Fiscal Year: 2002
    ..Modern statistical methods will be used to determine whether these outcome variables are associated with estrogen, thyroid, or Ah receptor abnormalities and specific contaminant exposures prenatally or postnatally. ..
  12. Effects of perinatal endocrine disrupters in children
    Philippe Grandjean; Fiscal Year: 2003
    ..Modern statistical methods will be used to determine whether these outcome variables are associated with estrogen, thyroid, or Ah receptor abnormalities and specific contaminant exposures prenatally or postnatally. ..
  13. MERCURY-ASSOCIATED NEUROBEHAVIORAL DEFICIT IN CHILDREN
    Philippe Grandjean; Fiscal Year: 2009
    ....
  14. Effects of perinatal endocrine disrupters in children
    Philippe Grandjean; Fiscal Year: 2002
    ..Modern statistical methods will be used to determine whether these outcome variables are associated with estrogen, thyroid, or Ah receptor abnormalities and specific contaminant exposures prenatally or postnatally. ..
  15. Health Effects of Lifetime Exposure to Food Contaminants
    Philippe Grandjean; Fiscal Year: 2007
    ..The results may therefore provide new information that could very likely have an impact on the preventive efforts and standard-setting of the EPA and other regulatory agencies in the U.S and elsewhere. ..
  16. Epidemiology of Immunotoxicant Exposure in Children
    Philippe Grandjean; Fiscal Year: 2006
    ..These results are expected to extend substantially the current documentation for PCB risk assessment. ..
  17. Effects of perinatal endocrine disrupters in children
    Philippe Grandjean; Fiscal Year: 2001
    ..Modern statistical methods will be used to determine whether these outcome variables are associated with estrogen, thyroid, or Ah receptor abnormalities and specific contaminant exposures prenatally or postnatally. ..