Research Topics
| Evangelos GragoudasSummaryAffiliation: Harvard University Country: USA Publications
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Detail Information
Publications
Uveal melanoma: proton beam irradiationEvangelos S Gragoudas
Department of Ophthalmology, Harvard Medical School, and Retina Service, Massachusetts Eye and Ear Infirmary, 243 Charles Street, Boston, MA 02114, USA
Ophthalmol Clin North Am 18:111-8, ix. 2005..Although this method does not alter survival, preservation of the globe and, in some instances, visual function, is achieved. This article presents the authors' and other investigators' experience with proton therapy...- Pegaptanib for neovascular age-related macular degenerationEvangelos S Gragoudas
Retina Service, Massachusetts Eye and Ear Infirmary and Harvard Medical School, 243 Charles St, Boston, MA 02114, USA
N Engl J Med 351:2805-16. 2004..Pegaptanib, an anti-vascular endothelial growth factor therapy, was evaluated in the treatment of neovascular age-related macular degeneration... - Proton beam irradiation of uveal melanomas: the first 30 years. The Weisenfeld LectureEvangelos S Gragoudas
Department of Ophthalmology, Retina Service, Massachusetts Eye and Ear Infirmary, Harvard Medical School, 243 Charles Street, Boston, MA 02114, USA
Invest Ophthalmol Vis Sci 47:4666-73. 2006 - Evidence-based estimates of outcome in patients irradiated for intraocular melanomaEvangelos Gragoudas
Retina Service, Massachusetts Eye and Ear Infirmary, 243 Charles St, Boston, MA 02114, USA
Arch Ophthalmol 120:1665-71. 2002..Until radiation therapy gained wide acceptance in the 1980s, enucleation was the standard treatment for the tumor. Long-term results after proton beam irradiation are now available... - Safety and efficacy of intravitreal injection of ranibizumab in combination with verteporfin PDT on experimental choroidal neovascularization in the monkeyDeeba Husain
Angiogenesis and Laser Laboratory, Retina Service, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA
Arch Ophthalmol 123:509-16. 2005..CLINICAL RELEVANCE: This combination therapy can potentially offer a new treatment modality for choroidal neovascularization in patients with macular degeneration and other diseases... - An antisense oligodeoxynucleotide against vascular endothelial growth factor in a nonhuman primate model of iris neovascularizationRobert B Bhisitkul
Department of Ophthalmology, Beckman Vision Center, University of California San Francisco, 94143, USA
Arch Ophthalmol 123:214-9. 2005..To evaluate an antisense oligodeoxynucleotide (AS-ODN) targeted against vascular endothelial growth factor for its effects on ocular angiogenesis and its intraocular localization in a nonhuman primate model of iris neovascularization... - Selective photodynamic therapy by targeted verteporfin delivery to experimental choroidal neovascularization mediated by a homing peptide to vascular endothelial growth factor receptor-2Reem Z Renno
Angiogenesis and Laser Laboratory, Retina Service, Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston 02114, USA
Arch Ophthalmol 122:1002-11. 2004..This study provides the basis for further preclinical studies of targeted PDT strategies and subsequent clinical trials... 
VEGF164-mediated inflammation is required for pathological, but not physiological, ischemia-induced retinal neovascularizationSusumu Ishida
Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Boston 02114, USA
J Exp Med 198:483-9. 2003..These processes provide positive and negative angiogenic regulation, respectively. Together, new therapeutic approaches for selectively targeting pathological, but not physiological, retinal neovascularization are outlined...- Reduced photoreceptor damage after photodynamic therapy through blockade of nitric oxide synthase in a model of choroidal neovascularizationHaicheng She
Angiogenesis and Laser Laboratories, Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts 02114, USA
Invest Ophthalmol Vis Sci 48:2268-77. 2007..To investigate the role of nitric oxide synthase (NOS) in photoreceptor degeneration associated with photodynamic therapy (PDT) in a laser-induced model of choroidal neovascularization (CNV)... - Verteporfin photodynamic therapy in the rat model of choroidal neovascularization: angiographic and histologic characterizationDavid N Zacks
Retina Service and Angiogenesis Laboratory, Massachusetts Eye and Ear Infirmary, Harvard Medical School, 243 Charles Street, Boston, MA 02114, USA
Invest Ophthalmol Vis Sci 43:2384-91. 2002..CONCLUSIONS: Verteporfin PDT for experimental CNV in the rat is a feasible, effective, and reproducible model that can be used for testing the efficacy of adjunctive therapy to verteporfin PDT... 
Photoreceptor protection after photodynamic therapy using dexamethasone in a rat model of choroidal neovascularizationHaicheng She
Department of Ophthalmology, Angiogenesis and Laser Laboratories, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston 02114, Massachusetts, USA
Invest Ophthalmol Vis Sci 49:5008-14. 2008..To study whether corticosteroids protect photoreceptors when combined with photodynamic therapy (PDT) in a laser-induced model of choroidal neovascularization (CNV)...
Long-term risk of local failure after proton therapy for choroidal/ciliary body melanomaEvangelos S Gragoudas
Clinical Research Unit, Retina Service, Massachusetts Eye and Ear Infirmary, Boston, USA
Trans Am Ophthalmol Soc 100:43-8; discussion 48-9. 2002..CONCLUSION: These data, based on relatively long-term follow-up, demonstrate that excellent local control is maintained after proton therapy and that patients with recurrences experience poorer survival...- Photodynamic therapy induces caspase-dependent apoptosis in rat CNV modelAkihisa Matsubara
Angiogenesis and Laser Laboratories, Retina Service, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, USA
Invest Ophthalmol Vis Sci 48:4741-7. 2007..To investigate the mechanism of cell death in laser-induced choroidal neovascularization (CNV) after photodynamic therapy (PDT)... - Prevention of experimental choroidal neovascularization with intravitreal anti-vascular endothelial growth factor antibody fragmentMagdalena G Krzystolik
Retina Service, Massachusetts Eye and Ear Infirmary, 243 Charles St, Boston, MA 02114, USA
Arch Ophthalmol 120:338-46. 2002.... - Mortality after diagnosis of small melanocytic lesions of the choroidAnne Marie Lane
Massachusetts Eye and Ear Infirmary, Boston, USA
Arch Ophthalmol 128:996-1000. 2010..To evaluate the risk of dying of metastatic choroidal melanoma in patients with small, indeterminate, pigmented lesions of the uveal tract... - Survival in patients with presymptomatic diagnosis of metastatic uveal melanomaIvana K Kim
Retina Service, Massachusetts Eye and Ear Infirmary, 243 Charles Street, Boston, MA 02114, USA
Arch Ophthalmol 128:871-5. 2010..To determine if patients diagnosed as having metastatic uveal melanoma before the onset of symptoms experience more favorable survival outcomes than patients diagnosed after the onset of symptoms... - Adjuvant interferon therapy for patients with uveal melanoma at high risk of metastasisAnne Marie Lane
Retina Service, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA
Ophthalmology 116:2206-12. 2009..To examine whether interferon (IFN)-alfa-2a treatment after radiation or enucleation reduces death rates in patients with uveal melanoma... - Effect of intravitreal injection of ranibizumab in combination with verteporfin PDT on normal primate retina and choroidIvana K Kim
Angiogenesis and Laser Laboratory, Retina Research Institute, Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA
Invest Ophthalmol Vis Sci 47:357-63. 2006..San Francisco, CA) directed against vascular endothelial growth factor (VEGF) in combination with verteporfin photodynamic therapy (PDT) on normal primate retina and choroid... - Melanocytoma of the optic nerve associated with sound-induced phosphenesIvana K Kim
Retina Service, Massachusetts Eye and Ear Infirmary, Boston 02114, USA
Arch Ophthalmol 124:273-7. 2006 - Tumor basal area and metastatic death after proton beam irradiation for choroidal melanomaWenjun Li
Retina Service, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, USA
Arch Ophthalmol 121:68-72. 2003..92 (95% confidence interval, 1.62-2.28). CONCLUSION: Tumor basal area is a better prognostic indicator than largest tumor diameter and tumor volume in the prediction of metastatic death after proton beam irradiation for uveal melanoma... - Dose-dependent effect of pitavastatin on VEGF and angiogenesis in a mouse model of choroidal neovascularizationHadi J Zambarakji
Angiogenesis Laboratory, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston 02114, USA
Invest Ophthalmol Vis Sci 47:2623-31. 2006..18 mg/kg per day. The higher dose of 18 mg/kg per day resulted in increased fluorescein leakage and a trend toward an increase in CNV size, indicating a potentiating effect in choroidal neovascular disease... - Natural history of radiation papillopathy after proton beam irradiation of parapapillary melanomaIvana K Kim
Retina Service, Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts 02114, USA
Ophthalmology 117:1617-22. 2010..To evaluate the natural history of radiation papillopathy after proton beam irradiation of parapapillary choroidal melanoma... - Histologic correlation of in vivo optical coherence tomography images of the human retinaTeresa C Chen
Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, 02114, USA
Am J Ophthalmol 141:1165-8. 2006..To correlate in vivo human retina optical coherence tomography (OCT)3 images with histology... - Investigating the effect of ciliary body photodynamic therapy in a glaucoma mouse modelAkihisa Matsubara
Angiogenesis and Laser Laboratories, Retina Service, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts 02114, USA
Invest Ophthalmol Vis Sci 47:2498-507. 2006..These results suggest that ciliary body PDT is a more selective cyclodestructive technique with potential clinical application in the treatment of glaucoma... - In vivo evaluation of laser-induced choroidal neovascularization using spectral-domain optical coherence tomographyAndrea Giani
Angiogenesis and Laser Laboratories, Retina Service, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts 02114, USA
Invest Ophthalmol Vis Sci 52:3880-7. 2011..To describe the in vivo evolution of laser-induced choroidal neovascularization (CNV) in mice using spectral domain optical coherence tomography (SD-OCT)... - Posterior uveal melanoma in young patients treated with proton beam therapyDemetrios Vavvas
Retina Service, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts 02131, USA
Retina 30:1267-71. 2010..The purpose was to study the clinical profile and prognosis of young patients with uveal melanoma treated by proton beam irradiation... - Increased choroidal neovascularization following laser induction in mice lacking lysyl oxidase-like 1Hyeong Gon Yu
Angiogenesis Laboratory and Laser Laboratory, Retina Research Institute, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA
Invest Ophthalmol Vis Sci 49:2599-605. 2008..This study investigated the influence of defective elastic fiber maintenance in the development of laser-induced CNV... - Conservation treatment of the eye: Conformal proton reirradiation for recurrent uveal melanomaLaura Marucci
Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA 02114, USA
Int J Radiat Oncol Biol Phys 64:1018-22. 2006..Although most patients lost vision, the majority were able to retain the reirradiated eye. Further evaluation is needed to assess metastasis-free survival of additional proton irradiation vs. enucleation after local recurrence... - Expression of leukocyte adhesion molecules in human subfoveal choroidal neovascular membranes treated with and without photodynamic therapyDeborah C Yeh
Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
Invest Ophthalmol Vis Sci 45:2368-73. 2004..Increasing numbers of PDT treatments may be associated with decreased ICAM-1 immunostaining in the proliferating edges of the CNVMs... - Proton beam irradiation using a light-field technique for the treatment of choroidal hemangiomasR V Paul Chan
Retina Service, New York Presbyterian Hospital, Weill Cornell Medical College, New York, NY, USA
Ophthalmologica 224:209-16. 2010..To describe the clinical outcomes of patients with circumscribed and diffuse choroidal hemangiomas treated by proton beam irradiation using a nonsurgical light-field technique... - Expression of pigment epithelium-derived factor in experimental choroidal neovascularizationReem Z Renno
Angiogenesis Laboratory, Retina Research Institute, Massachusetts Eye and Ear Infirmary, 245 Charles Street, Boston, MA 02114, USA
Invest Ophthalmol Vis Sci 43:1574-80. 2002..PEDF analogues may be a reasonable treatment strategy for CNV... - Proton beam irradiation for neovascular age-related macular degenerationHadi J Zambarakji
Retina Service, Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts 02114, USA
Ophthalmology 113:2012-9. 2006..Proton radiation may be useful as an adjuvant therapy or as an alternative for patients who decline or are not appropriate for approved therapies... - Endogenous endostatin inhibits choroidal neovascularizationAlexander G Marneros
Department of Developmental Biology, Harvard School of Dental Medicine, 188 Longwood Ave, Boston, MA 02115, USA
FASEB J 21:3809-18. 2007..Endostatin may have a regulatory role in the pathogenesis of CNV and could be used therapeutically to inhibit growth and leakage of CNV lesions... - Targeted disruption of the CD18 or ICAM-1 gene inhibits choroidal neovascularizationEiji Sakurai
Department of Ophthalmology, University of Kentucky, Lexington, Kentucky 40536 0284, USA
Invest Ophthalmol Vis Sci 44:2743-9. 2003..To investigate the role of the leukocyte adhesion molecules CD18 and intercellular adhesion molecule (ICAM)-1 in the development of choroidal neovascularization (CNV)... - Identification of Chlamydia pneumoniae within human choroidal neovascular membranes secondary to age-related macular degenerationMurat V Kalayoglu
Angiogenesis Laboratory, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA 02114, USA
Graefes Arch Clin Exp Ophthalmol 243:1080-90. 2005..pneumoniae. These data indicate that a pathogen capable of inducing chronic inflammation and pro-angiogenic cytokines can be detected in some AMD CNV, and suggest that infection may contribute to the pathogenesis of AMD... - Treatment of metastatic tumors of the choroid with proton beam irradiationEfthymia K Tsina
Retina Service, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts 02114, USA
Ophthalmology 112:337-43. 2005..This modality is accurate and efficient, because it only entails 2 treatment fractions and does not require surgery for tumor localization... - Localization of rose bengal, aluminum phthalocyanine tetrasulfonate, and chlorin e6 in the rabbit eyeRobert Haimovici
Laser Research Laboratory, Retina Service, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, USA
Retina 22:65-74. 2002..Differences in ocular localization of these photosensitizers were demonstrated. The significance of these findings for potential photodynamic therapy with these agents requires further investigation... - Photosensitizers in photodynamic therapy of choroidal neovascularizationRafael L Ufret-Vincenty
Massachusetts Eye and Ear Infirmary, Harvard Medical School, 243 Charles Street, Boston, MA 02114, USA
Int Ophthalmol Clin 44:63-80. 2004 - Inhibition of Hsp90 attenuates inflammation in endotoxin-induced uveitisVassiliki Poulaki
Angiogenesis Laser Laboratory, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, 243 Charles St, Boston, MA 02114, USA
FASEB J 21:2113-23. 2007..17-AAG has demonstrated a favorable safety profile in clinical trials in cancer patients and represents a promising therapeutic agent for the treatment of inflammatory eye diseases... - High-grade uveal B-cell lymphoma as the initial feature in Richter syndromeJessica P Fernandez-Suntay
Massachusetts Eye and Ear Infirmary, 243 Charles St, Boston, MA 02114, USA
Arch Ophthalmol 120:1383-5. 2002 - Vascular adhesion protein-1 blockade suppresses choroidal neovascularizationKousuke Noda
Angiogenesis Laboratory, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA
FASEB J 22:2928-35. 2008..Inhibition of VAP-1 may become a new therapeutic strategy in the treatment of AMD... - The expanded clinical spectrum of deferoxamine retinopathyRobert Haimovici
Department of Ophthalmology, Boston University School of Medicine, DOB-10 720 Harrison Avenue, Boston, MA 02118, USA
Ophthalmology 109:164-71. 2002..Patients who do not discontinue deferoxamine after the development of retinopathy risk further retinal/RPE injury and visual deterioration... - MRI of blood volume and cellular uptake of superparamagnetic iron in an animal model of choroidal melanomaMatthias Krause
Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, Mass 02114, USA
Ophthalmic Res 34:241-50. 2002..Further study is necessary to determine the feasibility of this technique for the tumor diagnosis and evaluation of tumor viability following treatments... - Role of alpha 4 integrin (CD49d) in the pathogenesis of diabetic retinopathyEirini Iliaki
Angiogenesis Laboratory, Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts 02114, USA
Invest Ophthalmol Vis Sci 50:4898-904. 2009..The authors have now studied the role of integrin alpha 4/CD49d in the pathogenesis of diabetic retinopathy... - In vivo imaging of endothelial injury in choriocapillaris during endotoxin-induced uveitisShinsuke Miyahara
Angiogenesis Laboratory, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA 02114 USA
FASEB J 22:1973-80. 2008..This technique may help to diagnose subclinical signs of ocular inflammatory diseases... - Characterization of azurocidin as a permeability factor in the retina: involvement in VEGF-induced and early diabetic blood-retinal barrier breakdownDimitra Skondra
Angiogenesis Laboratory, Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, MA 02114, USA
Invest Ophthalmol Vis Sci 49:726-31. 2008..Azurocidin, released by neutrophils during leukocyte-endothelial interaction, is a main cause of neutrophil-evoked vascular leakage. Its role in the retina, however, is unknown... - Controlled delivery of the anti-VEGF aptamer EYE001 with poly(lactic-co-glycolic)acid microspheresKaren G Carrasquillo
Angiogenesis and Retina Research Laboratory, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, 325 Cambridge Street, Boston, MA 02114, USA
Invest Ophthalmol Vis Sci 44:290-9. 2003..This method represents a promising approach for the transscleral delivery of drugs and the treatment of choroidal and retinal diseases... - Inhibition of vascular adhesion protein-1 suppresses endotoxin-induced uveitisKousuke Noda
Department of Ophthalmology, Massachusetts Eye and Ear Infirmary and Harvard Medical School, Boston, Massachusetts, USA
FASEB J 22:1094-103. 2008..VAP-1 inhibition may become a novel strategy in the treatment of ocular inflammatory diseases... - Treatment of experimental choroidal melanoma with an Nd:yttrium-lanthanum-fluoride laser at 1047 nmMatthias H J Krause
Retina Service, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, 243 Charles St, Boston, MA 02114, USA
Arch Ophthalmol 121:357-63. 2003..Focused irradiation at 1047 nm may provide more effective submillisecond heating of melanin than collimated irradiation, resulting in immediate photothermal disruption of tumor cells... - MRI of blood volume with superparamagnetic iron in choroidal melanoma treated with thermotherapyMatthias H J Krause
Massachusetts General Hospital-Nuclear Magnetic Resonance (MGH-NMR) Center, Harvard Medical School, Charlestown, MA, USA
Magn Reson Imaging 22:779-87. 2004..Further study is necessary to determine whether MRI can localize areas of tumor regrowth within tumors treated incompletely... - MRI of blood volume with MS 325 in experimental choroidal melanomaMatthias H J Krause
Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, MA 02114, USA
Magn Reson Imaging 21:725-32. 2003..Further studies are needed to investigate whether this technique allows the evaluation of tumor viability following treatments... - Verteporfin therapy of subfoveal choroidal neovascularization in age-related macular degeneration: meta-analysis of 2-year safety results in three randomized clinical trials: Treatment Of Age-Related Macular Degeneration With Photodynamic Therapy and VertMohammad Azab
Retina 24:1-12. 2004..This detailed safety profile of verteporfin therapy clarifies the adverse reaction information in the current verteporfin product prescription information... - Verteporfin therapy of subfoveal choroidal neovascularization in patients with age-related macular degeneration: additional information regarding baseline lesion composition's impact on vision outcomes-TAP report No. 3Neil M Bressler
Wilmer Photograph Reading Center, The Johns Hopkins University School of Medicine, Baltimore, MD 21205 2002, USA
Arch Ophthalmol 120:1443-54. 2002.... - [Photodynamic therapy of pigmented choroidal melanomas in rabbits]Likuan Hu
Tumor Center of Qilu Hospital, Shandong University, Jinan 250012, China
Zhonghua Yan Ke Za Zhi 38:491-4. 2002..CONCLUSION: These data suggest that photodynamic therapy have a role in the management of pigmented choroidal melanomas...