Raj Goyal

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Structure activity relationship of synaptic and junctional neurotransmission
    Raj K Goyal
    Center for Swallowing and Motility Disorders, GI Division, VA Boston Healthcare System and Harvard Medical School, Boston, USA
    Auton Neurosci 176:11-31. 2013
  2. doi request reprint Progress in understanding of inhibitory purinergic neuromuscular transmission in the gut
    R K Goyal
    VA Boston Healthcare System and Harvard Medical School, Boston, MA 02132, USA
    Neurogastroenterol Motil 25:203-7. 2013
  3. pmc CaMKII inhibition hyperpolarizes membrane and blocks nitrergic IJP by closing a Cl(-) conductance in intestinal smooth muscle
    Xue Dao He
    Center for Swallowing and Motility Disorders, Veterans Affairs Boston Healthcare System and Harvard Medical School, Boston, MA, USA
    Am J Physiol Gastrointest Liver Physiol 303:G240-6. 2012
  4. pmc Role of myosin Va in purinergic vesicular neurotransmission in the gut
    Arun Chaudhury
    Center for Swallowing and Motility Disorders, Veterans Affairs Boston Healthcare System, Massachusetts, USA
    Am J Physiol Gastrointest Liver Physiol 302:G598-607. 2012
  5. pmc Telomerase inhibition by siRNA causes senescence and apoptosis in Barrett's adenocarcinoma cells: mechanism and therapeutic potential
    Masood A Shammas
    Center for Swallowing and Motility Disorders, VA Boston Healthcare System, Boston, MA 02132, USA
    Mol Cancer 4:24. 2005
  6. pmc Mounting evidence against the role of ICC in neurotransmission to smooth muscle in the gut
    Raj K Goyal
    VA Medical Center, 1400 VFW Parkway, West Roxbury, MA 02132, USA
    Am J Physiol Gastrointest Liver Physiol 298:G10-3. 2010
  7. pmc Physiology of normal esophageal motility
    Raj K Goyal
    Center for Swallowing and Motility Disorders, Harvard Medical School, Boston, MA, USA
    J Clin Gastroenterol 42:610-9. 2008
  8. pmc Activation of small conductance Ca(2+)-dependent K+ channels by purinergic agonists in smooth muscle cells of the mouse ileum
    F Vogalis
    Centre for Swallowing and Motility Disorders, Brockton West Roxbury Veterans Administration Medical Center, MA 02132, USA
    J Physiol 502:497-508. 1997
  9. ncbi request reprint Neuronal NOS provides nitrergic inhibitory neurotransmitter in mouse lower esophageal sphincter
    C D Kim
    Center for Swallowing and Motility Disorders, Brockton West Roxbury Veterans Affairs Medical Center, Boston, Massachusetts 02132, USA
    Am J Physiol 277:G280-4. 1999
  10. pmc Neuronal constitutive nitric oxide synthase is involved in murine enteric inhibitory neurotransmission
    H Mashimo
    Gastrointestinal Unit, Massachusetts General Hospital, Boston, 02114, USA
    J Clin Invest 98:8-13. 1996

Collaborators

Detail Information

Publications30

  1. pmc Structure activity relationship of synaptic and junctional neurotransmission
    Raj K Goyal
    Center for Swallowing and Motility Disorders, GI Division, VA Boston Healthcare System and Harvard Medical School, Boston, USA
    Auton Neurosci 176:11-31. 2013
    ..Both synaptic and junctional communications are common between neurons; however, junctional transmission is the rule at many neuro-non-neural effectors...
  2. doi request reprint Progress in understanding of inhibitory purinergic neuromuscular transmission in the gut
    R K Goyal
    VA Boston Healthcare System and Harvard Medical School, Boston, MA 02132, USA
    Neurogastroenterol Motil 25:203-7. 2013
    ....
  3. pmc CaMKII inhibition hyperpolarizes membrane and blocks nitrergic IJP by closing a Cl(-) conductance in intestinal smooth muscle
    Xue Dao He
    Center for Swallowing and Motility Disorders, Veterans Affairs Boston Healthcare System and Harvard Medical School, Boston, MA, USA
    Am J Physiol Gastrointest Liver Physiol 303:G240-6. 2012
    ..These studies suggest that inhibition of CaMKII-dependent Cl(-) conductance mediates nitrergic sIJP by causing maximal closure of the Cl(-) conductance...
  4. pmc Role of myosin Va in purinergic vesicular neurotransmission in the gut
    Arun Chaudhury
    Center for Swallowing and Motility Disorders, Veterans Affairs Boston Healthcare System, Massachusetts, USA
    Am J Physiol Gastrointest Liver Physiol 302:G598-607. 2012
    ..Myosin Va associates with SLC17A9-stained vesicles and possibly transports them to varicosity membrane for exocytosis. In myosin Va-deficient mice, purinergic inhibitory neurotransmission is impaired...
  5. pmc Telomerase inhibition by siRNA causes senescence and apoptosis in Barrett's adenocarcinoma cells: mechanism and therapeutic potential
    Masood A Shammas
    Center for Swallowing and Motility Disorders, VA Boston Healthcare System, Boston, MA 02132, USA
    Mol Cancer 4:24. 2005
    ..Chemical inhibitors of telomerase have been shown to reactivate telomere shortening and cause replicative senescence and apoptotic cell death of tumor cells while having little or no effect on normal diploid cells...
  6. pmc Mounting evidence against the role of ICC in neurotransmission to smooth muscle in the gut
    Raj K Goyal
    VA Medical Center, 1400 VFW Parkway, West Roxbury, MA 02132, USA
    Am J Physiol Gastrointest Liver Physiol 298:G10-3. 2010
    ..3) The most recent report, in this issue of the Journal, concludes that impaired nitrergic neurotransmission may be due to smooth muscle defects associated with c-Kit receptor deficiency...
  7. pmc Physiology of normal esophageal motility
    Raj K Goyal
    Center for Swallowing and Motility Disorders, Harvard Medical School, Boston, MA, USA
    J Clin Gastroenterol 42:610-9. 2008
    ..Clinical disorders of esophageal motility can be classified on the basis of disorders of the inhibitory and excitatory innervations and the smooth muscles...
  8. pmc Activation of small conductance Ca(2+)-dependent K+ channels by purinergic agonists in smooth muscle cells of the mouse ileum
    F Vogalis
    Centre for Swallowing and Motility Disorders, Brockton West Roxbury Veterans Administration Medical Center, MA 02132, USA
    J Physiol 502:497-508. 1997
    ..These channels, along with an apamin-sensitive but TEA-resistant steady outward current, may mediate membrane hyperpolarization elicited by purinergic agonists...
  9. ncbi request reprint Neuronal NOS provides nitrergic inhibitory neurotransmitter in mouse lower esophageal sphincter
    C D Kim
    Center for Swallowing and Motility Disorders, Brockton West Roxbury Veterans Affairs Medical Center, Boston, Massachusetts 02132, USA
    Am J Physiol 277:G280-4. 1999
    ..These results indicate that in mouse LES, nNOS rather than eNOS is the enzymatic source of the NO that mediates NANC relaxation and rebound contraction...
  10. pmc Neuronal constitutive nitric oxide synthase is involved in murine enteric inhibitory neurotransmission
    H Mashimo
    Gastrointestinal Unit, Massachusetts General Hospital, Boston, 02114, USA
    J Clin Invest 98:8-13. 1996
    ....
  11. ncbi request reprint An intermediate conductance K+ channel in the cell membrane of mouse intestinal smooth muscle
    F Vogalis
    Brockton West Roxbury VA Medical Center and Harvard Medical School, 1400 VFW Parkway, Boston, MA 02132, USA
    Biochim Biophys Acta 1371:309-16. 1998
    ..Our results suggest that IK channels contribute significantly to the Ca2+-dependent K+ conductance in visceral smooth muscle...
  12. ncbi request reprint Role of HERG-like K(+) currents in opossum esophageal circular smooth muscle
    H I Akbarali
    Center for Swallowing and Motility Disorders, Harvard Medical School, West Roxbury Veterans Affairs Medical Center, West Roxbury, Massachusetts 02132, USA
    Am J Physiol 277:C1284-90. 1999
    ....
  13. ncbi request reprint Gastric stasis in neuronal nitric oxide synthase-deficient knockout mice
    H Mashimo
    West Roxbury Veterans Affairs Medical Center, West Roxbury, Massachusetts 02132, USA
    Gastroenterology 119:766-73. 2000
    ..Nitric oxide (NO) is a major inhibitory neurotransmitter in the gut. This study aimed to identify the effect of chronic deprivation of NO derived from neuronal (nNOS) or endothelial (eNOS) nitric oxide synthase on gastric emptying...
  14. ncbi request reprint Lower esophageal sphincter is achalasic in nNOS(-/-) and hypotensive in W/W(v) mutant mice
    D V Sivarao
    Center for Swallowing and Motility Disorders, Department of Veterans Affairs Medical Center, 1400 VFW Parkway, West Roxbury, Massachusetts 02132, USA
    Gastroenterology 121:34-42. 2001
    ..We determined whether mice with neuronal nitric oxide synthase gene disruption (nNOS(-/-)) and W/W(v) mice lacking ICC-IM have achalasia-like LES dysfunction...
  15. ncbi request reprint Swallowing reflex and brain stem neurons activated by superior laryngeal nerve stimulation in the mouse
    Q Sang
    Center for Swallowing and Motility Disorders, West Roxbury Division of Veterans Affairs Boston Healthcare System, West Roxbury, Massachusetts 02132, USA
    Am J Physiol Gastrointest Liver Physiol 280:G191-200. 2001
    ..These data are consistent with the role of SolI, SolIM, SolDM, NAsc, NAl, and DMVc circuit in oropharyngeal peristalsis and LES relaxation and SolCe, NAc, DMVc, and DMVr in esophageal peristalsis and LES responses...
  16. pmc Myosin Va plays a key role in nitrergic neurotransmission by transporting nNOSĪ± to enteric varicosity membrane
    Arun Chaudhury
    Center for Swallowing and Motility Disorders, VA Boston Healthcare System and Harvard Medical School, Boston, Massachusetts, USA
    Am J Physiol Gastrointest Liver Physiol 301:G498-507. 2011
    ..These studies reveal the critical importance of myosin Va in nitrergic neurotransmission by facilitating transport of nNOSĪ± to the varicosity membrane...
  17. ncbi request reprint Neural circuits in swallowing and abdominal vagal afferent-mediated lower esophageal sphincter relaxation
    R K Goyal
    Center for Swallowing and Motility Disorders, Department of Veterans Affairs Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    Am J Med 111:95S-105S. 2001
    ....
  18. pmc Telomere maintenance in laser capture microdissection-purified Barrett's adenocarcinoma cells and effect of telomerase inhibition in vivo
    Masood A Shammas
    Department of Surgery, Wayne State University and Karmanos Cancer Institute, Detroit, Michigan 48201, USA
    Clin Cancer Res 14:4971-80. 2008
    ....
  19. ncbi request reprint Growth arrest, apoptosis, and telomere shortening of Barrett's-associated adenocarcinoma cells by a telomerase inhibitor
    Masood A Shammas
    VA Boston Health Care System, Boston, MA, USA
    Gastroenterology 126:1337-46. 2004
    ..The purpose of this study was to evaluate effects of telomerase inhibition on BEAC...
  20. ncbi request reprint Differences in calmodulin and calmodulin-binding proteins in phasic and tonic smooth muscles
    Pawel T Szymanski
    Center for Swallowing and Motility Disorders, Harvard Medical School, West Roxbury, Massachusetts 02132, USA
    Am J Physiol Cell Physiol 282:C94-C104. 2002
    ..In contrast, low CaM, MLCK, and CaD content may be responsible for a small range of contractile force seen in tonic muscle of LES...
  21. ncbi request reprint High-fidelity DNA histograms in neoplastic progression in Barrett's esophagus
    Chenggong Yu
    Department of Medicine, VA Boston Healthcare System, Boston, MA 02132 4927, USA
    Lab Invest 87:466-72. 2007
    ....
  22. ncbi request reprint Monochloramine selectively inhibits the transient outward potassium current in colonic smooth muscle
    Madhu Prasad
    Department of Surgery, Veterans Affairs Medical Centers, West Roxbury, MA 02132, USA
    Surgery 134:319-28. 2003
    ..The aim of this study was to characterize the effect of the colon-specific oxidant monochloramine (NH(2)Cl) on I(TO) in SMCs of the mouse colon...
  23. ncbi request reprint Telomerase inhibition and cell growth arrest by G-quadruplex interactive agent in multiple myeloma
    Masood A Shammas
    Boston VA Health Care System, West Roxbury, MA, USA
    Mol Cancer Ther 2:825-33. 2003
    ..The aim of this study was to test the efficacy of telomerase inhibitor (TMPyP4 [tetra(N-methyl-4-pyridyl)-porphyrin chloride]; a G-quadruplex-intercalating porphyrin) as a potential therapeutic agent for multiple myeloma...
  24. ncbi request reprint Differential modulation of voltage-dependent K+ currents in colonic smooth muscle by oxidants
    Madhu Prasad
    Department of Surgery, Veterans Affairs Medical Center, West Roxbury, MA 02132, USA
    Am J Physiol Cell Physiol 286:C671-82. 2004
    ..These results suggest that I(to) is suppressed via modification of both methionine and cysteine residues, whereas enhancement of Idr likely results from methionine oxidation alone...
  25. ncbi request reprint Phenotype of columnar-lined esophagus in rats with esophagogastroduodenal anastomosis: similarity to human Barrett's esophagus
    Yinghao Su
    Center for Swallowing and Motility Disorders, VA Boston Healthcare System and Harvard Medical School, Boston, MA 02132, USA
    Lab Invest 84:753-65. 2004
    ..EGDA rats may serve as a useful model to study the pathogenesis, molecular biology, and chemopreventive interventions of human BE and EAC...
  26. ncbi request reprint Surveillance and screening for Barrett esophagus and adenocarcinoma
    Hiroshi Mashimo
    Center for Swallowing and Motility Disorders, VA Boston Healthcare System, Brigham and Women s Hospital, and Harvard Medical School, Boston, MA 02132, USA
    J Clin Gastroenterol 39:S33-41. 2005
    ..Effective screening programs depend on development of simple, inexpensive, and reliable methods to identify the small group of patients truly at high risk for adenocarcinoma for endoscopic screening...
  27. doi request reprint DNA ploidy abnormalities in basal and superficial regions of the crypts in Barrett's esophagus and associated neoplastic lesions
    Xiaoqi Zhang
    Departments of Medicine, Veterans Affairs Boston Healthcare System, Harvard Medical School, West Roxbury, MA 02132, USA
    Am J Surg Pathol 32:1327-35. 2008
    ..These results suggest that with neoplastic progression, dysplastic changes in BE begin in the basal crypt cells and then extend further up the crypts, and BCD represents a true early form of dysplasia limited to the crypt bases...
  28. pmc Pyloric sphincter dysfunction in nNOS-/- and W/Wv mutant mice: animal models of gastroparesis and duodenogastric reflux
    Digavalli V Sivarao
    Department of Veterans Affairs Medical Center, Center for Swallowing and Motility Disorders, West Roxbury, Massachusetts 02132, USA
    Gastroenterology 135:1258-66. 2008
    ..Nitrergic nerves and interstitial cells of Cajal (ICC) have been implicated in the regulation of pyloric motility. The purpose of these studies was to define their roles in pyloric function in vivo...
  29. pmc Specific killing of multiple myeloma cells by (-)-epigallocatechin-3-gallate extracted from green tea: biologic activity and therapeutic implications
    Masood A Shammas
    Veterans Administration Boston Health Care System, and Dana Farber Cancer Institute Harvard Medical School, 44 Binney Street, D1B25, Boston, MA 02115, USA
    Blood 108:2804-10. 2006
    ..Expression of related genes at the protein level were also confirmed by Western blot analysis. These data demonstrate potent and specific antimyeloma activity of EGCG and provide the rationale for its clinical evaluation...
  30. ncbi request reprint Musings on the wanderer: what's new in our understanding of vago-vagal reflex? IV. Current concepts of vagal efferent projections to the gut
    Howard Y Chang
    Center for Swallowing and Motility Disorders, VA Boston Healthcare System, Harvard Medical School, Boston, MA 02132, USA
    Am J Physiol Gastrointest Liver Physiol 284:G357-66. 2003
    ..Vagal effects on secretory functions are exerted either directly or via release of local mediators or circulating hormones...

Research Grants15

  1. Nitrergic Neuro-smooth Muscle Transmission in the Gut
    Raj K Goyal; Fiscal Year: 2010
    ..This proposal is to understand how these disorders are caused and how better treatments for these disorders can be developed. ..
  2. PHYSIOLOGY AND PATHOPHYSIOLOGY OF ESOPHAGEAL MOTILITY
    Raj Goyal; Fiscal Year: 2002
    ..The effects of NO on single cells will be relate to nitrergic neurotransmission and physiology with microelectrode, mechanical studies and measurement of esophageal motility in vivo. ..
  3. Nitrergic Neuro-smooth Muscle Transmission in the Gut
    Raj Goyal; Fiscal Year: 2009
    ..This information may help in understanding physiology, and the pathogenesis and rational treatment of clinical disorders due to deficiency of nitrergic neuro-smooth muscle transmission. ..