P J Goulder

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Evolution and transmission of stable CTL escape mutations in HIV infection
    P J Goulder
    Partners AIDS Research Center, Massachusetts General Hospital and Division of AIDS, Harvard Medical School, Boston, Massachusetts 02114, USA
    Nature 412:334-8. 2001
  2. pmc Differential narrow focusing of immunodominant human immunodeficiency virus gag-specific cytotoxic T-lymphocyte responses in infected African and caucasoid adults and children
    P J Goulder
    Partners AIDS Research Center, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    J Virol 74:5679-90. 2000
  3. pmc Substantial differences in specificity of HIV-specific cytotoxic T cells in acute and chronic HIV infection
    P J Goulder
    Partners AIDS Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Exp Med 193:181-94. 2001
  4. pmc Functionally inert HIV-specific cytotoxic T lymphocytes do not play a major role in chronically infected adults and children
    P J Goulder
    Partners AIDS Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Exp Med 192:1819-32. 2000
  5. pmc Levels of human immunodeficiency virus type 1-specific cytotoxic T-lymphocyte effector and memory responses decline after suppression of viremia with highly active antiretroviral therapy
    S A Kalams
    Partners AIDS Research Center and Infectious Disease Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Virol 73:6721-8. 1999
  6. pmc Cellular immune responses and viral diversity in individuals treated during acute and early HIV-1 infection
    M Altfeld
    Partners AIDS Research Center and Infectious Disease Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02129, USA
    J Exp Med 193:169-80. 2001
  7. pmc HLA-B57-restricted cytotoxic T-lymphocyte activity in a single infected subject toward two optimal epitopes, one of which is entirely contained within the other
    P J Goulder
    Partners AIDS Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Virol 74:5291-9. 2000
  8. pmc The HIV-1 regulatory proteins Tat and Rev are frequently targeted by cytotoxic T lymphocytes derived from HIV-1-infected individuals
    M M Addo
    Partners AIDS Research Center and Infectious Disease Division, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 98:1781-6. 2001
  9. pmc Rapid definition of five novel HLA-A*3002-restricted human immunodeficiency virus-specific cytotoxic T-lymphocyte epitopes by elispot and intracellular cytokine staining assays
    P J Goulder
    Partners AIDS Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Virol 75:1339-47. 2001
  10. ncbi request reprint Rapid characterization of HIV clade C-specific cytotoxic T lymphocyte responses in infected African children and adults
    P J Goulder
    Partners AIDS Research Center, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    Ann N Y Acad Sci 918:330-45. 2000

Collaborators

Detail Information

Publications14

  1. ncbi request reprint Evolution and transmission of stable CTL escape mutations in HIV infection
    P J Goulder
    Partners AIDS Research Center, Massachusetts General Hospital and Division of AIDS, Harvard Medical School, Boston, Massachusetts 02114, USA
    Nature 412:334-8. 2001
    ..These data suggest that CTL escape mutations in epitopes associated with suppression of viraemia will accumulate as the epidemic progresses, and therefore have important implications for vaccine design...
  2. pmc Differential narrow focusing of immunodominant human immunodeficiency virus gag-specific cytotoxic T-lymphocyte responses in infected African and caucasoid adults and children
    P J Goulder
    Partners AIDS Research Center, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    J Virol 74:5679-90. 2000
    ..The fine focusing of dominant CTL responses to these few regions of high immunogenicity is of significance to vaccine design...
  3. pmc Substantial differences in specificity of HIV-specific cytotoxic T cells in acute and chronic HIV infection
    P J Goulder
    Partners AIDS Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Exp Med 193:181-94. 2001
    ..This finding is an important consideration in vaccine design and in the evaluation of vaccine candidates...
  4. pmc Functionally inert HIV-specific cytotoxic T lymphocytes do not play a major role in chronically infected adults and children
    P J Goulder
    Partners AIDS Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Exp Med 192:1819-32. 2000
    ..These data together show that functionally inert CTLs do not play a significant role in chronic pediatric or adult HIV infection...
  5. pmc Levels of human immunodeficiency virus type 1-specific cytotoxic T-lymphocyte effector and memory responses decline after suppression of viremia with highly active antiretroviral therapy
    S A Kalams
    Partners AIDS Research Center and Infectious Disease Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Virol 73:6721-8. 1999
    ....
  6. pmc Cellular immune responses and viral diversity in individuals treated during acute and early HIV-1 infection
    M Altfeld
    Partners AIDS Research Center and Infectious Disease Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02129, USA
    J Exp Med 193:169-80. 2001
    ..These data also provide rationale for therapeutic immunization aimed at broadening CTL responses in treated primary HIV infection...
  7. pmc HLA-B57-restricted cytotoxic T-lymphocyte activity in a single infected subject toward two optimal epitopes, one of which is entirely contained within the other
    P J Goulder
    Partners AIDS Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Virol 74:5291-9. 2000
    ..In addition, these studies demonstrate marked differences in the length of peptides presented by HLA-B57, an allele which is associated with nonprogressive human immunodeficiency virus infection...
  8. pmc The HIV-1 regulatory proteins Tat and Rev are frequently targeted by cytotoxic T lymphocytes derived from HIV-1-infected individuals
    M M Addo
    Partners AIDS Research Center and Infectious Disease Division, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 98:1781-6. 2001
    ..Despite the small size of these proteins, multiple CTL epitopes were identified in each. These data indicate that Tat and Rev are frequently targeted by CTL in natural HIV-1 infection and may be important targets for HIV vaccines...
  9. pmc Rapid definition of five novel HLA-A*3002-restricted human immunodeficiency virus-specific cytotoxic T-lymphocyte epitopes by elispot and intracellular cytokine staining assays
    P J Goulder
    Partners AIDS Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Virol 75:1339-47. 2001
    ..This simple and convenient approach should prove useful especially in the characterization of CTL responses specific to HIV and other viruses, particularly in localities where performing cytotoxicity assays would be problematic...
  10. ncbi request reprint Rapid characterization of HIV clade C-specific cytotoxic T lymphocyte responses in infected African children and adults
    P J Goulder
    Partners AIDS Research Center, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    Ann N Y Acad Sci 918:330-45. 2000
    ....
  11. pmc Characterization of a novel respiratory syncytial virus-specific human cytotoxic T-lymphocyte epitope
    P J Goulder
    Partners AIDS Research Center, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    J Virol 74:7694-7. 2000
    ..This HLA B7-restricted epitope in nucleoprotein (NP) was detectable in four healthy, B7-positive adult subjects using B7-RSV-NP tetrameric complexes to stain CD8(+) T cells...
  12. pmc Identification of novel HLA-A2-restricted human immunodeficiency virus type 1-specific cytotoxic T-lymphocyte epitopes predicted by the HLA-A2 supertype peptide-binding motif
    M A Altfeld
    Partners AIDS Research Center and Infectious Disease Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    J Virol 75:1301-11. 2001
    ....
  13. ncbi request reprint Vpr is preferentially targeted by CTL during HIV-1 infection
    M Altfeld
    Partners AIDS Research Center and Infectious Disease Division, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA
    J Immunol 167:2743-52. 2001
    ..These findings will be important in evaluating the specificity and breadth of immune responses during acute and chronic infection, and in the design and testing of candidate HIV vaccines...
  14. ncbi request reprint Paediatric HIV infection: correlates of protective immunity and global perspectives in prevention and management
    P J Goulder
    Partners AIDS Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Br Med Bull 58:89-108. 2001
    ....