Research Topics
| C M GordonSummaryAffiliation: Harvard University Country: USA Publications
Research Grants
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Detail Information
Publications
Adrenal and gonadal steroids inhibit IL-6 secretion by human marrow cellsC M Gordon
Division of Adolescent Young Adult Medicine, Children s Hospital, Boston, MA 02115, USA
Cytokine 16:178-86. 2001..Second, the inhibitory effect of E(2)was abrogated in marrow from women receiving ERT...- Prevalence of vitamin D deficiency among healthy adolescentsCatherine M Gordon
Division of Adolescent Young Adult Medicine, Children s Hospital Boston and Harvard Medical School, Boston, Mass 02115, USA
Arch Pediatr Adolesc Med 158:531-7. 2004.... - Effects of nutrition, puberty, and gender on bone ultrasound measurements in adolescents and young adultsAndrea A Pettinato
Division of Adolescent Young Adult Medicine, Children s Hospital Boston, Boston, Massachusetts 02115, USA
J Adolesc Health 39:828-34. 2006..This study evaluated associations between radial and tibial speed of sound (SOS) measurements via QUS and demographic, anthropometric and nutritional variables... 
Skeletal measurements by quantitative ultrasound in adolescents and young women with anorexia nervosaAmy D DiVasta
Division of Adolescent Medicine, Children s Hospital Boston, Boston, Massachusetts 02115, USA
J Pediatr 150:286-90, 290.e1. 2007..To compare quantitative ultrasound (QUS) measurements in adolescents with anorexia nervosa (AN) with that in healthy control subjects and to determine the utility of QUS as a tool to evaluate skeletal status in these patients...
Special report on the 2007 Pediatric Position Development Conference of the International Society for Clinical DensitometryCatherine M Gordon
Children s Hospital Boston, Boston, MA 02115, USA
South Med J 101:740-3. 2008..This report describes the methodology and presents the results of this recent PDC...- State of the Art Review: Emerging Therapies: The Use of Insulin Sensitizers in the Treatment of Adolescents with Polycystic Ovary Syndrome (PCOS)David H Geller
Division of Pediatric Endocrinology, Cedars Sinai Medical Center, David Geffen UCLA School of Medicine 8700 Beverly Blvd, Rm 4220, Los Angeles, CA 90048, USA
Int J Pediatr Endocrinol 2011:9. 2011.... - Reflections on future research in adolescent reproductive healthCatherine M Gordon
Division of Adolescent Medicine, Children s Hospital, 300 Longwood Avenue, Boston, MA 02115, USA
Ann N Y Acad Sci 1135:296-305. 2008..Insights are also provided by five clinical investigators, including two outside experts, on topics of priority for a research agenda in the area of adolescent reproductive health, as well as how the research itself should be conducted... - Passion for participatory research on the menstrual cycleCatherine M Gordon
Division of Adolescent Medicine, Children s Hospital, 300 Longwood Avenue, Boston, MA 02115, USA
Ann N Y Acad Sci 1135:306-8. 2008..This could initially take the form of a Study of Puberty across the Nation (SPAN), similar to the Study of Women across the Nation (SWAN) that addresses the normal menopausal process... - Relationship between insulin-like growth factor I, dehydroepiandrosterone sulfate and proresorptive cytokines and bone density in cystic fibrosisC M Gordon
Children s Hospital, Division of Endocrinology, Boston, MA 02115, USA
Osteoporos Int 17:783-90. 2006.... - Prevalence of vitamin D deficiency among healthy infants and toddlersCatherine M Gordon
Divisions of Adolescent Medicine and Endocrinology, Children s Hospital Boston, 300 Longwood Ave, Boston, MA 02115, USA
Arch Pediatr Adolesc Med 162:505-12. 2008..To determine the prevalence of vitamin D deficiency and to examine whether 25-hydroxyvitamin D (25OHD) concentration varies as a function of skin pigmentation, season, sun exposure, breastfeeding, and vitamin D supplementation... - Dual energy X-ray absorptiometry interpretation and reporting in children and adolescents: the 2007 ISCD Pediatric Official PositionsCatherine M Gordon
Division of Endocrinology, Children s Hospital Boston, Boston, MA 02115, USA
J Clin Densitom 11:43-58. 2008..The rationale and evidence for development of the Official Positions are provided. Given the sparse data currently available in many of these areas, it is likely that these positions will change over time as new data become available... - Treatment of hypovitaminosis D in infants and toddlersCatherine M Gordon
Divisions of Adolescent Medicine and Endocrinology, Children s Hospital Boston, 300 Longwood Avenue, Boston, MA 02115, USA
J Clin Endocrinol Metab 93:2716-21. 2008..Hypovitaminosis D appears to be on the rise in young children, with implications for skeletal and overall health... - Nutrient status of adults with cystic fibrosisCatherine M Gordon
Division of Endocrinology, Children s Hospital Boston, Boston, MA 22015, USA
J Am Diet Assoc 107:2114-9. 2007..These findings call into question the applicability of established nutrient thresholds for patients with cystic fibrosis... - Hutchinson-Gilford progeria is a skeletal dysplasiaCatherine M Gordon
Division of Adolescent Medicine and Endocrinology, Children s Hospital Boston, Harvard Medical School, Boston, MA, USA
J Bone Miner Res 26:1670-9. 2011..Dietary intake was adequate, confirming that HGPS does not represent a model of malnutrition-induced bone loss. Taken together, these findings suggest that the phenotype of HGPS represents a unique skeletal dysplasia... - Approach to the adolescent requesting contraceptionCatherine M Gordon
Division of Endocrinology, Children s Hospital Boston, Massachusetts 02115, USA
J Clin Endocrinol Metab 97:9-15. 2012..They are usually unaware of the risks of thrombosis, stroke, or adverse bone health effects. Providers must be able to speak to these issues using an evidence-based approach... - Low prevalence of vitamin D deficiency among adolescents with anorexia nervosaA L Haagensen
Division of Endocrinology, Children s Hospital Boston, Boston, USA
Osteoporos Int 19:289-94. 2008..Girls with AN reported exceptional compliance with vitamin D supplementation and PTH concentrations were lower. Vitamin D deficiency was less common in the group with AN, but when race was considered, the trend was no longer significant... - DHEA and the skeleton (through the ages)C M Gordon
Division of Adolescent Young Adult Medicine, Children s Hospital, Boston, MA 02115, USA
Endocrine 11:1-11. 1999..The pattern of secretion of DHEA throughout the life cycle is discussed, as well as its potential usefulness in specific disease states as an agent with anabolic and antiosteolyic effects on bone... - Prevalence and predictors of abnormal liver enzymes in young women with anorexia nervosaHiu Fai Fong
Harvard MIT Division of Health Sciences and Technology, Harvard Medical School, Children s Hospital Boston, Boston, MA 02215, USA
J Pediatr 153:247-53. 2008..To determine the prevalence and predictors of abnormal liver enzyme levels in ambulatory young women with anorexia nervosa (AN)... - Variable deficits of bone mineral despite chronic glucocorticoid therapy in pediatric patients with inflammatory diseases: a Glaser Pediatric Research Network studyEmily Von Scheven
Children s Hospital, University of California at San Francisco, 94143, USA
J Pediatr Endocrinol Metab 19:821-30. 2006..To evaluate the relationship between chronic glucocorticoid (GC) exposure and bone mineral density (BMD) in children with rheumatic diseases and inflammatory bowel disease... - Bone density issues in the adolescent gynecology patientC M Gordon
Divisions of Adolescent Young Adult Medicine and Endocrinology, Children s Hospital, Boston, MA, USA
J Pediatr Adolesc Gynecol 13:157-61. 2000..This review places special emphasis on a patient commonly seen in the adolescent and gynecology practice, the female athlete... - Bone cross-sectional geometry in adolescents and young women with anorexia nervosa: a hip structural analysis studyA D DiVasta
Division of Adolescent Medicine, Children s Hospital Boston, Boston, MA 02115, USA
Osteoporos Int 18:797-804. 2007..Our objective was to determine whether hip cross-sectional geometry and bone strength were altered in adolescents with AN... - The effect of bed rest on bone turnover in young women hospitalized for anorexia nervosa: a pilot studyAmy D DiVasta
Division of Adolescent Medicine, Children s Hospital Boston, Boston, Massachusetts 02115, USA
J Clin Endocrinol Metab 94:1650-5. 2009..Malnourished adolescents with anorexia nervosa (AN) requiring medical hospitalization are at high risk for skeletal insults. Even short-term bed rest may further disrupt normal patterns of bone turnover... - Hormonal contraception and thrombotic risk: a multidisciplinary approachCameron C Trenor
Division of Hematology Oncology, Department of Medicine and Surgery, Children s Hospital Boston, Boston, Massachusetts 02115, USA
Pediatrics 127:347-57. 2011..Our multidisciplinary group has found that knowledge of the guidelines and individualized management plans have been particularly useful for informing discussions about hormonal and nonhormonal options across varied indications... - Vitamin D deficiency in children and adolescents: epidemiology, impact and treatmentSusanna Y Huh
Division of Gastroenterology and Nutrition, Children s Hospital Boston, Boston, MA 02115, USA
Rev Endocr Metab Disord 9:161-70. 2008..In this review, we discuss the definitions, epidemiology, clinical implications, and treatment of vitamin D deficiency in children and adolescents... - Irregular menses linked to vomiting in a nonclinical sample: findings from the National Eating Disorders Screening Program in high schoolsS Bryn Austin
Division of Adolescent and Young Adult Medicine, Children s Hospital, Boston, Massachusetts 02115, USA
J Adolesc Health 42:450-7. 2008..Using data from an eating disorders screening initiative conducted in high schools across the United States, we examined the relationship between vomiting frequency and irregular menses in a nonclinical sample of adolescent females... - Hormone replacement therapy and the adolescentAmy D DiVasta
Children s Hospital Boston, Division of Adolescent Medicine, 333 Longwood Avenue, Boston, MA 02115, USA
Curr Opin Obstet Gynecol 22:363-8. 2010..We present an update on hormonal replacement therapy (HRT) for adolescents and young women with deficiencies of pubertal hormones... - Vitamin D status in children and young adults with inflammatory bowel diseaseHelen M Pappa
Center for Inflammatory Bowel Disease, Division of Gastroenterology and Nutrition, Children s Hospital Boston, 300 Longwood Ave, Boston, MA 02115, USA
Pediatrics 118:1950-61. 2006.... - Malnutrition and hemodynamic status in adolescents hospitalized for anorexia nervosaAmy D DiVasta
Department of Cardiology, Children s Hospital Boston, 333 Longwood Ave, Boston, MA 02115, USA
Arch Pediatr Adolesc Med 164:706-13. 2010..To determine the effects of malnutrition on hemodynamic status of adolescents hospitalized for anorexia nervosa... - Total body and spinal bone mineral density across Tanner stage in perinatally HIV-infected and uninfected children and youth in PACTG 1045Denise L Jacobson
Center for Biostatistics in AIDS Research, Harvard School of Public Health, Boston, USA
AIDS 24:687-96. 2010..To characterize total body bone mineral content (BMC) and total body and spinal bone mineral density (BMD) in perinatally HIV-infected and uninfected children/youth across puberty... - Prevalence of transient hyperphosphatasemia among healthy infants and toddlersSusanna Y Huh
Division of Gastroenterology, Children s Hospital Boston, Boston, Massachusetts 02115, USA
Pediatrics 124:703-9. 2009..To describe the prevalence and clinical characteristics of transient hyperphosphatasemia (TH) in a cohort of healthy infants and toddlers... - Hormone replacement therapy for the adolescent patientAmy D DiVasta
Division of Adolescent Medicine, Children s Hospital Boston, 333 Longwood Avenue, Boston, MA 02115, USA
Ann N Y Acad Sci 1135:204-11. 2008..Both the benefits and risks associated with various methods of HRT are also discussed, as are special issues of concern regarding adolescent HRT, including eating disorders and bone health... - Oral health and bone density in adolescents and young women with anorexia nervosaBrain F Shaughnessy
Department of Dental Medicine, Children s Hospital Boston, MA 02115, USA
J Clin Pediatr Dent 33:87-92. 2008.... - Bone density in adolescents treated with a GnRH agonist and add-back therapy for endometriosisAmy D DiVasta
Division of Adolescent Medicine, Children s Hospital Boston, MA 02115, USA
J Pediatr Adolesc Gynecol 20:293-7. 2007..To evaluate the bone density of adolescents with endometriosis treated with a GnRH-agonist and "add-back" therapy with norethindrone acetate... - Polycystic ovary syndrome update in adolescenceAreej Hassan
Division of Adolescent, Young Adult Medicine, Children s Hospital Boston, Boston, MA 02115, USA
Curr Opin Pediatr 19:389-97. 2007..To provide an overview of our current understanding of polycystic ovary syndrome, its epidemiology and natural history, and potential therapeutic options... - Bone health in children and adolescents: a symposium at the annual meeting of the Pediatric Academic Societies/Lawson Wilkins Pediatric Endocrine Society, May 2003Catherine M Gordon
Division of Endocrinology, Children's Hospital Boston, Harvard Medical School, Boston, MA, USA
Curr Probl Pediatr Adolesc Health Care 34:226-42. 2004 - Normal bone accretion and effects of nutritional disorders in childhoodCatherine M Gordon
Department of Pediatrics, Harvard Medical School, and Divisions of Adolescent Medicine and Endocrinology, Children s Hospital, Boston, Massachusetts 02115, USA
J Womens Health (Larchmt) 12:137-43. 2003..The promotion of skeletal health is ultimately the encouragement of good general health principles for all young people. Approaches for working with children and adolescents are reviewed, including literature supporting each strategy... - Effects of oral dehydroepiandrosterone on bone density in young women with anorexia nervosa: a randomized trialCatherine M Gordon
Division of Adolescent Young Adult Medicine, Children s Hospital, 300 Longwood Avenue, Boston, MA 02115, USA
J Clin Endocrinol Metab 87:4935-41. 2002..Both therapies significantly decreased bone resorption. Replicating results from studies of the elderly, DHEA resulted in improvements in specific psychological parameters in these young women... - Adolescent androgen abnormalitiesDiane E J Stafford
Harvard Medical School, Division of Endocrinology, Children s Hospital, Boston, Massachusetts 02115, USA
Curr Opin Obstet Gynecol 14:445-51. 2002..The pathophysiologic role in the disorder are the subject of several recent reports... - Amenorrhea and bone health in adolescents and young womenCatherine M Gordon
Children s Hospital Bone Health Center and Department of Pediatrics, Harvard Medical School, Divisions of Adolescent Young Adult Medicine and Endocrinology, Children s Hospital, Boston, Massachusetts 02115, USA
Curr Opin Obstet Gynecol 15:377-84. 2003..We present an update on amenorrhea in adolescent girls and young women. Amenorrhea may herald the onset of estrogen deficiency, which can adversely affect peak bone mass and ultimate risk of osteoporosis... - Bone health in adolescentsAmy D DiVasta
Division of Adolescent Medicine, Children s Hospital Boston, Boston, MA 02115, USA
Adolesc Med Clin 17:639-52; abstract xi. 2006..Adolescent medicine specialists and gynecologists caring for teenagers must recognize the potential implications of these clinical settings on bone health to provide appropriate patient guidance and direct management... - Normal ovarian structure and function with normal glucose tolerance in girls with early treatment of classic congenital adrenal hyperplasiaAmy Fleischman
Division of Endocrinology, Department of Medicine, Children s Hospital Boston, MA 02115, USA
J Pediatr Adolesc Gynecol 20:67-72. 2007..Females with congenital adrenal hyperplasia provide a clinical model to evaluate the contribution of pre- and post-natal hyperandrogenism on ovarian structure and function... - Bone mineral status in children with congenital adrenal hyperplasiaAmy Fleischman
Division of Endocrinology, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
J Pediatr Endocrinol Metab 20:227-35. 2007..The normal bone status may be explained by the differential effects of glucocorticoids on growing bone, beneficial androgen effects, or other disease specific factors... - Report on the vitamin D status of adult and pediatric patients with inflammatory bowel disease and its significance for bone health and diseaseHelen M Pappa
Center for Inflammatory Bowel Disease, Division of Gastroenterology and Nutrition, Children s Hospital Boston, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA
Inflamm Bowel Dis 12:1162-74. 2006..These tasks may prove particularly difficult because of malabsorption and gastrointestinal losses that are associated with IBD... - Influence of bone density results on adolescents with anorexia nervosaNava Stoffman
Division of Adolescent/Young Adult Medicine, Children's Hospital Boston, Boston, Massachusetts 02115, USA
Int J Eat Disord 37:250-5. 2005..However, the experience may lead to positive behavioral changes and result in long-term improvement. Clinicians must be careful and sensitive when presenting these results... - Correlates of stress fractures among preadolescent and adolescent girlsKeith J Loud
Division of Adolescent/Young Adult Medicine, Children's Hospital Boston and Harvard Medical School, Boston, Massachusetts 02115, USA
Pediatrics 115:e399-406. 2005..In the meantime, clinicians should remain vigilant in identifying and treating disordered eating and menstrual irregularities among their highly active, young, female patients... - Bone marrow changes in adolescent girls with anorexia nervosaKirsten Ecklund
Department of Radiology, Children s Hospital Boston, Boston, MA, USA
J Bone Miner Res 25:298-304. 2010.... - Fertility concerns and sexual behavior in adolescent girls with polycystic ovary syndrome: implications for quality of lifeMaria E Trent
Division of Adolescent Medicine, Department of Pediatrics, Johns Hopkins School of Medicine, Baltimore, Maryland 21287, USA
J Pediatr Adolesc Gynecol 16:33-7. 2003..To examine the fertility concerns and sexual behavior of adolescent girls with polycystic ovary syndrome (PCOS) as compared to healthy adolescent girls and the effect of these concerns on health-related quality of life... - Screening for abnormal glucose tolerance in adolescents with polycystic ovary syndromeMark R Palmert
Division of Endocrinology, Department of Medicine, Children s Hospital, Boston, Massachusetts 02115, USA
J Clin Endocrinol Metab 87:1017-23. 2002..However, as DM may be preventable by lifestyle modifications, we would recommend that adolescents with PCOS undergo periodic screening for abnormal glucose tolerance using 2-h postchallenge plasma glucose levels... - Physiologic regulators of bone turnover in young women with anorexia nervosaCatherine M Gordon
Division of Adolescent/Young Adult Medicine, Children's Hospital, Boston, Massachusetts 02115, USA
J Pediatr 141:64-70. 2002..IGF-I was correlated with bone formation indices. Low cytokine levels suggest that these factors do not mediate the increased bone resorption of AN... - Family history predicts stress fracture in active female adolescentsKeith J Loud
Division of Adolescent Medicine, Children s Hospital Medical Center, Akron, Ohio, USA
Pediatrics 120:e364-72. 2007.... - Rickets in an otherwise healthy 11-month-oldAvery LeBoff Williams
Division of Endocrinology, Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA
Clin Pediatr (Phila) 47:409-12. 2008 - Skeletal health in adult patients with classic galactosemiaL A Batey
Children s Hospital Boston, Boston, MA 02115, USA
Osteoporos Int 24:501-9. 2013..Calcium level predicted hip and spine BMD, and gonadotropin levels were inversely associated with spinal BMD in women. These results afford insights into management strategies for these patients... - Neural substrates of anorexia nervosa: a behavioral challenge study with positron emission tomographyC M Gordon
Divisions of Adolescent/Young Adult Medicine and Endocrinology, Children's Hospital, Boston, Massachusetts, USA
J Pediatr 139:51-7. 2001..The high-calorie food phobia exhibited by patients with AN appears to be associated with exaggerated responses in visual association cortex, as has been previously observed in studies of specific phobias... - Salivary progesterone levels before menarche: a prospective study of adolescent girlsSusan H Gray
Department of Pediatrics, Boston Medical Center, Boston University School of Medicine, Boston, MA 02118, USA
J Clin Endocrinol Metab 95:3507-11. 2010..Our objective was to determine the frequency of ovulatory salivary progesterone levels before menarche in healthy girls... - Quality of life in adolescent girls with polycystic ovary syndromeMaria E Trent
Division of Pediatrics and Adolescent Medicine, Department of Pediatrics, The Johns Hopkins University School of Medicine, Park 307, 600 N Wolfe St, Baltimore, MD 21287, USA
Arch Pediatr Adolesc Med 156:556-60. 2002..To examine health-related quality of life (HRQL) in adolescents with polycystic ovary syndrome (PCOS), compared with healthy adolescents, and to determine whether clinically observed or self-perceived severity of illness affects their HRQL... - Adolescent bone healthKeith J Loud
Divisions of Adolescent Medicine and Sports Medicine, Children's Hospital Medical Center of Akron, Akron, Ohio, USA
Arch Pediatr Adolesc Med 160:1026-32. 2006..Finally, current recommendations regarding physical activity and nutrition, beneficial interventions for all adolescents, are presented... - Overweight status of adolescent girls with polycystic ovary syndrome: body mass index as mediator of quality of lifeMaria Trent
Division of General Pediatrics and Adolescent Medicine, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA
Ambul Pediatr 5:107-11. 2005..Clinical interventions that effectively address weight issues in adolescents with PCOS may improve overall HRQL and other obesity-related clinical outcomes... - Bone loss in children with Crohn disease: Evidence of "osteoimmune" alterationsCatherine M Gordon
J Pediatr 148:429-32. 2006 - The menstrual cycle and adolescent health. PrefaceCatherine M Gordon
Ann N Y Acad Sci 1135:xi-xii. 2008 - Clinical uses and misuses of dehydroepiandrosteroneEmanuela Binello
Harvard-MIT Division of Health Sciences and Technology, Cambridge, MA 02139, USA
Curr Opin Pharmacol 3:635-41. 2003..Research is ongoing at both the basic and the clinical level to elucidate mechanisms of action and establish efficacy and safety, as well as to expand new areas of potential application for this multi-faceted hormone...
Research Grants
- Effects of Adrenal and Gonadal HR in Young Women with ANCatherine Gordon; Fiscal Year: 2007..Specific Aim 2: To determine whether combined therapy with adrenal and gonadal steroid replacement changes bone structure to increase strength compared to placebo, as assessed through cross-sectional geometric analysis of DXA data. ..
- Effects of Adrenal and Gonadal HR in Young Women with ANCatherine M Gordon; Fiscal Year: 2010..Specific Aim 2: To determine whether combined therapy with adrenal and gonadal steroid replacement changes bone structure to increase strength compared to placebo, as assessed through cross-sectional geometric analysis of DXA data. ..