L J Goodyear

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Glucose ingestion causes GLUT4 translocation in human skeletal muscle
    L J Goodyear
    Research Division, Joslin Diabetes Center, Boston, Massachusetts 02215, USA
    Diabetes 45:1051-6. 1996
  2. ncbi request reprint Exercise, glucose transport, and insulin sensitivity
    L J Goodyear
    Research Division, Joslin Diabetes Center, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Annu Rev Med 49:235-61. 1998
  3. ncbi request reprint AMP-activated protein kinase (AMPK) is activated in muscle of subjects with type 2 diabetes during exercise
    N Musi
    Joslin Diabetes Center and Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Diabetes 50:921-7. 2001
  4. ncbi request reprint Targeted disruption of the glucose transporter 4 selectively in muscle causes insulin resistance and glucose intolerance
    A Zisman
    Research Division, Joslin Diabetes Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts 02215, USA
    Nat Med 6:924-8. 2000
  5. pmc Exercise modulates postreceptor insulin signaling and glucose transport in muscle-specific insulin receptor knockout mice
    J F Wojtaszewski
    Research Division, Joslin Diabetes Center, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Clin Invest 104:1257-64. 1999
  6. ncbi request reprint Insulin signaling and insulin sensitivity after exercise in human skeletal muscle
    J F Wojtaszewski
    Joslin Diabetes Center, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Diabetes 49:325-31. 2000
  7. pmc Altered extracellular signal-regulated kinase signaling and glycogen metabolism in skeletal muscle from p90 ribosomal S6 kinase 2 knockout mice
    S D Dufresne
    Research Division, Joslin Diabetes Center, Boston, Massachusetts 02215, USA
    Mol Cell Biol 21:81-7. 2001
  8. ncbi request reprint AMP-activated protein kinase activity and glucose uptake in rat skeletal muscle
    N Musi
    Research Division, Joslin Diabetes Center, Boston, Massachusetts 02215, USA
    Am J Physiol Endocrinol Metab 280:E677-84. 2001
  9. ncbi request reprint The muscle-specific protein phosphatase PP1G/R(GL)(G(M))is essential for activation of glycogen synthase by exercise
    W G Aschenbach
    Research Division, Joslin Diabetes Center and Harvard Medical School, Boston, MA 02215, USA
    J Biol Chem 276:39959-67. 2001
  10. ncbi request reprint Epinephrine and insulin stimulate different mitogen-activated protein kinase signaling pathways in rat skeletal muscle
    R Napoli
    Research Division, Joslin Diabetes Center, and Harvard Medical School, Boston, Massachusetts 02215, USA
    Diabetes 47:1549-54. 1998

Collaborators

Detail Information

Publications22

  1. ncbi request reprint Glucose ingestion causes GLUT4 translocation in human skeletal muscle
    L J Goodyear
    Research Division, Joslin Diabetes Center, Boston, Massachusetts 02215, USA
    Diabetes 45:1051-6. 1996
    ..These findings suggest that under physiological conditions the translocation of GLUT4 is an important mechanism for the stimulation of glucose uptake in human skeletal muscle...
  2. ncbi request reprint Exercise, glucose transport, and insulin sensitivity
    L J Goodyear
    Research Division, Joslin Diabetes Center, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Annu Rev Med 49:235-61. 1998
    ..However, there is now extensive epidemiological evidence demonstrating that long-term regular physical exercise can significantly reduce the risk of developing non-insulin-dependent diabetes mellitus...
  3. ncbi request reprint AMP-activated protein kinase (AMPK) is activated in muscle of subjects with type 2 diabetes during exercise
    N Musi
    Joslin Diabetes Center and Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Diabetes 50:921-7. 2001
    ..Pharmacological activation of AMPK may be an attractive target for the treatment of type 2 diabetes...
  4. ncbi request reprint Targeted disruption of the glucose transporter 4 selectively in muscle causes insulin resistance and glucose intolerance
    A Zisman
    Research Division, Joslin Diabetes Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts 02215, USA
    Nat Med 6:924-8. 2000
    ..These mice showed severe insulin resistance and glucose intolerance from an early age. Thus, GLUT4-mediated glucose transport in muscle is essential to the maintenance of normal glucose homeostasis...
  5. pmc Exercise modulates postreceptor insulin signaling and glucose transport in muscle-specific insulin receptor knockout mice
    J F Wojtaszewski
    Research Division, Joslin Diabetes Center, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Clin Invest 104:1257-64. 1999
    ..The synergistic activation of glucose transport with exercise plus insulin is retained in MIRKO mice, suggesting a phenomenon mediated by nonmuscle cells or by downstream signaling events...
  6. ncbi request reprint Insulin signaling and insulin sensitivity after exercise in human skeletal muscle
    J F Wojtaszewski
    Joslin Diabetes Center, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Diabetes 49:325-31. 2000
    ..Diabetes 46:1775-1781, 1997]); and 3) prior exercise increases insulin stimulation of both glucose uptake and glycogen synthase activity in the absence of an upregulation of signaling events in human skeletal muscle...
  7. pmc Altered extracellular signal-regulated kinase signaling and glycogen metabolism in skeletal muscle from p90 ribosomal S6 kinase 2 knockout mice
    S D Dufresne
    Research Division, Joslin Diabetes Center, Boston, Massachusetts 02215, USA
    Mol Cell Biol 21:81-7. 2001
    ..RSK2 knockout mice may be a good animal model for the study of Coffin-Lowry syndrome...
  8. ncbi request reprint AMP-activated protein kinase activity and glucose uptake in rat skeletal muscle
    N Musi
    Research Division, Joslin Diabetes Center, Boston, Massachusetts 02215, USA
    Am J Physiol Endocrinol Metab 280:E677-84. 2001
    ..Development of new compounds will be required to study contraction regulation of AMPK by pharmacological inhibition...
  9. ncbi request reprint The muscle-specific protein phosphatase PP1G/R(GL)(G(M))is essential for activation of glycogen synthase by exercise
    W G Aschenbach
    Research Division, Joslin Diabetes Center and Harvard Medical School, Boston, MA 02215, USA
    J Biol Chem 276:39959-67. 2001
    ....
  10. ncbi request reprint Epinephrine and insulin stimulate different mitogen-activated protein kinase signaling pathways in rat skeletal muscle
    R Napoli
    Research Division, Joslin Diabetes Center, and Harvard Medical School, Boston, Massachusetts 02215, USA
    Diabetes 47:1549-54. 1998
    ..Insulin and epinephrine have different effects on MAP kinase signaling pathways in skeletal muscle, which may be one of the underlying molecular mechanisms through which these hormones regulate opposing metabolic functions...
  11. ncbi request reprint AMP-activated protein kinase and muscle glucose uptake
    N Musi
    Research Division, Joslin Diabetes Center and Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215, USA
    Acta Physiol Scand 178:337-45. 2003
    ..The effects of AMPK on muscle glucose uptake makes this protein a promising pharmacological target for the treatment of type 2 diabetes...
  12. ncbi request reprint AMP-activated protein kinase regulation and action in skeletal muscle during exercise
    N Musi
    Research Division, Joslin Diabetes Center and Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02215, USA
    Biochem Soc Trans 31:191-5. 2003
    ..In summary, AMPK regulates several metabolic pathways during acute exercise and modifies the expression of many genes involved in the adaptive changes to exercise training...
  13. ncbi request reprint AMP-activated protein kinase: a critical signaling intermediary for exercise-stimulated glucose transport?
    L J Goodyear
    Research Division, Joslin Diabetes Center, Boston, MA 02215, USA
    Exerc Sport Sci Rev 28:113-6. 2000
    ..This brief report will discuss an emerging hypothesis that suggests that the AMP-activated protein kinase is a key signaling intermediary leading to exercise-stimulated GLUT4 translocation in skeletal muscle...
  14. ncbi request reprint Increased adenosine monophosphate-activated protein kinase activity in rat hearts with pressure-overload hypertrophy
    R Tian
    NMR Laboratory for Physiological Chemistry, Division of Cardiovascular Medicine, Joslin Diabetes Center, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Circulation 104:1664-9. 2001
    ..We hypothesized that chronic alterations in myocardial energetics in hypertrophied hearts (left ventricular hypertrophy, LVH) will lead to elevated AMPK activity, which in turn regulates substrate utilization...
  15. ncbi request reprint Static stretch increases c-Jun NH2-terminal kinase activity and p38 phosphorylation in rat skeletal muscle
    M D Boppart
    Research Division, Joslin Diabetes Center, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02215, USA
    Am J Physiol Cell Physiol 280:C352-8. 2001
    ..These studies suggest that the stretch component of a muscle contraction may be a major contributor to the increases in JNK activity and p38 phosphorylation observed after exercise in vivo...
  16. ncbi request reprint Diet and exercise in type 2 diabetes mellitus
    O Hamdy
    Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts, USA
    Endocrinol Metab Clin North Am 30:883-907. 2001
    ..Exercise programs should be designed to start slowly, build up gradually, and emphasize moderately intense exercise performed at least three times a week and preferably five to seven times a week for best results...
  17. pmc Marathon running transiently increases c-Jun NH2-terminal kinase and p38 activities in human skeletal muscle
    M D Boppart
    Research Division, Joslin Diabetes Center, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215, USA
    J Physiol 526:663-9. 2000
    ..The differential activation of the p38 isoforms with exercise in human skeletal muscle indicates that these proteins may have distinct functions in vivo...
  18. ncbi request reprint Differential effects of insulin and exercise on Rab4 distribution in rat skeletal muscle
    L A Sherman
    Joslin Diabetes Center, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02215, USA
    Endocrinology 137:266-73. 1996
    ..Although both insulin and exercise increase skeletal muscle glucose uptake by the translocation of GLUT4, the regulation of translocation may occur by different mechanisms...
  19. ncbi request reprint A muscle-specific insulin receptor knockout exhibits features of the metabolic syndrome of NIDDM without altering glucose tolerance
    J C Bruning
    Joslin Diabetes Center, Department of Medicine, Harvard Medical School, Boston, Massachusetts 02215, USA
    Mol Cell 2:559-69. 1998
    ..Thus, insulin resistance in muscle contributes to the altered fat metabolism associated with type 2 diabetes, but tissues other than muscle appear to be more involved in insulin-regulated glucose disposal than previously recognized...
  20. doi request reprint AMP-activated protein kinase in skeletal muscle: from structure and localization to its role as a master regulator of cellular metabolism
    C A Witczak
    Metabolism Section, Joslin Diabetes Center, Research Division, 1 Joslin Pl, Boston, MA 02215, USA
    Cell Mol Life Sci 65:3737-55. 2008
    ....
  21. pmc JNK1 deficiency does not enhance muscle glucose metabolism in lean mice
    C A Witczak
    Research Division, Joslin Diabetes Center, Department of Medicine, Brigham and Women s Hospital, and Harvard Medical School, Boston, MA 02215, USA
    Biochem Biophys Res Commun 350:1063-8. 2006
    ..This study is the first to directly demonstrate that enhanced skeletal muscle glucose metabolism does not underlie the beneficial effects of JNK1 deficiency in lean mice...
  22. pmc Insulin stimulation regulates AS160 and TBC1D1 phosphorylation sites in human skeletal muscle
    R J W Middelbeek
    Section on Integrative Physiology and Metabolism, Joslin Diabetes Center, Boston, MA, USA
    Nutr Diabetes 3:e74. 2013
    ....