Affiliation: Harvard University
Shrestha B, Chia C, Wu L, Kujawa S, Liberman M, Goodrich L. Sensory Neuron Diversity in the Inner Ear Is Shaped by Activity. Cell. 2018;174:1229-1246.e17 pubmed publisher
..These results elucidate the range, nature, and origins of SGN diversity, with implications for treatment of congenital deafness. ..
Goodrich L, Strutt D. Principles of planar polarity in animal development. Development. 2011;138:1877-92 pubmed publisher
..Here, we review the molecular mechanisms and cellular consequences of planar polarisation in diverse contexts, seeking to identify the common principles across the animal kingdom. ..
Yung A, Druckenbrod N, Cloutier J, Wu Z, Tessier Lavigne M, Goodrich L. Netrin-1 Confines Rhombic Lip-Derived Neurons to the CNS. Cell Rep. 2018;22:1666-1680 pubmed publisher
..We propose that Ntn1 confines rhombic lip-derived neurons by providing a preferred substrate for tangentially migrating neurons in the SPR, preventing their entry into nerve roots. ..
Yung A, Nishitani A, Goodrich L. Phenotypic analysis of mice completely lacking netrin 1. Development. 2015;142:3686-91 pubmed publisher
Druckenbrod N, Goodrich L. Sequential Retraction Segregates SGN Processes during Target Selection in the Cochlea. J Neurosci. 2015;35:16221-35 pubmed publisher
Krol A, Henle S, Goodrich L. Fat3 and Ena/VASP proteins influence the emergence of asymmetric cell morphology in the developing retina. Development. 2016;143:2172-82 pubmed publisher
..Thus, Fat-like proteins might control the polarized development of tissues by sculpting the cytoskeleton of individual cells. ..
Avilés E, Goodrich L. Configuring a robust nervous system with Fat cadherins. Semin Cell Dev Biol. 2017;69:91-101 pubmed publisher
..As we learn more about their biological functions and molecular properties, increasing evidence suggests that Fat cadherins mediate contact-induced changes that ultimately impose a structure to developing neuronal circuits. ..
Nishitani A, Ohta S, Yung A, Del Rio T, Gordon M, Abraira V, et al
. Distinct functions for netrin 1 in chicken and murine semicircular canal morphogenesis. Development. 2017;144:3349-3360 pubmed publisher
..These findings highlight the importance of apoptosis for tissue morphogenesis and suggest that Ntn1 may play divergent cellular roles despite its conserved expression during canal morphogenesis in chicken and mouse. ..