Jill Goldstein

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Sex differences in prefrontal cortical brain activity during fMRI of auditory verbal working memory
    Jill M Goldstein
    Department of Psychiatry, Harvard Medical School, Boston, MA 02120, USA
    Neuropsychology 19:509-19. 2005
  2. pmc Disruption of fetal hormonal programming (prenatal stress) implicates shared risk for sex differences in depression and cardiovascular disease
    J M Goldstein
    Departments of Psychiatry and Medicine, Harvard Medical School, Boston, MA, USA Brigham and Women s Hospital BWH, Connors Center for Women s Health and Gender Biology, 1620 Tremont St BC 3 34, Boston, MA 02120, USA BWH, Departments of Psychiatry and Medicine, 1620 Tremont St BC 3 34, Boston, MA 02120, USA Electronic address
    Front Neuroendocrinol 35:140-58. 2014
  3. pmc Sex differences in the neurobiology of fear conditioning and extinction: a preliminary fMRI study of shared sex differences with stress-arousal circuitry
    Kelimer Lebron-Milad
    Department of Psychiatry, Harvard Medical School and Massachusetts General Hospital, 149 13th St, Charlestown, MA, 02129, USA
    Biol Mood Anxiety Disord 2:7. 2012
  4. ncbi request reprint Hormonal cycle modulates arousal circuitry in women using functional magnetic resonance imaging
    Jill M Goldstein
    Department of Psychiatry, Harvard Medical School, Brigham and Women s Hospital, Connors Center for Women s Health and Gender Biology, Boston, Massachusetts 02115, USA
    J Neurosci 25:9309-16. 2005
  5. ncbi request reprint Cortical abnormalities in schizophrenia identified by structural magnetic resonance imaging
    J M Goldstein
    Department of Psychiatry, Institute of Psychiatric Epidemiology and Genetics, Massachusetts Mental Health Center, Boston 02115, USA
    Arch Gen Psychiatry 56:537-47. 1999
  6. ncbi request reprint Sex, hormones and affective arousal circuitry dysfunction in schizophrenia
    Jill M Goldstein
    Harvard Medical School, Department of Psychiatry, Brigham and Women s Hospital, Boston, MA 02120, USA
    Horm Behav 50:612-22. 2006
  7. ncbi request reprint Hypothalamic abnormalities in schizophrenia: sex effects and genetic vulnerability
    Jill M Goldstein
    Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA
    Biol Psychiatry 61:935-45. 2007
  8. pmc Sex differences in stress response circuitry activation dependent on female hormonal cycle
    Jill M Goldstein
    Department of Psychiatry, and Connors Center for Women s Health and Gender Biology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02120, USA
    J Neurosci 30:431-8. 2010
  9. pmc Specificity of familial transmission of schizophrenia psychosis spectrum and affective psychoses in the New England family study's high-risk design
    Jill M Goldstein
    Division of Women s Health, Mary Horrigan Connors Center for Women s Health and Gender Biology, and Department of Psychiatry, Brigham and Women s Hospital, Boston, Massachusetts 02120, USA
    Arch Gen Psychiatry 67:458-67. 2010
  10. pmc Sex-specific rates of transmission of psychosis in the New England high-risk family study
    Jill M Goldstein
    Brigham and Women s Hospital Departments of Psychiatry and Medicine, Division of Women s Health, Connors Center for Women s Health and Gender Biology, Boston, MA 02120, USA
    Schizophr Res 128:150-5. 2011

Detail Information

Publications37

  1. ncbi request reprint Sex differences in prefrontal cortical brain activity during fMRI of auditory verbal working memory
    Jill M Goldstein
    Department of Psychiatry, Harvard Medical School, Boston, MA 02120, USA
    Neuropsychology 19:509-19. 2005
    ..The findings suggest that combining men and women in fMRI studies of cognition may obscure or bias results...
  2. pmc Disruption of fetal hormonal programming (prenatal stress) implicates shared risk for sex differences in depression and cardiovascular disease
    J M Goldstein
    Departments of Psychiatry and Medicine, Harvard Medical School, Boston, MA, USA Brigham and Women s Hospital BWH, Connors Center for Women s Health and Gender Biology, 1620 Tremont St BC 3 34, Boston, MA 02120, USA BWH, Departments of Psychiatry and Medicine, 1620 Tremont St BC 3 34, Boston, MA 02120, USA Electronic address
    Front Neuroendocrinol 35:140-58. 2014
    ..Understanding the potential fetal origins of these sex differences will contribute to development of novel sex-dependent therapeutics. ..
  3. pmc Sex differences in the neurobiology of fear conditioning and extinction: a preliminary fMRI study of shared sex differences with stress-arousal circuitry
    Kelimer Lebron-Milad
    Department of Psychiatry, Harvard Medical School and Massachusetts General Hospital, 149 13th St, Charlestown, MA, 02129, USA
    Biol Mood Anxiety Disord 2:7. 2012
    ..abstract:..
  4. ncbi request reprint Hormonal cycle modulates arousal circuitry in women using functional magnetic resonance imaging
    Jill M Goldstein
    Department of Psychiatry, Harvard Medical School, Brigham and Women s Hospital, Connors Center for Women s Health and Gender Biology, Boston, Massachusetts 02115, USA
    J Neurosci 25:9309-16. 2005
    ..Findings have important implications for normal sex-specific physiological functioning and may contribute to understanding higher rates of mood and anxiety disorders in women and differential sensitivity to trauma than men...
  5. ncbi request reprint Cortical abnormalities in schizophrenia identified by structural magnetic resonance imaging
    J M Goldstein
    Department of Psychiatry, Institute of Psychiatric Epidemiology and Genetics, Massachusetts Mental Health Center, Boston 02115, USA
    Arch Gen Psychiatry 56:537-47. 1999
    ..We hypothesized, based on previous empirical and theoretical work, that dorsolateral prefrontal and paralimbic cortices would be significantly volumetrically reduced in patients with schizophrenia compared with normal controls...
  6. ncbi request reprint Sex, hormones and affective arousal circuitry dysfunction in schizophrenia
    Jill M Goldstein
    Harvard Medical School, Department of Psychiatry, Brigham and Women s Hospital, Boston, MA 02120, USA
    Horm Behav 50:612-22. 2006
    ..Studying the links between deficits in neuroendocrine systems and the affective arousal system in schizophrenia will provide clues to understanding the development of sex differences in schizophrenia and thereby its etiology...
  7. ncbi request reprint Hypothalamic abnormalities in schizophrenia: sex effects and genetic vulnerability
    Jill M Goldstein
    Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA
    Biol Psychiatry 61:935-45. 2007
    ..We tested the hypothesis that normal hypothalamic sexual dimorphism is disrupted in schizophrenia...
  8. pmc Sex differences in stress response circuitry activation dependent on female hormonal cycle
    Jill M Goldstein
    Department of Psychiatry, and Connors Center for Women s Health and Gender Biology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02120, USA
    J Neurosci 30:431-8. 2010
    ....
  9. pmc Specificity of familial transmission of schizophrenia psychosis spectrum and affective psychoses in the New England family study's high-risk design
    Jill M Goldstein
    Division of Women s Health, Mary Horrigan Connors Center for Women s Health and Gender Biology, and Department of Psychiatry, Brigham and Women s Hospital, Boston, Massachusetts 02120, USA
    Arch Gen Psychiatry 67:458-67. 2010
    ..However, few studies have investigated the specificity of the transmission of schizophrenia-psychosis spectrum (SPS) disorders and affective psychoses (APs) or observed high-risk offspring into mid-adulthood...
  10. pmc Sex-specific rates of transmission of psychosis in the New England high-risk family study
    Jill M Goldstein
    Brigham and Women s Hospital Departments of Psychiatry and Medicine, Division of Women s Health, Connors Center for Women s Health and Gender Biology, Boston, MA 02120, USA
    Schizophr Res 128:150-5. 2011
    ..This has important implications for molecular genetic studies of psychoses underscoring the impact of one's gender on gene-brain-behavior phenotypes of SCZ...
  11. ncbi request reprint Sex differences in clinical response to olanzapine compared with haloperidol
    Jill M Goldstein
    Harvard Institute of Psychiatric Epidemiology and Genetics, Department of Psychiatry, Harvard Medical School at Massachusetts Mental Health Center, MMHC, Boston, MA 02115, USA
    Psychiatry Res 110:27-37. 2002
    ..Finally, premenopausal women had a significantly better treatment response than postmenopausal women, regardless of treatment and chronicity...
  12. ncbi request reprint Impact of genetic vulnerability and hypoxia on overall intelligence by age 7 in offspring at high risk for schizophrenia compared with affective psychoses
    J M Goldstein
    Department of Psychiatry at Massachusetts Mental Health Center, Boston 02115, USA
    Schizophr Bull 26:323-34. 2000
    ..Specificity of the effects for schizophrenia compared with affective psychoses and sex effects were also tested. Low IQ at age 7 was significantly associated with genetic vulnerability to psychoses, in particular with schizophrenia...
  13. ncbi request reprint Normal sexual dimorphism of the adult human brain assessed by in vivo magnetic resonance imaging
    J M Goldstein
    Harvard Medical School Department of Psychiatry at Massachusetts Mental Health Center, Boston, MA 02115, USA
    Cereb Cortex 11:490-7. 2001
    ..These findings have implications for developmental studies that would directly test hypotheses about mechanisms relating sex steroid hormones to sexual dimorphisms in humans...
  14. ncbi request reprint Impact of normal sexual dimorphisms on sex differences in structural brain abnormalities in schizophrenia assessed by magnetic resonance imaging
    Jill M Goldstein
    Massachusetts Mental Health Center, Harvard Institute of Psychiatric Epidemiology and Genetics, 74 Fenwood Rd, Boston, MA 02115, USA
    Arch Gen Psychiatry 59:154-64. 2002
    ....
  15. ncbi request reprint Structural brain abnormalities among relatives of patients with schizophrenia: implications for linkage studies
    Stephen V Faraone
    Harvard Medical School Department of Psychiatry at the Massachusetts Mental Health Center, Boston, MA, USA
    Schizophr Res 60:125-40. 2003
    ....
  16. pmc Statistical analysis of fiber bundles using multi-tensor tractography: application to first-episode schizophrenia
    Yogesh Rathi
    Department of Psychiatry, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Magn Reson Imaging 29:507-15. 2011
    ..Thus, the changes affecting first-episode patients seem to be global in nature (spread throughout the brain)...
  17. pmc Neuroanatomic substrates of sex differences in language dysfunction in schizophrenia: a pilot study
    Deborah J Walder
    Psychiatric Neuroscience Division, Harvard Medical School Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02120, USA
    Schizophr Res 90:295-301. 2007
    ....
  18. pmc Children of parents with affective and nonaffective psychoses: a longitudinal study of behavior problems
    Jo Ann L Donatelli
    Department of Psychiatry, Community Health, Brown University, Providence, RI 02903, USA
    Am J Psychiatry 167:1331-8. 2010
    ..g., schizophrenia, other nonaffective psychoses, and affective psychoses) have distinct forms of behavioral problems (i.e., internalizing and externalizing)...
  19. ncbi request reprint Automatically parcellating the human cerebral cortex
    Bruce Fischl
    Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, MGH MIT Harvard Medical School, Massachusetts General Hospital, 13th Street, Charlestown, MA 02129, USA
    Cereb Cortex 14:11-22. 2004
    ..Examples are given from two different training sets generated using different neuroanatomical conventions, illustrating the flexibility of the algorithm. The technique is shown to be comparable in accuracy to manual labeling...
  20. ncbi request reprint A comparative profile analysis of neuropsychological functioning in patients with schizophrenia and bipolar psychoses
    Larry J Seidman
    Harvard Medical School Department of Psychiatry at Massachusetts Mental Health Center, and Harvard Institute of Psychiatric Epidemiology and Genetics, 74 Fenwood Road, Boston, MA 02115, USA
    Schizophr Res 53:31-44. 2002
    ..Further research is required to determine whether similar mechanisms underly the neurocognitive deficits in these disorders...
  21. pmc An fMRI study of working memory in persons with bipolar disorder or at genetic risk for bipolar disorder
    Heidi W Thermenos
    Department of Psychiatry, Harvard Medical School, Massachusetts Mental Health Center Division of Public Psychiatry, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    Am J Med Genet B Neuropsychiatr Genet 153:120-31. 2010
    ..Persons with BD and RELs exhibit altered activity in the frontopolar cortex and insula, which may represent biomarkers of genetic risk for BD...
  22. ncbi request reprint Auditory verbal working memory load and thalamic activation in nonpsychotic relatives of persons with schizophrenia: an fMRI replication
    Larry J Seidman
    Division of Public Psychiatry, Harvard Medical School Massachusetts Mental Health Center, Beth Israel Deaconess Medical Center, MA 02215, USA
    Neuropsychology 21:599-610. 2007
    ..This replication suggests that altered thalamic activation is a feature of neurobiological risk for schizophrenia...
  23. ncbi request reprint A review and new report of medial temporal lobe dysfunction as a vulnerability indicator for schizophrenia: a magnetic resonance imaging morphometric family study of the parahippocampal gyrus
    Larry J Seidman
    Commonwealth Research Center, Harvard Medical School, Department of Psychiatry, Massachusetts Mental Health Center, Boston, MA, USA
    Schizophr Bull 29:803-30. 2003
    ..Implications of genetic risk studies for prodromal research are discussed...
  24. ncbi request reprint Antipsychotic medication, prolactin elevation, and ovarian function in women with schizophrenia and schizoaffective disorder
    Carla M Canuso
    Commonwealth Research Center, Boston, MA 02115, USA
    Psychiatry Res 111:11-20. 2002
    ....
  25. ncbi request reprint The retrospective measurement of prenatal and perinatal events: accuracy of maternal recall
    Stephen L Buka
    Department of Epidemiology, Human Development and Health, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
    Schizophr Res 71:417-26. 2004
    ....
  26. ncbi request reprint The effect of working memory performance on functional MRI in schizophrenia
    Heidi W Thermenos
    Harvard Medical School, Department of Psychiatry, Massachusetts Mental Health Center, Boston, MA 02115, USA
    Schizophr Res 74:179-94. 2005
    ..We report functional magnetic resonance imaging (fMRI) data comparing subjects with schizophrenia and healthy controls performing a 2-back working memory (WM) task, addressing the effects of task performance...
  27. ncbi request reprint Decreased volume of left and total anterior insular lobule in schizophrenia
    Nikos Makris
    Athinoula A Martinos Center, Harvard Medical School Department of Neurology, Massachusetts General Hospital, Boston, MA 02129, United States
    Schizophr Res 83:155-71. 2006
    ....
  28. ncbi request reprint Left hippocampal volume as a vulnerability indicator for schizophrenia: a magnetic resonance imaging morphometric study of nonpsychotic first-degree relatives
    Larry J Seidman
    Neuropsychology Laboratory, Massachusetts Mental Health Center, 74 Fenwood Rd, Boston, MA 02115, USA
    Arch Gen Psychiatry 59:839-49. 2002
    ....
  29. ncbi request reprint Intellectual decline in schizophrenia: evidence from a prospective birth cohort 28 year follow-up study
    Larry J Seidman
    Department of Psychiatry at Massachusetts Mental Health Center, Harvard Medical School, Boston, USA
    J Clin Exp Neuropsychol 28:225-42. 2006
    ..Future research on this sample will evaluate the prospective roles of family history and perinatal complications on cognition, and assess the specificity of these findings...
  30. ncbi request reprint Sex differences in language dysfunction in schizophrenia
    Deborah J Walder
    Department of Psychiatry, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Am J Psychiatry 163:470-7. 2006
    ..The current study investigated this issue in the domains of phonology, semantics, and grammar, which have been closely linked with neuroanatomic regions for which sex differences have been identified...
  31. ncbi request reprint Fear conditioning and extinction: influence of sex and menstrual cycle in healthy humans
    Mohammed R Milad
    Department of Psychiatry, Massachusetts General Hospital Harvard Medical School, Boston, MA, USA
    Behav Neurosci 120:1196-203. 2006
    ..On Day 2, men and early cycle women expressed greater extinction memory than midcycle women. These data confirm sex differences in conditioned fear acquisition and suggest that midcycle hormones attenuate extinction recall...
  32. ncbi request reprint Gender and trauma as predictors of military attrition: a study of Marine Corps recruits
    Jessica Wolfe
    National Center for PTSD, VA Boston Healthcare System, Boston, MA 02130, USA
    Mil Med 170:1037-43. 2005
    ..These findings suggest that developing interventions to bolster recruits' coping skills may improve adaptation to the recruit training environment and thus decrease attrition...
  33. pmc Biomarkers for identifying first-episode schizophrenia patients using diffusion weighted imaging
    Yogesh Rathi
    Harvard Medical School, Boston, USA
    Med Image Comput Comput Assist Interv 13:657-65. 2010
    ..Classification results using leave-many-out cross-validation scheme are given for each representation. This algorithm is a first step towards early detection of schizophrenia...
  34. pmc Prenatal exposure to lead, delta-aminolevulinic acid, and schizophrenia: further evidence
    Mark G A Opler
    Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    Environ Health Perspect 116:1586-90. 2008
    ....
  35. ncbi request reprint Decreased absolute amygdala volume in cocaine addicts
    Nikos Makris
    Motivation and Emotion Neuroscience Collaboration, Department of Radiology, Harvard Medical School, Boston, MA 02129, USA
    Neuron 44:729-40. 2004
    ..These findings argue for a condition that predisposes the individual to cocaine dependence by affecting the amygdala, or a primary event early in the course of cocaine use...
  36. ncbi request reprint Functional magnetic resonance imaging during auditory verbal working memory in nonpsychotic relatives of persons with schizophrenia: a pilot study
    Heidi W Thermenos
    Department of Psychology and Brain Research Institute RP, University of California, Los Angeles, Los Angeles, California, USA
    Biol Psychiatry 55:490-500. 2004
    ....
  37. ncbi request reprint Adjustment for whole brain and cranial size in volumetric brain studies: a review of common adjustment factors and statistical methods
    Liam M O'Brien
    Colby College
    Harv Rev Psychiatry 14:141-51. 2006
    ..These issues come into play in logically framing the assessment of putative abnormalities in regional brain volumes...

Research Grants27

  1. Fetal Antecedents to Depression and Risk for CVD
    Jill Goldstein; Fiscal Year: 2009
    ..Findings will have important implications for understanding the etiology of MOD and CVD co-morbidity and the potential development of hormonal or immunoregulatory interventions to prevent them during fetal development. ..
  2. Gender and Brain Abnormalities in Schizophrenia
    Jill Goldstein; Fiscal Year: 2009
    ....
  3. Fetal Antecedents to Depression and Risk for CVD
    Jill M Goldstein; Fiscal Year: 2010
    ..Findings will have important implications for understanding the etiology of MOD and CVD co-morbidity and the potential development of hormonal or immunoregulatory interventions to prevent them during fetal development. ..
  4. Gender and Brain Abnormalities in Schizophrenia
    Jill M Goldstein; Fiscal Year: 2010
    ....
  5. Fetal Antecedents to Sex Differences in Depression: A Translational Approach
    Jill Goldstein; Fiscal Year: 2007
    ....
  6. Hormones/Genes in Women's Health: From Bench to Bedside
    Jill Goldstein; Fiscal Year: 2007
    ..abstract_text> ..
  7. Gender and Brain Abnormalities in Schizophrenia
    Jill Goldstein; Fiscal Year: 2007
    ....
  8. SEX AND STRUCTURAL BRAIN ABNORMALITIES IN SCHIZOPHRENIA
    Jill Goldstein; Fiscal Year: 1999
    ..Findings will contribute to understanding whether sex has an etiologic role in the development of schizophrenia. ..
  9. SEX & STRUCTURAL BRAIN ABNORMALITIES IN SCHIZOPHRENIA II
    Jill Goldstein; Fiscal Year: 2000
    ....
  10. SEX & STRUCTURAL BRAIN ABNORMALITIES IN SCHIZOPHRENIA II
    Jill Goldstein; Fiscal Year: 2001
    ....
  11. SEX & STRUCTURAL BRAIN ABNORMALITIES IN SCHIZOPHRENIA II
    Jill Goldstein; Fiscal Year: 2002
    ....
  12. SEX & STRUCTURAL BRAIN ABNORMALITIES IN SCHIZOPHRENIA II
    Jill Goldstein; Fiscal Year: 2003
    ....
  13. NEURODEVELOPMENTAL STUDY OF SCHIZOPHRENIA--PHASE III
    Jill Goldstein; Fiscal Year: 2003
    ..e., in limbic-diencephalic, paralimbic and cortical regions, and white matter tracts). This study has important implications for understand2ing the etiology and development of schizophrenia. ..
  14. Gender and Brain Abnormalities in Schizophrenia
    Jill Goldstein; Fiscal Year: 2004
    ....
  15. Gender and Brain Abnormalities in Schizophrenia
    Jill Goldstein; Fiscal Year: 2006
    ....
  16. Gender and Brain Abnormalities in Schizophrenia
    Jill Goldstein; Fiscal Year: 2004
    ....
  17. Fetal Antecedents to Depression and Risk for CVD
    Jill Goldstein; Fiscal Year: 2007
    ..Findings will have important implications for understanding the etiology of MOD and CVD co-morbidity and the potential development of hormonal or immunoregulatory interventions to prevent them during fetal development. ..
  18. Gender and Brain Abnormalities in Schizophrenia
    Jill M Goldstein; Fiscal Year: 2009
    ....