Affiliation: Harvard University
- The role played by cell-substrate interactions in the pathogenesis of osteoclast-mediated peri-implant osteolysisZhenxin Shen
New England Baptist Bone and Joint Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
Arthritis Res Ther 8:R70. 2006..We speculate that, in addition to the role of cytokines and growth factors, the substrate with which these cells interact plays a critical role in their differential phenotypic and functional properties...
- The role of bone in osteoarthritis pathogenesisSteven R Goldring
The Hospital for Special Surgery, Weill Medical College of Cornell University, 535 East 70th Street, New York, NY 10021, USA
Rheum Dis Clin North Am 34:561-71. 2008..In addition, the relationship of these changes to the alterations in articular cartilage and the other tissues comprising the diarthrodial joint are reviewed...
- NFATc1 regulation of the human beta3 integrin promoter in osteoclast differentiationTania N Crotti
Beth Israel Deaconess Medical Center, Boston, MA 02115, USA
Gene 372:92-102. 2006..Together these results establish the beta3 gene as a direct target of NFATc1 in RANKL-dependent osteoclast formation...
- Rheumatic diseases: the effects of inflammation on boneNicole C Walsh
Beth Israel Deaconess Medical Center, New England Baptist Bone and Joint Institute, Harvard Institutes of Medicine, Boston, MA 02115, USA
Immunol Rev 208:228-51. 2005..In this review, we provide an overview of the cell types, inflammatory mediators, and mechanisms that are implicated in bone loss and new bone formation in inflammatory joint diseases...
- Bisphosphonates: environmental protection for the joint?Steven R Goldring
Arthritis Rheum 50:2044-7. 2004
- A novel promoter regulates calcitonin receptor gene expression in human osteoclastsZhenxin Shen
New England Baptist Bone and Joint Institute, Boston, MA 02120, USA
Biochim Biophys Acta 1769:659-67. 2007....
- Amylin inhibits bone resorption while the calcitonin receptor controls bone formation in vivoRomain Dacquin
Department of Molecular and Human Genetics and Bone Disease Program of Texas, Baylor College of Medicine, One Baylor Plaza, Room S921, Houston, TX 77030, USA
J Cell Biol 164:509-14. 2004..Thus, amylin is a physiological regulator of bone resorption that acts through an unidentified receptor...
- ESE-1 is a novel transcriptional mediator of angiopoietin-1 expression in the setting of inflammationCourtney Brown
Beth Israel Deaconess Medical Center, Department of Medicine, New England Baptist Bone and Joint Institute, Harvard Institutes of Medicine, 4 Blackfan Circle, Boston, MA 02115, USA
J Biol Chem 279:12794-803. 2004..Our results support a novel paradigm for the ETS factor ESE-1 as a transcriptional mediator of angiogenesis in the setting of inflammation...
- Responses to the proinflammatory cytokines interleukin-1 and tumor necrosis factor alpha in cells derived from rheumatoid synovium and other joint tissues involve nuclear factor kappaB-mediated induction of the Ets transcription factor ESE-1Franck Grall
New England Baptist Bone and Joint Institute, Beth Israel Deaconess Medical Center and Harvard Medical School, and Beth Israel Deaconess Medical Center Genomics Center, Boston, Massachusetts 02115, USA
Arthritis Rheum 48:1249-60. 2003....
- PU.1 and NFATc1 mediate osteoclastic induction of the mouse beta3 integrin promoterTania N Crotti
The New England Baptist Bone and Joint Institute, Department of Rheumatology, Beth Israel Deaconess Medical Center, and Harvard Medical School, Boston, Massachusetts 02115, USA
J Cell Physiol 215:636-44. 2008..1, are involved in regulation of beta(3) integrin expression during osteoclast differentiation and suggest that PU.1 confers specificity to the NFATc1 response to macrophage lineage cells...
- Increase in expression of receptor activator of nuclear factor kappaB at sites of bone erosion correlates with progression of inflammation in evolving collagen-induced arthritisErik Lubberts
University Medical Center Nijmegen, Nijmegen, The Netherlands
Arthritis Rheum 46:3055-64. 2002..This study was undertaken to identify in vivo the hitherto-unknown origin and localization of RANK-expressing osteoclast precursor cells at sites of bone erosion in arthritis...
- Bone and joint destruction in rheumatoid arthritis: what is really happening?Steven R Goldring
Harvard Medical School, New England Baptist Bone and Joint Institute, Boston, Massachusetts 02215, USA
J Rheumatol Suppl 65:44-8. 2002..These observations suggest that osteoclasts mediate focal bone erosions in RA and that targeting of osteoclasts and osteoclast mediated bone resorption represents a rational approach to preventing or reducing focal bone loss in RA...
- Comparison of cathepsins K and S expression within the rheumatoid and osteoarthritic synoviumWu Shiun Hou
Mount Sinai School of Medicine, New York, New York 10029, USA
Arthritis Rheum 46:663-74. 2002....
- Pathogenesis of bone lesions in rheumatoid arthritisSteven R Goldring
Harvard Institutes of Medicine, Room 241, 4 Blackfan Circle, Boston, MA 02115, USA
Curr Rheumatol Rep 4:226-31. 2002....
- Pathogenesis of bone erosions in rheumatoid arthritisSteven R Goldring
Beth Israel Deaconess Medical Center, Harvard Medical School, and New England Baptist Bone and Joint Institute, Harvard Institutes of Medicine, Boston, Massachusetts 02115, USA
Curr Opin Rheumatol 14:406-10. 2002..These findings provide a rational framework for developing targeted therapies that can specifically inhibit or slow the progressive focal bone destruction associated with the rheumatoid synovial lesion...
- Relationship between cartilage stiffness and dGEMRIC index: correlation and predictionMarta Baldassarri
New England Baptist Bone and Joint Institute, Boston, Massachusetts, USA
J Orthop Res 25:904-12. 2007..A generalized relationship was found to provide good correspondence across sources and regions. Use of the dGEMRIC index as a predictive measure of stiffness is possible, depending on the application's acceptable error...
- OsteoarthritisMary B Goldring
Laboratory for Cartilage Biology, Research Division, The Hospital for Special Surgery, Weill College of Medicine of Cornell University, New York 10021, USA
J Cell Physiol 213:626-34. 2007....
- Eating bone or adding it: the Wnt pathway decidesSteven R Goldring
Nat Med 13:133-4. 2007
- Novel dexamethasone-HPMA copolymer conjugate and its potential application in treatment of rheumatoid arthritisDong Wang
Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, Omaha, NE 68198 6025, USA
Arthritis Res Ther 9:R2. 2007..This newly developed drug delivery system provides a unique method for selective targeting of glucocorticoids to inflamed joints which may potentially reduce systemic side effects...
- The Ets transcription factor ESE-1 mediates induction of the COX-2 gene by LPS in monocytesFranck T Grall
New England Baptist Bone and Joint Institute and BIDMC Genomics Center, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02115, USA
FEBS J 272:1676-87. 2005....
- Gene expression clustering using self-organizing maps: analysis of the macrophage response to particulate biomaterialsGrant E Garrigues
Biomaterials Laboratory, Massachusetts General Hospital, Harvard Medical School, GRJ 1115, 55 Fruit Street, Boston, MA 02114, USA
Biomaterials 26:2933-45. 2005..We also uncovered a novel set of genes, which not only validates and logically extends the current model of the pathogenesis of osteolysis and aseptic loosening, but also provides new targets for further research and therapeutics...
- MEK/ERK and signal transducer and activator of transcription signaling pathways modulate oncostatin M-stimulated CCL2 expression in human osteoblasts through a common transcription factorSze Kwan Lin
National Taiwan University Hospital, Taipei, Taiwan
Arthritis Rheum 50:785-93. 2004..To analyze the effects of oncostatin M (OSM), a gp130-type cytokine, on CCL2 expression in MG-63 cells, a human osteosarcoma cell line with a characteristic osteoblastic phenotype, and to investigate the signaling pathway involved...
- Nitric oxide promotes infectious bone resorption by enhancing cytokine-stimulated interstitial collagenase synthesis in osteoblastsSze Kwan Lin
Department of Dentistry, National Taiwan University Hospital, Taipei, Taiwan
J Bone Miner Res 18:39-46. 2003..These data suggest that NO derived from macrophages after LPS stimulation may enhance bone loss by augmenting the cytokine-induced MMP-1 production in osteoblasts...
- Microscopic metallic wear and tissue response in failed titanium hallux metatarsophalangeal implants: two casesNavid Ghalambor
The Hand Care Center, Orange, California, USA
Foot Ankle Int 23:158-62. 2002....
- CALCITONIN RECEPTOR GENE EXPRESSIONSteven Goldring; Fiscal Year: 2002..g. kidney). This will define the structural basis of CTR gene regulation and permit identification of potentially unique factors that regulate the CTR. ..
- CELLULAR RESPONSES TO INORGANIC PARTICULATESSteven Goldring; Fiscal Year: 2003..In addition, definition of the specific physical-chemical properties responsible for cell activation could lead to the introduction of materials that generate wear debris with reduced pro-inflammatory properties. ..