Allison Goldfine

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi Rapid identification of myocardial infarction risk associated with diabetes medications using electronic medical records
    John S Brownstein
    Children s Hospital Informatics Program at the Harvard MIT Division of Health Sciences and Technology, Boston, Massachusetts, USA
    Diabetes Care 33:526-31. 2010
  2. ncbi Therapeutic approaches to target inflammation in type 2 diabetes
    Allison B Goldfine
    Joslin Diabetes Center, Harvard Medical School, Boston, MA 02115, USA
    Clin Chem 57:162-7. 2011
  3. ncbi Modulation of β-cell function: a translational journey from the bench to the bedside
    A B Goldfine
    Section of Clinical Research, Joslin Diabetes Center, Boston, MA 02215, USA
    Diabetes Obes Metab 14:152-60. 2012
  4. ncbi Patients with neuroglycopenia after gastric bypass surgery have exaggerated incretin and insulin secretory responses to a mixed meal
    A B Goldfine
    Joslin Diabetes Center, One Joslin Place, Boston, Massachusetts 02215, USA
    J Clin Endocrinol Metab 92:4678-85. 2007
  5. ncbi Necdin and E2F4 are modulated by rosiglitazone therapy in diabetic human adipose and muscle tissue
    Allison B Goldfine
    Research Division, Joslin Diabetes Center, One Joslin Place, Boston, MA 02215, USA
    Diabetes 55:640-50. 2006
  6. ncbi Biomarkers in fasting serum to estimate glucose tolerance, insulin sensitivity, and insulin secretion
    Allison B Goldfine
    Joslin Diabetes Center, One Joslin Place, Boston, MA 02215, USA
    Clin Chem 57:326-37. 2011
  7. ncbi Exogenous insulin enhances glucose-stimulated insulin response in healthy humans independent of changes in free fatty acids
    Ximena Lopez
    Joslin Diabetes Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Clin Endocrinol Metab 96:3811-21. 2011
  8. ncbi Insulin augmentation of glucose-stimulated insulin secretion is impaired in insulin-resistant humans
    Florencia Halperin
    1Joslin Diabetes Center, Boston, Massachusetts, USA
    Diabetes 61:301-9. 2012
  9. ncbi Long-term Safety and Tolerability of Colesevelam HCl in Subjects with Type 2 Diabetes
    A B Goldfine
    Harvard Medical School, Joslin Diabetes Center, One Joslin Place, Boston, MA 02115, USA
    Horm Metab Res 42:23-30. 2010
  10. ncbi Family history of diabetes is a major determinant of endothelial function
    Allison B Goldfine
    Joslin Diabetes Center, Boston, Massachusetts 02215, USA
    J Am Coll Cardiol 47:2456-61. 2006

Research Grants

  1. Role of Insulin Regulation of Beta Cell Function in Vivo and in Vitro
    Allison Goldfine; Fiscal Year: 2007
  2. PHYSIOLOGY AND MOLECULAR DETERMINANTS OF DIABETES
    Allison Goldfine; Fiscal Year: 2004

Detail Information

Publications50

  1. ncbi Rapid identification of myocardial infarction risk associated with diabetes medications using electronic medical records
    John S Brownstein
    Children s Hospital Informatics Program at the Harvard MIT Division of Health Sciences and Technology, Boston, Massachusetts, USA
    Diabetes Care 33:526-31. 2010
    ..Our use of usual care electronic data sources from a large hospital network represents an innovative approach to rapid safety signal detection that may enable more effective postmarketing drug surveillance...
  2. ncbi Therapeutic approaches to target inflammation in type 2 diabetes
    Allison B Goldfine
    Joslin Diabetes Center, Harvard Medical School, Boston, MA 02115, USA
    Clin Chem 57:162-7. 2011
    ..Chronic inflammation may participate in the pathogenesis of insulin resistance, type 2 diabetes, and cardiovascular disease and may be a common denominator that links obesity to these disease states...
  3. ncbi Modulation of β-cell function: a translational journey from the bench to the bedside
    A B Goldfine
    Section of Clinical Research, Joslin Diabetes Center, Boston, MA 02215, USA
    Diabetes Obes Metab 14:152-60. 2012
    ....
  4. ncbi Patients with neuroglycopenia after gastric bypass surgery have exaggerated incretin and insulin secretory responses to a mixed meal
    A B Goldfine
    Joslin Diabetes Center, One Joslin Place, Boston, Massachusetts 02215, USA
    J Clin Endocrinol Metab 92:4678-85. 2007
    ..The etiology of the syndrome and metabolic characteristics remain incompletely understood. Recent studies suggest that levels of incretin hormones are increased after GB and may promote excessive beta-cell function and/or growth...
  5. ncbi Necdin and E2F4 are modulated by rosiglitazone therapy in diabetic human adipose and muscle tissue
    Allison B Goldfine
    Research Division, Joslin Diabetes Center, One Joslin Place, Boston, MA 02215, USA
    Diabetes 55:640-50. 2006
    ..These data suggest that changes in necdin and E2F4 expression after rosiglitazone exposure in humans are associated with altered adipocyte differentiation and may contribute to improved insulin sensitivity in humans treated with TZDs...
  6. ncbi Biomarkers in fasting serum to estimate glucose tolerance, insulin sensitivity, and insulin secretion
    Allison B Goldfine
    Joslin Diabetes Center, One Joslin Place, Boston, MA 02215, USA
    Clin Chem 57:326-37. 2011
    ..Biomarkers for estimating reduced glucose tolerance, insulin sensitivity, or impaired insulin secretion would be clinically useful, since these physiologic measures are important in the pathogenesis of type 2 diabetes mellitus...
  7. ncbi Exogenous insulin enhances glucose-stimulated insulin response in healthy humans independent of changes in free fatty acids
    Ximena Lopez
    Joslin Diabetes Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Clin Endocrinol Metab 96:3811-21. 2011
    ..Islet β-cells express both insulin receptors and insulin signaling proteins. Recent studies suggest insulin signaling is physiologically important for glucose sensing...
  8. ncbi Insulin augmentation of glucose-stimulated insulin secretion is impaired in insulin-resistant humans
    Florencia Halperin
    1Joslin Diabetes Center, Boston, Massachusetts, USA
    Diabetes 61:301-9. 2012
    ..This is consistent with an effect of insulin to regulate β-cell function in humans in vivo with therapeutic implications...
  9. ncbi Long-term Safety and Tolerability of Colesevelam HCl in Subjects with Type 2 Diabetes
    A B Goldfine
    Harvard Medical School, Joslin Diabetes Center, One Joslin Place, Boston, MA 02115, USA
    Horm Metab Res 42:23-30. 2010
    ..2 kg mean reduction from baseline). Colesevelam hydrochloride was safe and well-tolerated as long-term therapy for patients with type 2 diabetes...
  10. ncbi Family history of diabetes is a major determinant of endothelial function
    Allison B Goldfine
    Joslin Diabetes Center, Boston, Massachusetts 02215, USA
    J Am Coll Cardiol 47:2456-61. 2006
    ..We evaluated whether endothelial dysfunction was present in nondiabetic persons with a family history (FH) of diabetes and assessed its relationship with insulin resistance and atherosclerosis risk factors...
  11. ncbi Cardiology patient pages. Cardiovascular disease in the diabetic patient
    Allison B Goldfine
    Joslin Diabetes Center, Boston, Mass 02215, USA
    Circulation 107:e14-6. 2003
  12. ncbi Prevention of type 2 diabetes: are we ready?
    C Bouche
    Joslin Diabetes Center, Boston, MA 02215, USA
    Minerva Med 94:9-18. 2003
    ..Awareness of the extent of the problem and the potential benefits of prevention needs to be raised in both physicians and in the at high risk population...
  13. ncbi The use of colesevelam HCl in patients with type 2 diabetes mellitus: combining glucose- and lipid-lowering effects
    Allison B Goldfine
    Joslin Diabetes Center, Boston, MA 02115, USA
    Postgrad Med 121:13-8. 2009
    ....
  14. ncbi Beginning the treatment of musculoskeletal pain
    David G Borenstein
    Boston, MA, 02115, USA
    Postgrad Med 112:8-12. 2002
    ..1,2...
  15. ncbi Modulating LDL cholesterol and glucose in patients with type 2 diabetes mellitus: targeting the bile acid pathway
    Allison B Goldfine
    Clinical Research Section, Joslin Diabetes Center, 1 Joslin Place, Boston, Massachusetts 02115, USA
    Curr Opin Cardiol 23:502-11. 2008
    ..Therefore, it is important to treat both dyslipidemia and hyperglycemia to reduce complications. In this paper, the effect of elevated LDL-C and glucose concentrations on T2DM outcomes is reviewed...
  16. ncbi The effects of salsalate on glycemic control in patients with type 2 diabetes: a randomized trial
    Allison B Goldfine
    Joslin Diabetes Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Ann Intern Med 152:346-57. 2010
    ..Salsalate, a nonacetylated prodrug of salicylate, has been shown to decrease blood glucose concentration in small studies...
  17. ncbi Elevated plasma levels of the atherogenic mediator soluble CD40 ligand in diabetic patients: a novel target of thiazolidinediones
    Nerea Varo
    Cardiovascular Medicine, Brigham and Women s Hospital, Harvard Medical School, 221 Longwood Ave, Boston, Mass 02115, USA
    Circulation 107:2664-9. 2003
    ..This study therefore evaluated the hypothesis that diabetic patients have elevated plasma levels of soluble CD40L (sCD40L) and that treatment with the insulin-sensitizing thiazolidinediones lowers this index of inflammation...
  18. ncbi Ablation of ARNT/HIF1beta in liver alters gluconeogenesis, lipogenic gene expression, and serum ketones
    Xiaohui L Wang
    Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA
    Cell Metab 9:428-39. 2009
    ..These results demonstrate that a deficiency of ARNT action in the liver, coupled with that in beta cells, could contribute to the metabolic phenotype of human type 2 diabetes...
  19. ncbi Thyroid hormone-related regulation of gene expression in human fatty liver
    Jussi Pihlajamaki
    Research Division, Joslin Diabetes Center, One Joslin Place, Boston, Massachusetts 02215, USA
    J Clin Endocrinol Metab 94:3521-9. 2009
    ..Fatty liver is an important complication of obesity; however, regulatory mechanisms mediating altered gene expression patterns have not been identified...
  20. ncbi Inflammation and insulin resistance
    Steven E Shoelson
    Joslin Diabetes Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Clin Invest 116:1793-801. 2006
    ....
  21. ncbi Insulin resistance is a poor predictor of type 2 diabetes in individuals with no family history of disease
    Allison B Goldfine
    Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 100:2724-9. 2003
    ..Low S(I) and low S(G), both measures of glucose disposal, interact with this putative familial factor to result in a high risk of type 2 diabetes in the FH+ individuals, but not in the FH- individuals...
  22. ncbi Serum bile acids are higher in humans with prior gastric bypass: potential contribution to improved glucose and lipid metabolism
    Mary Elizabeth Patti
    Harvard Medical School, Harvard University, Boston, Massachusetts, USA
    Obesity (Silver Spring) 17:1671-7. 2009
    ..57, P = 0.004). Together, our data suggest that altered bile acid levels and composition may contribute to improved glucose and lipid metabolism in patients who have had GB...
  23. ncbi Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1
    Mary Elizabeth Patti
    Research Division, Joslin Diabetes Center, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 100:8466-71. 2003
    ..Decreased PGC1 expression may be responsible for decreased expression of NRF-dependent genes, leading to the metabolic disturbances characteristic of insulin resistance and DM...
  24. ncbi Serum ghrelin levels in response to glucose load in obese subjects post-gastric bypass surgery
    Nicholas A Tritos
    Joslin Diabetes Center, One Joslin Place, Boston, MA 02215, USA
    Obes Res 11:919-24. 2003
    ..Tonically low serum ghrelin levels may be involved in the mechanisms inducing sustained weight loss after GBP surgery...
  25. ncbi Glycation inactivation of the complement regulatory protein CD59: a possible role in the pathogenesis of the vascular complications of human diabetes
    Xuebin Qin
    Hematology Division, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Diabetes 53:2653-61. 2004
    ..We conclude that glycation inactivation of hCD59 that leads to increased MAC deposition may contribute to the extensive vascular pathology that complicates human diabetes...
  26. ncbi Endothelial function varies according to insulin resistance disease type
    Joshua A Beckman
    Cardiovascular Division, Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, USA
    Diabetes Care 30:1226-32. 2007
    ....
  27. ncbi Adiponectin: linking the fat cell to insulin sensitivity
    Allison B Goldfine
    Joslin Diabetes Center, Boston MA 02215, USA
    Lancet 362:1431-2. 2003
  28. ncbi Oral antioxidant therapy improves endothelial function in Type 1 but not Type 2 diabetes mellitus
    Joshua A Beckman
    Cardiovascular Division, Brigham and Women's Hospital, 75 Francis St, Boston, MA 02115, USA
    Am J Physiol Heart Circ Physiol 285:H2392-8. 2003
    ..Oral antioxidant therapy improves EDV in T1 but not T2 diabetes. These results are consistent with the lack of clinical benefit in studies that have included primarily T2 diabetic patients...
  29. ncbi Acute insulin secretion as a predictor of weight gain in healthy humans
    Robert J Silver
    Clinical Research Division, Joslin Diabetes Center, One Joslin Place, Boston, MA 02215, USA
    Obesity (Silver Spring) 14:67-72. 2006
    ..DISCUSSION: Our data suggest that neither AIRg nor S(I) plays a role in predicting weight gain in normoglycemic individuals with no family history of diabetes...
  30. ncbi The impact of vitamin D deficiency on diabetes and cardiovascular risk
    Merav Baz-Hecht
    Harvard Medical School, USA bJoslin Diabetes Center, Boston, Massachusetts 02215, USA
    Curr Opin Endocrinol Diabetes Obes 17:113-9. 2010
    ..To review the association between vitamin D deficiency and diabetes and cardiovascular risk...
  31. ncbi Inhibition of protein kinase Cbeta does not improve endothelial function in type 2 diabetes
    Joshua A Beckman
    Brigham and Women s Hospital, 75 Francis Street, Boston, Massachusetts 02115, USA
    J Clin Endocrinol Metab 95:3783-7. 2010
    ..Antagonism of protein kinase Cbeta (PKCbeta) restores endothelial function in experimental models of diabetes and prevents vascular dysfunction in response to hyperglycemia in healthy humans...
  32. ncbi Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters
    Markus Feuerer
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Joslin Diabetes Center, Boston, Massachusetts, USA
    Nat Med 15:930-9. 2009
    ..These observations suggest that harnessing the anti-inflammatory properties of T(reg) cells to inhibit elements of the metabolic syndrome may have therapeutic potential...
  33. ncbi Inhibition of protein kinase Cbeta prevents impaired endothelium-dependent vasodilation caused by hyperglycemia in humans
    Joshua A Beckman
    Cardiovascular Division, Brigham and Women's Hospital, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02115, USA
    Circ Res 90:107-11. 2002
    ..These findings suggest that hyperglycemia impairs endothelial function, in part, via protein kinase Cbeta activation...
  34. ncbi Assessing the cardiovascular safety of diabetes therapies
    Allison B Goldfine
    Section on Clinical Research, Joslin Diabetes Center and Harvard Medical School, Boston, USA
    N Engl J Med 359:1092-5. 2008
  35. ncbi Comparison of aspirin resistance in type 1 versus type 2 diabetes mellitus
    Sheena S Mehta
    Joslin Diabetes Center, Harvard Medical School, Boston Massachusetts, USA
    Am J Cardiol 97:567-70. 2006
    ..The results suggest that aspirin can inhibit platelet aggregation in most patients with diabetes and is a reasonable first-line antiplatelet agent in patients with diabetes...
  36. ncbi Salsalate improves glycemia and inflammatory parameters in obese young adults
    Amy Fleischman
    Harvard Medical School, Boston, Massachusetts, USA
    Diabetes Care 31:289-94. 2008
    ..The aim of the current study was to evaluate the efficacy of the anti-inflammatory drug salsalate to improve glycemia by reducing systemic inflammation in obese adults at risk for the development of type 2 diabetes...
  37. ncbi Increased glucose uptake in visceral versus subcutaneous adipose tissue revealed by PET imaging
    Thomas Christen
    Division of Cardiovascular Medicine, Brigham and Women s Hospital, Boston, MA, USA
    JACC Cardiovasc Imaging 3:843-51. 2010
    ..The current study tested the hypothesis that glucose utilization differs between visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT), and investigated potential mechanisms for such a finding...
  38. ncbi Activation of vascular protein kinase C-beta inhibits Akt-dependent endothelial nitric oxide synthase function in obesity-associated insulin resistance
    Keiko Naruse
    Joslin Diabetes Center, Harvard Medical School, One Joslin Place, Boston, MA 02215, USA
    Diabetes 55:691-8. 2006
    ....
  39. ncbi Identification and importance of brown adipose tissue in adult humans
    Aaron M Cypess
    Research Division, Joslin Diabetes Center, Boston, MA 02215, USA
    N Engl J Med 360:1509-17. 2009
    ....
  40. ncbi Effects of a low-glycemic load diet on resting energy expenditure and heart disease risk factors during weight loss
    Mark A Pereira
    Department of Medicine, Children's Hospital, Boston, Mass 02115, USA
    JAMA 292:2482-90. 2004
    ..Reduction in glycemic load may aid in the prevention or treatment of obesity, cardiovascular disease, and diabetes mellitus...
  41. ncbi The cellular fate of glucose and its relevance in type 2 diabetes
    Clara Bouche
    Harvard Medical School, Boston, Massachusetts 02115, USA
    Endocr Rev 25:807-30. 2004
    ..This review is focused on the cellular fate of glucose and relevance to human type 2 diabetes...
  42. ncbi Human insulin analog--induced lipoatrophy
    Ximena Lopez
    Joslin Diabetes Center, Boston, Massachusetts, USA
    Diabetes Care 31:442-4. 2008
    ..To characterize the pathophysiology of recombinant human insulin-induced lipoatrophy...
  43. ncbi Insulin enhances glucose-stimulated insulin secretion in healthy humans
    Clara Bouche
    Cellular and Molecular Physiology, Joslin Diabetes Center, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 107:4770-5. 2010
    ..In addition, hyperinsulinemia increases C-peptide clearance, which may lead to modest underestimation of beta-cell secretory response when using these methods during prolonged dynamic testing...
  44. ncbi Bariatric surgery for diabetes management
    Katherine J Frachetti
    Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Curr Opin Endocrinol Diabetes Obes 16:119-24. 2009
    ..To review the role of bariatric surgery in the treatment of patients with type 2 diabetes...
  45. ncbi Peptide YY levels are elevated after gastric bypass surgery
    Jean L Chan
    Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    Obesity (Silver Spring) 14:194-8. 2006
    ....
  46. ncbi Lactation after normal pregnancy is not associated with blood glucose fluctuations
    Rhonda Bentley-Lewis
    Division of Endocrinology, Diabetes, Hypertension, Brigham and Women's Hospital, Boston, MA 02115, USA
    Diabetes Care 30:2792-3. 2007
  47. ncbi Beta-cell insulin secretory response to oral hypoglycemic agents is blunted in humans in vivo during moderate hypoglycemia
    Waleed Aldhahi
    Joslin Diabetes Center, One Joslin Place, Boston, Massachusetts 02215, USA
    J Clin Endocrinol Metab 89:4553-7. 2004
    ..These findings may help to explain the relatively low incidence of severe hypoglycemia with clinical administration of these drugs...
  48. ncbi The rough road for rosiglitazone
    Allison B Goldfine
    Curr Opin Endocrinol Diabetes Obes 15:113-7. 2008
    ..Caution should be used in patients with underlying heart disease using nitrates, and when added to ongoing insulin-based therapy...
  49. ncbi Life and death in Denmark: lessons about diabetes and coronary heart disease
    Allison B Goldfine
    Circulation 117:1914-7. 2008
  50. ncbi Changing horizons: approaches to diabetes care, current and future
    Allison B Goldfine
    Curr Opin Endocrinol Diabetes Obes 14:95-7. 2007

Research Grants6

  1. Role of Insulin Regulation of Beta Cell Function in Vivo and in Vitro
    Allison Goldfine; Fiscal Year: 2007
    ..These studies may provide a unifying explanation linking the combined defects in insulin secretion and action that underlie type 2 diabetes. ..
  2. PHYSIOLOGY AND MOLECULAR DETERMINANTS OF DIABETES
    Allison Goldfine; Fiscal Year: 2004
    ....