A E Goldfeld
Affiliation: Harvard University
- Association of an HLA-DQ allele with clinical tuberculosisA E Goldfeld
Division of Adult Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
JAMA 279:226-8. 1998..Although tuberculosis (TB) is the leading worldwide cause of death due to an infectious disease, the extent to which progressive clinical disease is associated with genetic host factors remains undefined...
- Control of HIV-1 viremia and protection from AIDS are associated with HLA-Bw4 homozygosityP O Flores-Villanueva
Dana-Farber Cancer Institute, One Jimmy Fund Way, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 98:5140-5. 2001..We conclude that homozygosity for HLA-Bw4-bearing B alleles is associated with a significant advantage and that the HLA-Bw4 motif is important in AIDS pathogenesis...
- TNF-alpha promoter single nucleotide polymorphisms are markers of human ancestryA Baena
Center for Blood Research, Harvard Medical School, Boston, MA 02115, USA
Genes Immun 3:482-7. 2002..Comparisons of TNF-alpha promoter SNP allele frequencies can thus help elucidate variation of HLA haplotypes and their distribution among existing ethnic groups and shed light into the history of human populations...
- Diagnostic and clinical implications of response to tuberculin in two ethnically distinct populations from Peru and CambodiaJ C Delgado
Center for Blood Research, Institute for Biomedical Research, Boston, Massachusetts 02115, USA
Int J Tuberc Lung Dis 8:982-7. 2004..Proper interpretation of the tuberculin skin test (TST) requires knowledge about prior vaccination with BCG and the results of epidemiological studies with the test...
- Tumor necrosis factor alpha gene regulation in activated T cells involves ATF-2/Jun and NFATpE Y Tsai
Department of Medicine, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
Mol Cell Biol 16:459-67. 1996..This novel pairing of NFATp with ATF-2/Jun may account for the specific and immediate pattern of TNF-alpha gene transcription in stimulated T cells...
- Signaling through the lymphotoxin-beta receptor stimulates HIV-1 replication alone and in cooperation with soluble or membrane-bound TNF-alphaW L Marshall
Center for Blood Research and Division of Adult Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
J Immunol 162:6016-23. 1999..Given the critical role that LT-alpha1beta2 plays in lymphoid architecture, we speculate that LT-alpha1beta2 may be involved in HIV-associated abnormalities of the lymphoid organs...