Ary L Goldberger

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint What is physiologic complexity and how does it change with aging and disease?
    Ary L Goldberger
    Cardiovascular Division, Department of Medicine, and Margret and H A Rey Laboratory for Nonlinear Dynamics in Medicine, Beth Israel Deaconess Medical Center Harvard Medical School, Boston, MA, USA
    Neurobiol Aging 23:23-6. 2002
  2. pmc Fractal dynamics in physiology: alterations with disease and aging
    Ary L Goldberger
    Cardiovascular Division and Margret and H A Rey Laboratory for Nonlinear Dynamics in Medicine, Department of Medicine, Beth Israel Deaconess Medical Center Harvard Medical School, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 99:2466-72. 2002
  3. pmc Enhancement of sleep stability with Tai Chi exercise in chronic heart failure: preliminary findings using an ECG-based spectrogram method
    Gloria Y Yeh
    Division for Research and Education in Complementary and Integrative Medical Therapies, Harvard Medical School, Boston, MA 02215, USA
    Sleep Med 9:527-36. 2008
  4. pmc Differentiating obstructive from central and complex sleep apnea using an automated electrocardiogram-based method
    Robert Joseph Thomas
    Division of Pulmonary, Critical Care and Sleep Medicine, Beth Israel Deaconess Medical Center Boston, MA 02215, USA
    Sleep 30:1756-69. 2007
  5. pmc Prevalent hypertension and stroke in the Sleep Heart Health Study: association with an ECG-derived spectrographic marker of cardiopulmonary coupling
    Robert Joseph Thomas
    Division of Pulmonary, Critical Care and Sleep Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Sleep 32:897-904. 2009
  6. ncbi request reprint Statistical physics approach to categorize biologic signals: from heart rate dynamics to DNA sequences
    C K Peng
    Margret and H A Rey Institute for Nonlinear Dynamics in Medicine, Division of Interdisciplinary Medicine and Biotechnology, Beth Israel Deaconess Medical Center Harvard Medical School, Boston, Massachusetts 02215, USA
    Chaos 17:015115. 2007
  7. ncbi request reprint Broken asymmetry of the human heartbeat: loss of time irreversibility in aging and disease
    Madalena Costa
    Cardiovascular Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Phys Rev Lett 95:198102. 2005
  8. pmc Heritability of abnormalities in cardiopulmonary coupling in sleep apnea: use of an electrocardiogram-based technique
    Lamia H Ibrahim
    Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University Hospitals Case Medical Center, Cleveland, Ohio 44106 6003, USA
    Sleep 33:643-6. 2010
  9. ncbi request reprint Heart rate dynamics during three forms of meditation
    C K Peng
    Margret and H A Rey Institute for Nonlinear Dynamics in Physiology and Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Int J Cardiol 95:19-27. 2004
  10. pmc A systems biology approach to studying Tai Chi, physiological complexity and healthy aging: design and rationale of a pragmatic randomized controlled trial
    Peter M Wayne
    Osher Center for Integrative Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215, USA
    Contemp Clin Trials 34:21-34. 2013

Detail Information

Publications37

  1. ncbi request reprint What is physiologic complexity and how does it change with aging and disease?
    Ary L Goldberger
    Cardiovascular Division, Department of Medicine, and Margret and H A Rey Laboratory for Nonlinear Dynamics in Medicine, Beth Israel Deaconess Medical Center Harvard Medical School, Boston, MA, USA
    Neurobiol Aging 23:23-6. 2002
  2. pmc Fractal dynamics in physiology: alterations with disease and aging
    Ary L Goldberger
    Cardiovascular Division and Margret and H A Rey Laboratory for Nonlinear Dynamics in Medicine, Department of Medicine, Beth Israel Deaconess Medical Center Harvard Medical School, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 99:2466-72. 2002
    ..Elucidating the fractal and nonlinear mechanisms involved in physiologic control and complex signaling networks is emerging as a major challenge in the postgenomic era...
  3. pmc Enhancement of sleep stability with Tai Chi exercise in chronic heart failure: preliminary findings using an ECG-based spectrogram method
    Gloria Y Yeh
    Division for Research and Education in Complementary and Integrative Medical Therapies, Harvard Medical School, Boston, MA 02215, USA
    Sleep Med 9:527-36. 2008
    ....
  4. pmc Differentiating obstructive from central and complex sleep apnea using an automated electrocardiogram-based method
    Robert Joseph Thomas
    Division of Pulmonary, Critical Care and Sleep Medicine, Beth Israel Deaconess Medical Center Boston, MA 02215, USA
    Sleep 30:1756-69. 2007
    ..The objective of this study was to assess the utility of an electrocardiogram (ECG)-based cardiopulmonary coupling technique to distinguish obstructive from central or complex sleep apnea...
  5. pmc Prevalent hypertension and stroke in the Sleep Heart Health Study: association with an ECG-derived spectrographic marker of cardiopulmonary coupling
    Robert Joseph Thomas
    Division of Pulmonary, Critical Care and Sleep Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Sleep 32:897-904. 2009
    ..This study assesses, at a population level, the associations of this spectrographic biomarker with prevalent cardiovascular disease using the Sleep Heart Health Study (SHHS)-I dataset...
  6. ncbi request reprint Statistical physics approach to categorize biologic signals: from heart rate dynamics to DNA sequences
    C K Peng
    Margret and H A Rey Institute for Nonlinear Dynamics in Medicine, Division of Interdisciplinary Medicine and Biotechnology, Beth Israel Deaconess Medical Center Harvard Medical School, Boston, Massachusetts 02215, USA
    Chaos 17:015115. 2007
    ..We use human cardiac interbeat interval time series and DNA sequences as examples to illustrate the applicability of this generic approach to real-world problems...
  7. ncbi request reprint Broken asymmetry of the human heartbeat: loss of time irreversibility in aging and disease
    Madalena Costa
    Cardiovascular Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Phys Rev Lett 95:198102. 2005
    ..Loss of time irreversibility may provide a new way of assessing the functionality of living systems that operate far from equilibrium...
  8. pmc Heritability of abnormalities in cardiopulmonary coupling in sleep apnea: use of an electrocardiogram-based technique
    Lamia H Ibrahim
    Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University Hospitals Case Medical Center, Cleveland, Ohio 44106 6003, USA
    Sleep 33:643-6. 2010
    ..We evaluated the familial aggregation of distinctive spectrographic biomarkers of unstable sleep, related to elevated-low frequency cardiopulmonary coupling (e-LFC), to assess their utility in genetic studies...
  9. ncbi request reprint Heart rate dynamics during three forms of meditation
    C K Peng
    Margret and H A Rey Institute for Nonlinear Dynamics in Physiology and Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Int J Cardiol 95:19-27. 2004
    ..This study was designed to quantify and compare the instantaneous heart rate dynamics and cardiopulmonary interactions during sequential performance of three meditation protocols with different breathing patterns...
  10. pmc A systems biology approach to studying Tai Chi, physiological complexity and healthy aging: design and rationale of a pragmatic randomized controlled trial
    Peter M Wayne
    Osher Center for Integrative Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215, USA
    Contemp Clin Trials 34:21-34. 2013
    ....
  11. pmc Use of a tracing task to assess visuomotor performance: effects of age, sex, and handedness
    Leia A Stirling
    Wyss Institute for Biologically Inspired Engineering at Harvard University, Center for Life Science, 3 Blackfan Circle, 2nd Floor, Boston, MA 02180, USA
    J Gerontol A Biol Sci Med Sci 68:938-45. 2013
    ..Participants also performed the Trail Making Test (a measure of executive function)...
  12. ncbi request reprint Short-term fasting-induced autonomic activation and changes in catecholamine levels are not mediated by changes in leptin levels in healthy humans
    Jean L Chan
    Division of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Clin Endocrinol (Oxf) 66:49-57. 2007
    ..We evaluated whether inducing hypoleptinaemia (with and without administration of leptin at replacement doses) for 3 days would influence catecholamine levels and sympathetic and parasympathetic activity in healthy humans...
  13. pmc Frailty and the degradation of complex balance dynamics during a dual-task protocol
    Hyun Gu Kang
    Institute for Aging Research, Hebrew SeniorLife, 1200 Centre Street, Boston, MA 02131, USA
    J Gerontol A Biol Sci Med Sci 64:1304-11. 2009
    ....
  14. doi request reprint Multiscale analysis of heart rate dynamics: entropy and time irreversibility measures
    Madalena D Costa
    Division of Interdisciplinary Medicine and Biotechnology, Beth Israel Deaconess Medical Center Harvard Medical School, 330 Brookline Avenue, GZ 431, Boston, MA 02215, USA
    Cardiovasc Eng 8:88-93. 2008
    ..These new methods, with careful attention to their limitations, may be useful in diagnostics, risk stratification and detection of toxicity of cardiac drugs...
  15. ncbi request reprint Multiscale entropy analysis of biological signals
    Madalena Costa
    Margret and H A Rey Institute for Nonlinear Dynamics in Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Phys Rev E Stat Nonlin Soft Matter Phys 71:021906. 2005
    ....
  16. pmc Effect of mild, asymptomatic obstructive sleep apnea on daytime heart rate variability and impedance cardiography measurements
    Jay S Balachandran
    Sleep Disorders Research Program, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Am J Cardiol 109:140-5. 2012
    ..Further prospective outcomes-based studies are needed to evaluate the applicability of these metrics for noninvasive screening of obese patients with asymptomatic OSA, before the onset of overt cardiovascular disease...
  17. doi request reprint Relationship between delta power and the electrocardiogram-derived cardiopulmonary spectrogram: possible implications for assessing the effectiveness of sleep
    Robert Joseph Thomas
    Division of Pulmonary, Critical Care and Sleep Medicine, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA 02215, United States Electronic address
    Sleep Med 15:125-31. 2014
    ..Furthermore, we speculated that this correlation would be independent of conventional nonrapid eye movement (NREM) sleep stages...
  18. ncbi request reprint An electrocardiogram-based technique to assess cardiopulmonary coupling during sleep
    Robert Joseph Thomas
    Sleep Unit, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA
    Sleep 28:1151-61. 2005
    ..To evaluate a new automated measure of cardiopulmonary coupling during sleep using a single-lead electrocardiographic signal...
  19. pmc Gait unsteadiness and fall risk in two affective disorders: a preliminary study
    Jeffrey M Hausdorff
    Division on Aging, Harvard Medical School, Boston, MA, USA
    BMC Psychiatry 4:39. 2004
    ....
  20. ncbi request reprint Quantifying fractal dynamics of human respiration: age and gender effects
    C K Peng
    Margret and H A Rey Institute for Nonlinear Dynamics in Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    Ann Biomed Eng 30:683-92. 2002
    ....
  21. ncbi request reprint Multiscale entropy analysis of complex physiologic time series
    Madalena Costa
    Cardiovascular Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Phys Rev Lett 89:068102. 2002
    ..We find that MSE robustly separates healthy and pathologic groups and consistently yields higher values for simulated long-range correlated noise compared to uncorrelated noise...
  22. ncbi request reprint Complex patterns of abnormal heartbeats
    Verena Schulte-Frohlinde
    Center for Polymer Studies, Department of Physics, Boston University, Boston, Massachusetts 02215, USA
    Phys Rev E Stat Nonlin Soft Matter Phys 66:031901. 2002
    ..This work introduces methods that can be used to test mathematical models of arrhythmogenesis and to develop a new understanding of underlying electrophysiologic mechanisms of cardiac arrhythmia...
  23. ncbi request reprint PhysioNet: an NIH research resource for complex signals
    Madalena Costa
    Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    J Electrocardiol 36:139-44. 2003
    ..PhysioNet invites contributions of databases and software from the biomedical community...
  24. pmc Development of a new approach to quantifying stepping stability using ensemble empirical mode decomposition
    Xingran Cui
    Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA Electronic address
    Gait Posture 39:495-500. 2014
    ..27 to 0.73, p<0.05). These initial findings suggest that the SSI, an index based on the ensemble empirical mode decomposition, may be helpful for quantifying gait stability and fall risk during the challenges of everyday walking...
  25. ncbi request reprint Genomic classification using an information-based similarity index: application to the SARS coronavirus
    Albert C C Yang
    Cardiovascular Division and Margret and H A Rey Institute for Nonlinear Dynamics in Medicine, Beth Israel Deaconess Medical Center Harvard Medical School, Boston, Massachusetts 02215, USA
    J Comput Biol 12:1103-16. 2005
    ..The information based similarity index provides a new tool to measure the similarity between datasets based on their information content and may have a wide range of applications in the large-scale analysis of genomic databases...
  26. pmc Complex dynamics of human red blood cell flickering: alterations with in vivo aging
    Madalena Costa
    Division of Interdisciplinary Medicine and Biotechnology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Phys Rev E Stat Nonlin Soft Matter Phys 78:020901. 2008
    ..Quantitative assessment of multiscale flickering may provide a way of measuring RBC functionality. Membrane models need to account for the complex properties of these motions and their changes with in vivo senescence...
  27. ncbi request reprint Diurnal and ultradian dynamics of serum adiponectin in healthy men: comparison with leptin, circulating soluble leptin receptor, and cortisol patterns
    Alina Gavrila
    Division of Endocrinology and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    J Clin Endocrinol Metab 88:2838-43. 2003
    ..These data suggest that adiponectin and sOB-R levels might be influenced by common regulatory factors and challenge the notion that cortisol may have a direct inhibitory effect on adiponectin in humans...
  28. pmc Sinus versus nonsinus tachycardia in the emergency department: importance of age and heart rate
    Duane S Pinto
    Cardiovascular Division, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    BMC Cardiovasc Disord 3:7. 2003
    ..The emergency department diagnosis of sinus versus nonsinus tachycardia is an important clinical challenge. The objective of this study was to identify subjects with a high prevalence of nonsinus tachycardia...
  29. pmc Giles f. Filley lecture. Complex systems
    Ary L Goldberger
    Cardiology Division, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, GZ 435, Boston, MA 02215, USA
    Proc Am Thorac Soc 3:467-71. 2006
    ..This presentation provides a brief overview of an emerging area of biomedical research, including recent applications to cardiopulmonary medicine and chronic obstructive lung disease...
  30. doi request reprint Complexity-loss in fetal heart rate dynamics during labor as a potential biomarker of acidemia
    Madalena D Costa
    Division of Interdisciplinary Medicine and Biotechnology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA The Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, USA Electronic address
    Early Hum Dev 90:67-71. 2014
    ..Continuous fetal heart rate (FHR) monitoring remains central to intrapartum care. However, advances in signal analysis are needed to increase its accuracy in diagnosis of fetal hypoxia...
  31. doi request reprint Dynamical density delay maps: simple, new method for visualising the behaviour of complex systems
    Anton Burykin
    Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA 02115, USA
    BMC Med Inform Decis Mak 14:6. 2014
    ..However, capturing important dynamical properties, including nonstationarities may not be feasible from conventional time series graphical representations...
  32. pmc Multimodal pressure-flow method to assess dynamics of cerebral autoregulation in stroke and hypertension
    Vera Novak
    Division of Gerontology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Biomed Eng Online 3:39. 2004
    ..The autoregulatory dynamics are difficult to assess because of the nonstationarity and nonlinearity of the component signals...
  33. ncbi request reprint Effects of tai chi mind-body movement therapy on functional status and exercise capacity in patients with chronic heart failure: a randomized controlled trial
    Gloria Y Yeh
    Division for Research and Education in Complementary and Integrative Medical Therapies, Harvard Medical School, Boston, Massachusetts 02215, USA
    Am J Med 117:541-8. 2004
    ..To examine the effects of a 12-week tai chi program on quality of life and exercise capacity in patients with heart failure...
  34. ncbi request reprint Linguistic analysis of the human heartbeat using frequency and rank order statistics
    Albert C C Yang
    Department of Anesthesiology, Taipei Veterans General Hospital, Taipei, Taiwan
    Phys Rev Lett 90:108103. 2003
    ..Furthermore, we observe increased randomness in the heartbeat time series with physiologic aging and pathologic states and also uncover nonrandom patterns in the ventricular response to atrial fibrillation...
  35. ncbi request reprint Effects of chronic moderate alcohol consumption and novel environment on heart rate variability in primates (Macaca fascicularis)
    Carol A Shively
    Department of Pathology Comparative Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157 1040, USA
    Psychopharmacology (Berl) 192:183-91. 2007
    ..Although alcohol consumption often increases at times of stress, the interactive effects of stress and chronic moderate alcohol consumption on cardiac regulation have not been studied...
  36. ncbi request reprint The rule of bigeminy revisited: analysis in sudden cardiac death syndrome
    Claudia Lerma
    Department of Physiology, Centre for Nonlinear Dynamics, McGill University, Montreal, Quebec, Canada
    J Electrocardiol 40:78-88. 2007
    ..We evaluated these ventricular arrhythmias over extended periods in patients with sudden cardiac death syndrome...
  37. ncbi request reprint Chronic fatigue syndrome and hidden happenings of the heartbeat
    Ary L Goldberger
    Clin Auton Res 12:228-30. 2002