Diane R Gold

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Ozone exposure, vitamin C intake, and genetic susceptibility of asthmatic children in Mexico City: a cohort study
    Hortensia Moreno-Macias
    Universidad Autonoma Metropolitana, Unidad Iztapalapa, Avenida San Rafael Atlixco 186, edificio H 001, Col Vicentina, 09430, D F, Mexico City, Mexico
    Respir Res 14:14. 2013
  2. pmc Diversity of the gut microbiota and eczema in early life
    Erick Forno
    Channing Laboratory Boston, MA, USA
    Clin Mol Allergy 6:11. 2008
  3. ncbi request reprint Body-mass index as a predictor of incident asthma in a prospective cohort of children
    Diane R Gold
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Pediatr Pulmonol 36:514-21. 2003
  4. ncbi request reprint Immigration to the United States and acculturation as risk factors for asthma and allergy
    Diane R Gold
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School
    J Allergy Clin Immunol 116:38-41. 2005
  5. pmc Air pollution and ST-segment depression in elderly subjects
    Diane R Gold
    Channing Laboratory, Brigham and Women s Hospital, Department of Medicine, Harvard Medical School, Boston, Massachusetts 02215, USA
    Environ Health Perspect 113:883-7. 2005
  6. ncbi request reprint Population disparities in asthma
    Diane R Gold
    Harvard Medical School, Channing Laboratory, Brigham and Women s Hospital, Boston, Massachusetts 02467, USA
    Annu Rev Public Health 26:89-113. 2005
  7. pmc Associations of cord blood fatty acids with lymphocyte proliferation, IL-13, and IFN-gamma
    Diane R Gold
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    J Allergy Clin Immunol 117:931-8. 2006
  8. pmc Cord blood cytokines and acute lower respiratory illnesses in the first year of life
    Ngoc P Ly
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Pediatrics 119:e171-8. 2007
  9. ncbi request reprint Chronic caregiver stress and IgE expression, allergen-induced proliferation, and cytokine profiles in a birth cohort predisposed to atopy
    Rosalind J Wright
    Channing Laboratory, Brigham and Women s Hospital, 181 Longwood Avenue, Boston, MA 02115, USA
    J Allergy Clin Immunol 113:1051-7. 2004
  10. ncbi request reprint Day care attendance in early life, maternal history of asthma, and asthma at the age of 6 years
    Juan C Celedon
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Respir Crit Care Med 167:1239-43. 2003

Detail Information

Publications89

  1. pmc Ozone exposure, vitamin C intake, and genetic susceptibility of asthmatic children in Mexico City: a cohort study
    Hortensia Moreno-Macias
    Universidad Autonoma Metropolitana, Unidad Iztapalapa, Avenida San Rafael Atlixco 186, edificio H 001, Col Vicentina, 09430, D F, Mexico City, Mexico
    Respir Res 14:14. 2013
    ....
  2. pmc Diversity of the gut microbiota and eczema in early life
    Erick Forno
    Channing Laboratory Boston, MA, USA
    Clin Mol Allergy 6:11. 2008
    ..A modest number of prospective studies of the composition of the intestinal microbiota and eczema in early life have yielded conflicting results...
  3. ncbi request reprint Body-mass index as a predictor of incident asthma in a prospective cohort of children
    Diane R Gold
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Pediatr Pulmonol 36:514-21. 2003
    ..For girls, overweight contributes to development of asthma. For boys and girls, extremes of annual BMI growth rates increase the risk of asthma...
  4. ncbi request reprint Immigration to the United States and acculturation as risk factors for asthma and allergy
    Diane R Gold
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School
    J Allergy Clin Immunol 116:38-41. 2005
  5. pmc Air pollution and ST-segment depression in elderly subjects
    Diane R Gold
    Channing Laboratory, Brigham and Women s Hospital, Department of Medicine, Harvard Medical School, Boston, Massachusetts 02215, USA
    Environ Health Perspect 113:883-7. 2005
    ..Carbon monoxide was not a confounder of this association. ST-segment depression, possibly representing myocardial ischemia or inflammation, is associated with increased exposure to particles whose predominant source is traffic...
  6. ncbi request reprint Population disparities in asthma
    Diane R Gold
    Harvard Medical School, Channing Laboratory, Brigham and Women s Hospital, Boston, Massachusetts 02467, USA
    Annu Rev Public Health 26:89-113. 2005
    ..The relevance of the hygiene hypothesis to the U.S. urban situation is reviewed. Finally, we discuss community-level factors contributing to asthma disparities...
  7. pmc Associations of cord blood fatty acids with lymphocyte proliferation, IL-13, and IFN-gamma
    Diane R Gold
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    J Allergy Clin Immunol 117:931-8. 2006
    ..However, both n-3 eicosapentaenoic acid (EPA) and n-6 arachidonic acid (AA) are required for normal fetal development...
  8. pmc Cord blood cytokines and acute lower respiratory illnesses in the first year of life
    Ngoc P Ly
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Pediatrics 119:e171-8. 2007
    ..The purpose of this work was to examine the relation between cytokine secretions by cord blood mononuclear cells and acute lower respiratory illness in a birth cohort of 297 children...
  9. ncbi request reprint Chronic caregiver stress and IgE expression, allergen-induced proliferation, and cytokine profiles in a birth cohort predisposed to atopy
    Rosalind J Wright
    Channing Laboratory, Brigham and Women s Hospital, 181 Longwood Avenue, Boston, MA 02115, USA
    J Allergy Clin Immunol 113:1051-7. 2004
    ..Psychologic stress modifies immune function and cytokine production...
  10. ncbi request reprint Day care attendance in early life, maternal history of asthma, and asthma at the age of 6 years
    Juan C Celedon
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Respir Crit Care Med 167:1239-43. 2003
    ..Our findings suggest that maternal history of asthma influences the relation between day care-related exposures and childhood asthma...
  11. pmc Endotoxin exposure and eczema in the first year of life
    Wanda Phipatanakul
    Department of Pediatrics, Division of Allergy and Immunology, Children s Hospital, Boston, Massachusetts 02115, USA
    Pediatrics 114:13-8. 2004
    ..The objective of this study was to examine the relation between endotoxin exposure in early life and eczema in the first year of life in children with parental history of asthma or allergies...
  12. pmc Increased risk of paroxysmal atrial fibrillation episodes associated with acute increases in ambient air pollution
    David Q Rich
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Environ Health Perspect 114:120-3. 2006
    ..ICDs also detect paroxysmal atrial fibrillation episodes (PAF) that result in rapid ventricular rates. In this same cohort of ICD patients, we assessed the association between ambient air pollution and episodes of PAF...
  13. pmc Effects of endotoxin exposure on childhood asthma risk are modified by a genetic polymorphism in ACAA1
    Joanne E Sordillo
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
    BMC Med Genet 12:158. 2011
    ..Polymorphisms in the endotoxin-mediated TLR4 pathway genes have been associated with asthma and atopy. We aimed to examine how genetic polymorphisms in innate immunity pathways interact with endotoxin to influence asthma risk in children...
  14. pmc Maternal antioxidant intake in pregnancy and wheezing illnesses in children at 2 y of age
    Augusto A Litonjua
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Clin Nutr 84:903-11. 2006
    ..Low intakes of dietary antioxidants may contribute to increases in asthma and allergy...
  15. pmc Prenatal maternal stress and cord blood innate and adaptive cytokine responses in an inner-city cohort
    Rosalind J Wright
    The Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Respir Crit Care Med 182:25-33. 2010
    ..Objectives: Associations among prenatal maternal stress and cord blood mononuclear cell (CBMC) cytokine responses were prospectively examined in the Urban Environment and Childhood Asthma Study (n = 557 families)...
  16. ncbi request reprint Bottle feeding in the bed or crib before sleep time and wheezing in early childhood
    Juan C Celedon
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Pediatrics 110:e77. 2002
    ..We examined whether bottle feeding in the bed or crib before sleep time in the first year of life is associated with wheezing in the first 5 years of life...
  17. ncbi request reprint Allergen-induced cytokine production, atopic disease, IgE, and wheeze in children
    J Paola Contreras
    Pulmonary and Critical Care Division, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Allergy Clin Immunol 112:1072-7. 2003
    ..The early childhood allergen-induced immune responses associated with atopic disease and IgE production in early life are not well understood...
  18. pmc Higher adiposity in infancy associated with recurrent wheeze in a prospective cohort of children
    Elsie M Taveras
    Obesity Prevention Program, Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, Boston, MA 02215, USA
    J Allergy Clin Immunol 121:1161-1166.e3. 2008
    ..Few prospective data link early childhood adiposity with asthma-related symptoms...
  19. pmc Relationships among prenatal aeroallergen exposure and maternal and cord blood IgE: project ACCESS
    Junenette L Peters
    Department of Environmental Health, Harvard School of Public Health, Boston, Mass 02215, USA
    J Allergy Clin Immunol 123:1041-6. 2009
    ..Whereas some evidence suggests that antigen sensitization may begin prenatally, the influence of maternal allergen exposure during pregnancy has not been fully elucidated...
  20. pmc T-wave alternans, air pollution and traffic in high-risk subjects
    Antonella Zanobetti
    Exposure, Epidemiology and Risk Program, Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA
    Am J Cardiol 104:665-70. 2009
    ..6 for a 1 microg/m(3) increase in 6-hour mean BC). In conclusion, after hospitalization for coronary artery disease, being in traffic and short-term ambient or indoor BC exposure increased TWA, a marker of cardiac electrical instability...
  21. pmc Prenatal, perinatal, and heritable influences on cord blood immune responses
    Ben M Willwerth
    Pulmonary and Critical Care Division, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Ann Allergy Asthma Immunol 96:445-53. 2006
    ..Maternal and perinatal environmental exposures, as well as inherited factors, may influence neonatal immune responses...
  22. pmc Opposing effects of particle pollution, ozone, and ambient temperature on arterial blood pressure
    Barbara Hoffmann
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA
    Environ Health Perspect 120:241-6. 2012
    ..Diabetes increases the risk of hypertension and orthostatic hypotension and raises the risk of cardiovascular death during heat waves and high pollution episodes...
  23. pmc Endotoxin exposure in inner-city schools and homes of children with asthma
    William J Sheehan
    Department of Pediatrics, Division of Allergy and Immunology, Children s Hospital, 300 Longwood Ave, Boston, MA 02115, USA
    Ann Allergy Asthma Immunol 108:418-22. 2012
    ..Endotoxins are stimulators of the immune system and, despite their potential to protect against allergy, have been associated with early wheezing and asthma morbidity...
  24. pmc Within-home versus between-home variability of house dust endotoxin in a birth cohort
    Joseph H Abraham
    Harvard School of Public Health, Boston, Massachusetts, USA
    Environ Health Perspect 113:1516-21. 2005
    ..These results suggest that room-to-room and home-to-home differences in endotoxin influence the total variability more than factors affecting endotoxin levels within a room over time...
  25. ncbi request reprint Predictors of cord blood IgE levels in children at risk for asthma and atopy
    Christina V Scirica
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Allergy Clin Immunol 119:81-8. 2007
    ..Increased cord blood IgE levels, in conjunction with a family history of atopy, are associated with the development of allergic diseases in children. However, little is known about predictors of cord blood IgE levels...
  26. ncbi request reprint A longitudinal analysis of wheezing in young children: the independent effects of early life exposure to house dust endotoxin, allergens, and pets
    Augusto A Litonjua
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
    J Allergy Clin Immunol 110:736-42. 2002
    ..It has been postulated that exposure to bacterial endotoxins and animals early in life might confer protection against the development of asthma and allergies...
  27. pmc Parental characteristics, somatic fetal growth, and season of birth influence innate and adaptive cord blood cytokine responses
    Diane R Gold
    Channing Laboratory, Brigham and Women s Hospital, Boston, Mass, USA
    J Allergy Clin Immunol 124:1078-87. 2009
    ....
  28. doi request reprint Systemic inflammation, heart rate variability and air pollution in a cohort of senior adults
    Heike Luttmann-Gibson
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02215, USA
    Occup Environ Med 67:625-30. 2010
    ..We examined the association between inflammation and autonomic dysfunction and effect modification of inflammation on the association between air pollution and heart rate variability (HRV) in elderly subjects...
  29. pmc Association of variants in innate immune genes with asthma and eczema
    Sunita Sharma
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Pediatr Allergy Immunol 23:315-23. 2012
    ..We investigate the association between polymorphisms of genes in the innate immune pathway with childhood asthma and eczema. In addition, we compare individual associations with those discovered using a multivariate approach...
  30. pmc Modeling the association between particle constituents of air pollution and health outcomes
    Elizabeth Mostofsky
    Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Am J Epidemiol 176:317-26. 2012
    ..5. Although the different methods yield results with different interpretations, the relative rankings of the association between constituents and ischemic stroke were fairly consistent across models...
  31. ncbi request reprint Infant home endotoxin is associated with reduced allergen-stimulated lymphocyte proliferation and IL-13 production in childhood
    Joseph H Abraham
    Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
    J Allergy Clin Immunol 116:431-7. 2005
    ..Infant endotoxin exposure has been proposed as a factor that might protect against allergy and the early childhood immune responses that increase the risk of IgE production to allergens...
  32. ncbi request reprint Low-normal gestational age as a predictor of asthma at 6 years of age
    Benjamin A Raby
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Pediatrics 114:e327-32. 2004
    ..However, the role of these factors in the development of asthma in later life among children who do not develop perinatal respiratory disease remains unclear...
  33. ncbi request reprint Focused exposures to airborne traffic particles and heart rate variability in the elderly
    Sara Dubowsky Adar
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA
    Epidemiology 18:95-103. 2007
    ..Because these risks may be particularly great for traffic-related particles, we examined associations between particles and heart rate variability as 44 subjects participated in 4 repeated trips aboard a diesel bus...
  34. pmc Reduction in heart rate variability with traffic and air pollution in patients with coronary artery disease
    Antonella Zanobetti
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02215, USA
    Environ Health Perspect 118:324-30. 2010
    ..Ambient particulate pollution and traffic have been linked to myocardial infarction and cardiac death risk. Possible mechanisms include autonomic cardiac dysfunction...
  35. pmc Mouse exposure and wheeze in the first year of life
    Wanda Phipatanakul
    Division of Allergy and Immunology, Department of Pediatrics, Children s Hospital Boston, Boston, Massachusetts 02115, USA
    Ann Allergy Asthma Immunol 94:593-9. 2005
    ..Studies have found that exposure to mice is highly prevalent among children with asthma living in urban areas...
  36. ncbi request reprint Respiratory illnesses in early life and asthma and atopy in childhood
    Clare D Ramsey
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Allergy Clin Immunol 119:150-6. 2007
    ..The relation between respiratory illnesses in early life and the development of asthma and atopy in childhood is incompletely understood...
  37. ncbi request reprint Short-term effects of air pollution on heart rate variability in senior adults in Steubenville, Ohio
    Heike Luttmann-Gibson
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02215, USA
    J Occup Environ Med 48:780-8. 2006
    ..We examined the association between ambient air pollution levels and heart rate variability (HRV) in a panel study of 32 subjects...
  38. pmc Exposure to dust mite allergen and endotoxin in early life and asthma and atopy in childhood
    Juan C Celedon
    Channing Laboratory, Division of Pulmonary and Critical Care Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Allergy Clin Immunol 120:144-9. 2007
    ..There has been no longitudinal study of the relation between concurrent exposure to dust mite allergen and endotoxin in early life and asthma and atopy at school age...
  39. ncbi request reprint Ambient pollution and blood pressure in cardiac rehabilitation patients
    Antonella Zanobetti
    Department of Environmental Health, Exposure Epidemiology and Risk Program, Harvard School of Public Health, 401 Park Dr, Landmark Center, Suite 415, PO Box 15698, Boston, Mass 02215, USA
    Circulation 110:2184-9. 2004
    ..We investigated the associations between fine particulate pollution (PM2.5) and blood pressure during 631 repeated visits for cardiac rehabilitation in 62 Boston residents with cardiovascular disease...
  40. pmc Allergen exposure modifies the relation of sensitization to fraction of exhaled nitric oxide levels in children at risk for allergy and asthma
    Joanne E Sordillo
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
    J Allergy Clin Immunol 127:1165-72.e5. 2011
    ..Studies on airway inflammation, measured as fraction of exhaled nitric oxide (FENO), have focused on its relation to control of asthma, but the contribution of allergen exposure to the increase in FENO levels is unknown...
  41. pmc The school inner-city asthma study: design, methods, and lessons learned
    Wanda Phipatanakul
    Division of Allergy and Immunology, Department of Pediatrics, Children s Hospital, Boston, MA 02115, USA
    J Asthma 48:1007-14. 2011
    ..Children spend a significant amount of time in school. Little is known about the role of allergen exposure in school environments and asthma morbidity...
  42. pmc Particulate air pollution as a risk factor for ST-segment depression in patients with coronary artery disease
    Kai Jen Chuang
    Exposure, Epidemiology, and Risk Program, Department of Environmental Health, Harvard School of Public Health, Boston, MA 02215, USA
    Circulation 118:1314-20. 2008
    ..The association of particulate matter (PM) with cardiovascular morbidity and mortality is well documented. PM-induced ischemia is considered a potential mechanism linking PM to adverse cardiovascular outcomes...
  43. ncbi request reprint Maternal intake of vitamin D during pregnancy and risk of recurrent wheeze in children at 3 y of age
    Carlos A Camargo
    Center for D receptor Activation Research, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Am J Clin Nutr 85:788-95. 2007
    ..Vitamin D deficiency and asthma are common at higher latitudes. Although vitamin D has important immunologic effects, its relation with asthma is unknown...
  44. pmc Maternal dietary pattern during pregnancy is not associated with recurrent wheeze in children
    Nancy E Lange
    Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Allergy Clin Immunol 126:250-5, 255.e1-4. 2010
    ..Previous studies have found associations between individual foods or nutrients consumed during pregnancy and asthma or wheeze in children, but these may be confounded by overall dietary pattern...
  45. ncbi request reprint Variation in total and specific IgE: effects of ethnicity and socioeconomic status
    Augusto A Litonjua
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    J Allergy Clin Immunol 115:751-7. 2005
    ..Asthma is common in minority and disadvantaged populations, whereas atopic disorders other than asthma appear to be less prevalent. It is unclear whether the same holds true for objective markers of sensitization...
  46. ncbi request reprint Exposure to cat allergen, maternal history of asthma, and wheezing in first 5 years of life
    Juan C Celedon
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Lancet 360:781-2. 2002
    ..There was no association between wheezing and exposure to dog or dog allergen, and the father's allergy status had no effect on the relation between childhood wheezing and cat exposure...
  47. pmc Associations of PM10 with sleep and sleep-disordered breathing in adults from seven U.S. urban areas
    Antonella Zanobetti
    Department of Environmental Health, Exposure Epidemiology and Risk Program, Harvard School of Public Health, 401 Park Drive, Landmark Center, Suite 415, PO Box 15698, Boston, MA 02215, USA
    Am J Respir Crit Care Med 182:819-25. 2010
    ..S. adults, and may be more prevalent in poor urban environments. SDB and air pollution have been linked to increased cardiovascular diseases and mortality, but the association between pollution and SDB is poorly understood...
  48. pmc Association of air pollution with increased incidence of ventricular tachyarrhythmias recorded by implanted cardioverter defibrillators
    Douglas W Dockery
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02215, USA
    Environ Health Perspect 113:670-4. 2005
    ..The associations with sulfate suggest a link with stationary fossil fuel combustion sources...
  49. pmc Prenatal fatty acid status and child adiposity at age 3 y: results from a US pregnancy cohort
    Sara M A Donahue
    Obesity Prevention Program, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA 02215, USA
    Am J Clin Nutr 93:780-8. 2011
    ..Exposure to polyunsaturated fatty acids (PUFAs) in early life may influence adiposity development...
  50. ncbi request reprint Sensitization to aeroallergens and airway hyperresponsiveness at 7 years of age
    Elizabeth C TePas
    Channing Laboratory, Brigham and Women s Hospital, 181 Longwood Ave, Boston, MA 02115, USA
    Chest 129:1500-8. 2006
    ..To investigate the relationship between current and early life factors and airway responsiveness to inhaled methacholine in children with a median age of 7.0 years...
  51. doi request reprint Dust mite exposure modifies the effect of functional IL10 polymorphisms on allergy and asthma exacerbations
    Gary M Hunninghake
    Channing Laboratory, Brigham and Women s Hospital, Boston, Mass 02115, USA
    J Allergy Clin Immunol 122:93-8, 98.e1-5. 2008
    ..The allergenicity of dust mite exposure might be dependent on variants in the gene for IL-10 (IL10)...
  52. pmc Association of birth weight with asthma-related outcomes at age 2 years
    Elsie M Taveras
    Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, Boston, Massachusetts 02215, USA
    Pediatr Pulmonol 41:643-8. 2006
    ....
  53. ncbi request reprint Lack of association between antibiotic use in the first year of life and asthma, allergic rhinitis, or eczema at age 5 years
    Juan C Celedon
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Am J Respir Crit Care Med 166:72-5. 2002
    ..4; OR for two or more versus no courses of antibiotics, 0.9; 95% CI, 0.5 to 1.4). Our findings do not support the hypothesis that antibiotic use in early life is associated with the subsequent development of asthma and atopy in childhood...
  54. pmc Particulate air pollution, oxidative stress genes, and heart rate variability in an elderly cohort
    Teresa Chahine
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02215, USA
    Environ Health Perspect 115:1617-22. 2007
    ..We have extended this to include a longitudinal analysis with more subjects and examination of the GT short tandem repeat polymorphism in the heme oxygenase-1 (HMOX-1) promoter...
  55. pmc Mouse allergens in urban elementary schools and homes of children with asthma
    William J Sheehan
    Division of Allergy and Immunology, Department of Pediatrics, Children s Hospital, Boston, Massachusetts 02115, USA
    Ann Allergy Asthma Immunol 102:125-30. 2009
    ..The association between allergens in schools and childhood asthma has not been well studied, particularly in the United States...
  56. pmc Community violence and asthma morbidity: the Inner-City Asthma Study
    Rosalind J Wright
    Beth Israel Deaconess Medical Center, Pulmonary and Critical Care Division, and the Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Am J Public Health 94:625-32. 2004
    ..We examined the association between exposure to violence and asthma among urban children...
  57. pmc Diagnostic accuracy of the bronchodilator response in children
    Sze Man Tse
    Channing Division of Network Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Mass Massachusetts General Hospital, Department of Pediatrics, Division of Pediatric Pulmonary Medicine, Boston, Mass Electronic address
    J Allergy Clin Immunol 132:554-559.e5. 2013
    ..The validity of the commonly used definition of BDR, a 12% or greater change in FEV1 from baseline, has been questioned in childhood...
  58. pmc Home characteristics as predictors of bacterial and fungal microbial biomarkers in house dust
    Joanne E Sordillo
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Environ Health Perspect 119:189-95. 2011
    ....
  59. ncbi request reprint Diabetes enhances vulnerability to particulate air pollution-associated impairment in vascular reactivity and endothelial function
    Marie S O'Neill
    Department of Environmental Health, Harvard School of Public Health, Boston, Mass, USA
    Circulation 111:2913-20. 2005
    ..We examined whether endothelium-dependent and -independent vascular reactivity was associated with particle exposure in individuals with and without diabetes...
  60. ncbi request reprint Recurrent wheeze in early childhood and asthma among children at risk for atopy
    Ngoc P Ly
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Pediatrics 117:e1132-8. 2006
    ..We examined the relation between early wheeze and asthma at 7 years of age among children with parental history of asthma or allergies followed from birth...
  61. doi request reprint Birth by cesarean section, allergic rhinitis, and allergic sensitization among children with a parental history of atopy
    Michael Pistiner
    Division of Immunology, Children s Hospital Boston, Boston, Mass, USA
    J Allergy Clin Immunol 122:274-9. 2008
    ..Studies of the relation between cesarean delivery and allergic diseases in children not selected on the basis of a family history of atopy have yielded inconsistent findings...
  62. ncbi request reprint The role of indoor allergen sensitization and exposure in causing morbidity in women with asthma
    Sarah A Lewis
    Channing Laboratory, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Am J Respir Crit Care Med 165:961-6. 2002
    ..07), with adjustment for race and poverty. We conclude that cockroach and cat allergens may contribute to asthma morbidity in sensitized women...
  63. ncbi request reprint Ambient air pollution and oxygen saturation
    Dawn L DeMeo
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Am J Respir Crit Care Med 170:383-7. 2004
    ..Further investigation may contribute to our understanding of the mechanisms through which particulates may increase respiratory and cardiac morbidity among vulnerable populations...
  64. pmc Fungal levels in the home and allergic rhinitis by 5 years of age
    Paul C Stark
    Biostatistics Research Center, Institute for Clinical Research and Health Policy Studies, Department of Medicine, Tufts New England Medical Center, Boston, Massachusetts, USA
    Environ Health Perspect 113:1405-9. 2005
    ..High measured fungal concentrations and reports of water damage, mold, or mildew in homes may predispose children with a family history of asthma or allergy to the development of allergic rhinitis...
  65. pmc Home endotoxin exposure and wheeze in infants: correction for bias due to exposure measurement error
    Nora Horick
    Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Environ Health Perspect 114:135-40. 2006
    ..2-26) among the 360 children in households with dust endotoxin levels between the 5th and 95th percentiles...
  66. ncbi request reprint Polymorphisms in the 5' region of the CD14 gene are associated with eczema in young children
    Augusto A Litonjua
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Allergy Clin Immunol 115:1056-62. 2005
    ..Variants in the CD14 gene (CD14) are hypothesized to be associated with atopic disorders. However, most studies have only investigated one polymorphism in this gene...
  67. pmc Diabetes, obesity, and hypertension may enhance associations between air pollution and markers of systemic inflammation
    Sara D Dubowsky
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA
    Environ Health Perspect 114:992-8. 2006
    ..We found modest positive associations between PM2.5 and indicators of systemic inflammation, with larger associations suggested for individuals with diabetes, obesity, hypertension, and elevated mean inflammatory markers...
  68. pmc Autonomic effects of controlled fine particulate exposure in young healthy adults: effect modification by ozone
    Asghar A Fakhri
    Cardiovascular Epidemiology Research Unit, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Environ Health Perspect 117:1287-92. 2009
    ....
  69. ncbi request reprint Day care attendance, respiratory tract illnesses, wheezing, asthma, and total serum IgE level in early childhood
    Juan C Celedon
    Channing Laboratory, 181 Longwood Ave, Boston, MA 02115, USA
    Arch Pediatr Adolesc Med 156:241-5. 2002
    ..It has been hypothesized that day care--related infections may explain the inverse relation between day care attendance in early life and asthma in childhood...
  70. doi request reprint Asthma and obesity: common early-life influences in the inception of disease
    Augusto A Litonjua
    Channing Laboratory, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Allergy Clin Immunol 121:1075-84; quiz 1085-6. 2008
    ....
  71. ncbi request reprint Parental stress as a predictor of wheezing in infancy: a prospective birth-cohort study
    Rosalind J Wright
    Department of Pulmonary and Critical Care Medicine, The Beth Israel Deaconess Medical Center, Boston, MA, USA
    Am J Respir Crit Care Med 165:358-65. 2002
    ..These findings suggest a more direct mechanism may be operating between stress and wheeze in early childhood. Stress may contribute significantly to the population burden of preventable childhood respiratory illness...
  72. ncbi request reprint Fungal levels in the home and lower respiratory tract illnesses in the first year of life
    Paul C Stark
    Channing Laboratory, 181 Longwood Avenue, Boston, MA 02115, USA
    Am J Respir Crit Care Med 168:232-7. 2003
    ..Actual mechanisms remain unknown, but fungi and their components (glucans, mycotoxins, and proteins) may increase the risk of LRI by acting as irritants or through increasing susceptibility to infection...
  73. ncbi request reprint Cytokines, allergy, and asthma
    P Ly Ngoc
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Curr Opin Allergy Clin Immunol 5:161-6. 2005
    ..This review examines recent articles on the relationship of cytokines to allergy and asthma with particular emphasis on immune mechanisms involved in disease development in early life...
  74. pmc Perinatal predictors of atopic dermatitis occurring in the first six months of life
    Megan M Moore
    Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, Boston, Massachusetts 02215, USA
    Pediatrics 113:468-74. 2004
    ..The purpose of this prospective study was to investigate several perinatal predictors of atopic dermatitis occurring in the first 6 months of life...
  75. ncbi request reprint Effects of passive smoking on heart rate variability, heart rate and blood pressure: an observational study
    Denise Felber Dietrich
    Institute of Social and Preventive Medicine, University of Basel, Switzerland
    Int J Epidemiol 36:834-40. 2007
    ..This study tests the hypothesis that ETS exposure reduces HRV in the general population and discusses possible pathways...
  76. pmc Effect of physical activity on heart rate variability in normal weight, overweight and obese subjects: results from the SAPALDIA study
    Denise Felber Dietrich
    Institute of Social and Preventive Medicine, University of Basel, Steinengraben 49, 4051 Basel, Switzerland
    Eur J Appl Physiol 104:557-65. 2008
    ..Regular physical exercise has strong beneficial effects on cardiac autonomic nervous function and thus appears to offset the negative effect of obesity on HRV...
  77. ncbi request reprint Prevalence and titer of IgE antibodies to mouse allergens
    Thomas A E Platts-Mills
    Asthma and Allergic Diseases Center, University of Virginia, Charlottesville, VA 22908, USA
    J Allergy Clin Immunol 120:1058-64. 2007
    ..Positive skin tests to allergens derived from mouse urine have been reported among patients with asthma. Very few data are available detailing the titer of IgE Ab to mouse allergen and how it varies by location and population...
  78. pmc Dust mite, cockroach, cat, and dog allergen concentrations in homes of asthmatic children in the northeastern United States: impact of socioeconomic factors and population density
    Brian P Leaderer
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut 06520 8034, USA
    Environ Health Perspect 110:419-25. 2002
    ..Mite and cockroach allergens have distinct and opposite associations with socioeconomic factors and population density...
  79. ncbi request reprint Inhaled corticosteroids for young children with wheezing
    Diane R Gold
    N Engl J Med 354:2058-60. 2006
  80. pmc Differences in heart rate variability associated with long-term exposure to NO2
    Denise Felber Dietrich
    Institute of Social and Preventive Medicine, University of Basel, Basel, Switzerland
    Environ Health Perspect 116:1357-61. 2008
    ..Short-term studies have shown that subjects exposed to higher traffic-associated air pollutant levels have lower HRV...
  81. ncbi request reprint Spatial cluster detection for censored outcome data
    Andrea J Cook
    Department of Biostatistics, University of Washington, Seattle, Washington 98105, USA
    Biometrics 63:540-9. 2007
    ....
  82. ncbi request reprint Symptoms of wheeze and persistent cough in the first year of life: associations with indoor allergens, air contaminants, and maternal history of asthma
    Kathleen Belanger
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT 06520 8034, USA
    Am J Epidemiol 158:195-202. 2003
    ..23, 95% CI: 1.01, 1.49). This appears to have been the first study to measure all of these home exposures (indoor allergens, nitrogen dioxide, fungi) and to prospectively measure the frequency of infant wheeze and persistent cough...
  83. pmc Characterization of lipopolysaccharides present in settled house dust
    Ju Hyeong Park
    Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA
    Appl Environ Microbiol 70:262-7. 2004
    ..These data suggest that the Limulus assay may underestimate exposure to certain types of LPS. Because nontoxic LPS may have immune modulating effects, analysis of 3-OHFAs may be useful in epidemiologic studies...
  84. ncbi request reprint Less childhood obesity--less persistence of wheeze in teenage girls and boys?
    Diane R Gold
    Am J Respir Crit Care Med 170:8-9. 2004
  85. ncbi request reprint Effects of ultrafine and fine particulate and gaseous air pollution on cardiac autonomic control in subjects with coronary artery disease: the ULTRA study
    Kirsi L Timonen
    Unit of Environmental Epidemiology, National Public Health Institute, Kuopio, Finland
    J Expo Sci Environ Epidemiol 16:332-41. 2006
    ..5 and HRV. The results suggest that the cardiovascular effects of ambient ultrafine and PM2.5 can differ from each other and that their effect may be modified by the characteristics of the exposed subjects and the sources of PM2.5...
  86. pmc Nuclear factor kappa B activation in human cord blood mononuclear cells
    Christian H Schroeter
    Pulmonary and Critical Care Division, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, U S A
    Pediatr Res 56:212-8. 2004
    ..Whether differential NF-kappaB activity in cord blood is related to the subsequent development of immune diseases requires further investigation...
  87. pmc Prediction of residential pet and cockroach allergen levels using questionnaire information
    Ulrike Gehring
    GSF National Research Center for Environment and Health, Institute of Epidemiology, Neuherberg, Germany
    Environ Health Perspect 112:834-9. 2004
    ..Knowledge of past pet ownership can improve pet allergen exposure assessment by means of questionnaire. However, for epidemiologic purposes, measured concentrations of allergens are necessary...
  88. pmc Neonatal immune responses to TLR2 stimulation: influence of maternal atopy on Foxp3 and IL-10 expression
    Bianca Schaub
    University Children s Hospital Munich, Department of Pulmonary, LMU, Munich, Germany
    Respir Res 7:40. 2006
    ..However, little is known about the immunological effects of microbial stimulation on early immune responses and in association with maternal atopy...
  89. ncbi request reprint Heart rate variability in an ageing population and its association with lifestyle and cardiovascular risk factors: results of the SAPALDIA study
    Denise Felber Dietrich
    Institute of Social and Preventive Medicine, University of Basel, Steinengraben 49, 4051 Basel, Switzerland
    Europace 8:521-9. 2006
    ....