Research Topics
Genomes and Genes | C GodsonSummaryAffiliation: Harvard University Country: USA Publications
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Publications
The Mel1a melatonin receptor is coupled to parallel signal transduction pathwaysC Godson
Laboratory of Developmental Chronobiology, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
Endocrinology 138:397-404. 1997..Thus, we show that the melatonin signal is transduced by parallel pathways involving inhibition of adenylyl cyclase and potentiation of phospholipase activation...
Melatonin receptors are for the birds: molecular analysis of two receptor subtypes differentially expressed in chick brainS M Reppert
Laboratory of Developmental Chronobiology, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
Neuron 15:1003-15. 1995..Expression of CKA and CKB results in similar ligand binding and functional characteristics. The widespread distribution of CKA and CKB mRNA in brain provides a molecular substrate for the profound actions of melatonin in birds...
Structure, characterization, and expression of the gene encoding the mouse Mel1a melatonin receptorA L Roca
Laboratory of Developmental Chronobiology, Massachusetts General Hospital, Boston 02114, USA
Endocrinology 137:3469-77. 1996..These results provide information on Mel1a receptor gene structure essential for designing transgenic and gene knock-out studies and analyzing the transcriptional regulation of receptor gene expression...
Molecular characterization of a second melatonin receptor expressed in human retina and brain: the Mel1b melatonin receptorS M Reppert
Laboratory of Developmental Chronobiology, Massachusetts General Hospital, Boston, MA 02114, USA
Proc Natl Acad Sci U S A 92:8734-8. 1995..The Mel1b melatonin receptor may mediate the reported actions of melatonin in retina and participate in some of the neurobiological effects of melatonin in mammals...
