Robert Glynn

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Regression methods when the eye is the unit of analysis
    Robert J Glynn
    Division of Preventive Medicine and Channing Lab, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02215, USA
    Ophthalmic Epidemiol 19:159-65. 2012
  2. pmc Role of disease risk scores in comparative effectiveness research with emerging therapies
    Robert J Glynn
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 1620 Tremont Street, Boston, MA 02120, USA
    Pharmacoepidemiol Drug Saf 21:138-47. 2012
  3. pmc Awareness, accuracy, and predictive validity of self-reported cholesterol in women
    Peng yun A Huang
    Division of Preventive Medicine, Boston, MA 02215, USA
    J Gen Intern Med 22:606-13. 2007
  4. ncbi request reprint Current and remote blood pressure and cognitive decline
    R J Glynn
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02215, USA
    JAMA 281:438-45. 1999
  5. ncbi request reprint Selective prescribing led to overestimation of the benefits of lipid-lowering drugs
    Robert J Glynn
    Division of Pharmacoepidemiology and Pharmacoeconomics, Harvard Medical School, Brigham and Women s Hospital, Boston, MA 02120, USA
    J Clin Epidemiol 59:819-28. 2006
  6. pmc Evaluation of risk factors for cataract types in a competing risks framework
    Robert J Glynn
    Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA
    Ophthalmic Epidemiol 16:98-106. 2009
  7. ncbi request reprint Comparison of risk factors for the competing risks of coronary heart disease, stroke, and venous thromboembolism
    Robert J Glynn
    Division of Preventive Medicine and the Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Am J Epidemiol 162:975-82. 2005
  8. ncbi request reprint Methods to evaluate risks for composite end points and their individual components
    Robert J Glynn
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Harvard School of Public Health, 900 Commonwealth Avenue East, Boston, MA 02215 1204, USA
    J Clin Epidemiol 57:113-22. 2004
  9. ncbi request reprint Multiple imputation to estimate the association between eyes in disease progression with interval-censored data
    Robert J Glynn
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, USA
    Stat Med 23:3307-18. 2004
  10. ncbi request reprint Effect of low-dose aspirin on the occurrence of venous thromboembolism: a randomized trial
    Robert J Glynn
    Brigham and Women s Hospital, Harvard Medical School, and Harvard School of Public Health, Boston, Massachusetts 02215, USA
    Ann Intern Med 147:525-33. 2007

Collaborators

Detail Information

Publications95

  1. pmc Regression methods when the eye is the unit of analysis
    Robert J Glynn
    Division of Preventive Medicine and Channing Lab, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02215, USA
    Ophthalmic Epidemiol 19:159-65. 2012
    ..Advances have occurred in the development and accessibility of analytic approaches to evaluate determinants of eye-specific outcomes including information from both eyes of some subjects...
  2. pmc Role of disease risk scores in comparative effectiveness research with emerging therapies
    Robert J Glynn
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 1620 Tremont Street, Boston, MA 02120, USA
    Pharmacoepidemiol Drug Saf 21:138-47. 2012
    ..Usefulness of propensity scores and regression models to balance potential confounders at treatment initiation may be limited for newly introduced therapies with evolving use patterns...
  3. pmc Awareness, accuracy, and predictive validity of self-reported cholesterol in women
    Peng yun A Huang
    Division of Preventive Medicine, Boston, MA 02215, USA
    J Gen Intern Med 22:606-13. 2007
    ....
  4. ncbi request reprint Current and remote blood pressure and cognitive decline
    R J Glynn
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02215, USA
    JAMA 281:438-45. 1999
    ..Previous studies raise the possibility that blood pressure (BP) in middle age predicts later cognitive decline...
  5. ncbi request reprint Selective prescribing led to overestimation of the benefits of lipid-lowering drugs
    Robert J Glynn
    Division of Pharmacoepidemiology and Pharmacoeconomics, Harvard Medical School, Brigham and Women s Hospital, Boston, MA 02120, USA
    J Clin Epidemiol 59:819-28. 2006
    ..Selective use of these drugs in frail people may confound these relationships...
  6. pmc Evaluation of risk factors for cataract types in a competing risks framework
    Robert J Glynn
    Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA
    Ophthalmic Epidemiol 16:98-106. 2009
    ..One can compare the impact of risk factors on different types of cataract with methods of competing risk survival analysis that account for tied events...
  7. ncbi request reprint Comparison of risk factors for the competing risks of coronary heart disease, stroke, and venous thromboembolism
    Robert J Glynn
    Division of Preventive Medicine and the Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Am J Epidemiol 162:975-82. 2005
    ..CHD and stroke have broadly comparable risk factor profiles that differ widely from the profile for VTE...
  8. ncbi request reprint Methods to evaluate risks for composite end points and their individual components
    Robert J Glynn
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Harvard School of Public Health, 900 Commonwealth Avenue East, Boston, MA 02215 1204, USA
    J Clin Epidemiol 57:113-22. 2004
    ..Both randomized and observational studies commonly examine composite end points, but the literature on model development and criticism in this setting is limited...
  9. ncbi request reprint Multiple imputation to estimate the association between eyes in disease progression with interval-censored data
    Robert J Glynn
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, USA
    Stat Med 23:3307-18. 2004
    ..A simulation study suggests that the method performs well. Results highlight the advantage of multiple imputation that data imputed under one model can be analysed under several alternative models...
  10. ncbi request reprint Effect of low-dose aspirin on the occurrence of venous thromboembolism: a randomized trial
    Robert J Glynn
    Brigham and Women s Hospital, Harvard Medical School, and Harvard School of Public Health, Boston, Massachusetts 02215, USA
    Ann Intern Med 147:525-33. 2007
    ..Short-term aspirin therapy can lower the risk for venous thromboembolism (VTE) in high-risk patients, but whether the long-term use of low-dose aspirin reduces risk in healthy adults is uncertain...
  11. pmc Rosuvastatin for primary prevention in older persons with elevated C-reactive protein and low to average low-density lipoprotein cholesterol levels: exploratory analysis of a randomized trial
    Robert J Glynn
    Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA
    Ann Intern Med 152:488-96, W174. 2010
    ..Randomized data on statins for primary prevention in older persons are limited, and the relative hazard of cardiovascular disease associated with an elevated cholesterol level weakens with advancing age...
  12. ncbi request reprint Design of cluster-randomized trials of quality improvement interventions aimed at medical care providers
    Robert J Glynn
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, and Harvard Medical School, Boston, Massachusetts, USA
    Med Care 45:S38-43. 2007
    ..Such trials are frequently embedded in health care systems with available automated records, which can be used to enhance the design of the trial...
  13. ncbi request reprint Commentary: genes as instruments for evaluation of markers and causes
    Robert J Glynn
    Division of Preventive Medicine, Brigham, Women s Hospital, 900 Commonwealth Avenue, Boston, MA 02215, USA
    Int J Epidemiol 35:932-4. 2006
  14. pmc A randomized trial of rosuvastatin in the prevention of venous thromboembolism
    Robert J Glynn
    Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    N Engl J Med 360:1851-61. 2009
    ..Observational studies have yielded variable estimates of the effect of statin therapy on the risk of venous thromboembolism, and evidence from randomized trials is lacking...
  15. ncbi request reprint Effects of random allocation to vitamin E supplementation on the occurrence of venous thromboembolism: report from the Women's Health Study
    Robert J Glynn
    Division of Preventive Medicine, Brigham and Women s Hospital, 900 Commonwealth Ave E, Boston, MA 02215 1204, USA
    Circulation 116:1497-503. 2007
    ..Supplementation with vitamin E may antagonize vitamin K in healthy adults, but it is unclear whether intake of vitamin E decreases the risk of venous thromboembolism (VTE)...
  16. ncbi request reprint Development of predictive models for long-term cardiovascular risk associated with systolic and diastolic blood pressure
    Robert J Glynn
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215 1204, USA
    Hypertension 39:105-10. 2002
    ..These predictive models may be useful for risk estimation associated with hypertension in similar populations and may also be used to infer the benefits of antihypertensive therapy...
  17. ncbi request reprint Pulse pressure and mortality in older people
    R J Glynn
    Division of Preventive Medicine, Brigham and Women s Hospital, 900 Commonwealth Ave E, Boston, MA 02215, USA
    Arch Intern Med 160:2765-72. 2000
    ..We examined which combinations of systolic, diastolic, pulse, and mean arterial pressure best predict total and cardiovascular mortality in older adults...
  18. doi request reprint Tracking of high-sensitivity C-reactive protein after an initially elevated concentration: the JUPITER Study
    Robert J Glynn
    Center for Cardiovascular Disease Prevention, Division of Preventive Medicine, Division of Cardiovascular Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Clin Chem 55:305-12. 2009
    ..Although studies of specific populations have suggested that hsCRP is a reliable longitudinal marker, it is unclear how strongly hsCRP tracks in individuals after a single increased concentration...
  19. doi request reprint Number needed to treat with rosuvastatin to prevent first cardiovascular events and death among men and women with low low-density lipoprotein cholesterol and elevated high-sensitivity C-reactive protein: justification for the use of statins in prevention
    Paul M Ridker
    Center for Cardiovascular Disease Prevention and the Division of Cardiovascular Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Circ Cardiovasc Qual Outcomes 2:616-23. 2009
    ..However, whether the absolute risk reduction among such individuals justifies wide application of statin therapy in primary prevention is a controversial issue with broad policy and public health implications...
  20. pmc Influence of systolic and diastolic blood pressure on the risk of incident atrial fibrillation in women
    David Conen
    Center for Arrhythmia Prevention, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass, USA
    Circulation 119:2146-52. 2009
    ..The influence of systolic and diastolic blood pressure (BP) on incident atrial fibrillation (AF) is not well studied among initially healthy, middle-aged women...
  21. doi request reprint Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein
    Paul M Ridker
    Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    N Engl J Med 359:2195-207. 2008
    ....
  22. pmc Rationale and design of the Post-MI FREEE trial: a randomized evaluation of first-dollar drug coverage for post-myocardial infarction secondary preventive therapies
    Niteesh K Choudhry
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02120, USA
    Am Heart J 156:31-6. 2008
    ..Removing patient out-of-pocket drug costs may increase adherence, improve clinical outcomes, and even reduce overall health costs for high-risk patients. The existing data are inadequate to assess whether this strategy is effective...
  23. doi request reprint HDL cholesterol and residual risk of first cardiovascular events after treatment with potent statin therapy: an analysis from the JUPITER trial
    Paul M Ridker
    Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Lancet 376:333-9. 2010
    ..We addressed, using the JUPITER trial cohort, whether this association remains when LDL-cholesterol concentrations are reduced to the very low ranges with high-dose statin treatment...
  24. pmc Association of renin-angiotensin and endothelial nitric oxide synthase gene polymorphisms with blood pressure progression and incident hypertension: prospective cohort study
    David Conen
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, 900 Commonwealth Avenue East, Boston, MA 02215, USA
    J Hypertens 26:1780-6. 2008
    ..The aim of the present study was to assess the relationship of six previously characterized gene variants in the renin-angiotensin system and the NOS3 gene with blood pressure progression and incident hypertension...
  25. pmc Emergency hospital admissions after income-based deductibles and prescription copayments in older users of inhaled medications
    Colin R Dormuth
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Clin Ther 30:1038-50. 2008
    ..Objective: The aim of this study was to compare the effects of 2 recent cost-sharing policies on emergency hospitalizations due to chronic obstructive pulmonary disease, asthma, or emphysema (CAE), and on physician visits...
  26. ncbi request reprint Relationship between selective cyclooxygenase-2 inhibitors and acute myocardial infarction in older adults
    Daniel H Solomon
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Harvard Medical School, 1620 Tremont St, Suite 3030, Boston, Mass 02120, USA
    Circulation 109:2068-73. 2004
    ..We studied the relative risk of acute myocardial infarction (AMI) among users of celecoxib, rofecoxib, and NSAIDs in Medicare beneficiaries with a comprehensive drug benefit...
  27. doi request reprint Reduction in C-reactive protein and LDL cholesterol and cardiovascular event rates after initiation of rosuvastatin: a prospective study of the JUPITER trial
    Paul M Ridker
    Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Lancet 373:1175-82. 2009
    ..8 mmol/L (<70 mg/dL). However, the benefit of lowering both LDL cholesterol and hsCRP after the start of statin therapy is controversial. We prospectively tested this hypothesis...
  28. ncbi request reprint Blood pressure and risk of secondary cardiovascular events in women: the Women's Antioxidant Cardiovascular Study (WACS)
    Peter J Mason
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02215 1204, USA
    Circulation 109:1623-9. 2004
    ..In apparently healthy people, the relation between blood pressure and risk of subsequent cardiovascular disease (CVD) is linear. In persons with CVD, the relation is uncertain...
  29. doi request reprint Statins for the primary prevention of cardiovascular events in women with elevated high-sensitivity C-reactive protein or dyslipidemia: results from the Justification for the Use of Statins in Prevention: An Intervention Trial Evaluating Rosuvastatin (JUP
    Samia Mora
    Center for Cardiovascular Disease Prevention, Divisions of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Circulation 121:1069-77. 2010
    ..We analyzed sex-specific outcomes in the Justification for the Use of Statins in Prevention: An Intervention Trial Evaluating Rosuvastatin (JUPITER) and synthesized the results with prior trials...
  30. ncbi request reprint Determinants of selective cyclooxygenase-2 inhibitor prescribing: are patient or physician characteristics more important?
    Daniel H Solomon
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Med 115:715-20. 2003
    ..We examined the relative effects of patient risk factors for gastrointestinal toxicity, other patient characteristics, and physician prescribing preferences on the decision to prescribe a selective COX-2 inhibitor...
  31. pmc Improved comorbidity adjustment for predicting mortality in Medicare populations
    Sebastian Schneeweiss
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Health Serv Res 38:1103-20. 2003
    ..To define and improve the performance of existing comorbidity scores in predicting mortality in Medicare enrollees...
  32. ncbi request reprint Long-term, low-intensity warfarin therapy for the prevention of recurrent venous thromboembolism
    Paul M Ridker
    Center for Cardiovascular Disease Prevention and the Division of Preventive Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston 02215, USA
    N Engl J Med 348:1425-34. 2003
    ..0 and 3.0. However, for long-term management, no therapeutic agent has shown an acceptable benefit-to-risk ratio...
  33. ncbi request reprint Impact of two sequential drug cost-sharing policies on the use of inhaled medications in older patients with chronic obstructive pulmonary disease or asthma
    Colin R Dormuth
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Clin Ther 28:964-78; discussion 962-3. 2006
    ..Evaluations of drug cost-sharing policies within the same population are needed for a fair comparison of different options...
  34. ncbi request reprint Hemoglobin A1c level and future cardiovascular events among women
    Gavin J Blake
    Cardiovascular Division, The Center for Cardiovascular Disease Prevention, and the Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass, USA
    Arch Intern Med 164:757-61. 2004
    ..We sought to test this hypothesis prospectively in a cohort of women without overt cardiovascular disease...
  35. pmc Risk of cardiovascular events among women with high normal blood pressure or blood pressure progression: prospective cohort study
    David Conen
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 900 Commonwealth Avenue, Boston, MA 02215, USA
    BMJ 335:432. 2007
    ..To compare cardiovascular risk among women with high normal blood pressure (130-9/85-9 mm Hg) against those with normal blood pressure (120-9/75-84 mm Hg) and those with baseline hypertension...
  36. ncbi request reprint Plasma concentration of C-reactive protein and the calculated Framingham Coronary Heart Disease Risk Score
    Michelle A Albert
    Center for Cardiovascular Disease Prevention, Division Cardiovascular Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02115, USA
    Circulation 108:161-5. 2003
    ..Although C-reactive protein (CRP) predicts vascular risk, few data are available evaluating the relation between CRP and the Framingham Coronary Heart Disease Risk Score (FCRS)...
  37. ncbi request reprint Age-related cataract in a randomized trial of beta-carotene in women
    William Christen
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Ophthalmic Epidemiol 11:401-12. 2004
    ..To examine the development of age-related cataract in a trial of beta-carotene supplementation in women...
  38. doi request reprint Efficacy of rosuvastatin among men and women with moderate chronic kidney disease and elevated high-sensitivity C-reactive protein: a secondary analysis from the JUPITER (Justification for the Use of Statins in Prevention-an Intervention Trial Evaluating
    Paul M Ridker
    Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Am Coll Cardiol 55:1266-73. 2010
    ..We evaluated the efficacy of statin therapy in primary prevention among individuals with moderate chronic kidney disease (CKD)...
  39. ncbi request reprint Nephrologist care and mortality in patients with chronic renal insufficiency
    Jerry Avorn
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Arch Intern Med 162:2002-6. 2002
    ..We sought to determine whether early or frequent access to nephrologist care prior to the initiation of dialysis was associated with a difference in mortality rates in the first year after dialysis began...
  40. ncbi request reprint Physician gender and changes in drug prescribing after the implementation of reference pricing in British Columbia
    Margreet S Duetz
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Clin Ther 25:273-84. 2003
    ..Gender-specific attitudes and communication styles are known to influence both the content and outcome of medical visits. Therefore, gender-specific differences in response to cost containment may also occur...
  41. ncbi request reprint Cholesterol and the risk of renal dysfunction in apparently healthy men
    Elke S Schaeffner
    Divisions of Preventive Medicine, and Aging, and Cardiovascular Disease, and Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, USA
    J Am Soc Nephrol 14:2084-91. 2003
    ..5 mg/dl...
  42. pmc Vitamins E and C in the prevention of prostate and total cancer in men: the Physicians' Health Study II randomized controlled trial
    J Michael Gaziano
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02120, USA
    JAMA 301:52-62. 2009
    ..No previous trial in men at usual risk has examined vitamin C alone in the prevention of cancer...
  43. ncbi request reprint Perspective on selected issues in cardiovascular disease research with a focus on black Americans
    Michelle A Albert
    Center for Cardiovascular Disease Prevention, Division of Cardiovascular Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02115, USA
    Circulation 110:e7-12. 2004
  44. ncbi request reprint Effect of physical activity on serum C-reactive protein
    Michelle A Albert
    Center for Cardiovascular Disease Prevention, Divisions of Cardiovascular Diseases and Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Cardiol 93:221-5. 2004
    ..This study examines the association between physical activity and C-reactive protein levels, indicating that high levels of strenuous aerobic activity are associated with lower C-reactive protein levels among men...
  45. ncbi request reprint Valsartan, blood pressure reduction, and C-reactive protein: primary report of the Val-MARC trial
    Paul M Ridker
    Center for Cardiovascular Disease Prevention, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass, USA
    Hypertension 48:73-9. 2006
    ..These data raise the hypothesis that angiotensin receptor blockade may have anti-inflammatory effects in addition to blood pressure-lowering effects...
  46. ncbi request reprint Baseline characteristics of participants in the JUPITER trial, a randomized placebo-controlled primary prevention trial of statin therapy among individuals with low low-density lipoprotein cholesterol and elevated high-sensitivity C-reactive protein
    Paul M Ridker
    JUPITER Coordinating Center, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Am J Cardiol 100:1659-64. 2007
    ..In conclusion, as 20 mg of rosuvastatin can reduce LDL cholesterol by up to 50%, JUPITER will also provide crucial safety data for several thousand patients who should achieve LDL cholesterol levels<50 mg/dl on a long-term basis...
  47. doi request reprint Relation of baseline high-sensitivity C-reactive protein level to cardiovascular outcomes with rosuvastatin in the Justification for Use of statins in Prevention: an Intervention Trial Evaluating Rosuvastatin (JUPITER)
    Paul M Ridker
    Center for Cardiovascular Disease Prevention, Boston, Massachusetts, USA
    Am J Cardiol 106:204-9. 2010
    ..In conclusion, as the absolute risk increased with increasing hs-CRP, the absolute risk reduction associated with rosuvastatin within JUPITER was also greatest among those with the greatest entry hs-CRP levels...
  48. ncbi request reprint Ten-year trends of cardiovascular drug use after myocardial infarction among community-dwelling persons > or =65 years of age
    Soko Setoguchi
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Am J Cardiol 100:1061-7. 2007
    ..The underuse of statins and BBs was marked in black patients and did not improve over time...
  49. ncbi request reprint Alcohol consumption and plasma concentration of C-reactive protein
    Michelle A Albert
    Center for Cardiovascular Disease Prevention, Division of Cardiovascular Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02115, USA
    Circulation 107:443-7. 2003
    ..Moderate alcohol intake has been associated with lower cardiovascular mortality. However, data evaluating the relationship between C-reactive protein (CRP), a predictor of cardiovascular risk, and alcohol consumption are sparse...
  50. ncbi request reprint Nonsteroidal anti-inflammatory drug use and acute myocardial infarction
    Daniel H Solomon
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Arch Intern Med 162:1099-104. 2002
    ..Although aspirin has been shown to protect patients from acute myocardial infarction (AMI), the effect of nonaspirin nonsteroidal anti-inflammatory drugs (NSAIDs) is not clear...
  51. ncbi request reprint JNC 7 category and risk of cardiovascular death in men: are there differences by age?
    Thomas S Bowman
    Harvard University General Internal Medicine Fellowship Program, Veterans Affairs Boston Healthcare System Massachusetts Veterans Affairs Epidemiology, Research, and Information Center, Boston, MA 02120, USA
    Am J Geriatr Cardiol 14:126-31; quiz 132-3. 2005
    ..22). In this large cohort, the JNC 7 categorization of prehypertension was not associated with a significantly increased risk of cardiovascular disease death, and there was no significant effect modification by age...
  52. pmc Socioeconomic status, blood pressure progression, and incident hypertension in a prospective cohort of female health professionals
    David Conen
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Eur Heart J 30:1378-84. 2009
    ..The aim of this study was to examine the association between socioeconomic status, blood pressure (BP) progression, and incident hypertension...
  53. pmc Effects of prescription coinsurance and income-based deductibles on net health plan spending for older users of inhaled medications
    Colin R Dormuth
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Med Care 47:508-16. 2009
    ..We analyzed the impact on health plan spending of a switch in public drug insurance from full coverage to a prescription copayment (copay), and then to income-based deductibles plus coinsurance (IBD)...
  54. pmc Evaluating uses of data mining techniques in propensity score estimation: a simulation study
    Soko Setoguchi
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02130, USA
    Pharmacoepidemiol Drug Saf 17:546-55. 2008
    ....
  55. ncbi request reprint Combination therapy versus monotherapy as initial treatment for stage 2 hypertension: a prespecified subgroup analysis of a community-based, randomized, open-label trial
    Brendan M Everett
    The Center for Cardiovascular Disease Prevention, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA
    Clin Ther 30:661-72. 2008
    ....
  56. pmc Inflammation and progressive nephropathy in type 1 diabetes in the diabetes control and complications trial
    Julie Lin
    Renal Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Diabetes Care 31:2338-43. 2008
    ..Early albuminuria probably reflects vascular endothelial dysfunction, which may be mediated in part by chronic inflammation...
  57. doi request reprint Confounding control in healthcare database research: challenges and potential approaches
    M Alan Brookhart
    Department of Medicine, Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Med Care 48:S114-20. 2010
    ..Such reporting allows the reader to assess the sensitivity of the results to model assumptions that are often not supported by strong subject-matter knowledge...
  58. pmc Subgroup analyses to determine cardiovascular risk associated with nonsteroidal antiinflammatory drugs and coxibs in specific patient groups
    Daniel H Solomon
    Brigham and Women s Hospital, 1620 Tremont Street, Boston, MA 02120, USA
    Arthritis Rheum 59:1097-104. 2008
    ..There is substantial concern regarding the potential cardiovascular adverse effects of selective coxibs and nonselective NSAIDs, but many patients with arthritis experience important clinical benefits from these agents...
  59. ncbi request reprint Accuracy of Medicare claims-based diagnosis of acute myocardial infarction: estimating positive predictive value on the basis of review of hospital records
    Yuka Kiyota
    Division of Pharmacoepidemiology and Pharmacoeconomics, Boston, Mass USA
    Am Heart J 148:99-104. 2004
    ....
  60. doi request reprint Rosuvastatin in the prevention of stroke among men and women with elevated levels of C-reactive protein: justification for the Use of Statins in Prevention: an Intervention Trial Evaluating Rosuvastatin (JUPITER)
    Brendan M Everett
    Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, 900 Commonwealth Ave, Boston, MA 02215, USA
    Circulation 121:143-50. 2010
    ..We evaluated whether statin therapy might reduce stroke rates among individuals with low levels of cholesterol but elevated levels of high-sensitivity C-reactive protein...
  61. ncbi request reprint Pharmacogenetic testing in the clinical management of schizophrenia: a decision-analytic model
    Roy H Perlis
    Pharmacogenomics Research Program, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    J Clin Psychopharmacol 25:427-34. 2005
    ..More consistent reporting of test parameters such as sensitivity and specificity would greatly facilitate assessment of future pharmacogenetic studies...
  62. ncbi request reprint Mild renal insufficiency and risk of congestive heart failure in men and women > or =70 years of age
    Claudia U Chae
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, 900 Commonwealth Avenue East, Boston, MA 02215 1204, USA
    Am J Cardiol 92:682-6. 2003
    ..43, 95% CI 1.17 to 1.74). Thus, mild renal insufficiency was a strong independent predictor of CHF in this cohort, suggesting that serum creatinine may offer a readily accessible tool to identify elderly patients at risk for CHF...
  63. ncbi request reprint Dopamine antagonists and the development of breast cancer
    Philip S Wang
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, 221 Longwood Ave, Boston, MA 02115, USA
    Arch Gen Psychiatry 59:1147-54. 2002
    ..Although animal studies have raised the possibility that prolactin-elevating dopamine antagonists used to treat psychotic disorders may initiate and promote breast cancers, epidemiologic studies in humans have been limited and inconsistent...
  64. pmc Differential effect of soluble intercellular adhesion molecule-1 on the progression of atherosclerosis as compared to arterial thrombosis: a prospective analysis of the Women's Health Study
    Michelle A Albert
    Center for Cardiovascular Disease Prevention, Donald W Reynolds Center for Cardiovascular Disease Research, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Atherosclerosis 197:297-302. 2008
    ....
  65. pmc Comparison of prospective and retrospective indicators of the quality of end-of-life cancer care
    Soko Setoguchi
    Division of General Medicine and Primary Care, Brigham and Women s Hospital, Boston, MA 02120 1613, USA
    J Clin Oncol 26:5671-8. 2008
    ..To compare prospectively and retrospectively defined benchmarks for the quality of end-of-life care, including a novel indicator for the use of opiate analgesia...
  66. ncbi request reprint Statins and the risk of lung, breast, and colorectal cancer in the elderly
    Soko Setoguchi
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 1620 Tremont St, Suite 3030, Boston, MA 02130, USA
    Circulation 115:27-33. 2007
    ..Long-term statin users tend to be healthier, less frail, and more adherent to therapy than nonusers, however. This could explain such apparent "protective" effects...
  67. ncbi request reprint A prospective study of serum lipids and risk of diabetic macular edema in type 1 diabetes
    Biljana Miljanovic
    Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, 900 Commonwealth Ave East, Boston, MA 02215, USA
    Diabetes 53:2883-92. 2004
    ..Lipid-lowering treatment among type 1 diabetic subjects, recommended to prevent cardiovascular disease, may also decrease risk of CSME, an important cause of vision loss...
  68. doi request reprint Improvements in long-term mortality after myocardial infarction and increased use of cardiovascular drugs after discharge: a 10-year trend analysis
    Soko Setoguchi
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02120, USA
    J Am Coll Cardiol 51:1247-54. 2008
    ..We sought to assess the relationship between increasing use of cardiovascular medications and trends in long-term prognosis after myocardial infarction (MI) in the elderly...
  69. ncbi request reprint Vitamin E and age-related cataract in a randomized trial of women
    William G Christen
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Ophthalmology 115:822-829.e1. 2008
    ..To investigate whether vitamin E supplementation decreases the risk of age-related cataract in women...
  70. pmc Omega-6 fatty acids and risk of heart failure in the Physicians' Health Study
    Andrew B Petrone
    Brigham and Women s Hospital, Boston, MA 02120, USA
    Am J Clin Nutr 97:66-71. 2013
    ..Although 1 in 5 adults will develop heart failure (HF) in their lifetime, data on the effect of plasma omega-6 (n-3) PUFAs on risk of HF are currently sparse...
  71. doi request reprint False Claims Act prosecution did not deter off-label drug use in the case of neurontin
    Aaron S Kesselheim
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Health Aff (Millwood) 30:2318-27. 2011
    ....
  72. ncbi request reprint Results of multivariable logistic regression, propensity matching, propensity adjustment, and propensity-based weighting under conditions of nonuniform effect
    Tobias Kurth
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Am J Epidemiol 163:262-70. 2006
    ..Researchers need to be clear about the population for which an overall treatment estimate is most suitable...
  73. pmc High-sensitivity C-reactive protein, other markers of inflammation, and the incidence of macular degeneration in women
    Debra A Schaumberg
    Division of Preventive Medicine, 900 Commonwealth Ave E, Boston, MA 02215, USA
    Arch Ophthalmol 125:300-5. 2007
    ..To investigate whether high-sensitivity C-reactive protein (hsCRP) and other biomarkers of inflammation predict age-related macular degeneration (AMD)...
  74. ncbi request reprint Analgesic use and change in kidney function in apparently healthy men
    Tobias Kurth
    Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215 1204, USA
    Am J Kidney Dis 42:234-44. 2003
    ..Studies using a single creatinine measurement have yielded inconsistent results regarding analgesic use and kidney function...
  75. ncbi request reprint A randomized trial of beta carotene and age-related cataract in US physicians
    William G Christen
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, 900 Commonwealth Ave E, Third Floor, Boston, MA 02215 1204, USA
    Arch Ophthalmol 121:372-8. 2003
    ..To examine the development of age-related cataract in a trial of beta carotene supplementation in men...
  76. ncbi request reprint Comparison of baseline characteristics and mortality experience of participants and nonparticipants in a randomized clinical trial: the Physicians' Health Study
    Howard D Sesso
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215, USA
    Control Clin Trials 23:686-702. 2002
    ..In contrast, diseases and risk factors explain some, but not all, of the lower mortality rates of physicians based on eligibility status and their ability to complete a run-in phase...
  77. ncbi request reprint Agreement of diagnosis and its date for hematologic malignancies and solid tumors between medicare claims and cancer registry data
    Soko Setoguchi
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Cancer Causes Control 18:561-9. 2007
    ..However, linkage between cancer registry and claims data including pharmacy-dispensing information is not always available. We examined the accuracy of claims-based definitions of incident cancers and their date of diagnosis...
  78. ncbi request reprint Quasi-experimental longitudinal designs to evaluate drug benefit policy changes with low policy compliance
    Sebastian Schneeweiss
    Divison of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 221 Longwood Ave BLI 341, Boston, MA 02115, USA
    J Clin Epidemiol 55:833-41. 2002
    ..Results from nonrandomized comparisons of subgroups defined by their compliance to a policy change should generally be interpreted cautiously, and several biases should be explored...
  79. pmc Noncompliance with antihypertensive medications: the impact of depressive symptoms and psychosocial factors
    Philip S Wang
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School Boston, Mass 02115, USA
    J Gen Intern Med 17:504-11. 2002
    ..Addressing the epidemic of poor compliance with antihypertensive medications will require identifying factors associated with poor adherence, including modifiable psychosocial and behavioral characteristics of patients...
  80. ncbi request reprint Association between blood pressure and cognitive function in a biracial community population of older persons
    Martha Clare Morris
    Department of Internal Medicine, Rush University and Rush Presbyterian St Luke s Medical Center, Chicago, Ill 60612, USA
    Neuroepidemiology 21:123-30. 2002
    ..The cross-sectional association between blood pressure and cognitive functions is small and curvilinear and more apparent in persons with cardiovascular conditions...
  81. ncbi request reprint Outcomes of reference pricing for angiotensin-converting-enzyme inhibitors
    Sebastian Schneeweiss
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    N Engl J Med 346:822-9. 2002
    ..Although reference pricing may reduce the costs of prescription drugs, there is concern that patients may switch to less effective medications or stop treatment...
  82. pmc Metabolic abnormalities and risk for colorectal cancer in the physicians' health study
    TIL STURMER
    Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, 900 Commonwealth Avenue East, Boston, MA 02215, USA
    Cancer Epidemiol Biomarkers Prev 15:2391-7. 2006
    ....
  83. ncbi request reprint Clinical and economic consequences of reference pricing for dihydropyridine calcium channel blockers
    Sebastian Schneeweiss
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital and Harvard Medical School, Boston, Mass 02120, USA
    Clin Pharmacol Ther 74:388-400. 2003
    ....
  84. ncbi request reprint Measuring the cost-effectiveness of lipid-lowering drugs in the elderly: the outcomes research and economic analysis components of the PROSPER trial
    Jerry Avorn
    Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Control Clin Trials 23:757-73. 2002
    ....
  85. ncbi request reprint Alcohol consumption and the risk of renal dysfunction in apparently healthy men
    Elke S Schaeffner
    Department of Medicine, Charite Campus Virchow, Berlin, Germany
    Arch Intern Med 165:1048-53. 2005
    ..Moderate alcohol consumption has been consistently associated with beneficial health effects on cardiovascular disease. In contrast, the association between alcohol consumption and renal dysfunction is less clear...
  86. ncbi request reprint Effect of intensive glycemic control on levels of markers of inflammation in type 1 diabetes mellitus in the diabetes control and complications trial
    Debra A Schaumberg
    Division of Preventive Medicine, Brigham and Womens Hospital, Boston, Mass, USA
    Circulation 111:2446-53. 2005
    ..The present study examined the effect of intensive therapy on levels of several markers of inflammation that have been linked to risk of CVD...
  87. ncbi request reprint Suboptimal antidepressant use in the elderly
    Philip S Wang
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02120, USA
    J Clin Psychopharmacol 25:118-26. 2005
    ..Suboptimal antidepressant use remains common in the elderly, especially the use of inadequately intensive regimens. Interventions are needed to improve the quality and outcomes of antidepressant use in this vulnerable population...
  88. ncbi request reprint Value of an Endpoints Committee versus the use of nosologists for validating cause of death
    Howard D Sesso
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215 1204, USA
    Contemp Clin Trials 27:333-9. 2006
    ..Few studies have directly compared the use of nosologists versus other sources of mortality information deemed a gold standard, including the use of an Endpoints Committee (EC), which is commonly utilized in clinical studies...
  89. ncbi request reprint C-reactive protein and coronary heart disease
    Robert J Glynn
    N Engl J Med 351:295-8; author reply 295-8. 2004
  90. ncbi request reprint The Wilcoxon signed rank test for paired comparisons of clustered data
    Bernard Rosner
    Channing Laboratory, Harvard Medical School, Boston, Massachusetts 02115, USA
    Biometrics 62:185-92. 2006
    ....
  91. ncbi request reprint Should clozapine continue to be restricted to third-line status for schizophrenia?: a decision-analytic model
    Philip S Wang
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, 1620 Tremont Street, Suite 3030 Boston, MA 02120, USA
    J Ment Health Policy Econ 7:77-85. 2004
    ..Clozapine is currently restricted to patients who have failed at least two trials of other antipsychotic medications because of concerns that its use as a first-line agent would lead to greater mortality, mainly through agranulocytosis...
  92. ncbi request reprint Use of the case-crossover design to study prolonged drug exposures and insidious outcomes
    Philip S Wang
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Ann Epidemiol 14:296-303. 2004
    ..We investigated whether case-crossover methods can be used to study prolonged exposures and insidious outcomes...
  93. ncbi request reprint How well do patients report noncompliance with antihypertensive medications?: a comparison of self-report versus filled prescriptions
    Philip S Wang
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Pharmacoepidemiol Drug Saf 13:11-9. 2004
    ..Although self-reports are often the only means available in routine practice, their accuracy and agreement with other data sources remain questionable...
  94. ncbi request reprint Incorporation of clustering effects for the Wilcoxon rank sum test: a large-sample approach
    Bernard Rosner
    Channing Laboratory, Harvard Medical School, 181 Longwood Avenue, Boston, Massachusetts, USA
    Biometrics 59:1089-98. 2003
    ..In this article, we present large-sample theory and simulation results for this test procedure and apply it to diabetic retinopathy data from type I diabetics in the Sorbinil Retinopathy Trial...
  95. pmc A review of the application of propensity score methods yielded increasing use, advantages in specific settings, but not substantially different estimates compared with conventional multivariable methods
    TIL STURMER
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Harvard Medical School, 1620 Tremont Street, Suite 3030, Boston, MA 02120, USA
    J Clin Epidemiol 59:437-47. 2006
    ..Such analyses have been proposed to address confounding by indication, but there is little empirical evidence that they achieve better control than conventional multivariate outcome modeling...

Research Grants19

  1. Medication Use, Cormobidity and Outcomes in Aging Populations
    Robert J Glynn; Fiscal Year: 2010
    ..These studies are intended to advance methodologic strategies for evaluation of drug use and its effects in older people and to lay the foundation for interventions to improve prescribing in this population. ..
  2. Determinants of Venous Thromboembolism in Older People
    Robert Glynn; Fiscal Year: 2009
    ..Results will help identify high-risk older people, and potentially modifiable behaviors that influence risk of ..
  3. Medication Use, Cormobidity and Outcomes in Aging Populations
    Robert Glynn; Fiscal Year: 2009
    ..These studies are intended to advance methodologic strategies for evaluation of drug use and its effects in older people and to lay the foundation for interventions to improve prescribing in this population. ..
  4. Determinants of Venous Thromboembolism in Older People
    Robert Glynn; Fiscal Year: 2007
    ..Results will help identify high-risk older people, and potentially modifiable behaviors that influence risk of ..
  5. Medication Use, Comorbidity and Outcomes in Aging populations
    Robert Glynn; Fiscal Year: 2007
    ..These studies are intended to advance methodologic strategies for evaluation of drug use and its effects in older people and to lay the foundation for interventions to improve prescribing in this population. ..
  6. Epidemiology of Venous Thromboembolism
    Robert Glynn; Fiscal Year: 2004
    ..The results of this work may lead to new strategies for VTE preventio. ..
  7. Medication Use, Comorbidity and Outcomes in Older People
    Robert Glynn; Fiscal Year: 2004
    ..Clarification of the epidemiology of drug use, based on current longitudinal data, can lead to improved prescribing practices and thereby decrease morbidity and mortality in high-risk populations. ..
  8. SECONDARY PREVENTION TRIAL OF VENOUS THROMBOSIS-DCC
    Robert Glynn; Fiscal Year: 2002
    ..Events will be assessed by yearly visits and bi-monthly questionnaires at the time of the INR monitoring. ..
  9. Determinants of Venous Thromboembolism in Older People
    Robert J Glynn; Fiscal Year: 2010
    ..Results will help identify high-risk older people, and potentially modifiable behaviors that influence risk of ..