Research Topics
Genomes and Genes
| Edward L GiovannucciSummaryAffiliation: Harvard University Country: USA Publications
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Publications
Epidemiology of vitamin d and colorectal cancerEdward Giovannucci
Department of Nutrition, 665 Huntington Avenue, Boston, MA 02115, USA
Anticancer Agents Med Chem 13:11-9. 2013..Thus, improving vitamin D status could be potentially beneficial against colorectal cancer incidence and mortality...
Commentary. On the epidemiology of influenza: reply to Radonovich et alJohn J Cannell
Department of Psychiatry, Atascadero State Hospital, 10333 El Camino Real, Atascadero, CA 93423, USA
Virol J 6:121. 2009..On the epidemiology of influenza: reply to Radonovich LJ, Martinello RA, Hodgson M, Milton DK, Nardell EA. Influenza and ultraviolet germicidal irradiation. Virol J. 2008, 5:149...- On the epidemiology of influenzaJohn J Cannell
Department of Psychiatry, Atascadero State Hospital, 10333 El Camino Real, Atascadero, CA 93423, USA
Virol J 5:29. 2008..quot; If true, our revision of Edgar Hope-Simpson's theory has profound implications for the prevention of influenza... - Prevalence and correlates of vitamin D status in African American menMarilyn Tseng
Cancer Prevention and Control Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
BMC Public Health 9:191. 2009..Few studies have examined vitamin D insufficiency in African American men although they are at very high risk. We examined the prevalence and correlates of vitamin D insufficiency among African American men in Philadelphia... 
25-hydroxyvitamin D and risk of myocardial infarction in men: a prospective studyEdward Giovannucci
Department of Nutrition, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115, USA
Arch Intern Med 168:1174-80. 2008..Vitamin D deficiency may be involved in the development of atherosclerosis and coronary heart disease in humans...- Vitamin D and cardiovascular diseaseEdward Giovannucci
Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
Curr Atheroscler Rep 11:456-61. 2009..Further study, including properly designed randomized control trials, is required to further establish the role of vitamin D on cardiovascular diseases... - Strengths and limitations of current epidemiologic studies: vitamin D as a modifier of colon and prostate cancer riskEdward Giovannucci
Department of Nutrition, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115, USA
Nutr Rev 65:S77-9. 2007 - Epidemiology of vitamin D and colorectal cancer: casual or causal link?Edward Giovannucci
Harvard School of Public Health, and Channing Laboratory, Brigham and Women s Hospital, Boston, MA 02115, USA
J Steroid Biochem Mol Biol 121:349-54. 2010..These studies are reviewed... - Diabetes and cancer: a consensus reportEdward Giovannucci
Departments of Nutrition and Epidemiology, Harvard School of Public Health, 655 Huntington Avenue, Boston, MA 02115, USA
CA Cancer J Clin 60:207-21. 2010..In addition, key unanswered questions for future research are posed... - Vitamin D status and cancer incidence and mortalityEdward Giovannucci
Department of Nutrition, Harvard School of Public Health and Brigham and Women's Hospital, Boston, MA 02115, USA
Adv Exp Med Biol 624:31-42. 2008 - Diabetes and cancer: a consensus reportEdward Giovannucci
Department of Nutrition, Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
Diabetes Care 33:1674-85. 2010..In addition, key unanswered questions for future research are posed... - Role of vitamin and mineral supplementation and aspirin use in cancer survivorsEdward Giovannucci
ScD, Department of Nutrition, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115, USA
J Clin Oncol 28:4081-5. 2010..The potential beneficial or adverse effects of dietary supplements and aspirin in survivors of cancer warrant further study... - A meta-analysis of diabetes mellitus and the risk of prostate cancerJocelyn S Kasper
Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
Cancer Epidemiol Biomarkers Prev 15:2056-62. 2006..Studies investigating the association between diabetes mellitus and prostate cancer have reported inconsistent findings. We examined this association by conducting a detailed meta-analysis of the studies published on the subject... - Commentary: Serum lycopene and prostate cancer progression: a re-consideration of findings from the prostate cancer prevention trialEdward Giovannucci
Departments of Nutrition and Epidemiology, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02136, USA
Cancer Causes Control 22:1055-9. 2011.... - Vitamin D receptor expression is associated with PIK3CA and KRAS mutations in colorectal cancerShoko Kure
Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts 02115, USA
Cancer Epidemiol Biomarkers Prev 18:2765-72. 2009..Our data support potential interactions between the VDR, RAS-MAPK and PI3K-AKT pathways, and possible influence by KRAS or PIK3CA mutation on therapy or chemoprevention targeting VDR... - Epigenomic diversity of colorectal cancer indicated by LINE-1 methylation in a database of 869 tumorsYoshifumi Baba
Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA, USA
Mol Cancer 9:125. 2010..Thus, it is of particular interest to examine whether its wide variation can be attributed to clinical, pathologic or molecular features... - A prospective cohort study shows unique epigenetic, genetic, and prognostic features of synchronous colorectal cancersKatsuhiko Nosho
Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts 02115, USA
Gastroenterology 137:1609-20.e1-3. 2009..Synchronous colon cancers have not been compared with control solitary cancers in a prospective study... - CDK8 expression in 470 colorectal cancers in relation to beta-catenin activation, other molecular alterations and patient survivalRon Firestein
Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
Int J Cancer 126:2863-73. 2010..These data support a potential link between CDK8 and beta-catenin, and suggest that CDK8 may identify a subset of colon cancer patients with a poor prognosis... - Choline intake and risk of lethal prostate cancer: incidence and survivalErin L Richman
Departments of Epidemiology and Nutrition, Harvard School of Public Health, Boston, MA, USA
Am J Clin Nutr 96:855-63. 2012..These foods are sources of choline-a nutrient that may affect prostate cancer progression through cell membrane function and one-carbon metabolism. No study has examined dietary choline and the risk of lethal prostate cancer... - Variant ABO blood group alleles, secretor status, and risk of pancreatic cancer: results from the pancreatic cancer cohort consortiumBrian M Wolpin
Department of Medical Oncology, Dana Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA
Cancer Epidemiol Biomarkers Prev 19:3140-9. 2010..We hypothesized: 1) A(1) allele would confer greater risk than A(2) allele, 2) protective effect of the O allele would be equivalent for O01 and O02 variants, 3) secretor phenotype would modify the association with risk... - Prospective cohort studies of vitamin B-6 intake and colorectal cancer incidence: modification by time?Xuehong Zhang
Channing Division of Network Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Am J Clin Nutr 96:874-81. 2012..The relation between vitamin B-6 intake and colorectal cancer risk remains uncertain... - ABO blood group and the risk of pancreatic cancerBrian M Wolpin
Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
J Natl Cancer Inst 101:424-31. 2009..ABO blood type is an inherited characteristic that in previous small studies has been associated with the risk of gastrointestinal malignancies... - A cohort study of tumoral LINE-1 hypomethylation and prognosis in colon cancerShuji Ogino
Center for Molecular Oncologic Pathology, Dana Farber Cancer Institute, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
J Natl Cancer Inst 100:1734-8. 2008..In conclusion, tumoral LINE-1 hypomethylation is independently associated with shorter survival among colon cancer patients... - Cohort study of fatty acid synthase expression and patient survival in colon cancerShuji Ogino
Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA 02115, USA
J Clin Oncol 26:5713-20. 2008..Fatty acid synthase (FASN) is physiologically regulated by energy balance and is often upregulated in colorectal cancer. Nonetheless, the influence of FASN expression on patient outcome is uncertain... - Negative lymph node count is associated with survival of colorectal cancer patients, independent of tumoral molecular alterations and lymphocytic reactionShuji Ogino
Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts 02115, USA
Am J Gastroenterol 105:420-33. 2010.... - Interaction of molecular markers and physical activity on mortality in patients with colon cancerJeffrey A Meyerhardt
Dana Farber Cancer Institute, Boston, MA 02115, USA
Clin Cancer Res 15:5931-6. 2009..Physical activity in colon cancer survivors has been associated with lower cancer recurrences and improved survival. Whether molecular features of the tumor portend more or less likelihood for benefit from exercise is unknown... - HIF1A overexpression is associated with poor prognosis in a cohort of 731 colorectal cancersYoshifumi Baba
Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA 02115, USA
Am J Pathol 176:2292-301. 2010..039). In conclusion, HIF1A expression is independently associated with poor prognosis in colorectal cancer, suggesting HIF1A as a biomarker with potentially important therapeutic implications... - Genetic variation in RNASEL associated with prostate cancer risk and progressionMara S Meyer
Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
Carcinogenesis 31:1597-603. 2010..The results of this study support a link between RNASEL and prostate cancer and suggest that the association may be mediated through inflammation. These novel findings warrant replication in future studies... - Lifestyle and dietary factors in the prevention of lethal prostate cancerKathryn M Wilson
Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
Asian J Androl 14:365-74. 2012..We present a summary of evidence for the following selected behavioral risk factors: obesity and weight change, physical activity, smoking, antioxidant intake, vitamin D and calcium, and coffee intake... - PIK3CA mutation is associated with poor prognosis among patients with curatively resected colon cancerShuji Ogino
Department of Medical Oncology, Dana Farber Cancer Institute, Brigham and Women s Hospital, Harvard Medical School, 44 Binney St, Room JF 215C, Boston, MA 02115 USA
J Clin Oncol 27:1477-84. 2009..PIK3CA mutation and subsequent activation of the AKT pathway play an important role in colorectal carcinogenesis. However, little is known about the prognostic role of PIK3CA mutation in colon cancer... - DNMT3B expression might contribute to CpG island methylator phenotype in colorectal cancerKatsuhiko Nosho
Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts, USA
Clin Cancer Res 15:3663-71. 2009..We hypothesized that cellular DNMT3B level might influence the occurrence of widespread CpG island methylation (i.e., the CpG island methylator phenotype, CIMP) in colon cancer... - Twenty-four non-synonymous polymorphisms in the one-carbon metabolic pathway and risk of colorectal adenoma in the Nurses' Health StudyAditi Hazra
Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
Carcinogenesis 28:1510-9. 2007..Further investigation is required to validate the association of the polymorphisms in the one-carbon metabolic genes and risk of colorectal adenoma... - Colorectal cancer expression of peroxisome proliferator-activated receptor gamma (PPARG, PPARgamma) is associated with good prognosisShuji Ogino
Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, and Department of Pathology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
Gastroenterology 136:1242-50. 2009..There is controversy over the pro-oncogenic or antioncogenic effects of PPARG, and little is known about its prognostic significance in colon cancer... - PTGER2 overexpression in colorectal cancer is associated with microsatellite instability, independent of CpG island methylator phenotypeYoshifumi Baba
Department of Medical Oncology, Dana FarberCancer Institute and Harvard Medical School, Boston, Massachusetts, USA
Cancer Epidemiol Biomarkers Prev 19:822-31. 2010..However, the prognostic significance of PTGER2 expression or its relationship with MSI, CIMP, LINE-1 hypomethylation, or PTGS2 (COX-2) remains uncertain... - Physical activity and survival after colorectal cancer diagnosisJeffrey A Meyerhardt
Division of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
J Clin Oncol 24:3527-34. 2006..Physically active individuals have a lower risk of developing colorectal cancer but the influence of exercise on cancer survival is unknown... - Aspirin dose and duration of use and risk of colorectal cancer in menAndrew T Chan
Gastrointestinal Unit, Massachusetts General Hospital and Harvard Medical School, Boston, USA
Gastroenterology 134:21-8. 2008..Long-term data on the risk of colorectal cancer according to dose, duration, and consistency of aspirin therapy are limited... - Aspirin use, body mass index, physical activity, plasma C-peptide, and colon cancer risk in US health professionalsXuehong Zhang
Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA
Am J Epidemiol 174:459-67. 2011..10) for the low and 0.65 (95% CI: 0.46, 0.92) for the high group. Reductions in colon cancer risk associated with aspirin use were not significantly modified by body mass index, physical activity, or plasma C-peptide level in this study... - Genetic variants in the UGT1A6 enzyme, aspirin use, and the risk of colorectal adenomaAndrew T Chan
Gastrointestinal Unit, Massachusetts General Hospital and Harvard Medical School, GRJ 722, Boston, MA 02114, USA
J Natl Cancer Inst 97:457-60. 2005.... - Hemochromatosis gene mutations, body iron stores, dietary iron, and risk of colorectal adenoma in womenAndrew T Chan
Gastrointestinal Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
J Natl Cancer Inst 97:917-26. 2005..We assessed dietary iron intake and genetic and biochemical markers of iron status in a prospective, nested case-control study of women enrolled in the Nurses' Health Study... - CpG island methylator phenotype, microsatellite instability, BRAF mutation and clinical outcome in colon cancerShuji Ogino
Center for Molecular Oncologic Pathology, Dana Farber Cancer Institute, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115 USA
Gut 58:90-6. 2009..The independent effect of CIMP, MSI and BRAF mutation on prognosis remains uncertain... - Comprehensive biostatistical analysis of CpG island methylator phenotype in colorectal cancer using a large population-based sampleKatsuhiko Nosho
Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA, USA
PLoS ONE 3:e3698. 2008..CIMP-high is independently associated with clinical and key molecular features in colorectal cancer. Our data also suggest that KRAS mutation is related with a random CpG island methylation pattern which may lead to CIMP-low tumors... - A cohort study of STMN1 expression in colorectal cancer: body mass index and prognosisShuji Ogino
Department of Medical Oncology, Center for Molecular Oncologic Pathology, Dana Farber Cancer Institute, Brigham and Women s Hospital and Harvard Medical School, 44 Binney St, Room JF 215C, Boston, Massachusetts 02115, USA
Am J Gastroenterol 104:2047-56. 2009..STMN1 activity is influenced by p53, p27, and the PI3K/AKT pathway. However, its prognostic significance in colon cancer is uncertain... - Insulin, the insulin-like growth factor axis, and mortality in patients with nonmetastatic colorectal cancerBrian M Wolpin
Department of Medical Oncology, Dana Farber Cancer Institute, 44 Binney St, Boston, MA 02115, USA
J Clin Oncol 27:176-85. 2009..Excess energy balance leads to increased circulating insulin and depressed levels of circulating insulin-like growth factor binding protein (IGFBP) -1, which promote cancer cell growth in preclinical models... - A cohort study of p27 localization in colon cancer, body mass index, and patient survivalShuji Ogino
Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Brigham and Women s Hospital, Boston, and Harvard Medical School 02115, USA
Cancer Epidemiol Biomarkers Prev 18:1849-58. 2009..08). In conclusion, p27 alterations in colon cancer are associated with superior prognosis. Adverse prognostic effect of obesity seems limited to patients with nuclear p27 expression, suggesting a host-tumor interaction... - Family history of cancer and risk of pancreatic cancer: a pooled analysis from the Pancreatic Cancer Cohort Consortium (PanScan)Eric J Jacobs
Department of Epidemiology, American Cancer Society, Atlanta, GA, USA
Int J Cancer 127:1421-8. 2010..47). Our results confirm a moderate sized association between a family history of pancreatic cancer and risk of pancreatic cancer and also provide evidence for an association with a family history of prostate cancer worth further study... - Cumulative risk of colon cancer up to age 70 years by risk factor status using data from the Nurses' Health StudyEsther K Wei
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
Am J Epidemiol 170:863-72. 2009..For women with a high risk factor profile, adopting a healthier lifestyle could dramatically reduce colon cancer risk... - The association between betaine and choline intakes and the plasma concentrations of homocysteine in womenStephanie E Chiuve
Department of Nutrition, Harvard School of Public Health, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
Am J Clin Nutr 86:1073-81. 2007..Elevated total homocysteine (tHcy), a risk factor for many chronic diseases, can be remethylated to methionine by folate. Alternatively, tHcy can be metabolized by other 1-carbon nutrients, ie, betaine and its precursor, choline... - Hypomethylation of the IGF2 DMR in colorectal tumors, detected by bisulfite pyrosequencing, is associated with poor prognosisYoshifumi Baba
Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts, USA
Gastroenterology 139:1855-64. 2010..IGF2 LOI correlates with hypomethylation at the differentially methylated region (DMR)-0. An assay for methylation of the DMR0 could overcome the limitations of the conventional IGF2 LOI assay... - Risk of colon cancer and coffee, tea, and sugar-sweetened soft drink intake: pooled analysis of prospective cohort studiesXuehong Zhang
Department of Nutrition, Department of Epidemiology, Harvard School of Public Health, 655 Huntington Ave, Boston, MA 02115, USA
J Natl Cancer Inst 102:771-83. 2010..The relationships between coffee, tea, and sugar-sweetened carbonated soft drink consumption and colon cancer risk remain unresolved... - Plasma vitamin D metabolites and risk of colorectal cancer in womenDiane Feskanich
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
Cancer Epidemiol Biomarkers Prev 13:1502-8. 2004..We therefore examined risk in relation to plasma concentrations of these vitamin D metabolites... - A Prospective Study of Plasma Adiponectin and Pancreatic Cancer Risk in Five US CohortsYing Bao
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Ave, Boston, MA 02115
J Natl Cancer Inst 105:95-103. 2013..10). Conclusions In this pooled analysis, low prediagnostic levels of circulating adiponectin were associated with an elevated risk of pancreatic cancer... - Higher predicted vitamin D status is associated with reduced risk of Crohn's diseaseAshwin N Ananthakrishnan
Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02214, USA
Gastroenterology 142:482-9. 2012..Vitamin D influences innate immunity, which is believed to be involved in the pathogenesis of Crohn's disease (CD) and ulcerative colitis (UC). However, data examining vitamin D status in relation to risk of CD and UC are lacking... - A prospective study of intakes of zinc and heme iron and colorectal cancer risk in men and womenXuehong Zhang
Channing Laboratory at Landmark Center West Wing, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 401 Park Drive, Boston, MA 02115, USA
Cancer Causes Control 22:1627-37. 2011..Our study does not support strong roles of zinc and heme iron intake in colorectal cancer risk; however, a suggestive inverse association of dietary zinc intake with rectal cancer risk in women requires further study... - Association of the TCF7L2 polymorphism with colorectal cancer and adenoma riskAditi Hazra
Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
Cancer Causes Control 19:975-80. 2008..37-1.08; P for heterogeneity 0.52 for the association in women and men). In summary, the marginal association of the TCF7L2 SNP with CRC might be due to chance, but warrants further laboratory and epidemiological investigation... - Circulating prediagnostic interleukin-6 and C-reactive protein and prostate cancer incidence and mortalityJennifer Rider Stark
Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
Int J Cancer 124:2683-9. 2009..02). Adjusted hazard ratios were 1.73 (95% CI: 0.86, 3.51) comparing the highest to lowest IL-6 level. Our study suggests that IL-6 may potentially be involved in the development or progression of prostate cancer... - Prospective study of Trichomonas vaginalis infection and prostate cancer incidence and mortality: Physicians' Health StudyJennifer R Stark
Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
J Natl Cancer Inst 101:1406-11. 2009..We confirmed these findings in an independent population and related serostatus for antibodies against T vaginalis to prostate cancer incidence and mortality... - Alcohol intake and methylenetetrahydrofolate reductase polymorphism modify the relation of folate intake to plasma homocysteineStephanie E Chiuve
Department of Nutrition and the Channing Laboratory, Harvard Medical School, Boston, MA, USA
Am J Clin Nutr 82:155-62. 2005..Folate metabolism may be altered by alcohol intake and 2 common polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene, 677C-->T and 1298A-->C... - Primary prevention of colorectal cancerAndrew T Chan
Gastrointestinal Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
Gastroenterology 138:2029-2043.e10. 2010..Taken together, modifications in diet and lifestyle should substantially reduce the risk of colorectal cancer and could complement screening in reducing colorectal cancer incidence... - Fruits, vegetables, and colon cancer risk in a pooled analysis of 14 cohort studiesAnita Koushik
Department of Nutrition, Harvard School of Public Health, Boston, MA, USA
J Natl Cancer Inst 99:1471-83. 2007..Statistical power to examine associations by colon site has been limited in previous studies... - A nested case control study of plasma 25-hydroxyvitamin D concentrations and risk of colorectal cancerKana Wu
Department of Nutrition, Harvard School of Public Health, 665 Huntington Ave, Bldg 2, Boston, MA 02115, USA
J Natl Cancer Inst 99:1120-9. 2007..We investigated this relationship in a nested case-control study within the Health Professionals Follow-up Study (HPFS), a large ongoing study of male health professionals living in the United States... - Lymphocytic reaction to colorectal cancer is associated with longer survival, independent of lymph node count, microsatellite instability, and CpG island methylator phenotypeShuji Ogino
Center for Molecular Oncologic Pathology, Dana Farber Cancer Institute, Brigham and Women s Hospital, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
Clin Cancer Res 15:6412-20. 2009.... - Joint association of alcohol and folate intake with risk of major chronic disease in womenRui Jiang
Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
Am J Epidemiol 158:760-71. 2003..Adequate folate intake may be important in the primary prevention of overall major chronic disease in women, especially among younger women consuming more than two alcoholic drinks per day... - Frequent nut consumption and decreased risk of cholecystectomy in womenChung Jyi Tsai
Channing Laboratory, Department of Medicine, Harvard Medical School and Brigham and Women s Hospital, Boston, MA, USA
Am J Clin Nutr 80:76-81. 2004..Gallstone disease is a major source of morbidity in the developed countries. Nuts are rich in several compounds that may protect against gallstone disease... - Inflammatory markers are associated with risk of colorectal cancer and chemopreventive response to anti-inflammatory drugsAndrew T Chan
Gastrointestinal Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
Gastroenterology 140:799-808, quiz e11. 2011..We investigated whether plasma inflammatory markers were associated with risk of CRC and if use of anti-inflammatory drugs was differentially associated with risk of CRC according to levels of inflammatory markers... - Dietary protein and the risk of cholecystectomy in a cohort of US women: the Nurses' Health StudyChung Jyi Tsai
Channing Laboratory, Department of Medicine, Harvard Medical School and Brigham and Women s Hospital, Boston, MA, USA
Am J Epidemiol 160:11-8. 2004..These results suggest that increased consumption of vegetable protein in the context of an energy-balanced diet can reduce the risk of cholecystectomy in women... - Prediagnostic plasma folate and the risk of death in patients with colorectal cancerBrian M Wolpin
Department of MedicalOncology, Dana Farber Cancer Institute, Boston, MA, USA
J Clin Oncol 26:3222-8. 2008..Therefore, high priority has been given to research investigating the influence of folate on cancer progression in patients with colorectal cancer... - Circulating 25-hydroxyvitamin d levels and survival in patients with colorectal cancerKimmie Ng
Division of Medical Oncology, Dana Farber Cancer Institute Boston, MA 02115, USA
J Clin Oncol 26:2984-91. 2008..Higher plasma 25-hydroxyvitamin D(3) (25(OH)D) levels are associated with a decreased incidence of colorectal cancer, but the influence of plasma 25(OH)D on the outcome of patients with established colorectal cancer is unknown... - Long-term use of aspirin and nonsteroidal anti-inflammatory drugs and risk of colorectal cancerAndrew T Chan
Gastrointestinal Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Mass 02114, USA
JAMA 294:914-23. 2005..However, data on long-term risk of colorectal cancer according to dose, timing, or duration of therapy with aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) remain limited... - A prospective study on supplemental vitamin e intake and risk of colon cancer in women and menKana Wu
Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA
Cancer Epidemiol Biomarkers Prev 11:1298-304. 2002..Considering the paucity of epidemiological data on this association, further studies of vitamin E and colon cancer are warranted... - Glycemic load, glycemic index, and carbohydrate intake in relation to risk of cholecystectomy in womenChung Jyi Tsai
Channing Laboratory, Department of Medicine, Harvard Medical School and Brigham and Women s Hospital, Boston, Massachusetts, USA
Gastroenterology 129:105-12. 2005..High-carbohydrate diets with a high glycemic response may exacerbate the metabolic consequences of the insulin-resistance syndrome. The effect on the incidence of gallstone disease is not clear... - A prospective study of physical activity and incident and fatal prostate cancerEdward L Giovannucci
Department of Nutrition, Harvard School of Public Health, Boston, Mass, USA
Arch Intern Med 165:1005-10. 2005..Whether physical activity has benefits against prostate cancer incidence or progression is unclear. Therefore, we assessed physical activity in relation to prostate cancer incidence, mortality, and Gleason histologic grade... - Nonsynonymous polymorphisms in genes in the one-carbon metabolism pathway and associations with colorectal cancerAnita Koushik
Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
Cancer Epidemiol Biomarkers Prev 15:2408-17. 2006..Our results corroborate previous findings for MTHFR Ala(222)Val and suggest that other genes involved in one-carbon metabolism, particularly those that affect DNA methylation, may be associated with colorectal cancer risk... - Association between serum concentrations of micronutrients and lower urinary tract symptoms in older men in the Third National Health and Nutrition Examination SurveySabine Rohrmann
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
Urology 64:504-9. 2004..The effect modification of the association with vitamin C by cigarette smoking warrants additional examination... - Dietary macronutrient and energy intake and urinary incontinence in womenNancy N Maserejian
Department of Epidemiology, New England Research Institutes, Watertown, Massachusetts, USA
Am J Epidemiol 171:1116-25. 2010..0001). Results suggest that dietary changes, particularly decreasing saturated fat relative to polyunsaturated fat and decreasing total calories, could independently account for some of the benefits of weight loss in women with UI... - Dietary choline and betaine and the risk of distal colorectal adenoma in womenEunyoung Cho
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Ave, Boston, MA 02115, USA
J Natl Cancer Inst 99:1224-31. 2007..No epidemiologic study has examined the association of intake of these nutrients and colorectal adenoma risk... - A prospective study of plasma vitamin D metabolites, vitamin D receptor polymorphisms, and prostate cancerHaojie Li
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
PLoS Med 4:e103. 2007..Few studies have explored the joint association of circulating vitamin D levels with VDR polymorphisms... - p53 Arg72Pro polymorphism and risk of colorectal adenoma and cancerAnita Koushik
Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
Int J Cancer 119:1863-8. 2006..09, 95% CI = 1.28-3.40) but not proximal colon or rectal cancers. Our results suggest that Arg72Pro may play a role in the early stages of colorectal neoplasia and possibly in progression to invasive disease, depending on site and sex... - Association between the Met326Ile polymorphism of the p85alpha regulatory subunit of phosphatidylinositol 3-kinase and prostate cancer risk: a prospective studyAimée E Paradis
The Lank Center for Genitourinary Oncology, Department of Adult Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
Cancer Epidemiol Biomarkers Prev 12:172-3. 2003 - XRCC2 and XRCC3 polymorphisms are not associated with risk of colorectal adenomaGregory J Tranah
Department of Epidemiology, and Harvard Center for Cancer Prevention, Harvard School of Public Health, Boston, MA, USA
Cancer Epidemiol Biomarkers Prev 13:1090-1. 2004 - Sex steroid hormones and the androgen receptor gene CAG repeat and subsequent risk of prostate cancer in the prostate-specific antigen eraElizabeth A Platz
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Room E6138, 615 North Wolfe Street, Baltimore, MD 21205, USA
Cancer Epidemiol Biomarkers Prev 14:1262-9. 2005..We investigated plasma levels of sex steroid hormones and length of the androgen receptor gene CAG repeat in relation to incident prostate cancer diagnosed in the prostate-specific antigen (PSA) era... - Diabetes mellitus and risk of prostate cancer in the health professionals follow-up studyJocelyn S Kasper
Department of Nutrition, Harvard School of Public Health, Harvard University, Boston, MA 02115, USA
Int J Cancer 124:1398-403. 2009..Results are consistent with the hypothesis that diabetes is associated with reduced PCa risk. Potential biological mechanisms are discussed... - O6-methylguanine-DNA methyltransferase Leu84Phe and Ile143Val polymorphisms and risk of colorectal cancer in the Nurses' Health Study and Physicians' Health Study (United States)Gregory J Tranah
Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
Cancer Causes Control 17:721-31. 2006..Two non-synonymous MGMT coding region variants, Leu84Phe and Ile143Val, lie in close proximity to the reactive 145Cys residue and to a conserved estrogen receptor interacting helix... - ATAAA repeat upstream of glutathione S-transferase P1 and prostate cancer riskElizabeth A Platz
Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
Urology 59:159-64. 2002..Upstream of its promoter is a polymorphic ATAAA repeat of unknown functional significance. We evaluated whether this polymorphism is associated with prostate cancer... - Epoxide hydrolase and CYP2C9 polymorphisms, cigarette smoking, and risk of colorectal carcinoma in the Nurses' Health Study and the Physicians' Health StudyGregory J Tranah
Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
Mol Carcinog 44:21-30. 2005..Our results indicate that individuals exposed to tobacco carcinogens were at increased risk of colorectal cancer and that overall risk is related to mEH and CYP2C9 genotype, although the results were not consistent between men and women... - Prospective study of fruits and vegetables and risk of oral premalignant lesions in menNancy Nairi Maserejian
Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
Am J Epidemiol 164:556-66. 2006..7). The risk of oral premalignant lesions was significantly reduced with higher consumption of fruits, particularly citrus fruits and juices, while no consistent associations were apparent for vegetables... - Hormonal profile of diabetic men and the potential link to prostate cancerJocelyn S Kasper
Department of Nutrition, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
Cancer Causes Control 19:703-10. 2008..To investigate potential biological mechanisms, hormonal profiles of diabetic men and non-diabetic controls were compared... - A prospective cohort study of red wine consumption and risk of prostate cancerSiobhan Sutcliffe
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
Int J Cancer 120:1529-35. 2007..These findings suggest that red wine does not contribute appreciably to the etiology of prostate cancer... - Dietary carotenoids and risk of lung cancer in a pooled analysis of seven cohort studiesSatu Mannisto
Harvard School of Public Health, Department of Nutrition, Boston, Massachusetts, USA
Cancer Epidemiol Biomarkers Prev 13:40-8. 2004..Although smoking is the strongest risk factor for lung cancer, greater intake of foods high in beta-cryptoxanthin, such as citrus fruit, may modestly lower the risk... - Vitamin D receptor (VDR) gene polymorphisms and haplotypes, interactions with plasma 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D, and prostate cancer riskBahar Mikhak
Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
Prostate 67:911-23. 2007..The vitamin D receptor (VDR) is required for actions of vitamin D. The binding of 1,25-dihydroxyvitamin D to the VDR on prostatic epithelial cells prompts the regulation of cancer-related genes... - Manganese superoxide dismutase (MnSOD) gene polymorphism, interactions with carotenoid levels and prostate cancer riskBahar Mikhak
Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
Carcinogenesis 29:2335-40. 2008..On the other hand, some epidemiologic studies suggest that the Ala allele is associated with a higher risk of cancer, including prostate cancer... - Glycemic index, glycemic load, and carbohydrate intake in relation to risk of distal colorectal adenoma in womenKyungwon Oh
Department of Nutrition and Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
Cancer Epidemiol Biomarkers Prev 13:1192-8. 2004..Our findings do not support the hypothesis that a high glycemic index diet, a high glycemic load diet, or high carbohydrate intake overall are associated with risk of colorectal adenoma... - Associations of obesity with lower urinary tract symptoms and noncancer prostate surgery in the Third National Health and Nutrition Examination SurveySabine Rohrmann
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
Am J Epidemiol 159:390-7. 2004..Results suggest that being overweight in young adulthood may be associated with a lower prevalence of LUTS later in life, whereas weight gain and central adiposity in adulthood are possibly associated with a higher prevalence of LUTS... - A large study of androgen receptor germline variants and their relation to sex hormone levels and prostate cancer risk. Results from the National Cancer Institute Breast and Prostate Cancer Cohort ConsortiumSara Lindstrom
Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
J Clin Endocrinol Metab 95:E121-7. 2010..A long-standing hypothesis has been that inherited variation in the androgen receptor (AR) gene plays a role in prostate cancer initiation. However, studies to date have been inconclusive and often suffered from small sample sizes... - Fiber from fruit and colorectal neoplasiaMia A Papas
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Room E6143, 615 North Wolfe Street, Baltimore, MD 21205, USA
Cancer Epidemiol Biomarkers Prev 13:1267-70. 2004 - History of peptic ulcer disease and pancreatic cancer risk in menYing Bao
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
Gastroenterology 138:541-9. 2010..We investigated the association between pancreatic cancer and the occurrence of gastric or duodenal ulcer in a large US cohort... - Plasma insulin-like growth factor-1 and binding protein-3 and subsequent risk of prostate cancer in the PSA eraElizabeth A Platz
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health and the Brady Urological Institute and the Kimmel Comprehensive Cancer Center, Baltimore, MD 21205, USA
Cancer Causes Control 16:255-62. 2005..We prospectively investigated the associations of plasma IGF-1 and IGFBP-3 concentrations with prostate cancer detected in the PSA era... - Dietary glycemic load and risk of colorectal cancer in the Women's Health StudySusan Higginbotham
Department of Epidemiology, University of California at Los Angeles, USA
J Natl Cancer Inst 96:229-33. 2004..09, 95% CI = 1.13 to 3.87; P(trend) =.08) were also statistically significantly associated with increased risk. Thus, our data indicate that a diet with a high dietary glycemic load may increase the risk of colorectal cancer in women... - Plasma C-peptide is inversely associated with calcium intake in women and with plasma 25-hydroxy vitamin D in menTianying Wu
Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
J Nutr 139:547-54. 2009..03) in men and 12% lower (P = 0.01) in women. The results suggest that calcium intake or systemic vitamin D status, after adjustment for intake of dairy products, is associated with decreased insulin secretion... - Prospective weight change and colon cancer risk in male US health professionalsLau Caspar Thygesen
Department of Nutrition, Harvard School of Public Health, Boston, USA
Int J Cancer 123:1160-5. 2008..5. Our results add support that overweight and obesity are modifiable risk factors for colon cancer among men and suggest that weight has an important influence on colon cancer risk even in later life... - A common 8q24 variant in prostate and breast cancer from a large nested case-control studyFredrick R Schumacher
Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
Cancer Res 67:2951-6. 2007..590). Although the gene responsible has yet to be identified, the validation of this marker in this large sample of prostate cancer cases leaves little room for the possibility of a false-positive result... - Vitamin D and prevention of colorectal adenoma: a meta-analysisMelissa Y Wei
Department of Nutrition, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
Cancer Epidemiol Biomarkers Prev 17:2958-69. 2008..This meta-analysis examined the overall relationship between circulating (plasma or serum) 25-hydroxyvitamin D [25(OH)D], vitamin D intake (dietary, supplemental, or total), and colorectal adenoma incidence in published studies...
Research Grants
- RANDOMIZED TRIAL OF FOLATE AND COLORECTAL ADENOMAEdward Giovannucci; Fiscal Year: 2003..abstract_text> ..
- DIET AND GENETIC INTERACTIONS IN PROSTATE CANCEREdward Giovannucci; Fiscal Year: 2001..The buccal brushings, along with providing the basis for the specific aims in this application, will allow for the rapid testing of future specific hypotheses. ..
- Energy Balance-Related Hormones & Prostate Cancer Incidence & ProgressionEdward Giovannucci; Fiscal Year: 2010....