Edward L Giovannucci

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Lycopene, Tomato Products, and Prostate Cancer Incidence: A Review and Reassessment in the PSA Screening Era
    Melissa Y Wei
    Department of Medicine, Emory University School of Medicine, Atlanta, GA 30303, USA
    J Oncol 2012:271063. 2012
  2. ncbi request reprint Epidemiology of vitamin D and colorectal cancer
    Edward Giovannucci
    Department of Nutrition, Havard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
    Anticancer Agents Med Chem 13:11-9. 2013
  3. pmc Commentary. On the epidemiology of influenza: reply to Radonovich et al
    John J Cannell
    Department of Psychiatry, Atascadero State Hospital, 10333 El Camino Real, Atascadero, CA 93423, USA
    Virol J 6:121. 2009
  4. pmc On the epidemiology of influenza
    John J Cannell
    Department of Psychiatry, Atascadero State Hospital, 10333 El Camino Real, Atascadero, CA 93423, USA
    Virol J 5:29. 2008
  5. pmc Prevalence and correlates of vitamin D status in African American men
    Marilyn Tseng
    Cancer Prevention and Control Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    BMC Public Health 9:191. 2009
  6. doi request reprint Diabetes and cancer: a consensus report
    Edward Giovannucci
    Departments of Nutrition and Epidemiology, Harvard School of Public Health, 655 Huntington Avenue, Boston, MA 02115, USA
    CA Cancer J Clin 60:207-21. 2010
  7. doi request reprint Commentary: Serum lycopene and prostate cancer progression: a re-consideration of findings from the prostate cancer prevention trial
    Edward Giovannucci
    Departments of Nutrition and Epidemiology, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02136, USA
    Cancer Causes Control 22:1055-9. 2011
  8. pmc Diabetes and cancer: a consensus report
    Edward Giovannucci
    Department of Nutrition, Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
    Diabetes Care 33:1674-85. 2010
  9. doi request reprint Epidemiology of vitamin D and colorectal cancer: casual or causal link?
    Edward Giovannucci
    Harvard School of Public Health, and Channing Laboratory, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Steroid Biochem Mol Biol 121:349-54. 2010
  10. ncbi request reprint Vitamin D and cardiovascular disease
    Edward Giovannucci
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Curr Atheroscler Rep 11:456-61. 2009

Research Grants

  1. Energy Balance-Related Hormones & Prostate Cancer Incidence & Progression
    Edward Giovannucci; Fiscal Year: 2009
  2. RANDOMIZED TRIAL OF FOLATE AND COLORECTAL ADENOMA
    Edward Giovannucci; Fiscal Year: 2003
  3. RANDOMIZED TRIAL OF FOLATE AND COLORECTAL ADENOMA
    Edward Giovannucci; Fiscal Year: 2002
  4. RANDOMIZED TRIAL OF FOLATE AND COLORECTAL ADENOMA
    Edward Giovannucci; Fiscal Year: 2001
  5. DIET AND GENETIC INTERACTIONS IN PROSTATE CANCER
    Edward Giovannucci; Fiscal Year: 2001
  6. DIET AND GENETIC INTERACTIONS IN PROSTATE CANCER
    Edward Giovannucci; Fiscal Year: 2000
  7. RANDOMIZED TRIAL OF FOLATE AND COLORECTAL ADENOMA
    Edward Giovannucci; Fiscal Year: 2000
  8. Energy Balance-Related Hormones & Prostate Cancer Incidence & Progression
    Edward Giovannucci; Fiscal Year: 2010

Collaborators

Detail Information

Publications183 found, 100 shown here

  1. pmc Lycopene, Tomato Products, and Prostate Cancer Incidence: A Review and Reassessment in the PSA Screening Era
    Melissa Y Wei
    Department of Medicine, Emory University School of Medicine, Atlanta, GA 30303, USA
    J Oncol 2012:271063. 2012
    ..This paper examines the lycopene and prostate cancer association in light of epidemiologic methodologic issues with particular emphasis on the effect of PSA screening on this association...
  2. ncbi request reprint Epidemiology of vitamin D and colorectal cancer
    Edward Giovannucci
    Department of Nutrition, Havard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
    Anticancer Agents Med Chem 13:11-9. 2013
    ..Thus, improving vitamin D status could be potentially beneficial against colorectal cancer incidence and mortality...
  3. pmc Commentary. On the epidemiology of influenza: reply to Radonovich et al
    John J Cannell
    Department of Psychiatry, Atascadero State Hospital, 10333 El Camino Real, Atascadero, CA 93423, USA
    Virol J 6:121. 2009
    ..On the epidemiology of influenza: reply to Radonovich LJ, Martinello RA, Hodgson M, Milton DK, Nardell EA. Influenza and ultraviolet germicidal irradiation. Virol J. 2008, 5:149...
  4. pmc On the epidemiology of influenza
    John J Cannell
    Department of Psychiatry, Atascadero State Hospital, 10333 El Camino Real, Atascadero, CA 93423, USA
    Virol J 5:29. 2008
    ..If true, our revision of Edgar Hope-Simpson's theory has profound implications for the prevention of influenza...
  5. pmc Prevalence and correlates of vitamin D status in African American men
    Marilyn Tseng
    Cancer Prevention and Control Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    BMC Public Health 9:191. 2009
    ..Few studies have examined vitamin D insufficiency in African American men although they are at very high risk. We examined the prevalence and correlates of vitamin D insufficiency among African American men in Philadelphia...
  6. doi request reprint Diabetes and cancer: a consensus report
    Edward Giovannucci
    Departments of Nutrition and Epidemiology, Harvard School of Public Health, 655 Huntington Avenue, Boston, MA 02115, USA
    CA Cancer J Clin 60:207-21. 2010
    ..In addition, key unanswered questions for future research are posed...
  7. doi request reprint Commentary: Serum lycopene and prostate cancer progression: a re-consideration of findings from the prostate cancer prevention trial
    Edward Giovannucci
    Departments of Nutrition and Epidemiology, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02136, USA
    Cancer Causes Control 22:1055-9. 2011
    ....
  8. pmc Diabetes and cancer: a consensus report
    Edward Giovannucci
    Department of Nutrition, Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
    Diabetes Care 33:1674-85. 2010
    ..In addition, key unanswered questions for future research are posed...
  9. doi request reprint Epidemiology of vitamin D and colorectal cancer: casual or causal link?
    Edward Giovannucci
    Harvard School of Public Health, and Channing Laboratory, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Steroid Biochem Mol Biol 121:349-54. 2010
    ..These studies are reviewed...
  10. ncbi request reprint Vitamin D and cardiovascular disease
    Edward Giovannucci
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Curr Atheroscler Rep 11:456-61. 2009
    ..Further study, including properly designed randomized control trials, is required to further establish the role of vitamin D on cardiovascular diseases...
  11. pmc Role of vitamin and mineral supplementation and aspirin use in cancer survivors
    Edward Giovannucci
    ScD, Department of Nutrition, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115, USA
    J Clin Oncol 28:4081-5. 2010
    ..The potential beneficial or adverse effects of dietary supplements and aspirin in survivors of cancer warrant further study...
  12. ncbi request reprint Strengths and limitations of current epidemiologic studies: vitamin D as a modifier of colon and prostate cancer risk
    Edward Giovannucci
    Department of Nutrition, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115, USA
    Nutr Rev 65:S77-9. 2007
  13. ncbi request reprint A meta-analysis of diabetes mellitus and the risk of prostate cancer
    Jocelyn S Kasper
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 15:2056-62. 2006
    ..Studies investigating the association between diabetes mellitus and prostate cancer have reported inconsistent findings. We examined this association by conducting a detailed meta-analysis of the studies published on the subject...
  14. pmc 25-hydroxyvitamin D and risk of myocardial infarction in men: a prospective study
    Edward Giovannucci
    Department of Nutrition, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115, USA
    Arch Intern Med 168:1174-80. 2008
    ..Vitamin D deficiency may be involved in the development of atherosclerosis and coronary heart disease in humans...
  15. doi request reprint Vitamin D status and cancer incidence and mortality
    Edward Giovannucci
    Department of Nutrition, Harvard School of Public Health and Brigham and Women s Hospital, Boston, MA 02115, USA
    Adv Exp Med Biol 624:31-42. 2008
  16. pmc Vitamin D receptor expression is associated with PIK3CA and KRAS mutations in colorectal cancer
    Shoko Kure
    Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts 02115, USA
    Cancer Epidemiol Biomarkers Prev 18:2765-72. 2009
    ..Our data support potential interactions between the VDR, RAS-MAPK and PI3K-AKT pathways, and possible influence by KRAS or PIK3CA mutation on therapy or chemoprevention targeting VDR...
  17. pmc Epigenomic diversity of colorectal cancer indicated by LINE-1 methylation in a database of 869 tumors
    Yoshifumi Baba
    Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA, USA
    Mol Cancer 9:125. 2010
    ..Thus, it is of particular interest to examine whether its wide variation can be attributed to clinical, pathologic or molecular features...
  18. pmc A prospective cohort study shows unique epigenetic, genetic, and prognostic features of synchronous colorectal cancers
    Katsuhiko Nosho
    Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts 02115, USA
    Gastroenterology 137:1609-20.e1-3. 2009
    ..Synchronous colon cancers have not been compared with control solitary cancers in a prospective study...
  19. pmc Modification of the association between obesity and lethal prostate cancer by TMPRSS2:ERG
    Andreas Pettersson
    Affiliations of authors Department of Epidemiology AP, AM, MF, REG, KLP, JRR, EJN, MJS, ELG, LAM and Department of Nutrition MJS, ELG, Harvard School of Public Health, Boston, MA Channing Division of Network Medicine AP, KLP, JRR, MJS, ELG, LAM and Division of Preventive Medicine HDS, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA Department of Pathology, Brigham and Women s Hospital, Boston, MA RTL, ECS, ML Center for Molecular Oncologic Pathology RTL, RF, ECS, MF, SF, NEM, ML, Department of Radiation Oncology NEM, Centre for Regenerative Medicine
    J Natl Cancer Inst 105:1881-90. 2013
    ..TMPRSS2:ERG is a hormonally regulated gene fusion present in about half of prostate tumors. We investigated whether obesity, which deregulates several hormonal pathways, interacts with TMPRSS2:ERG to impact prostate cancer outcomes...
  20. pmc CDK8 expression in 470 colorectal cancers in relation to beta-catenin activation, other molecular alterations and patient survival
    Ron Firestein
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
    Int J Cancer 126:2863-73. 2010
    ..These data support a potential link between CDK8 and beta-catenin, and suggest that CDK8 may identify a subset of colon cancer patients with a poor prognosis...
  21. pmc Dose response to vitamin D supplementation in African Americans: results of a 4-arm, randomized, placebo-controlled trial
    Kimmie Ng
    Department of Medical Oncology KN, JAM, and CSF and Center for Community Based Research JBS, EG S, and KME, Dana Farber Cancer Institute, Boston, MA the Division of Public Health Sciences, Washington University School of Medicine, St Louis, MO BFD the Division of Gastroenterology, Massachusetts General Hospital, Boston, MA ATC the Channing Division of Network Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA ATC, ELG, and CSF the Division of Pediatrics, Medical University of South Carolina, Charleston, SC BWH the Division of General Medicine, Brigham and Women s Hospital, Boston, MA PDC the Department of Psychology and Neuroscience, Duke University, Durham, NC GGB and the Departments of Nutrition JBS and ELG and Social and Behavioral Sciences KME, Harvard School of Public Health, Boston, MA
    Am J Clin Nutr 99:587-98. 2014
    ..Nonetheless, the relation between vitamin D supplementation and 25(OH)D concentrations in African Americans remains undefined...
  22. pmc Hyperglycemia, insulin resistance, impaired pancreatic β-cell function, and risk of pancreatic cancer
    Brian M Wolpin
    Department of Medicine, Brigham and Women s Hospital, and Harvard Medical School, Boston, MA 02215, USA
    J Natl Cancer Inst 105:1027-35. 2013
    ..Hemoglobin A1c (HbA1c) is a measure of hyperglycemia, whereas plasma insulin and proinsulin are markers of peripheral insulin resistance, and the proinsulin to insulin ratio marks pancreatic β-cell dysfunction...
  23. pmc Prediagnostic body mass index and pancreatic cancer survival
    Chen Yuan
    Chen Yuan, Shuji Ogino, Kimmie Ng, Zhi Rong Qian, Douglas A Rubinson, and Brian M Wolpin, Dana Farber Cancer Institute Ying Bao, Shuji Ogino, Kimmie Ng, Meir J Stampfer, Edward L Giovannucci, and Brian M Wolpin, Brigham and Women s Hospital, Harvard Medical School and Chen Wu, Peter Kraft, Shuji Ogino, Meir J Stampfer, and Edward L Giovannucci, Harvard School of Public Health, Boston, MA
    J Clin Oncol 31:4229-34. 2013
    ..Although obesity is associated with increased incidence of pancreatic cancer, studies have not prospectively evaluated prediagnostic body mass index (BMI) and survival...
  24. pmc Weight change at 1 mo of antiretroviral therapy and its association with subsequent mortality, morbidity, and CD4 T cell reconstitution in a Tanzanian HIV-infected adult cohort
    Christopher R Sudfeld
    Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
    Am J Clin Nutr 97:1278-87. 2013
    ..The development of low-cost point-of-care technologies to improve HIV treatment is a major focus of current research in resource-limited settings...
  25. pmc Choline intake and risk of lethal prostate cancer: incidence and survival
    Erin L Richman
    Departments of Epidemiology and Nutrition, Harvard School of Public Health, Boston, MA, USA
    Am J Clin Nutr 96:855-63. 2012
    ..These foods are sources of choline-a nutrient that may affect prostate cancer progression through cell membrane function and one-carbon metabolism. No study has examined dietary choline and the risk of lethal prostate cancer...
  26. pmc Variant ABO blood group alleles, secretor status, and risk of pancreatic cancer: results from the pancreatic cancer cohort consortium
    Brian M Wolpin
    Department of Medical Oncology, Dana Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 19:3140-9. 2010
    ..We hypothesized: 1) A(1) allele would confer greater risk than A(2) allele, 2) protective effect of the O allele would be equivalent for O01 and O02 variants, 3) secretor phenotype would modify the association with risk...
  27. pmc A Prospective Study of Macrophage Inhibitory Cytokine-1 (MIC-1/GDF15) and Risk of Colorectal Cancer
    Raaj S Mehta
    Affiliations of authors Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA RSM, ATC Gastrointestinal Research Group, Institute of Medical Sciences, Aberdeen University, Aberdeen, United Kingdom NB Department of Epidemiology XG, SO, ELG and Department of Nutrition MS, KW, XG, ELG, Harvard School of Public Health, Boston, MA Department of Pathology, University of Tokyo, Tokyo, Japan TM Channing Division of Network Medicine, Department of Medicine CSF, ELG, ATC and Department of Pathology SO, Brigham and Women s Hospital and Harvard Medical School, Boston, MA Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA CSF, SO
    J Natl Cancer Inst 106:dju016. 2014
    ..Chronic inflammation plays a role in the development of colorectal cancer (CRC). The novel plasma inflammatory biomarker macrophage inhibitory cytokine-1 (MIC-1, GDF15) may have a direct mechanistic role in colorectal carcinogenesis...
  28. pmc Prospective cohort studies of vitamin B-6 intake and colorectal cancer incidence: modification by time?
    Xuehong Zhang
    Channing Division of Network Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Am J Clin Nutr 96:874-81. 2012
    ..The relation between vitamin B-6 intake and colorectal cancer risk remains uncertain...
  29. pmc A cohort study of tumoral LINE-1 hypomethylation and prognosis in colon cancer
    Shuji Ogino
    Center for Molecular Oncologic Pathology, Dana Farber Cancer Institute, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Natl Cancer Inst 100:1734-8. 2008
    ..In conclusion, tumoral LINE-1 hypomethylation is independently associated with shorter survival among colon cancer patients...
  30. pmc Interaction of molecular markers and physical activity on mortality in patients with colon cancer
    Jeffrey A Meyerhardt
    Dana Farber Cancer Institute, Boston, MA 02115, USA
    Clin Cancer Res 15:5931-6. 2009
    ..Physical activity in colon cancer survivors has been associated with lower cancer recurrences and improved survival. Whether molecular features of the tumor portend more or less likelihood for benefit from exercise is unknown...
  31. pmc Genetic variation in RNASEL associated with prostate cancer risk and progression
    Mara S Meyer
    Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
    Carcinogenesis 31:1597-603. 2010
    ..The results of this study support a link between RNASEL and prostate cancer and suggest that the association may be mediated through inflammation. These novel findings warrant replication in future studies...
  32. pmc HIF1A overexpression is associated with poor prognosis in a cohort of 731 colorectal cancers
    Yoshifumi Baba
    Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA 02115, USA
    Am J Pathol 176:2292-301. 2010
    ..039). In conclusion, HIF1A expression is independently associated with poor prognosis in colorectal cancer, suggesting HIF1A as a biomarker with potentially important therapeutic implications...
  33. pmc ABO blood group and the risk of pancreatic cancer
    Brian M Wolpin
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    J Natl Cancer Inst 101:424-31. 2009
    ..ABO blood type is an inherited characteristic that in previous small studies has been associated with the risk of gastrointestinal malignancies...
  34. pmc Negative lymph node count is associated with survival of colorectal cancer patients, independent of tumoral molecular alterations and lymphocytic reaction
    Shuji Ogino
    Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Gastroenterol 105:420-33. 2010
    ....
  35. pmc Cohort study of fatty acid synthase expression and patient survival in colon cancer
    Shuji Ogino
    Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA 02115, USA
    J Clin Oncol 26:5713-20. 2008
    ..Fatty acid synthase (FASN) is physiologically regulated by energy balance and is often upregulated in colorectal cancer. Nonetheless, the influence of FASN expression on patient outcome is uncertain...
  36. pmc Lifestyle and dietary factors in the prevention of lethal prostate cancer
    Kathryn M Wilson
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Asian J Androl 14:365-74. 2012
    ..We present a summary of evidence for the following selected behavioral risk factors: obesity and weight change, physical activity, smoking, antioxidant intake, vitamin D and calcium, and coffee intake...
  37. pmc PIK3CA mutation is associated with poor prognosis among patients with curatively resected colon cancer
    Shuji Ogino
    Department of Medical Oncology, Dana Farber Cancer Institute, Brigham and Women s Hospital, Harvard Medical School, 44 Binney St, Room JF 215C, Boston, MA 02115 USA
    J Clin Oncol 27:1477-84. 2009
    ..PIK3CA mutation and subsequent activation of the AKT pathway play an important role in colorectal carcinogenesis. However, little is known about the prognostic role of PIK3CA mutation in colon cancer...
  38. pmc Colorectal cancer expression of peroxisome proliferator-activated receptor gamma (PPARG, PPARgamma) is associated with good prognosis
    Shuji Ogino
    Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, and Department of Pathology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Gastroenterology 136:1242-50. 2009
    ..There is controversy over the pro-oncogenic or antioncogenic effects of PPARG, and little is known about its prognostic significance in colon cancer...
  39. ncbi request reprint Twenty-four non-synonymous polymorphisms in the one-carbon metabolic pathway and risk of colorectal adenoma in the Nurses' Health Study
    Aditi Hazra
    Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Carcinogenesis 28:1510-9. 2007
    ..Further investigation is required to validate the association of the polymorphisms in the one-carbon metabolic genes and risk of colorectal adenoma...
  40. pmc PTGER2 overexpression in colorectal cancer is associated with microsatellite instability, independent of CpG island methylator phenotype
    Yoshifumi Baba
    Department of Medical Oncology, Dana FarberCancer Institute and Harvard Medical School, Boston, Massachusetts, USA
    Cancer Epidemiol Biomarkers Prev 19:822-31. 2010
    ..However, the prognostic significance of PTGER2 expression or its relationship with MSI, CIMP, LINE-1 hypomethylation, or PTGS2 (COX-2) remains uncertain...
  41. pmc DNMT3B expression might contribute to CpG island methylator phenotype in colorectal cancer
    Katsuhiko Nosho
    Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts, USA
    Clin Cancer Res 15:3663-71. 2009
    ..We hypothesized that cellular DNMT3B level might influence the occurrence of widespread CpG island methylation (i.e., the CpG island methylator phenotype, CIMP) in colon cancer...
  42. ncbi request reprint Plasma vitamin D metabolites and risk of colorectal cancer in women
    Diane Feskanich
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Cancer Epidemiol Biomarkers Prev 13:1502-8. 2004
    ..We therefore examined risk in relation to plasma concentrations of these vitamin D metabolites...
  43. pmc Association of nut consumption with total and cause-specific mortality
    Ying Bao
    From the Channing Division of Network Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School Y B, F B H, E L G, M J S, W C W, C S F, the Departments of Epidemiology F B H, E L G, M J S, W C W and Nutrition F B H, E L G, M J S, W C W, Harvard School of Public Health, and the Department of Medical Oncology, Dana Farber Cancer Institute C S F all in Boston and the Department of Epidemiology, Richard M Fairbanks School of Public Health, and Melvin and Bren Simon Cancer Center, Indiana University, Indianapolis J H
    N Engl J Med 369:2001-11. 2013
    ..Increased nut consumption has been associated with a reduced risk of major chronic diseases, including cardiovascular disease and type 2 diabetes mellitus. However, the association between nut consumption and mortality remains unclear...
  44. pmc Comprehensive biostatistical analysis of CpG island methylator phenotype in colorectal cancer using a large population-based sample
    Katsuhiko Nosho
    Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA, USA
    PLoS ONE 3:e3698. 2008
    ..In stratified analyses, the relations of CIMP-high with poor differentiation, KRAS mutation and LINE-1 hypomethylation significantly differed according to MSI status...
  45. pmc Insulin, the insulin-like growth factor axis, and mortality in patients with nonmetastatic colorectal cancer
    Brian M Wolpin
    Department of Medical Oncology, Dana Farber Cancer Institute, 44 Binney St, Boston, MA 02115, USA
    J Clin Oncol 27:176-85. 2009
    ..Excess energy balance leads to increased circulating insulin and depressed levels of circulating insulin-like growth factor binding protein (IGFBP) -1, which promote cancer cell growth in preclinical models...
  46. pmc A cohort study of p27 localization in colon cancer, body mass index, and patient survival
    Shuji Ogino
    Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Brigham and Women s Hospital, Boston, and Harvard Medical School 02115, USA
    Cancer Epidemiol Biomarkers Prev 18:1849-58. 2009
    ..08). In conclusion, p27 alterations in colon cancer are associated with superior prognosis. Adverse prognostic effect of obesity seems limited to patients with nuclear p27 expression, suggesting a host-tumor interaction...
  47. ncbi request reprint Hemochromatosis gene mutations, body iron stores, dietary iron, and risk of colorectal adenoma in women
    Andrew T Chan
    Gastrointestinal Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    J Natl Cancer Inst 97:917-26. 2005
    ..We assessed dietary iron intake and genetic and biochemical markers of iron status in a prospective, nested case-control study of women enrolled in the Nurses' Health Study...
  48. pmc CpG island methylator phenotype, microsatellite instability, BRAF mutation and clinical outcome in colon cancer
    Shuji Ogino
    Center for Molecular Oncologic Pathology, Dana Farber Cancer Institute, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115 USA
    Gut 58:90-6. 2009
    ..The independent effect of CIMP, MSI and BRAF mutation on prognosis remains uncertain...
  49. ncbi request reprint Physical activity and survival after colorectal cancer diagnosis
    Jeffrey A Meyerhardt
    Division of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    J Clin Oncol 24:3527-34. 2006
    ..Physically active individuals have a lower risk of developing colorectal cancer but the influence of exercise on cancer survival is unknown...
  50. pmc A cohort study of STMN1 expression in colorectal cancer: body mass index and prognosis
    Shuji Ogino
    Department of Medical Oncology, Center for Molecular Oncologic Pathology, Dana Farber Cancer Institute, Brigham and Women s Hospital and Harvard Medical School, 44 Binney St, Room JF 215C, Boston, Massachusetts 02115, USA
    Am J Gastroenterol 104:2047-56. 2009
    ..STMN1 activity is influenced by p53, p27, and the PI3K/AKT pathway. However, its prognostic significance in colon cancer is uncertain...
  51. pmc Aspirin use, body mass index, physical activity, plasma C-peptide, and colon cancer risk in US health professionals
    Xuehong Zhang
    Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA
    Am J Epidemiol 174:459-67. 2011
    ..10) for the low and 0.65 (95% CI: 0.46, 0.92) for the high group. Reductions in colon cancer risk associated with aspirin use were not significantly modified by body mass index, physical activity, or plasma C-peptide level in this study...
  52. pmc Aspirin dose and duration of use and risk of colorectal cancer in men
    Andrew T Chan
    Gastrointestinal Unit, Massachusetts General Hospital and Harvard Medical School, Boston, USA
    Gastroenterology 134:21-8. 2008
    ..Long-term data on the risk of colorectal cancer according to dose, duration, and consistency of aspirin therapy are limited...
  53. ncbi request reprint Genetic variants in the UGT1A6 enzyme, aspirin use, and the risk of colorectal adenoma
    Andrew T Chan
    Gastrointestinal Unit, Massachusetts General Hospital and Harvard Medical School, GRJ 722, Boston, MA 02114, USA
    J Natl Cancer Inst 97:457-60. 2005
    ....
  54. ncbi request reprint Fruits, vegetables, and colon cancer risk in a pooled analysis of 14 cohort studies
    Anita Koushik
    Department of Nutrition, Harvard School of Public Health, Boston, MA, USA
    J Natl Cancer Inst 99:1471-83. 2007
    ..Statistical power to examine associations by colon site has been limited in previous studies...
  55. ncbi request reprint Joint association of alcohol and folate intake with risk of major chronic disease in women
    Rui Jiang
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Am J Epidemiol 158:760-71. 2003
    ..Adequate folate intake may be important in the primary prevention of overall major chronic disease in women, especially among younger women consuming more than two alcoholic drinks per day...
  56. pmc Aspirin use, 8q24 single nucleotide polymorphism rs6983267, and colorectal cancer according to CTNNB1 alterations
    Hongmei Nan
    Affiliations of authors Division of Cancer Epidemiology, Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD HN Channing Division of Network Medicine, Department of Medicine HN, DJH, ELG, CSF, ATC and Department of Epidemiology DJH, PK, ELG, SO, Brigham and Women s Hospital and Harvard Medical School, Boston, MA Center for Molecular Oncologic Pathology TM, YI, AK, MY, SO, Department of Medical Oncology TM, MS, YI, AK, MY, CSF, SO, MLF, and Department of Biostatistics and Computational Biology LW, Dana Farber Cancer Institute, Boston, MA Department of Epidemiology DJH, ELG, SO and Department of Nutrition, Harvard School of Public Health, Boston, Simancas 47130
    J Natl Cancer Inst 105:1852-61. 2013
    ....
  57. pmc Associations of self-reported sleep duration and snoring with colorectal cancer risk in men and women
    Xuehong Zhang
    Channing Division of Network Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Sleep 36:681-8. 2013
    ..We assessed the relationship between sleep duration, snoring and colorectal cancer risk...
  58. pmc Risk of colon cancer and coffee, tea, and sugar-sweetened soft drink intake: pooled analysis of prospective cohort studies
    Xuehong Zhang
    Department of Nutrition, Department of Epidemiology, Harvard School of Public Health, 655 Huntington Ave, Boston, MA 02115, USA
    J Natl Cancer Inst 102:771-83. 2010
    ..The relationships between coffee, tea, and sugar-sweetened carbonated soft drink consumption and colon cancer risk remain unresolved...
  59. pmc Family history of cancer and risk of pancreatic cancer: a pooled analysis from the Pancreatic Cancer Cohort Consortium (PanScan)
    Eric J Jacobs
    Department of Epidemiology, American Cancer Society, Atlanta, GA, USA
    Int J Cancer 127:1421-8. 2010
    ..47). Our results confirm a moderate sized association between a family history of pancreatic cancer and risk of pancreatic cancer and also provide evidence for an association with a family history of prostate cancer worth further study...
  60. pmc Hypomethylation of the IGF2 DMR in colorectal tumors, detected by bisulfite pyrosequencing, is associated with poor prognosis
    Yoshifumi Baba
    Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts, USA
    Gastroenterology 139:1855-64. 2010
    ..IGF2 LOI correlates with hypomethylation at the differentially methylated region (DMR)-0. An assay for methylation of the DMR0 could overcome the limitations of the conventional IGF2 LOI assay...
  61. pmc The association between betaine and choline intakes and the plasma concentrations of homocysteine in women
    Stephanie E Chiuve
    Department of Nutrition, Harvard School of Public Health, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Clin Nutr 86:1073-81. 2007
    ..Elevated total homocysteine (tHcy), a risk factor for many chronic diseases, can be remethylated to methionine by folate. Alternatively, tHcy can be metabolized by other 1-carbon nutrients, ie, betaine and its precursor, choline...
  62. pmc Cumulative risk of colon cancer up to age 70 years by risk factor status using data from the Nurses' Health Study
    Esther K Wei
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Am J Epidemiol 170:863-72. 2009
    ..For women with a high risk factor profile, adopting a healthier lifestyle could dramatically reduce colon cancer risk...
  63. pmc A prospective study of plasma adiponectin and pancreatic cancer risk in five US cohorts
    Ying Bao
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Ave, Boston, MA 02115, USA
    J Natl Cancer Inst 105:95-103. 2013
    ..Although development of pancreatic cancer is associated with states of insulin resistance and chronic inflammation, the mechanistic basis of the associations is poorly understood...
  64. pmc Higher predicted vitamin D status is associated with reduced risk of Crohn's disease
    Ashwin N Ananthakrishnan
    Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02214, USA
    Gastroenterology 142:482-9. 2012
    ..Vitamin D influences innate immunity, which is believed to be involved in the pathogenesis of Crohn's disease (CD) and ulcerative colitis (UC). However, data examining vitamin D status in relation to risk of CD and UC are lacking...
  65. pmc A prospective study of intakes of zinc and heme iron and colorectal cancer risk in men and women
    Xuehong Zhang
    Channing Laboratory at Landmark Center West Wing, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 401 Park Drive, Boston, MA 02115, USA
    Cancer Causes Control 22:1627-37. 2011
    ..Our study does not support strong roles of zinc and heme iron intake in colorectal cancer risk; however, a suggestive inverse association of dietary zinc intake with rectal cancer risk in women requires further study...
  66. pmc Association of the TCF7L2 polymorphism with colorectal cancer and adenoma risk
    Aditi Hazra
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Cancer Causes Control 19:975-80. 2008
    ..37-1.08; P for heterogeneity 0.52 for the association in women and men). In summary, the marginal association of the TCF7L2 SNP with CRC might be due to chance, but warrants further laboratory and epidemiological investigation...
  67. pmc Primary prevention of colorectal cancer
    Andrew T Chan
    Gastrointestinal Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Gastroenterology 138:2029-2043.e10. 2010
    ..Taken together, modifications in diet and lifestyle should substantially reduce the risk of colorectal cancer and could complement screening in reducing colorectal cancer incidence...
  68. pmc Prospective study of Trichomonas vaginalis infection and prostate cancer incidence and mortality: Physicians' Health Study
    Jennifer R Stark
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    J Natl Cancer Inst 101:1406-11. 2009
    ..We confirmed these findings in an independent population and related serostatus for antibodies against T vaginalis to prostate cancer incidence and mortality...
  69. pmc Circulating prediagnostic interleukin-6 and C-reactive protein and prostate cancer incidence and mortality
    Jennifer Rider Stark
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Int J Cancer 124:2683-9. 2009
    ..02). Adjusted hazard ratios were 1.73 (95% CI: 0.86, 3.51) comparing the highest to lowest IL-6 level. Our study suggests that IL-6 may potentially be involved in the development or progression of prostate cancer...
  70. ncbi request reprint A nested case control study of plasma 25-hydroxyvitamin D concentrations and risk of colorectal cancer
    Kana Wu
    Department of Nutrition, Harvard School of Public Health, 665 Huntington Ave, Bldg 2, Boston, MA 02115, USA
    J Natl Cancer Inst 99:1120-9. 2007
    ..We investigated this relationship in a nested case-control study within the Health Professionals Follow-up Study (HPFS), a large ongoing study of male health professionals living in the United States...
  71. ncbi request reprint Alcohol intake and methylenetetrahydrofolate reductase polymorphism modify the relation of folate intake to plasma homocysteine
    Stephanie E Chiuve
    Department of Nutrition and the Channing Laboratory, Harvard Medical School, Boston, MA, USA
    Am J Clin Nutr 82:155-62. 2005
    ..Folate metabolism may be altered by alcohol intake and 2 common polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene, 677C-->T and 1298A-->C...
  72. pmc Inflammatory markers are associated with risk of colorectal cancer and chemopreventive response to anti-inflammatory drugs
    Andrew T Chan
    Gastrointestinal Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Gastroenterology 140:799-808, quiz e11. 2011
    ..We investigated whether plasma inflammatory markers were associated with risk of CRC and if use of anti-inflammatory drugs was differentially associated with risk of CRC according to levels of inflammatory markers...
  73. pmc Lymphocytic reaction to colorectal cancer is associated with longer survival, independent of lymph node count, microsatellite instability, and CpG island methylator phenotype
    Shuji Ogino
    Center for Molecular Oncologic Pathology, Dana Farber Cancer Institute, Brigham and Women s Hospital, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
    Clin Cancer Res 15:6412-20. 2009
    ....
  74. ncbi request reprint Circulating 25-hydroxyvitamin d levels and survival in patients with colorectal cancer
    Kimmie Ng
    Division of Medical Oncology, Dana Farber Cancer Institute Boston, MA 02115, USA
    J Clin Oncol 26:2984-91. 2008
    ..Higher plasma 25-hydroxyvitamin D(3) (25(OH)D) levels are associated with a decreased incidence of colorectal cancer, but the influence of plasma 25(OH)D on the outcome of patients with established colorectal cancer is unknown...
  75. pmc Prediagnostic plasma folate and the risk of death in patients with colorectal cancer
    Brian M Wolpin
    Department of MedicalOncology, Dana Farber Cancer Institute, Boston, MA, USA
    J Clin Oncol 26:3222-8. 2008
    ..Therefore, high priority has been given to research investigating the influence of folate on cancer progression in patients with colorectal cancer...
  76. ncbi request reprint Nonsynonymous polymorphisms in genes in the one-carbon metabolism pathway and associations with colorectal cancer
    Anita Koushik
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 15:2408-17. 2006
    ..Our results corroborate previous findings for MTHFR Ala(222)Val and suggest that other genes involved in one-carbon metabolism, particularly those that affect DNA methylation, may be associated with colorectal cancer risk...
  77. ncbi request reprint Dietary protein and the risk of cholecystectomy in a cohort of US women: the Nurses' Health Study
    Chung Jyi Tsai
    Channing Laboratory, Department of Medicine, Harvard Medical School and Brigham and Women s Hospital, Boston, MA, USA
    Am J Epidemiol 160:11-8. 2004
    ..These results suggest that increased consumption of vegetable protein in the context of an energy-balanced diet can reduce the risk of cholecystectomy in women...
  78. pmc Long-term use of aspirin and nonsteroidal anti-inflammatory drugs and risk of colorectal cancer
    Andrew T Chan
    Gastrointestinal Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Mass 02114, USA
    JAMA 294:914-23. 2005
    ..However, data on long-term risk of colorectal cancer according to dose, timing, or duration of therapy with aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) remain limited...
  79. ncbi request reprint A prospective study on supplemental vitamin e intake and risk of colon cancer in women and men
    Kana Wu
    Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Cancer Epidemiol Biomarkers Prev 11:1298-304. 2002
    ..Considering the paucity of epidemiological data on this association, further studies of vitamin E and colon cancer are warranted...
  80. ncbi request reprint Glycemic load, glycemic index, and carbohydrate intake in relation to risk of cholecystectomy in women
    Chung Jyi Tsai
    Channing Laboratory, Department of Medicine, Harvard Medical School and Brigham and Women s Hospital, Boston, Massachusetts, USA
    Gastroenterology 129:105-12. 2005
    ..High-carbohydrate diets with a high glycemic response may exacerbate the metabolic consequences of the insulin-resistance syndrome. The effect on the incidence of gallstone disease is not clear...
  81. ncbi request reprint Frequent nut consumption and decreased risk of cholecystectomy in women
    Chung Jyi Tsai
    Channing Laboratory, Department of Medicine, Harvard Medical School and Brigham and Women s Hospital, Boston, MA, USA
    Am J Clin Nutr 80:76-81. 2004
    ..Gallstone disease is a major source of morbidity in the developed countries. Nuts are rich in several compounds that may protect against gallstone disease...
  82. ncbi request reprint A prospective study of physical activity and incident and fatal prostate cancer
    Edward L Giovannucci
    Department of Nutrition, Harvard School of Public Health, Boston, Mass, USA
    Arch Intern Med 165:1005-10. 2005
    ..Whether physical activity has benefits against prostate cancer incidence or progression is unclear. Therefore, we assessed physical activity in relation to prostate cancer incidence, mortality, and Gleason histologic grade...
  83. ncbi request reprint Association between serum concentrations of micronutrients and lower urinary tract symptoms in older men in the Third National Health and Nutrition Examination Survey
    Sabine Rohrmann
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    Urology 64:504-9. 2004
    ..To evaluate the association of serum micronutrients with lower urinary tract symptoms (LUTS)...
  84. pmc Dietary choline and betaine and the risk of distal colorectal adenoma in women
    Eunyoung Cho
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Ave, Boston, MA 02115, USA
    J Natl Cancer Inst 99:1224-31. 2007
    ..No epidemiologic study has examined the association of intake of these nutrients and colorectal adenoma risk...
  85. ncbi request reprint p53 Arg72Pro polymorphism and risk of colorectal adenoma and cancer
    Anita Koushik
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Int J Cancer 119:1863-8. 2006
    ..09, 95% CI = 1.28-3.40) but not proximal colon or rectal cancers. Our results suggest that Arg72Pro may play a role in the early stages of colorectal neoplasia and possibly in progression to invasive disease, depending on site and sex...
  86. pmc A prospective study of plasma vitamin D metabolites, vitamin D receptor polymorphisms, and prostate cancer
    Haojie Li
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS Med 4:e103. 2007
    ..Few studies have explored the joint association of circulating vitamin D levels with VDR polymorphisms...
  87. pmc Dietary macronutrient and energy intake and urinary incontinence in women
    Nancy N Maserejian
    Department of Epidemiology, New England Research Institutes, Watertown, Massachusetts, USA
    Am J Epidemiol 171:1116-25. 2010
    ..0001). Results suggest that dietary changes, particularly decreasing saturated fat relative to polyunsaturated fat and decreasing total calories, could independently account for some of the benefits of weight loss in women with UI...
  88. ncbi request reprint XRCC2 and XRCC3 polymorphisms are not associated with risk of colorectal adenoma
    Gregory J Tranah
    Department of Epidemiology, and Harvard Center for Cancer Prevention, Harvard School of Public Health, Boston, MA, USA
    Cancer Epidemiol Biomarkers Prev 13:1090-1. 2004
  89. ncbi request reprint Association between the Met326Ile polymorphism of the p85alpha regulatory subunit of phosphatidylinositol 3-kinase and prostate cancer risk: a prospective study
    Aimée E Paradis
    The Lank Center for Genitourinary Oncology, Department of Adult Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cancer Epidemiol Biomarkers Prev 12:172-3. 2003
  90. ncbi request reprint Sex steroid hormones and the androgen receptor gene CAG repeat and subsequent risk of prostate cancer in the prostate-specific antigen era
    Elizabeth A Platz
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Room E6138, 615 North Wolfe Street, Baltimore, MD 21205, USA
    Cancer Epidemiol Biomarkers Prev 14:1262-9. 2005
    ..We investigated plasma levels of sex steroid hormones and length of the androgen receptor gene CAG repeat in relation to incident prostate cancer diagnosed in the prostate-specific antigen (PSA) era...
  91. pmc Diabetes mellitus and risk of prostate cancer in the health professionals follow-up study
    Jocelyn S Kasper
    Department of Nutrition, Harvard School of Public Health, Harvard University, Boston, MA 02115, USA
    Int J Cancer 124:1398-403. 2009
    ..Results are consistent with the hypothesis that diabetes is associated with reduced PCa risk. Potential biological mechanisms are discussed...
  92. ncbi request reprint Epoxide hydrolase and CYP2C9 polymorphisms, cigarette smoking, and risk of colorectal carcinoma in the Nurses' Health Study and the Physicians' Health Study
    Gregory J Tranah
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
    Mol Carcinog 44:21-30. 2005
    ..Our results indicate that individuals exposed to tobacco carcinogens were at increased risk of colorectal cancer and that overall risk is related to mEH and CYP2C9 genotype, although the results were not consistent between men and women...
  93. ncbi request reprint O6-methylguanine-DNA methyltransferase Leu84Phe and Ile143Val polymorphisms and risk of colorectal cancer in the Nurses' Health Study and Physicians' Health Study (United States)
    Gregory J Tranah
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Cancer Causes Control 17:721-31. 2006
    ..Two non-synonymous MGMT coding region variants, Leu84Phe and Ile143Val, lie in close proximity to the reactive 145Cys residue and to a conserved estrogen receptor interacting helix...
  94. doi request reprint Hormonal profile of diabetic men and the potential link to prostate cancer
    Jocelyn S Kasper
    Department of Nutrition, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
    Cancer Causes Control 19:703-10. 2008
    ..To investigate potential biological mechanisms, hormonal profiles of diabetic men and non-diabetic controls were compared...
  95. ncbi request reprint Prospective study of fruits and vegetables and risk of oral premalignant lesions in men
    Nancy Nairi Maserejian
    Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
    Am J Epidemiol 164:556-66. 2006
    ..7). The risk of oral premalignant lesions was significantly reduced with higher consumption of fruits, particularly citrus fruits and juices, while no consistent associations were apparent for vegetables...
  96. pmc Manganese superoxide dismutase (MnSOD) gene polymorphism, interactions with carotenoid levels and prostate cancer risk
    Bahar Mikhak
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Carcinogenesis 29:2335-40. 2008
    ..On the other hand, some epidemiologic studies suggest that the Ala allele is associated with a higher risk of cancer, including prostate cancer...
  97. ncbi request reprint ATAAA repeat upstream of glutathione S-transferase P1 and prostate cancer risk
    Elizabeth A Platz
    Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    Urology 59:159-64. 2002
    ..Upstream of its promoter is a polymorphic ATAAA repeat of unknown functional significance. We evaluated whether this polymorphism is associated with prostate cancer...
  98. ncbi request reprint Dietary carotenoids and risk of lung cancer in a pooled analysis of seven cohort studies
    Satu Mannisto
    Harvard School of Public Health, Department of Nutrition, Boston, Massachusetts, USA
    Cancer Epidemiol Biomarkers Prev 13:40-8. 2004
    ..Although smoking is the strongest risk factor for lung cancer, greater intake of foods high in beta-cryptoxanthin, such as citrus fruit, may modestly lower the risk...
  99. ncbi request reprint Vitamin D receptor (VDR) gene polymorphisms and haplotypes, interactions with plasma 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D, and prostate cancer risk
    Bahar Mikhak
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Prostate 67:911-23. 2007
    ..The vitamin D receptor (VDR) is required for actions of vitamin D. The binding of 1,25-dihydroxyvitamin D to the VDR on prostatic epithelial cells prompts the regulation of cancer-related genes...
  100. ncbi request reprint A prospective cohort study of red wine consumption and risk of prostate cancer
    Siobhan Sutcliffe
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Int J Cancer 120:1529-35. 2007
    ..These findings suggest that red wine does not contribute appreciably to the etiology of prostate cancer...
  101. ncbi request reprint Glycemic index, glycemic load, and carbohydrate intake in relation to risk of distal colorectal adenoma in women
    Kyungwon Oh
    Department of Nutrition and Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 13:1192-8. 2004
    ..Our findings do not support the hypothesis that a high glycemic index diet, a high glycemic load diet, or high carbohydrate intake overall are associated with risk of colorectal adenoma...

Research Grants13

  1. Energy Balance-Related Hormones & Prostate Cancer Incidence & Progression
    Edward Giovannucci; Fiscal Year: 2009
    ....
  2. RANDOMIZED TRIAL OF FOLATE AND COLORECTAL ADENOMA
    Edward Giovannucci; Fiscal Year: 2003
    ..abstract_text> ..
  3. RANDOMIZED TRIAL OF FOLATE AND COLORECTAL ADENOMA
    Edward Giovannucci; Fiscal Year: 2002
    ..abstract_text> ..
  4. RANDOMIZED TRIAL OF FOLATE AND COLORECTAL ADENOMA
    Edward Giovannucci; Fiscal Year: 2001
    ..abstract_text> ..
  5. DIET AND GENETIC INTERACTIONS IN PROSTATE CANCER
    Edward Giovannucci; Fiscal Year: 2001
    ..The buccal brushings, along with providing the basis for the specific aims in this application, will allow for the rapid testing of future specific hypotheses. ..
  6. DIET AND GENETIC INTERACTIONS IN PROSTATE CANCER
    Edward Giovannucci; Fiscal Year: 2000
    ..The buccal brushings, along with providing the basis for the specific aims in this application, will allow for the rapid testing of future specific hypotheses. ..
  7. RANDOMIZED TRIAL OF FOLATE AND COLORECTAL ADENOMA
    Edward Giovannucci; Fiscal Year: 2000
    ..abstract_text> ..
  8. Energy Balance-Related Hormones & Prostate Cancer Incidence & Progression
    Edward Giovannucci; Fiscal Year: 2010
    ....