E Giovannucci

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Insulin, insulin-like growth factors and colon cancer: a review of the evidence
    E Giovannucci
    Channing Laboratory, Department of Medicine, Harvard Medical School and Brigham and Women s Hospital, Boston, MA 02115, USA
    J Nutr 131:3109S-20S. 2001
  2. ncbi request reprint Body mass index and risk of prostate cancer in U.S. health professionals
    Edward Giovannucci
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Natl Cancer Inst 95:1240-4. 2003
  3. ncbi request reprint Smoking and risk of total and fatal prostate cancer in United States health professionals
    E Giovannucci
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Cancer Epidemiol Biomarkers Prev 8:277-82. 1999
  4. ncbi request reprint Plasma insulin-like growth factor-I and prostate cancer risk: a prospective study
    J M Chan
    Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
    Science 279:563-6. 1998
  5. ncbi request reprint Physical activity and benign prostatic hyperplasia
    E A Platz
    Department of Epidemiology, Harvard School of Public Health, Boston, Mass 02115, USA
    Arch Intern Med 158:2349-56. 1998
  6. ncbi request reprint Racial variation in insulin-like growth factor-1 and binding protein-3 concentrations in middle-aged men
    E A Platz
    Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA
    Cancer Epidemiol Biomarkers Prev 8:1107-10. 1999
  7. ncbi request reprint Racial variation in prostate cancer incidence and in hormonal system markers among male health professionals
    E A Platz
    Department of Nutrition, Harvard School of Public Health, Boston, MA, USA
    J Natl Cancer Inst 92:2009-17. 2000
  8. pmc Cyclin D1 A870G polymorphism and the risk of colorectal cancer and adenoma
    E S Schernhammer
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Br J Cancer 94:928-34. 2006
  9. ncbi request reprint Recreational physical activity and the risk of cholecystectomy in women
    M F Leitzmann
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    N Engl J Med 341:777-84. 1999
  10. pmc Predicted vitamin D status and pancreatic cancer risk in two prospective cohort studies
    Y Bao
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Br J Cancer 102:1422-7. 2010

Collaborators

Detail Information

Publications111 found, 100 shown here

  1. ncbi request reprint Insulin, insulin-like growth factors and colon cancer: a review of the evidence
    E Giovannucci
    Channing Laboratory, Department of Medicine, Harvard Medical School and Brigham and Women s Hospital, Boston, MA 02115, USA
    J Nutr 131:3109S-20S. 2001
    ..Efforts to counter these patterns are likely to have the most potential to reduce colon cancer incidence, as well as cardiovascular disease and diabetes mellitus...
  2. ncbi request reprint Body mass index and risk of prostate cancer in U.S. health professionals
    Edward Giovannucci
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Natl Cancer Inst 95:1240-4. 2003
    ....
  3. ncbi request reprint Smoking and risk of total and fatal prostate cancer in United States health professionals
    E Giovannucci
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Cancer Epidemiol Biomarkers Prev 8:277-82. 1999
    ..Our results indicate that although smoking was unrelated to prostate cancer incidence, recent tobacco use had a substantial impact on the occurrence of fatal prostate cancer...
  4. ncbi request reprint Plasma insulin-like growth factor-I and prostate cancer risk: a prospective study
    J M Chan
    Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
    Science 279:563-6. 1998
    ..This association was independent of baseline prostate-specific antigen levels. Identification of plasma IGF-I as a predictor of prostate cancer risk may have implications for risk reduction and treatment...
  5. ncbi request reprint Physical activity and benign prostatic hyperplasia
    E A Platz
    Department of Epidemiology, Harvard School of Public Health, Boston, Mass 02115, USA
    Arch Intern Med 158:2349-56. 1998
    ..Therefore, we assessed whether physical activity leads to fewer lower urinary tract symptoms in the Health Professionals Follow-up Study...
  6. ncbi request reprint Racial variation in insulin-like growth factor-1 and binding protein-3 concentrations in middle-aged men
    E A Platz
    Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA
    Cancer Epidemiol Biomarkers Prev 8:1107-10. 1999
    ..Although differences in circulating IGF-1 do not seem to account for the greater prostate cancer risk among African-American men, their absolute lower levels of IGFBP-3 may be contributory...
  7. ncbi request reprint Racial variation in prostate cancer incidence and in hormonal system markers among male health professionals
    E A Platz
    Department of Nutrition, Harvard School of Public Health, Boston, MA, USA
    J Natl Cancer Inst 92:2009-17. 2000
    ..Whether differences in the distribution of known or suspected risk factors among racial groups explain this variation is unknown...
  8. pmc Cyclin D1 A870G polymorphism and the risk of colorectal cancer and adenoma
    E S Schernhammer
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Br J Cancer 94:928-34. 2006
    ..Moreover, the A870G genotype may enhance the protective effect of postmenopausal oestrogen use on the development of colorectal neoplasia...
  9. ncbi request reprint Recreational physical activity and the risk of cholecystectomy in women
    M F Leitzmann
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    N Engl J Med 341:777-84. 1999
    ..Physical activity may be an important determinant of the risk of gallstone disease in women, both independently and as a result of its role in maintaining body weight...
  10. pmc Predicted vitamin D status and pancreatic cancer risk in two prospective cohort studies
    Y Bao
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Br J Cancer 102:1422-7. 2010
    ..Studies evaluating vitamin D status in relation to pancreatic cancer risk have yielded inconsistent results...
  11. ncbi request reprint Whole-grain consumption and risk of coronary heart disease: results from the Nurses' Health Study
    S Liu
    Division of Preventive Medicine and Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Am J Clin Nutr 70:412-9. 1999
    ..Although current dietary guidelines for Americans recommend increased intake of grain products to prevent coronary heart disease (CHD), epidemiologic data relating whole-grain intake to the risk of CHD are sparse...
  12. ncbi request reprint Coffee and alcohol consumption and the risk of pancreatic cancer in two prospective United States cohorts
    D S Michaud
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 10:429-37. 2001
    ..Data from these two large cohorts do not support any overall association between coffee intake or alcohol intake and risk of pancreatic cancer...
  13. ncbi request reprint Prospective study of colorectal cancer risk in men and plasma levels of insulin-like growth factor (IGF)-I and IGF-binding protein-3
    J Ma
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Natl Cancer Inst 91:620-5. 1999
    ..We therefore examined associations of plasma levels of IGF-I and IGFBP-3 with the risk of colorectal cancer in a prospective case-control study nested in the Physicians' Health Study...
  14. ncbi request reprint A prospective study of coffee consumption and the risk of symptomatic gallstone disease in men
    M F Leitzmann
    Department of Nutrition, Harvard School of Public Health, Boston, Mass 02115, USA
    JAMA 281:2106-12. 1999
    ..Coffee has several metabolic effects that could reduce the risk of gallstone formation...
  15. ncbi request reprint A prospective study of plasma insulin-like growth factor-1 and binding protein-3 and risk of colorectal neoplasia in women
    E Giovannucci
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cancer Epidemiol Biomarkers Prev 9:345-9. 2000
    ..These analyses indicate that high levels of circulating IGF-1 and particularly low levels of IGFBP-3 are associated independently with an elevated risk of large or tubulovillous/villous colorectal adenoma and cancer...
  16. ncbi request reprint A prospective study of physical activity and prostate cancer in male health professionals
    E Giovannucci
    Channing Laboratory, Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cancer Res 58:5117-22. 1998
    ....
  17. ncbi request reprint Prospective study of adult onset diabetes mellitus (type 2) and risk of colorectal cancer in women
    F B Hu
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    J Natl Cancer Inst 91:542-7. 1999
    ..We prospectively examined the relationship between diabetes and risk of colorectal cancer in a cohort of 118403 women aged 30 through 55 years who were without previously diagnosed cancer at baseline in 1976...
  18. ncbi request reprint Blood donations and risk of coronary heart disease in men
    A Ascherio
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Circulation 103:52-7. 2001
    ..In experimental animals, iron overload appears to promote atherosclerosis and ischemic myocardial damage, but the results of epidemiological studies that relate iron stores to risk of coronary heart disease (CHD) have been inconsistent...
  19. pmc Prospective analysis of vitamin D and endometrial cancer risk
    J J Liu
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Ann Oncol 24:687-92. 2013
    ..This is the first prospective cohort analysis on the association between vitamin D and endometrial cancer incorporating time-varying predicted plasma 25-hydroxyvitamin D [25(OH)D]...
  20. pmc Cholecystectomy and the risk for developing colorectal cancer and distal colorectal adenomas
    E S Schernhammer
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Br J Cancer 88:79-83. 2003
    ..In this large prospective cohort study, a history of cholecystectomy appears to increase modestly the risk of colorectal cancer, even after adjustment for other colorectal cancer risk factors...
  21. ncbi request reprint A prospective study of methylenetetrahydrofolate reductase and methionine synthase gene polymorphisms, and risk of colorectal adenoma
    J Chen
    Department of Epidemiology, Harvard School of Public Health, Brigham and Woman s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Carcinogenesis 19:2129-32. 1998
    ....
  22. ncbi request reprint Risk of bladder cancer by geographic region in a U.S. cohort of male health professionals
    D S Michaud
    Department of Nutrition, Harvard School of Public Health, Boston, MA, USA
    Epidemiology 12:719-26. 2001
    ..77, 95% CI = 1.15-2.71, adjusted for smoking). Diet and other known characteristics do not appear to be responsible for the regional variations in bladder cancer rates in the United States...
  23. pmc Dietary glycemic index, glycemic load, insulin index, fiber and whole-grain intake in relation to risk of prostate cancer
    K Nimptsch
    Department of Nutrition, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
    Cancer Causes Control 22:51-61. 2011
    ..The recently developed insulin index (II) quantifies the postprandial insulin secretion, also taking into account these additional characteristics...
  24. pmc A prospective study of whole-grain intake and risk of type 2 diabetes mellitus in US women
    S Liu
    Brigham and Women s Hospital, Harvard Medical School, Boston, USA
    Am J Public Health 90:1409-15. 2000
    ..This study examined the association between intake of whole vs refined grain and the risk of type 2 diabetes mellitus...
  25. ncbi request reprint Relation of consumption of vitamin E, vitamin C, and carotenoids to risk for stroke among men in the United States
    A Ascherio
    Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Ann Intern Med 130:963-70. 1999
    ..Antioxidants increase the resistance of low-density lipoprotein to oxidation and may thereby reduce risk for atherosclerosis...
  26. ncbi request reprint A prospective study on intake of animal products and risk of prostate cancer
    D S Michaud
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Cancer Causes Control 12:557-67. 2001
    ..We examine these associations among 51,529 men who contributed detailed dietary data...
  27. ncbi request reprint Insulin-like growth factor-I and binding protein-3 and risk of cancer
    E Giovannucci
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Horm Res 51:34-41. 1999
    ..Further study is required to determine the clinical relevance of these findings...
  28. ncbi request reprint Fruit and vegetable consumption and colorectal cancer incidence
    K B Michels
    Harvard University, Boston, MA, USA
    IARC Sci Publ 156:139-40. 2002
  29. ncbi request reprint Dietary influences of 1,25(OH)2 vitamin D in relation to prostate cancer: a hypothesis
    E Giovannucci
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Cancer Causes Control 9:567-82. 1998
    ..The studies examining these dietary factors in relation to prostate cancer risk will be reviewed...
  30. ncbi request reprint Milk intake, circulating levels of insulin-like growth factor-I, and risk of colorectal cancer in men
    J Ma
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Natl Cancer Inst 93:1330-6. 2001
    ..A high ratio of IGF-I to IGF-binding protein-3 (IGFBP-3) has been linked to an increased risk of colorectal cancer...
  31. pmc One-carbon metabolism factors and endometrial cancer risk
    J J Liu
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Br J Cancer 108:183-7. 2013
    ..This is the largest prospective cohort analysis to assess how dietary factors involved in one-carbon metabolism are associated with endometrial cancer incidence, using 26 years of follow-up data from the Nurses' Health Study...
  32. doi request reprint Estimating the global and regional burden of suboptimal nutrition on chronic disease: methods and inputs to the analysis
    R Micha
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Eur J Clin Nutr 66:119-29. 2012
    ..The objective of this study was to develop systematic and comparable methods to quantitatively assess the impact of suboptimal dietary habits on CVD, diabetes and cancer burdens globally and in 21 world regions...
  33. ncbi request reprint The relationship between a polymorphism in CYP17 with plasma hormone levels and prostate cancer
    C A Haiman
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 10:743-8. 2001
    ..These results suggest that CYP17 genotype may possibly confer a small increased susceptibility to prostate cancer but is not a strong predictor of endogenous steroid hormone levels in men...
  34. ncbi request reprint CAG repeat within the androgen receptor gene and incidence of surgery for benign prostatic hyperplasia in U.S. physicians
    E Giovannucci
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Prostate 39:130-4. 1999
    ..Because benign prostatic hyperplasia (BPH) is an androgen-dependent condition, we examined the hypothesis that a shorter AR gene CAG repeat length increases the risk of developing of BPH...
  35. ncbi request reprint An updated review of the epidemiological evidence that cigarette smoking increases risk of colorectal cancer
    E Giovannucci
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 10:725-31. 2001
    ....
  36. pmc Prognostic significance of AMP-activated protein kinase expression and modifying effect of MAPK3/1 in colorectal cancer
    Y Baba
    Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, 44 Binney Street, Room JF 215C, Boston, MA 02115, USA
    Br J Cancer 103:1025-33. 2010
    ..AMP-activated protein kinase activation is cytotoxic to cancer cells, supporting AMPK as a tumour suppressor and a potential therapeutic target. However, no study has examined its prognostic role in colorectal cancers...
  37. pmc Obesity, gender, and colon cancer
    E Giovannucci
    Harvard Medical School, Channing Laboratory, 181 Longwood Avenue, Boston, MA 02115, USA
    Gut 51:147. 2002
  38. pmc Aspirin use and lung cancer in men
    C N Holick
    Department of Nutrition, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
    Br J Cancer 89:1705-8. 2003
    ..64), and results remained null when consistent use of aspirin over time was examined. These findings do not suggest that regular aspirin use is associated with a reduced lung cancer risk...
  39. pmc The CAG repeat within the androgen receptor gene and its relationship to prostate cancer
    E Giovannucci
    Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 94:3320-3. 1997
    ..The clinical implications of these results should be evaluated further...
  40. pmc Discovery of colorectal cancer PIK3CA mutation as potential predictive biomarker: power and promise of molecular pathological epidemiology
    S Ogino
    1 Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA 2 Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA, USA 3 Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
    Oncogene 33:2949-55. 2014
    ..As consequences, next-generation hybrid molecular biological and population scientists can advance science, moving closer to personalized precision medicine and health care. ..
  41. ncbi request reprint Nutrition, insulin, insulin-like growth factors and cancer
    E Giovannucci
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Horm Metab Res 35:694-704. 2003
    ..Further study is required to test these conclusions...
  42. pmc Toenail selenium concentrations and bladder cancer risk in women and men
    D S Michaud
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Br J Cancer 93:804-6. 2005
    ..These findings may be due to chance and more studies are needed to determine whether associations between selenium and bladder cancer risk differ by sex...
  43. pmc Gonorrhoea and male bladder cancer in a prospective study
    D S Michaud
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Br J Cancer 96:169-71. 2007
    ..92, 95% CI=1.10-3.33). Our finding warrants further examination of the role of gonorrhoea in bladder carcinogenesis...
  44. ncbi request reprint A methylenetetrahydrofolate reductase polymorphism and the risk of colorectal cancer
    J Chen
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Cancer Res 56:4862-4. 1996
    ..In contrast, when 5-methyltetrahydrofolate is depleted by alcohol consumption, val/val individuals may be less able to compensate, leading to potentially oncogenic alterations in DNA methylation...
  45. ncbi request reprint The role of fat, fatty acids, and total energy intake in the etiology of human colon cancer
    E Giovannucci
    Channing Laboratory, Department of Medicine, Harvard Medical School, Boston, MA, USA
    Am J Clin Nutr 66:1564S-1571S. 1997
    ..Mechanisms whereby fat or red meat may influence colon carcinogenesis are discussed, although none appear compelling...
  46. ncbi request reprint Should smokers be considered a high-risk group for colorectal cancer?
    E Giovannucci
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 665 Huntington Avenue, Boston, MA 02115, USA
    Dig Liver Dis 36:643-5. 2004
  47. ncbi request reprint Tomatoes, tomato-based products, lycopene, and cancer: review of the epidemiologic literature
    E Giovannucci
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Natl Cancer Inst 91:317-31. 1999
    ....
  48. pmc Gallstones, cholecystectomy, and the risk for developing pancreatic cancer
    E S Schernhammer
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Br J Cancer 86:1081-4. 2002
    ..11, 95% CI, 0.78-1.56); this risk did not increase with increasing time following cholecystectomy or gallstones. Gallstones or cholecystectomy do not appear to be significant risk factors for pancreatic cancer...
  49. ncbi request reprint No association between the I105V polymorphism of the glutathione S-transferase P1 gene (GSTP1) and prostate cancer risk: a prospective study
    T F Shepard
    The Lank Center for Genitourinary Oncology, Department of Adult Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cancer Epidemiol Biomarkers Prev 9:1267-8. 2000
  50. ncbi request reprint The impact of cancer treatment on quality of life outcomes for patients with localized prostate cancer
    C G Bacon
    Department of Health and Social Behavior, Harvard School of Public Health and Channing Laboratory, Boston, Massachusetts, USA
    J Urol 166:1804-10. 2001
    ..It is important for patients with prostate cancer and health care providers to consider these differences while making treatment decisions...
  51. doi request reprint Multiple loci identified in a genome-wide association study of prostate cancer
    Gilles Thomas
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
    Nat Genet 40:310-5. 2008
    ..Our findings point to multiple loci with moderate effects associated with susceptibility to prostate cancer that, taken together, in the future may predict high risk in select individuals...
  52. ncbi request reprint Dietary factors and biomarkers involved in the methylenetetrahydrofolate reductase genotype-colorectal adenoma pathway
    Maria Elena Martinez
    Arizona Cancer Center, University of Arizona, Tucson, Arizona, USA
    Gastroenterology 131:1706-16. 2006
    ..We assessed 2 polymorphisms in the MTHFR gene (C677T and A1298C) in relation to colorectal adenoma recurrence and conducted analyses to investigate their joint effects with plasma and dietary markers of folate status...
  53. ncbi request reprint Folate intake, MTHFR polymorphisms, and risk of esophageal, gastric, and pancreatic cancer: a meta-analysis
    Susanna C Larsson
    Division of Nutritional Epidemiology, National Institute of Environmental Medicine, Karolinska Institutet, SE 171 77 Stockholm, Sweden
    Gastroenterology 131:1271-83. 2006
    ....
  54. ncbi request reprint A prospective cohort study of red wine consumption and risk of prostate cancer
    Siobhan Sutcliffe
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Int J Cancer 120:1529-35. 2007
    ..These findings suggest that red wine does not contribute appreciably to the etiology of prostate cancer...
  55. ncbi request reprint Prospective study of fruits and vegetables and risk of oral premalignant lesions in men
    Nancy Nairi Maserejian
    Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
    Am J Epidemiol 164:556-66. 2006
    ..7). The risk of oral premalignant lesions was significantly reduced with higher consumption of fruits, particularly citrus fruits and juices, while no consistent associations were apparent for vegetables...
  56. ncbi request reprint O6-methylguanine-DNA methyltransferase Leu84Phe and Ile143Val polymorphisms and risk of colorectal cancer in the Nurses' Health Study and Physicians' Health Study (United States)
    Gregory J Tranah
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Cancer Causes Control 17:721-31. 2006
    ..Two non-synonymous MGMT coding region variants, Leu84Phe and Ile143Val, lie in close proximity to the reactive 145Cys residue and to a conserved estrogen receptor interacting helix...
  57. ncbi request reprint Folate fortification, plasma folate, homocysteine and colorectal adenoma recurrence
    Maria Elena Martinez
    Arizona Cancer Center, University of Arizona, Tucson, AZ, USA
    Int J Cancer 119:1440-6. 2006
    ..Our finding, suggesting that multivitamins or supplemental folate only benefit individuals with lower plasma folate concentrations, should be taken into consideration when designing and interpreting results of intervention studies...
  58. ncbi request reprint Folate intake and pancreatic cancer incidence: a prospective study of Swedish women and men
    Susanna C Larsson
    Division of Nutritional Epidemiology, The National Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    J Natl Cancer Inst 98:407-13. 2006
    ..We examined the association between folate intake and risk of pancreatic cancer in a population-based prospective study of Swedish women and men...
  59. ncbi request reprint Calcium and dairy food intakes are inversely associated with colorectal cancer risk in the Cohort of Swedish Men
    Susanna C Larsson
    Division of Nutritional Epidemiology, National Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    Am J Clin Nutr 83:667-73; quiz 728-9. 2006
    ..Recent epidemiologic studies have generally reported a modest inverse association between calcium intake and the risk of colorectal cancer. However, findings pertaining to specific subsites in the colorectum have been conflicting...
  60. ncbi request reprint Vitamin D intake and the risk for pancreatic cancer in two cohort studies
    Halcyon G Skinner
    Department of Preventive Medicine, 680 North Lake Shore Drive, Suite 1102, Chicago, IL 60611, USA
    Cancer Epidemiol Biomarkers Prev 15:1688-95. 2006
    ..In two U.S. cohorts, higher intakes of vitamin D were associated with lower risks for pancreatic cancer. Our results point to a potential role for vitamin D in the pathogenesis and prevention of pancreatic cancer...
  61. ncbi request reprint Commentary: vitamin D and colorectal cancer--twenty-five years later
    Edward Giovannucci
    Channing Laboratory, Department of Medicine, Harvard Medical School and Brigham and Women s Hospital, Boston, MA 02115, USA
    Int J Epidemiol 35:222-4. 2006
  62. ncbi request reprint Dietary carbohydrate, glycemic index, and glycemic load in relation to risk of colorectal cancer in women
    Susanna C Larsson
    Division of Nutritional Epidemiology, National Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    Am J Epidemiol 165:256-61. 2007
    ..Results did not vary by body mass index. The findings from this prospective study do not support the hypothesis that a high carbohydrate intake, a high glycemic index, and a high glycemic load increase the risk of colorectal cancer...
  63. ncbi request reprint Dietary carotenoids and risk of colorectal cancer in a pooled analysis of 11 cohort studies
    Satu Mannisto
    National Public Health Institute, Helsinki, Finland
    Am J Epidemiol 165:246-55. 2007
    ..00). The associations observed were generally similar across studies, for both sexes, and for colon cancer and rectal cancer. These pooled data did not suggest that carotenoids play an important role in the etiology of colorectal cancer...
  64. doi request reprint Large-scale evaluation of genetic variants in candidate genes for colorectal cancer risk in the Nurses' Health Study and the Health Professionals' Follow-up Study
    Aditi Hazra
    Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Harvard School of Public Health, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 17:311-9. 2008
    ..00003). The SNP500Cancer database and the Illumina GoldenGate Assay allowed us to test a larger number of SNPs than previously possible. We identified several SNPs worthy of investigation in larger studies...
  65. pmc Leisure-time physical activity patterns and risk of colon cancer in women
    Kathleen Y Wolin
    Department of Surgery, School of Medicine, Washington University in St Louis, St Louis, MO, USA
    Int J Cancer 121:2776-81. 2007
    ..A significant inverse association exists between physical activity, including that of moderate intensity, such as walking, and risk of colon cancer in women that is more pronounced for distal tumors...
  66. pmc Plasma antibodies against Chlamydia trachomatis, human papillomavirus, and human herpesvirus type 8 in relation to prostate cancer: a prospective study
    Siobhan Sutcliffe
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Room E6132 A, 615 North Wolfe Street, Baltimore, MD 21205, USA
    Cancer Epidemiol Biomarkers Prev 16:1573-80. 2007
    ..70; 95% CI, 0.52-0.95). As this study is the first, to our knowledge, to observe such an inverse association, similar additional studies are warranted...
  67. pmc Body mass index, physical activity, and risk of multiple myeloma
    Brenda M Birmann
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 16:1474-8. 2007
    ..In conclusion, obesity seems to have an etiologic role in multiple myeloma, but the role of other correlates of energy balance remains uncertain...
  68. doi request reprint Hormonal profile of diabetic men and the potential link to prostate cancer
    Jocelyn S Kasper
    Department of Nutrition, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
    Cancer Causes Control 19:703-10. 2008
    ..To investigate potential biological mechanisms, hormonal profiles of diabetic men and non-diabetic controls were compared...
  69. ncbi request reprint Vitamin D receptor (VDR) gene polymorphisms and haplotypes, interactions with plasma 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D, and prostate cancer risk
    Bahar Mikhak
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Prostate 67:911-23. 2007
    ..The vitamin D receptor (VDR) is required for actions of vitamin D. The binding of 1,25-dihydroxyvitamin D to the VDR on prostatic epithelial cells prompts the regulation of cancer-related genes...
  70. ncbi request reprint A common 8q24 variant in prostate and breast cancer from a large nested case-control study
    Fredrick R Schumacher
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
    Cancer Res 67:2951-6. 2007
    ..590). Although the gene responsible has yet to be identified, the validation of this marker in this large sample of prostate cancer cases leaves little room for the possibility of a false-positive result...
  71. ncbi request reprint Genome-wide association study of prostate cancer identifies a second risk locus at 8q24
    Meredith Yeager
    SAIC Frederick, National Cancer Institute NCI Frederick Cancer Research and Development Center, Frederick, Maryland 21702, USA
    Nat Genet 39:645-9. 2007
    ..We estimate that the population attributable risk of the new locus, marked by rs6983267, is higher than the locus marked by rs1447295 (21% versus 9%)...
  72. pmc Periodontal disease, tooth loss, and cancer risk in male health professionals: a prospective cohort study
    Dominique S Michaud
    Department of Epidemiology and Public Health, Imperial College London, London, UK
    Lancet Oncol 9:550-8. 2008
    ..We aimed to assess whether periodontal disease or tooth loss is associated with cancer risk...
  73. ncbi request reprint Folate and risk of breast cancer: a meta-analysis
    Susanna C Larsson
    Division of Nutritional Epidemiology, The National Institute of Environmental Medicine, Karolinska Institutet, PO Box 210, SE 171 77 Stockholm, Sweden
    J Natl Cancer Inst 99:64-76. 2007
    ..We performed a meta-analysis of prospective and case-control studies to examine folate intake and levels in relation to risk of breast cancer...
  74. ncbi request reprint Statin drugs and risk of advanced prostate cancer
    Elizabeth A Platz
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Rm E6138, 615 N Wolfe St, Baltimore, MD 21205, USA
    J Natl Cancer Inst 98:1819-25. 2006
    ..We investigated the association of statin use with total and advanced prostate cancer, the latter being the most important endpoint to prevent...
  75. pmc Prospective weight change and colon cancer risk in male US health professionals
    Lau Caspar Thygesen
    Department of Nutrition, Harvard School of Public Health, Boston, USA
    Int J Cancer 123:1160-5. 2008
    ..5. Our results add support that overweight and obesity are modifiable risk factors for colon cancer among men and suggest that weight has an important influence on colon cancer risk even in later life...
  76. ncbi request reprint Vitamin D and prevention of colorectal cancer
    Edward D Gorham
    Naval Health Research Center, San Diego, CA 92186, USA
    J Steroid Biochem Mol Biol 97:179-94. 2005
    ..Inadequate photosynthesis or oral intake of Vitamin D are associated with high incidence rates of colorectal cancer, but the dose-response relationship has not been adequately studied...
  77. ncbi request reprint Dietary iron, zinc, and calcium and the risk of lung cancer
    Wei Zhou
    Occupational Health Program, Department of Environmental Health, Harvard School of Public Health, and the Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts 02115, USA
    Epidemiology 16:772-9. 2005
    ..Dietary intakes of these micronutrients have been associated with altered risks of colorectal, breast, and prostate cancers...
  78. ncbi request reprint Dietary carotenoids and risk of lung cancer in a pooled analysis of seven cohort studies
    Satu Mannisto
    Harvard School of Public Health, Department of Nutrition, Boston, Massachusetts, USA
    Cancer Epidemiol Biomarkers Prev 13:40-8. 2004
    ..Although smoking is the strongest risk factor for lung cancer, greater intake of foods high in beta-cryptoxanthin, such as citrus fruit, may modestly lower the risk...
  79. ncbi request reprint A prospective study of aspirin use and the risk of pancreatic cancer in women
    Eva S Schernhammer
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Natl Cancer Inst 96:22-8. 2004
    ....
  80. ncbi request reprint Fatty acids and risk of prostate cancer in a nested case-control study in male smokers
    Satu Mannisto
    Department of Epidemiology and Health Promotion, National Public Health Institute, Helsinki, Finland
    Cancer Epidemiol Biomarkers Prev 12:1422-8. 2003
    ..High serum myristic acid associated with an increased risk of prostate cancer...
  81. ncbi request reprint Fruits, vegetables and lung cancer: a pooled analysis of cohort studies
    Stephanie A Smith-Warner
    Department of Nutrition, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
    Int J Cancer 107:1001-11. 2003
    ..However, we cannot rule out the possibility that our results are due to residual confounding by smoking. The primary focus for reducing lung cancer incidence should continue to be smoking prevention and cessation...
  82. ncbi request reprint Dietary meat, dairy products, fat, and cholesterol and pancreatic cancer risk in a prospective study
    Dominique S Michaud
    Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA
    Am J Epidemiol 157:1115-25. 2003
    ..Future prospective studies should examine the influence of cooking practices as well as other dietary habits on the risk of pancreatic cancer...
  83. ncbi request reprint Height and the survival of prostate cancer patients
    Honglei Chen
    Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Cancer Epidemiol Biomarkers Prev 12:215-8. 2003
    ..Our results suggest that greater height may be associated with better survival of prostate cancer patients...
  84. ncbi request reprint Association between the Met326Ile polymorphism of the p85alpha regulatory subunit of phosphatidylinositol 3-kinase and prostate cancer risk: a prospective study
    Aimée E Paradis
    The Lank Center for Genitourinary Oncology, Department of Adult Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cancer Epidemiol Biomarkers Prev 12:172-3. 2003
  85. ncbi request reprint Dietary fat and cancer
    Lawrence Kushi
    Division of Research, Kaiser Permanente, Oakland, California 94612, USA
    Am J Med 113:63S-70S. 2002
    ..This conclusion is consistent with current recommendations for cancer prevention as promulgated by the American Cancer Society...
  86. ncbi request reprint Vitamin and carotenoid intake and risk of squamous cell carcinoma of the skin
    Teresa T Fung
    Department of Nutrition, Harvard School of Public Health, Boston, MA, USA
    Int J Cancer 103:110-5. 2003
    ..No evidence was found that vitamins A, C and E; folate; or carotenoids play an important protective role against incident SCC...
  87. ncbi request reprint Dietary fat and risk of lung cancer in a pooled analysis of prospective studies
    Stephanie A Smith-Warner
    Harvard School of Public Health, Department of Nutrition, Boston, Massachusetts 02115, USA
    Cancer Epidemiol Biomarkers Prev 11:987-92. 2002
    ..These data do not support an important relation between fat or cholesterol intakes and lung cancer risk. The means to prevent this important disease remains avoidance of smoking...
  88. ncbi request reprint Dietary sugar, glycemic load, and pancreatic cancer risk in a prospective study
    Dominique S Michaud
    Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20852, USA
    J Natl Cancer Inst 94:1293-300. 2002
    ..We investigated whether diets high in foods that increase postprandial glucose levels are associated with an increased risk of pancreatic cancer...
  89. ncbi request reprint Insulin-like growth factor-I (IGF-I) and IGF binding protein-3 as predictors of advanced-stage prostate cancer
    June M Chan
    Department of Epidemiology and Biostatistics and Urology, University of California at San Francisco, 94118, USA
    J Natl Cancer Inst 94:1099-106. 2002
    ....
  90. ncbi request reprint Tomato products, lycopene, and prostate cancer risk
    Elizabeth C Miller
    Division of Hematology and Oncology, James Cancer Hospital, Solove Research Institute, Ohio State University Medical Center, Columbus, OH, USA
    Urol Clin North Am 29:83-93. 2002
    ..The use of lycopene and other extracts for the treatment of prostate cancer is a separate issue that warrants individual attention and investigation...
  91. ncbi request reprint Prevalence of and racial/ethnic variation in lower urinary tract symptoms and noncancer prostate surgery in U.S. men
    Elizabeth A Platz
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    Urology 59:877-83. 2002
    ..To estimate the proportion of U.S. men affected by specific lower urinary tract symptoms (LUTS) and to assess whether the prevalence of LUTS varies by race/ethnicity...
  92. ncbi request reprint Intakes of energy and macronutrients and the risk of benign prostatic hyperplasia
    Sadao Suzuki
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Am J Clin Nutr 75:689-97. 2002
    ..Benign prostatic hyperplasia (BPH) is a common disease of older men. Although the etiology remains unclear, nutritional factors may have an effect on the disease...
  93. ncbi request reprint Prostate cancer association studies: pitfalls and solutions to cancer misclassification in the PSA era
    Elizabeth A Platz
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
    J Cell Biochem 91:553-71. 2004
    ....
  94. ncbi request reprint Dietary glycemic load and risk of colorectal cancer in the Women's Health Study
    Susan Higginbotham
    Department of Epidemiology, University of California at Los Angeles, USA
    J Natl Cancer Inst 96:229-33. 2004
    ..09, 95% CI = 1.13 to 3.87; P(trend) =.08) were also statistically significantly associated with increased risk. Thus, our data indicate that a diet with a high dietary glycemic load may increase the risk of colorectal cancer in women...
  95. ncbi request reprint Associations of obesity with lower urinary tract symptoms and noncancer prostate surgery in the Third National Health and Nutrition Examination Survey
    Sabine Rohrmann
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Am J Epidemiol 159:390-7. 2004
    ..Results suggest that being overweight in young adulthood may be associated with a lower prevalence of LUTS later in life, whereas weight gain and central adiposity in adulthood are possibly associated with a higher prevalence of LUTS...
  96. ncbi request reprint Vitamin D is associated with improved survival in early-stage non-small cell lung cancer patients
    Wei Zhou
    Occupational Health Program, Department of Environmental Health, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 14:2303-9. 2005
    ..In conclusion, the joint effects of surgery season and recent vitamin D intake seem to be associated with the survival of early-stage non-small cell lung cancer patients...
  97. ncbi request reprint Diabetes and colorectal cancer incidence in the cohort of Swedish men
    Susanna C Larsson
    Division of Nutritional Epidemiology, The National Institute of Environmental Medicine, Karolinska Institutet, P O Box 210, SE 171 77 Stockholm, Sweden
    Diabetes Care 28:1805-7. 2005
  98. ncbi request reprint Association of cigarette smoking, alcohol consumption and physical activity with lower urinary tract symptoms in older American men: findings from the third National Health And Nutrition Examination Survey
    Sabine Rohrmann
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    BJU Int 96:77-82. 2005
    ..To examine the association of cigarette smoking, alcohol consumption and physical activity with lower urinary tract symptoms (LUTS) in older men...
  99. ncbi request reprint Plasma insulin-like growth factor-1 and binding protein-3 and subsequent risk of prostate cancer in the PSA era
    Elizabeth A Platz
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health and the Brady Urological Institute and the Kimmel Comprehensive Cancer Center, Baltimore, MD 21205, USA
    Cancer Causes Control 16:255-62. 2005
    ..We prospectively investigated the associations of plasma IGF-1 and IGFBP-3 concentrations with prostate cancer detected in the PSA era...
  100. ncbi request reprint Epoxide hydrolase and CYP2C9 polymorphisms, cigarette smoking, and risk of colorectal carcinoma in the Nurses' Health Study and the Physicians' Health Study
    Gregory J Tranah
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
    Mol Carcinog 44:21-30. 2005
    ..Our results indicate that individuals exposed to tobacco carcinogens were at increased risk of colorectal cancer and that overall risk is related to mEH and CYP2C9 genotype, although the results were not consistent between men and women...
  101. ncbi request reprint Sex steroid hormones and the androgen receptor gene CAG repeat and subsequent risk of prostate cancer in the prostate-specific antigen era
    Elizabeth A Platz
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Room E6138, 615 North Wolfe Street, Baltimore, MD 21205, USA
    Cancer Epidemiol Biomarkers Prev 14:1262-9. 2005
    ..We investigated plasma levels of sex steroid hormones and length of the androgen receptor gene CAG repeat in relation to incident prostate cancer diagnosed in the prostate-specific antigen (PSA) era...