E Giovannucci

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Dietary influences of 1,25(OH)2 vitamin D in relation to prostate cancer: a hypothesis
    E Giovannucci
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Cancer Causes Control 9:567-82. 1998
  2. ncbi request reprint A prospective study of plasma insulin-like growth factor-1 and binding protein-3 and risk of colorectal neoplasia in women
    E Giovannucci
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cancer Epidemiol Biomarkers Prev 9:345-9. 2000
  3. ncbi request reprint Diet, body weight, and colorectal cancer: a summary of the epidemiologic evidence
    Edward Giovannucci
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Womens Health (Larchmt) 12:173-82. 2003
  4. ncbi request reprint Prospective study of predictors of vitamin D status and cancer incidence and mortality in men
    Edward Giovannucci
    Department of Medicine, Harvard Medical School, Brigham and Women s Hospital, Boston, MA, USA
    J Natl Cancer Inst 98:451-9. 2006
  5. ncbi request reprint Nutritional predictors of insulin-like growth factor I and their relationships to cancer in men
    Edward Giovannucci
    Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cancer Epidemiol Biomarkers Prev 12:84-9. 2003
  6. ncbi request reprint Modifiable risk factors for colon cancer
    Edward Giovannucci
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Department of Nutrition, Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Gastroenterol Clin North Am 31:925-43. 2002
  7. ncbi request reprint Dinucleotide repeat in the insulin-like growth factor-I gene is not related to risk of colorectal adenoma
    Edward Giovannucci
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cancer Epidemiol Biomarkers Prev 11:1509-10. 2002
  8. ncbi request reprint An updated review of the epidemiological evidence that cigarette smoking increases risk of colorectal cancer
    E Giovannucci
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 10:725-31. 2001
  9. ncbi request reprint Cancer incidence and mortality and vitamin D in black and white male health professionals
    Edward Giovannucci
    Channing Laboratory, Department of Medicine, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 15:2467-72. 2006
  10. ncbi request reprint A review of epidemiologic studies of tomatoes, lycopene, and prostate cancer
    Edward Giovannucci
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 1812 Longwood Avenue, Boston, MA 02115, USA
    Exp Biol Med (Maywood) 227:852-9. 2002

Collaborators

Detail Information

Publications182 found, 100 shown here

  1. ncbi request reprint Dietary influences of 1,25(OH)2 vitamin D in relation to prostate cancer: a hypothesis
    E Giovannucci
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Cancer Causes Control 9:567-82. 1998
    ..The studies examining these dietary factors in relation to prostate cancer risk will be reviewed...
  2. ncbi request reprint A prospective study of plasma insulin-like growth factor-1 and binding protein-3 and risk of colorectal neoplasia in women
    E Giovannucci
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cancer Epidemiol Biomarkers Prev 9:345-9. 2000
    ..These analyses indicate that high levels of circulating IGF-1 and particularly low levels of IGFBP-3 are associated independently with an elevated risk of large or tubulovillous/villous colorectal adenoma and cancer...
  3. ncbi request reprint Diet, body weight, and colorectal cancer: a summary of the epidemiologic evidence
    Edward Giovannucci
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Womens Health (Larchmt) 12:173-82. 2003
    ..The majority of colon cancers, as well as many other conditions, may be prevented by lifestyle alterations in the intake of these nutritional factors, in addition to other factors, such as smoking...
  4. ncbi request reprint Prospective study of predictors of vitamin D status and cancer incidence and mortality in men
    Edward Giovannucci
    Department of Medicine, Harvard Medical School, Brigham and Women s Hospital, Boston, MA, USA
    J Natl Cancer Inst 98:451-9. 2006
    ....
  5. ncbi request reprint Nutritional predictors of insulin-like growth factor I and their relationships to cancer in men
    Edward Giovannucci
    Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cancer Epidemiol Biomarkers Prev 12:84-9. 2003
    ..The age-related decline in plasma IGF-I may be exacerbated by low intakes of protein and minerals. The potential role of these dietary factors on cancer risk through altering IGF-I levels requires study...
  6. ncbi request reprint Modifiable risk factors for colon cancer
    Edward Giovannucci
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Department of Nutrition, Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Gastroenterol Clin North Am 31:925-43. 2002
    ....
  7. ncbi request reprint Dinucleotide repeat in the insulin-like growth factor-I gene is not related to risk of colorectal adenoma
    Edward Giovannucci
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cancer Epidemiol Biomarkers Prev 11:1509-10. 2002
  8. ncbi request reprint An updated review of the epidemiological evidence that cigarette smoking increases risk of colorectal cancer
    E Giovannucci
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 10:725-31. 2001
    ....
  9. ncbi request reprint Cancer incidence and mortality and vitamin D in black and white male health professionals
    Edward Giovannucci
    Channing Laboratory, Department of Medicine, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 15:2467-72. 2006
    ..Our results suggest that the high frequency of hypovitaminosis D in Blacks may be an important, and easily modifiable, contributor to their higher risk of cancer incidence and mortality...
  10. ncbi request reprint A review of epidemiologic studies of tomatoes, lycopene, and prostate cancer
    Edward Giovannucci
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 1812 Longwood Avenue, Boston, MA 02115, USA
    Exp Biol Med (Maywood) 227:852-9. 2002
    ..Although not definitive, the available data suggest that increased consumption of tomatoes and tomato-based products may be prudent...
  11. ncbi request reprint Epidemiologic studies of folate and colorectal neoplasia: a review
    Edward Giovannucci
    Channing Laboratory, Department of Medicine, Harvard Medical School and Brigham and Women s Hospital, Boston, MA 02115, USA
    J Nutr 132:2350S-2355S. 2002
    ..The cumulative data indicate that maintaining adequate folate levels may be important in lowering risk of colorectal cancer...
  12. ncbi request reprint Risk of cancer after growth-hormone treatment
    Edward Giovannucci
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Lancet 360:268-9. 2002
  13. pmc Obesity, gender, and colon cancer
    E Giovannucci
    Harvard Medical School, Channing Laboratory, 181 Longwood Avenue, Boston, MA 02115, USA
    Gut 51:147. 2002
  14. pmc Risk factors for prostate cancer incidence and progression in the health professionals follow-up study
    Edward Giovannucci
    Channing Laboratory, Department of Medicine, Harvard Medical School and Brigham and Women s Hospital, Boston, MA 02115, USA
    Int J Cancer 121:1571-8. 2007
    ..The complexity of the clinical and pathologic manifestations of prostate cancer must be considered in the design and interpretation of studies...
  15. ncbi request reprint Metabolic syndrome, hyperinsulinemia, and colon cancer: a review
    Edward Giovannucci
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Am J Clin Nutr 86:s836-42. 2007
    ..Future studies should also be based on better measurements of insulin resistance, beta-cell depletion, and insulin responses to better assess which aspects of insulin resistance are most closely related to the risk of colon neoplasia...
  16. ncbi request reprint A prospective study of tomato products, lycopene, and prostate cancer risk
    Edward Giovannucci
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    J Natl Cancer Inst 94:391-8. 2002
    ..Overall, however, the data are inconclusive. We evaluated additional data from the HPFS to determine if the association would persist...
  17. ncbi request reprint A prospective study of calcium intake and incident and fatal prostate cancer
    Edward Giovannucci
    Channing Laboratory, Department of Medicine, Harvard Medical School and Brigham and Women s Hospital, Harvard School of Public Health, 665 Huntington Avenue, Boston, Massachusetts 02115, USA
    Cancer Epidemiol Biomarkers Prev 15:203-10. 2006
    ....
  18. ncbi request reprint Methylenetetrahydrofolate reductase, alcohol dehydrogenase, diet, and risk of colorectal adenomas
    Edward Giovannucci
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston Massachusetts 02115, USA
    Cancer Epidemiol Biomarkers Prev 12:970-9. 2003
    ....
  19. ncbi request reprint The epidemiology of vitamin D and colorectal cancer: recent findings
    Edward Giovannucci
    Channing Laboratory, Department of Medicine, Harvard Medical School and Brigham and Women s Hospital, Boston, Massachusetts, USA
    Curr Opin Gastroenterol 22:24-9. 2006
    ..To highlight the human studies published over the past year examining the influence of vitamin D on risk of colorectal cancer...
  20. ncbi request reprint Glycemic index and colorectal carcinogenesis
    Edward Giovannucci
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Eur J Epidemiol 19:405-7. 2004
  21. ncbi request reprint The role of fat, fatty acids, and total energy intake in the etiology of human colon cancer
    E Giovannucci
    Channing Laboratory, Department of Medicine, Harvard Medical School, Boston, MA, USA
    Am J Clin Nutr 66:1564S-1571S. 1997
    ..Mechanisms whereby fat or red meat may influence colon carcinogenesis are discussed, although none appear compelling...
  22. ncbi request reprint Alcohol, one-carbon metabolism, and colorectal cancer: recent insights from molecular studies
    Edward Giovannucci
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston MA 02115, USA
    J Nutr 134:2475S-2481S. 2004
    ....
  23. ncbi request reprint A prospective study of physical activity and prostate cancer in male health professionals
    E Giovannucci
    Channing Laboratory, Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cancer Res 58:5117-22. 1998
    ....
  24. ncbi request reprint Height, predictors of C-peptide and cancer risk in men
    Edward Giovannucci
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Int J Epidemiol 33:217-25. 2004
    ..However, the relative importance of these hormonal factors during pre-adulthood and adulthood is unknown...
  25. ncbi request reprint Should smokers be considered a high-risk group for colorectal cancer?
    E Giovannucci
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 665 Huntington Avenue, Boston, MA 02115, USA
    Dig Liver Dis 36:643-5. 2004
  26. ncbi request reprint Tomatoes, tomato-based products, lycopene, and cancer: review of the epidemiologic literature
    E Giovannucci
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Natl Cancer Inst 91:317-31. 1999
    ....
  27. ncbi request reprint The epidemiology of vitamin D and cancer incidence and mortality: a review (United States)
    Edward Giovannucci
    Channing Laboratory, Department of Medicine, Harvard Medical School and Brigham and Women s Hospital, 181 Longwood Avenue, Boston, MA 02115, USA
    Cancer Causes Control 16:83-95. 2005
    ..Given the potential benefits from vitamin D, further research should be a priority...
  28. ncbi request reprint A prospective study of physical activity and incident and fatal prostate cancer
    Edward L Giovannucci
    Department of Nutrition, Harvard School of Public Health, Boston, Mass, USA
    Arch Intern Med 165:1005-10. 2005
    ..Whether physical activity has benefits against prostate cancer incidence or progression is unclear. Therefore, we assessed physical activity in relation to prostate cancer incidence, mortality, and Gleason histologic grade...
  29. ncbi request reprint Nutrition, insulin, insulin-like growth factors and cancer
    E Giovannucci
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Horm Metab Res 35:694-704. 2003
    ..Further study is required to test these conclusions...
  30. ncbi request reprint Smoking and risk of total and fatal prostate cancer in United States health professionals
    E Giovannucci
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Cancer Epidemiol Biomarkers Prev 8:277-82. 1999
    ..Our results indicate that although smoking was unrelated to prostate cancer incidence, recent tobacco use had a substantial impact on the occurrence of fatal prostate cancer...
  31. ncbi request reprint CAG repeat within the androgen receptor gene and incidence of surgery for benign prostatic hyperplasia in U.S. physicians
    E Giovannucci
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Prostate 39:130-4. 1999
    ..Because benign prostatic hyperplasia (BPH) is an androgen-dependent condition, we examined the hypothesis that a shorter AR gene CAG repeat length increases the risk of developing of BPH...
  32. ncbi request reprint Tomato products, lycopene, and prostate cancer: a review of the epidemiological literature
    Edward Giovannucci
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Nutr 135:2030S-1S. 2005
  33. ncbi request reprint A prospective study of cruciferous vegetables and prostate cancer
    Edward Giovannucci
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Cancer Epidemiol Biomarkers Prev 12:1403-9. 2003
    ..These findings suggest that future studies of cruciferous vegetables should focus on early stages of prostate cancer...
  34. ncbi request reprint Commentary: vitamin D and colorectal cancer--twenty-five years later
    Edward Giovannucci
    Channing Laboratory, Department of Medicine, Harvard Medical School and Brigham and Women s Hospital, Boston, MA 02115, USA
    Int J Epidemiol 35:222-4. 2006
  35. ncbi request reprint The role of obesity and related metabolic disturbances in cancers of the colon, prostate, and pancreas
    Edward Giovannucci
    Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA
    Gastroenterology 132:2208-25. 2007
    ..The mechanisms for these associations, however, remain speculative and deserve further study. Hyperinsulinemia may be important, but the role of oxidative stress initiated by hyperglycemia also deserves further attention...
  36. ncbi request reprint Racial variation in prostate cancer incidence and in hormonal system markers among male health professionals
    E A Platz
    Department of Nutrition, Harvard School of Public Health, Boston, MA, USA
    J Natl Cancer Inst 92:2009-17. 2000
    ..Whether differences in the distribution of known or suspected risk factors among racial groups explain this variation is unknown...
  37. ncbi request reprint Plasma insulin-like growth factor-I and prostate cancer risk: a prospective study
    J M Chan
    Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
    Science 279:563-6. 1998
    ..This association was independent of baseline prostate-specific antigen levels. Identification of plasma IGF-I as a predictor of prostate cancer risk may have implications for risk reduction and treatment...
  38. ncbi request reprint Physical activity and benign prostatic hyperplasia
    E A Platz
    Department of Epidemiology, Harvard School of Public Health, Boston, Mass 02115, USA
    Arch Intern Med 158:2349-56. 1998
    ..Therefore, we assessed whether physical activity leads to fewer lower urinary tract symptoms in the Health Professionals Follow-up Study...
  39. ncbi request reprint Racial variation in insulin-like growth factor-1 and binding protein-3 concentrations in middle-aged men
    E A Platz
    Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA
    Cancer Epidemiol Biomarkers Prev 8:1107-10. 1999
    ..Although differences in circulating IGF-1 do not seem to account for the greater prostate cancer risk among African-American men, their absolute lower levels of IGFBP-3 may be contributory...
  40. pmc Cyclin D1 A870G polymorphism and the risk of colorectal cancer and adenoma
    E S Schernhammer
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Br J Cancer 94:928-34. 2006
    ..Moreover, the A870G genotype may enhance the protective effect of postmenopausal oestrogen use on the development of colorectal neoplasia...
  41. ncbi request reprint Recreational physical activity and the risk of cholecystectomy in women
    M F Leitzmann
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    N Engl J Med 341:777-84. 1999
    ..Physical activity may be an important determinant of the risk of gallstone disease in women, both independently and as a result of its role in maintaining body weight...
  42. ncbi request reprint Whole-grain consumption and risk of coronary heart disease: results from the Nurses' Health Study
    S Liu
    Division of Preventive Medicine and Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Am J Clin Nutr 70:412-9. 1999
    ..Although current dietary guidelines for Americans recommend increased intake of grain products to prevent coronary heart disease (CHD), epidemiologic data relating whole-grain intake to the risk of CHD are sparse...
  43. ncbi request reprint Coffee and alcohol consumption and the risk of pancreatic cancer in two prospective United States cohorts
    D S Michaud
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 10:429-37. 2001
    ..Data from these two large cohorts do not support any overall association between coffee intake or alcohol intake and risk of pancreatic cancer...
  44. pmc Predicted vitamin D status and pancreatic cancer risk in two prospective cohort studies
    Y Bao
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Br J Cancer 102:1422-7. 2010
    ..Studies evaluating vitamin D status in relation to pancreatic cancer risk have yielded inconsistent results...
  45. ncbi request reprint A prospective study of methylenetetrahydrofolate reductase and methionine synthase gene polymorphisms, and risk of colorectal adenoma
    J Chen
    Department of Epidemiology, Harvard School of Public Health, Brigham and Woman s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Carcinogenesis 19:2129-32. 1998
    ....
  46. ncbi request reprint Milk intake, circulating levels of insulin-like growth factor-I, and risk of colorectal cancer in men
    J Ma
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Natl Cancer Inst 93:1330-6. 2001
    ..A high ratio of IGF-I to IGF-binding protein-3 (IGFBP-3) has been linked to an increased risk of colorectal cancer...
  47. ncbi request reprint Insulin, insulin-like growth factors and colon cancer: a review of the evidence
    E Giovannucci
    Channing Laboratory, Department of Medicine, Harvard Medical School and Brigham and Women s Hospital, Boston, MA 02115, USA
    J Nutr 131:3109S-20S. 2001
    ..Efforts to counter these patterns are likely to have the most potential to reduce colon cancer incidence, as well as cardiovascular disease and diabetes mellitus...
  48. ncbi request reprint A prospective study of coffee consumption and the risk of symptomatic gallstone disease in men
    M F Leitzmann
    Department of Nutrition, Harvard School of Public Health, Boston, Mass 02115, USA
    JAMA 281:2106-12. 1999
    ..Coffee has several metabolic effects that could reduce the risk of gallstone formation...
  49. ncbi request reprint Blood donations and risk of coronary heart disease in men
    A Ascherio
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Circulation 103:52-7. 2001
    ..In experimental animals, iron overload appears to promote atherosclerosis and ischemic myocardial damage, but the results of epidemiological studies that relate iron stores to risk of coronary heart disease (CHD) have been inconsistent...
  50. ncbi request reprint Prospective study of colorectal cancer risk in men and plasma levels of insulin-like growth factor (IGF)-I and IGF-binding protein-3
    J Ma
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Natl Cancer Inst 91:620-5. 1999
    ..We therefore examined associations of plasma levels of IGF-I and IGFBP-3 with the risk of colorectal cancer in a prospective case-control study nested in the Physicians' Health Study...
  51. pmc Prospective analysis of vitamin D and endometrial cancer risk
    J J Liu
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Ann Oncol 24:687-92. 2013
    ..This is the first prospective cohort analysis on the association between vitamin D and endometrial cancer incorporating time-varying predicted plasma 25-hydroxyvitamin D [25(OH)D]...
  52. ncbi request reprint Prospective study of adult onset diabetes mellitus (type 2) and risk of colorectal cancer in women
    F B Hu
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    J Natl Cancer Inst 91:542-7. 1999
    ..We prospectively examined the relationship between diabetes and risk of colorectal cancer in a cohort of 118403 women aged 30 through 55 years who were without previously diagnosed cancer at baseline in 1976...
  53. ncbi request reprint A methylenetetrahydrofolate reductase polymorphism and the risk of colorectal cancer
    J Chen
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Cancer Res 56:4862-4. 1996
    ..In contrast, when 5-methyltetrahydrofolate is depleted by alcohol consumption, val/val individuals may be less able to compensate, leading to potentially oncogenic alterations in DNA methylation...
  54. pmc Cholecystectomy and the risk for developing colorectal cancer and distal colorectal adenomas
    E S Schernhammer
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Br J Cancer 88:79-83. 2003
    ..In this large prospective cohort study, a history of cholecystectomy appears to increase modestly the risk of colorectal cancer, even after adjustment for other colorectal cancer risk factors...
  55. ncbi request reprint Fruit and vegetable consumption and colorectal cancer incidence
    K B Michels
    Harvard University, Boston, MA, USA
    IARC Sci Publ 156:139-40. 2002
  56. ncbi request reprint The relationship between a polymorphism in CYP17 with plasma hormone levels and prostate cancer
    C A Haiman
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 10:743-8. 2001
    ..These results suggest that CYP17 genotype may possibly confer a small increased susceptibility to prostate cancer but is not a strong predictor of endogenous steroid hormone levels in men...
  57. ncbi request reprint Association between serum concentrations of micronutrients and lower urinary tract symptoms in older men in the Third National Health and Nutrition Examination Survey
    Sabine Rohrmann
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    Urology 64:504-9. 2004
    ..To evaluate the association of serum micronutrients with lower urinary tract symptoms (LUTS)...
  58. ncbi request reprint Relation of consumption of vitamin E, vitamin C, and carotenoids to risk for stroke among men in the United States
    A Ascherio
    Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Ann Intern Med 130:963-70. 1999
    ..Antioxidants increase the resistance of low-density lipoprotein to oxidation and may thereby reduce risk for atherosclerosis...
  59. ncbi request reprint Association between markers of the metabolic syndrome and lower urinary tract symptoms in the Third National Health and Nutrition Examination Survey (NHANES III)
    S Rohrmann
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Int J Obes (Lond) 29:310-6. 2005
    ..To examine the association of components of the metabolic syndrome with lower urinary tract symptoms (LUTS), which often result from prostate enlargement and heightened tone of prostate and bladder smooth muscle...
  60. pmc Dietary glycemic index, glycemic load, insulin index, fiber and whole-grain intake in relation to risk of prostate cancer
    K Nimptsch
    Department of Nutrition, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
    Cancer Causes Control 22:51-61. 2011
    ..The recently developed insulin index (II) quantifies the postprandial insulin secretion, also taking into account these additional characteristics...
  61. pmc The CAG repeat within the androgen receptor gene and its relationship to prostate cancer
    E Giovannucci
    Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 94:3320-3. 1997
    ..The clinical implications of these results should be evaluated further...
  62. pmc A prospective study of whole-grain intake and risk of type 2 diabetes mellitus in US women
    S Liu
    Brigham and Women s Hospital, Harvard Medical School, Boston, USA
    Am J Public Health 90:1409-15. 2000
    ..This study examined the association between intake of whole vs refined grain and the risk of type 2 diabetes mellitus...
  63. ncbi request reprint Risk of bladder cancer by geographic region in a U.S. cohort of male health professionals
    D S Michaud
    Department of Nutrition, Harvard School of Public Health, Boston, MA, USA
    Epidemiology 12:719-26. 2001
    ..77, 95% CI = 1.15-2.71, adjusted for smoking). Diet and other known characteristics do not appear to be responsible for the regional variations in bladder cancer rates in the United States...
  64. pmc Diabetes mellitus and risk of prostate cancer in the health professionals follow-up study
    Jocelyn S Kasper
    Department of Nutrition, Harvard School of Public Health, Harvard University, Boston, MA 02115, USA
    Int J Cancer 124:1398-403. 2009
    ..Results are consistent with the hypothesis that diabetes is associated with reduced PCa risk. Potential biological mechanisms are discussed...
  65. ncbi request reprint Association between the Met326Ile polymorphism of the p85alpha regulatory subunit of phosphatidylinositol 3-kinase and prostate cancer risk: a prospective study
    Aimée E Paradis
    The Lank Center for Genitourinary Oncology, Department of Adult Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cancer Epidemiol Biomarkers Prev 12:172-3. 2003
  66. ncbi request reprint Sex steroid hormones and the androgen receptor gene CAG repeat and subsequent risk of prostate cancer in the prostate-specific antigen era
    Elizabeth A Platz
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Room E6138, 615 North Wolfe Street, Baltimore, MD 21205, USA
    Cancer Epidemiol Biomarkers Prev 14:1262-9. 2005
    ..We investigated plasma levels of sex steroid hormones and length of the androgen receptor gene CAG repeat in relation to incident prostate cancer diagnosed in the prostate-specific antigen (PSA) era...
  67. ncbi request reprint XRCC2 and XRCC3 polymorphisms are not associated with risk of colorectal adenoma
    Gregory J Tranah
    Department of Epidemiology, and Harvard Center for Cancer Prevention, Harvard School of Public Health, Boston, MA, USA
    Cancer Epidemiol Biomarkers Prev 13:1090-1. 2004
  68. ncbi request reprint No association between the I105V polymorphism of the glutathione S-transferase P1 gene (GSTP1) and prostate cancer risk: a prospective study
    T F Shepard
    The Lank Center for Genitourinary Oncology, Department of Adult Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cancer Epidemiol Biomarkers Prev 9:1267-8. 2000
  69. ncbi request reprint A prospective cohort study of red wine consumption and risk of prostate cancer
    Siobhan Sutcliffe
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Int J Cancer 120:1529-35. 2007
    ..These findings suggest that red wine does not contribute appreciably to the etiology of prostate cancer...
  70. ncbi request reprint Prospective study of fruits and vegetables and risk of oral premalignant lesions in men
    Nancy Nairi Maserejian
    Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
    Am J Epidemiol 164:556-66. 2006
    ..7). The risk of oral premalignant lesions was significantly reduced with higher consumption of fruits, particularly citrus fruits and juices, while no consistent associations were apparent for vegetables...
  71. ncbi request reprint O6-methylguanine-DNA methyltransferase Leu84Phe and Ile143Val polymorphisms and risk of colorectal cancer in the Nurses' Health Study and Physicians' Health Study (United States)
    Gregory J Tranah
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Cancer Causes Control 17:721-31. 2006
    ..Two non-synonymous MGMT coding region variants, Leu84Phe and Ile143Val, lie in close proximity to the reactive 145Cys residue and to a conserved estrogen receptor interacting helix...
  72. pmc Manganese superoxide dismutase (MnSOD) gene polymorphism, interactions with carotenoid levels and prostate cancer risk
    Bahar Mikhak
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Carcinogenesis 29:2335-40. 2008
    ..On the other hand, some epidemiologic studies suggest that the Ala allele is associated with a higher risk of cancer, including prostate cancer...
  73. ncbi request reprint Vitamin D receptor (VDR) gene polymorphisms and haplotypes, interactions with plasma 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D, and prostate cancer risk
    Bahar Mikhak
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Prostate 67:911-23. 2007
    ..The vitamin D receptor (VDR) is required for actions of vitamin D. The binding of 1,25-dihydroxyvitamin D to the VDR on prostatic epithelial cells prompts the regulation of cancer-related genes...
  74. ncbi request reprint Epoxide hydrolase and CYP2C9 polymorphisms, cigarette smoking, and risk of colorectal carcinoma in the Nurses' Health Study and the Physicians' Health Study
    Gregory J Tranah
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
    Mol Carcinog 44:21-30. 2005
    ..Our results indicate that individuals exposed to tobacco carcinogens were at increased risk of colorectal cancer and that overall risk is related to mEH and CYP2C9 genotype, although the results were not consistent between men and women...
  75. doi request reprint Hormonal profile of diabetic men and the potential link to prostate cancer
    Jocelyn S Kasper
    Department of Nutrition, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
    Cancer Causes Control 19:703-10. 2008
    ..To investigate potential biological mechanisms, hormonal profiles of diabetic men and non-diabetic controls were compared...
  76. ncbi request reprint ATAAA repeat upstream of glutathione S-transferase P1 and prostate cancer risk
    Elizabeth A Platz
    Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    Urology 59:159-64. 2002
    ..Upstream of its promoter is a polymorphic ATAAA repeat of unknown functional significance. We evaluated whether this polymorphism is associated with prostate cancer...
  77. ncbi request reprint Dietary carotenoids and risk of lung cancer in a pooled analysis of seven cohort studies
    Satu Mannisto
    Harvard School of Public Health, Department of Nutrition, Boston, Massachusetts, USA
    Cancer Epidemiol Biomarkers Prev 13:40-8. 2004
    ..Although smoking is the strongest risk factor for lung cancer, greater intake of foods high in beta-cryptoxanthin, such as citrus fruit, may modestly lower the risk...
  78. ncbi request reprint Insulin-like growth factor-I and binding protein-3 and risk of cancer
    E Giovannucci
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Horm Res 51:34-41. 1999
    ..Further study is required to determine the clinical relevance of these findings...
  79. pmc A large study of androgen receptor germline variants and their relation to sex hormone levels and prostate cancer risk. Results from the National Cancer Institute Breast and Prostate Cancer Cohort Consortium
    Sara Lindstrom
    Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
    J Clin Endocrinol Metab 95:E121-7. 2010
    ..A long-standing hypothesis has been that inherited variation in the androgen receptor (AR) gene plays a role in prostate cancer initiation. However, studies to date have been inconclusive and often suffered from small sample sizes...
  80. ncbi request reprint Dietary glycemic load and risk of colorectal cancer in the Women's Health Study
    Susan Higginbotham
    Department of Epidemiology, University of California at Los Angeles, USA
    J Natl Cancer Inst 96:229-33. 2004
    ..09, 95% CI = 1.13 to 3.87; P(trend) =.08) were also statistically significantly associated with increased risk. Thus, our data indicate that a diet with a high dietary glycemic load may increase the risk of colorectal cancer in women...
  81. ncbi request reprint Plasma insulin-like growth factor-1 and binding protein-3 and subsequent risk of prostate cancer in the PSA era
    Elizabeth A Platz
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health and the Brady Urological Institute and the Kimmel Comprehensive Cancer Center, Baltimore, MD 21205, USA
    Cancer Causes Control 16:255-62. 2005
    ..We prospectively investigated the associations of plasma IGF-1 and IGFBP-3 concentrations with prostate cancer detected in the PSA era...
  82. ncbi request reprint Fiber from fruit and colorectal neoplasia
    Mia A Papas
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Room E6143, 615 North Wolfe Street, Baltimore, MD 21205, USA
    Cancer Epidemiol Biomarkers Prev 13:1267-70. 2004
  83. pmc History of peptic ulcer disease and pancreatic cancer risk in men
    Ying Bao
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Gastroenterology 138:541-9. 2010
    ..We investigated the association between pancreatic cancer and the occurrence of gastric or duodenal ulcer in a large US cohort...
  84. ncbi request reprint Associations of obesity with lower urinary tract symptoms and noncancer prostate surgery in the Third National Health and Nutrition Examination Survey
    Sabine Rohrmann
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Am J Epidemiol 159:390-7. 2004
    ..Results suggest that being overweight in young adulthood may be associated with a lower prevalence of LUTS later in life, whereas weight gain and central adiposity in adulthood are possibly associated with a higher prevalence of LUTS...
  85. pmc Plasma C-peptide is inversely associated with calcium intake in women and with plasma 25-hydroxy vitamin D in men
    Tianying Wu
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    J Nutr 139:547-54. 2009
    ..03) in men and 12% lower (P = 0.01) in women. The results suggest that calcium intake or systemic vitamin D status, after adjustment for intake of dairy products, is associated with decreased insulin secretion...
  86. doi request reprint Vitamin D and prevention of colorectal adenoma: a meta-analysis
    Melissa Y Wei
    Department of Nutrition, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 17:2958-69. 2008
    ..This meta-analysis examined the overall relationship between circulating (plasma or serum) 25-hydroxyvitamin D [25(OH)D], vitamin D intake (dietary, supplemental, or total), and colorectal adenoma incidence in published studies...
  87. pmc Prospective weight change and colon cancer risk in male US health professionals
    Lau Caspar Thygesen
    Department of Nutrition, Harvard School of Public Health, Boston, USA
    Int J Cancer 123:1160-5. 2008
    ..5. Our results add support that overweight and obesity are modifiable risk factors for colon cancer among men and suggest that weight has an important influence on colon cancer risk even in later life...
  88. pmc The Mediterranean and Dietary Approaches to Stop Hypertension (DASH) diets and colorectal cancer
    Teresa T Fung
    Department of Nutrition, Simmons College, Boston, MA, USA
    Am J Clin Nutr 92:1429-35. 2010
    ....
  89. ncbi request reprint Prevalence of and racial/ethnic variation in lower urinary tract symptoms and noncancer prostate surgery in U.S. men
    Elizabeth A Platz
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    Urology 59:877-83. 2002
    ..To estimate the proportion of U.S. men affected by specific lower urinary tract symptoms (LUTS) and to assess whether the prevalence of LUTS varies by race/ethnicity...
  90. ncbi request reprint A common 8q24 variant in prostate and breast cancer from a large nested case-control study
    Fredrick R Schumacher
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
    Cancer Res 67:2951-6. 2007
    ..590). Although the gene responsible has yet to be identified, the validation of this marker in this large sample of prostate cancer cases leaves little room for the possibility of a false-positive result...
  91. ncbi request reprint Prostate cancer association studies: pitfalls and solutions to cancer misclassification in the PSA era
    Elizabeth A Platz
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
    J Cell Biochem 91:553-71. 2004
    ....
  92. ncbi request reprint Statin drugs and risk of advanced prostate cancer
    Elizabeth A Platz
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Rm E6138, 615 N Wolfe St, Baltimore, MD 21205, USA
    J Natl Cancer Inst 98:1819-25. 2006
    ..We investigated the association of statin use with total and advanced prostate cancer, the latter being the most important endpoint to prevent...
  93. ncbi request reprint Dietary fat and risk of lung cancer in a pooled analysis of prospective studies
    Stephanie A Smith-Warner
    Harvard School of Public Health, Department of Nutrition, Boston, Massachusetts 02115, USA
    Cancer Epidemiol Biomarkers Prev 11:987-92. 2002
    ..These data do not support an important relation between fat or cholesterol intakes and lung cancer risk. The means to prevent this important disease remains avoidance of smoking...
  94. ncbi request reprint Vitamin and carotenoid intake and risk of squamous cell carcinoma of the skin
    Teresa T Fung
    Department of Nutrition, Harvard School of Public Health, Boston, MA, USA
    Int J Cancer 103:110-5. 2003
    ..No evidence was found that vitamins A, C and E; folate; or carotenoids play an important protective role against incident SCC...
  95. ncbi request reprint Vitamin D is associated with improved survival in early-stage non-small cell lung cancer patients
    Wei Zhou
    Occupational Health Program, Department of Environmental Health, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 14:2303-9. 2005
    ..In conclusion, the joint effects of surgery season and recent vitamin D intake seem to be associated with the survival of early-stage non-small cell lung cancer patients...
  96. ncbi request reprint Intakes of energy and macronutrients and the risk of benign prostatic hyperplasia
    Sadao Suzuki
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Am J Clin Nutr 75:689-97. 2002
    ..Benign prostatic hyperplasia (BPH) is a common disease of older men. Although the etiology remains unclear, nutritional factors may have an effect on the disease...
  97. pmc Plasma antibodies against Chlamydia trachomatis, human papillomavirus, and human herpesvirus type 8 in relation to prostate cancer: a prospective study
    Siobhan Sutcliffe
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Room E6132 A, 615 North Wolfe Street, Baltimore, MD 21205, USA
    Cancer Epidemiol Biomarkers Prev 16:1573-80. 2007
    ..70; 95% CI, 0.52-0.95). As this study is the first, to our knowledge, to observe such an inverse association, similar additional studies are warranted...
  98. ncbi request reprint Fruits, vegetables and lung cancer: a pooled analysis of cohort studies
    Stephanie A Smith-Warner
    Department of Nutrition, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
    Int J Cancer 107:1001-11. 2003
    ..However, we cannot rule out the possibility that our results are due to residual confounding by smoking. The primary focus for reducing lung cancer incidence should continue to be smoking prevention and cessation...
  99. pmc Coffee, tea, caffeine intake, and risk of adult glioma in three prospective cohort studies
    Crystal N Holick
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
    Cancer Epidemiol Biomarkers Prev 19:39-47. 2010
    ..Our findings suggest that consumption of caffeinated beverages, including coffee and tea, may reduce the risk of adult glioma, but further research is warranted to confirm these findings in other populations...
  100. ncbi request reprint Association of cigarette smoking, alcohol consumption and physical activity with lower urinary tract symptoms in older American men: findings from the third National Health And Nutrition Examination Survey
    Sabine Rohrmann
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    BJU Int 96:77-82. 2005
    ..To examine the association of cigarette smoking, alcohol consumption and physical activity with lower urinary tract symptoms (LUTS) in older men...
  101. ncbi request reprint Epoxide hydrolase polymorphisms, cigarette smoking and risk of colorectal adenoma in the Nurses' Health Study and the Health Professionals Follow-up Study
    Gregory J Tranah
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Carcinogenesis 25:1211-8. 2004
    ....