Affiliation: Harvard University
- Regulation of epithelial and lymphocyte cell adhesion by adenosine deaminase-CD26 interactionSilvia Gines
Department of Biochemistry and Molecular Biology, University of Barcelona, Marti i Franques 1, 08028 Barcelona, Spain
Biochem J 361:203-9. 2002..Taken together, these results suggest that the ADA-CD26 interaction on the cell surface has a role in lymphocyte-epithelial cell adhesion...
- Enhanced Akt signaling is an early pro-survival response that reflects N-methyl-D-aspartate receptor activation in Huntington's disease knock-in striatal cellsSilvia Gines
Molecular Neurogenetics Unit, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
J Biol Chem 278:50514-22. 2003....
- Reversal of a full-length mutant huntingtin neuronal cell phenotype by chemical inhibitors of polyglutamine-mediated aggregationJin Wang
Molecular Neurogenetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02129, USA
BMC Neurosci 6:1. 2005....
- Decreased association of the transcription factor Sp1 with genes downregulated in Huntington's diseaseAlice S Chen-Plotkin
MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital B114 2000, 114 16th Street, Charlestown, MA 02129 4404, USA
Neurobiol Dis 22:233-41. 2006..Moreover, the altered binding seen with Sp1 is not found with another transcription factor, NF-Y. These findings suggest that mutant huntingtin dissociates Sp1 from target promoters, inhibiting transcription of specific genes...
- Huntington's diseaseMarcy E MacDonald
Molecular Neurogenetics Unit, Center for Human Genetics Research, Massachusetts General Hospital, Charlestown, MA 02129, USA
Neuromolecular Med 4:7-20. 2003....
- Specific progressive cAMP reduction implicates energy deficit in presymptomatic Huntington's disease knock-in miceSilvia Gines
Molecular Neurogenetics Unit, Massachusetts General Hospital, Building 149, 13th St, Charlestown, MA 02129, USA
Hum Mol Genet 12:497-508. 2003....
- A human single-chain Fv intrabody preferentially targets amino-terminal Huntingtin's fragments in striatal models of Huntington's diseaseTodd W Miller
Division of Genetic Disorders Wadsworth Center, New York State Department of Health, and Department of Biomedical Sciences, University at Albany, NY 12208, USA
Neurobiol Dis 19:47-56. 2005..Intrabodies may be used as potential curative agents, and as drug discovery tools, for HD and other misfolded protein disorders...