Silvia Gines

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Regulation of epithelial and lymphocyte cell adhesion by adenosine deaminase-CD26 interaction
    Silvia Gines
    Department of Biochemistry and Molecular Biology, University of Barcelona, Marti i Franques 1, 08028 Barcelona, Spain
    Biochem J 361:203-9. 2002
  2. ncbi request reprint Enhanced Akt signaling is an early pro-survival response that reflects N-methyl-D-aspartate receptor activation in Huntington's disease knock-in striatal cells
    Silvia Gines
    Molecular Neurogenetics Unit, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    J Biol Chem 278:50514-22. 2003
  3. pmc Reversal of a full-length mutant huntingtin neuronal cell phenotype by chemical inhibitors of polyglutamine-mediated aggregation
    Jin Wang
    Molecular Neurogenetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02129, USA
    BMC Neurosci 6:1. 2005
  4. ncbi request reprint Decreased association of the transcription factor Sp1 with genes downregulated in Huntington's disease
    Alice S Chen-Plotkin
    MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital B114 2000, 114 16th Street, Charlestown, MA 02129 4404, USA
    Neurobiol Dis 22:233-41. 2006
  5. ncbi request reprint Huntington's disease
    Marcy E MacDonald
    Molecular Neurogenetics Unit, Center for Human Genetics Research, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Neuromolecular Med 4:7-20. 2003
  6. ncbi request reprint Specific progressive cAMP reduction implicates energy deficit in presymptomatic Huntington's disease knock-in mice
    Silvia Gines
    Molecular Neurogenetics Unit, Massachusetts General Hospital, Building 149, 13th St, Charlestown, MA 02129, USA
    Hum Mol Genet 12:497-508. 2003
  7. ncbi request reprint A human single-chain Fv intrabody preferentially targets amino-terminal Huntingtin's fragments in striatal models of Huntington's disease
    Todd W Miller
    Division of Genetic Disorders Wadsworth Center, New York State Department of Health, and Department of Biomedical Sciences, University at Albany, NY 12208, USA
    Neurobiol Dis 19:47-56. 2005

Detail Information

Publications7

  1. pmc Regulation of epithelial and lymphocyte cell adhesion by adenosine deaminase-CD26 interaction
    Silvia Gines
    Department of Biochemistry and Molecular Biology, University of Barcelona, Marti i Franques 1, 08028 Barcelona, Spain
    Biochem J 361:203-9. 2002
    ..Taken together, these results suggest that the ADA-CD26 interaction on the cell surface has a role in lymphocyte-epithelial cell adhesion...
  2. ncbi request reprint Enhanced Akt signaling is an early pro-survival response that reflects N-methyl-D-aspartate receptor activation in Huntington's disease knock-in striatal cells
    Silvia Gines
    Molecular Neurogenetics Unit, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    J Biol Chem 278:50514-22. 2003
    ....
  3. pmc Reversal of a full-length mutant huntingtin neuronal cell phenotype by chemical inhibitors of polyglutamine-mediated aggregation
    Jin Wang
    Molecular Neurogenetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02129, USA
    BMC Neurosci 6:1. 2005
    ....
  4. ncbi request reprint Decreased association of the transcription factor Sp1 with genes downregulated in Huntington's disease
    Alice S Chen-Plotkin
    MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital B114 2000, 114 16th Street, Charlestown, MA 02129 4404, USA
    Neurobiol Dis 22:233-41. 2006
    ..Moreover, the altered binding seen with Sp1 is not found with another transcription factor, NF-Y. These findings suggest that mutant huntingtin dissociates Sp1 from target promoters, inhibiting transcription of specific genes...
  5. ncbi request reprint Huntington's disease
    Marcy E MacDonald
    Molecular Neurogenetics Unit, Center for Human Genetics Research, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Neuromolecular Med 4:7-20. 2003
    ....
  6. ncbi request reprint Specific progressive cAMP reduction implicates energy deficit in presymptomatic Huntington's disease knock-in mice
    Silvia Gines
    Molecular Neurogenetics Unit, Massachusetts General Hospital, Building 149, 13th St, Charlestown, MA 02129, USA
    Hum Mol Genet 12:497-508. 2003
    ....
  7. ncbi request reprint A human single-chain Fv intrabody preferentially targets amino-terminal Huntingtin's fragments in striatal models of Huntington's disease
    Todd W Miller
    Division of Genetic Disorders Wadsworth Center, New York State Department of Health, and Department of Biomedical Sciences, University at Albany, NY 12208, USA
    Neurobiol Dis 19:47-56. 2005
    ..Intrabodies may be used as potential curative agents, and as drug discovery tools, for HD and other misfolded protein disorders...