GRACE B GILL

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Regulation of the initiation of eukaryotic transcription
    G Gill
    Department of Pathology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
    Essays Biochem 37:33-43. 2001
  2. pmc Direct binding of CoREST1 to SUMO-2/3 contributes to gene-specific repression by the LSD1/CoREST1/HDAC complex
    Jian Ouyang
    Department of Anatomy and Cellular Biology, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA
    Mol Cell 34:145-54. 2009
  3. ncbi request reprint Post-translational modification by the small ubiquitin-related modifier SUMO has big effects on transcription factor activity
    Grace Gill
    Department of Pathology, Harvard Medical School, 200 Longwood Avenue, Boston, Massachusetts 02115, USA
    Curr Opin Genet Dev 13:108-13. 2003
  4. ncbi request reprint SUMO and ubiquitin in the nucleus: different functions, similar mechanisms?
    Grace Gill
    Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genes Dev 18:2046-59. 2004
  5. ncbi request reprint Something about SUMO inhibits transcription
    Grace Gill
    Department of Pathology, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Curr Opin Genet Dev 15:536-41. 2005
  6. ncbi request reprint SUMO engages multiple corepressors to regulate chromatin structure and transcription
    Jian Ouyang
    Department of Anatomy and Cellular Biology, Tufts University School of Medicine, Boston, MA, USA
    Epigenetics 4:440-4. 2009
  7. doi request reprint Regulation of transcription factor activity by SUMO modification
    Jian Ouyang
    Department of Anatomy and Cellular Biology, Tufts University School of Medicine, Boston, MA, USA
    Methods Mol Biol 497:141-52. 2009
  8. pmc Sp1 and Sp3 regulate transcription of the cyclin-dependent kinase 5 regulatory subunit 2 (p39) promoter in neuronal cells
    Alvaro Valin
    Department of Anatomy and Cellular Biology, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA
    Biochim Biophys Acta 1789:204-11. 2009
  9. pmc The SUMO-specific protease SENP5 is required for cell division
    Alessandra Di Bacco
    Department of Pathology, Harvard Medical School, 77 Ave Louis Pasteur, Boston, MA 02115, USA
    Mol Cell Biol 26:4489-98. 2006
  10. pmc NXP-2 association with SUMO-2 depends on lysines required for transcriptional repression
    Adam Rosendorff
    Department of Medicine, Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 103:5308-13. 2006

Collaborators

Detail Information

Publications14

  1. ncbi request reprint Regulation of the initiation of eukaryotic transcription
    G Gill
    Department of Pathology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
    Essays Biochem 37:33-43. 2001
    ..Although some co-activators may serve as bridges to connect activators with the transcription machinery, the mechanism of action of many co-activators has not yet been determined...
  2. pmc Direct binding of CoREST1 to SUMO-2/3 contributes to gene-specific repression by the LSD1/CoREST1/HDAC complex
    Jian Ouyang
    Department of Anatomy and Cellular Biology, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA
    Mol Cell 34:145-54. 2009
    ..Our results reveal that direct interactions between CoREST1 and SUMO-2 mediate SUMO-dependent changes in chromatin structure and transcription that are important for cell-type-specific gene expression...
  3. ncbi request reprint Post-translational modification by the small ubiquitin-related modifier SUMO has big effects on transcription factor activity
    Grace Gill
    Department of Pathology, Harvard Medical School, 200 Longwood Avenue, Boston, Massachusetts 02115, USA
    Curr Opin Genet Dev 13:108-13. 2003
    ..Recent studies provide new insights into how post-translational modification by SUMO regulates gene expression by altering transcription factor stability, localization, DNA binding, and activation...
  4. ncbi request reprint SUMO and ubiquitin in the nucleus: different functions, similar mechanisms?
    Grace Gill
    Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genes Dev 18:2046-59. 2004
    ..Studies of SUMO and ubiquitin in the nucleus are yielding new insights into regulation of gene expression, genome maintenance, and signal transduction...
  5. ncbi request reprint Something about SUMO inhibits transcription
    Grace Gill
    Department of Pathology, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Curr Opin Genet Dev 15:536-41. 2005
    ..Histone deacetylase co-repressors have been found to function as substrates, effectors, and regulators of SUMOylation, suggesting that complex crosstalk between acetylation and SUMOylation is important for gene regulation...
  6. ncbi request reprint SUMO engages multiple corepressors to regulate chromatin structure and transcription
    Jian Ouyang
    Department of Anatomy and Cellular Biology, Tufts University School of Medicine, Boston, MA, USA
    Epigenetics 4:440-4. 2009
    ..These findings suggest that SUMOylation plays a central role in coordinating histone modifications and chromatin structure important for regulation of gene expression...
  7. doi request reprint Regulation of transcription factor activity by SUMO modification
    Jian Ouyang
    Department of Anatomy and Cellular Biology, Tufts University School of Medicine, Boston, MA, USA
    Methods Mol Biol 497:141-52. 2009
    ..Here we describe general strategies to address how post-translational modification by SUMO regulates the activity of a DNA-binding transcription factor...
  8. pmc Sp1 and Sp3 regulate transcription of the cyclin-dependent kinase 5 regulatory subunit 2 (p39) promoter in neuronal cells
    Alvaro Valin
    Department of Anatomy and Cellular Biology, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA
    Biochim Biophys Acta 1789:204-11. 2009
    ..Our data suggest that the ubiquitously expressed transcription factors Sp1 and Sp3 regulate transcription of the cdk5 regulator p39 in neuronal cells, possibly in cooperation with tissue-specific transcription factors...
  9. pmc The SUMO-specific protease SENP5 is required for cell division
    Alessandra Di Bacco
    Department of Pathology, Harvard Medical School, 77 Ave Louis Pasteur, Boston, MA 02115, USA
    Mol Cell Biol 26:4489-98. 2006
    ....
  10. pmc NXP-2 association with SUMO-2 depends on lysines required for transcriptional repression
    Adam Rosendorff
    Department of Medicine, Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 103:5308-13. 2006
    ..SUMO-2-associated proteins identified in this study may contribute to SUMO-dependent regulation of transcription or other processes...
  11. ncbi request reprint SUMO changes Sox for developmental diversity
    Grace Gill
    Department of Pathology, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA
    Mol Cell 20:495-6. 2005
    ....
  12. ncbi request reprint SUMO-1 modification represses Sp3 transcriptional activation and modulates its subnuclear localization
    Sarah Ross
    Department of Pathology, Harvard Medical School, Children s Hospital, Boston, MA 02115, USA
    Mol Cell 10:831-42. 2002
    ..These studies reveal a direct effect of SUMO-1 modification on activity of a dual function transcription factor and provide a mechanism for functional specificity within the Sp transcription factor family...
  13. ncbi request reprint GC box-binding transcription factors control the neuronal specific transcription of the cyclin-dependent kinase 5 regulator p35
    Sarah Ross
    Department of Pathology and Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 277:4455-64. 2002
    ....
  14. pmc Specific and covalent targeting of conjugating and deconjugating enzymes of ubiquitin-like proteins
    Joris Hemelaar
    Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Cell Biol 24:84-95. 2004
    ..The UBL probes described here will be valuable tools for the further characterization of the enzymatic pathways that govern modification by UBLs...