Research Topics
| GRACE B GILLSummaryAffiliation: Harvard University Country: USA Publications
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Detail Information
Publications
Regulation of the initiation of eukaryotic transcriptionG Gill
Department of Pathology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
Essays Biochem 37:33-43. 2001..Although some co-activators may serve as bridges to connect activators with the transcription machinery, the mechanism of action of many co-activators has not yet been determined...- Post-translational modification by the small ubiquitin-related modifier SUMO has big effects on transcription factor activityGrace Gill
Department of Pathology, Harvard Medical School, 200 Longwood Avenue, Boston, Massachusetts 02115, USA
Curr Opin Genet Dev 13:108-13. 2003..Recent studies provide new insights into how post-translational modification by SUMO regulates gene expression by altering transcription factor stability, localization, DNA binding, and activation... 
Direct binding of CoREST1 to SUMO-2/3 contributes to gene-specific repression by the LSD1/CoREST1/HDAC complexJian Ouyang
Department of Anatomy and Cellular Biology, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA
Mol Cell 34:145-54. 2009..Our results reveal that direct interactions between CoREST1 and SUMO-2 mediate SUMO-dependent changes in chromatin structure and transcription that are important for cell-type-specific gene expression...- SUMO and ubiquitin in the nucleus: different functions, similar mechanisms?Grace Gill
Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
Genes Dev 18:2046-59. 2004..Studies of SUMO and ubiquitin in the nucleus are yielding new insights into regulation of gene expression, genome maintenance, and signal transduction... - Something about SUMO inhibits transcriptionGrace Gill
Department of Pathology, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
Curr Opin Genet Dev 15:536-41. 2005..Histone deacetylase co-repressors have been found to function as substrates, effectors, and regulators of SUMOylation, suggesting that complex crosstalk between acetylation and SUMOylation is important for gene regulation... - SUMO engages multiple corepressors to regulate chromatin structure and transcriptionJian Ouyang
Department of Anatomy and Cellular Biology, Tufts University School of Medicine, Boston, MA, USA
Epigenetics 4:440-4. 2009..These findings suggest that SUMOylation plays a central role in coordinating histone modifications and chromatin structure important for regulation of gene expression... 
Regulation of transcription factor activity by SUMO modificationJian Ouyang
Department of Anatomy and Cellular Biology, Tufts University School of Medicine, Boston, MA, USA
Methods Mol Biol 497:141-52. 2009..Here we describe general strategies to address how post-translational modification by SUMO regulates the activity of a DNA-binding transcription factor...- Sp1 and Sp3 regulate transcription of the cyclin-dependent kinase 5 regulatory subunit 2 (p39) promoter in neuronal cellsAlvaro Valin
Department of Anatomy and Cellular Biology, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA
Biochim Biophys Acta 1789:204-11. 2009..Our data suggest that the ubiquitously expressed transcription factors Sp1 and Sp3 regulate transcription of the cdk5 regulator p39 in neuronal cells, possibly in cooperation with tissue-specific transcription factors... - The SUMO-specific protease SENP5 is required for cell divisionAlessandra Di Bacco
Department of Pathology, Harvard Medical School, 77 Ave Louis Pasteur, Boston, MA 02115, USA
Mol Cell Biol 26:4489-98. 2006.... - NXP-2 association with SUMO-2 depends on lysines required for transcriptional repressionAdam Rosendorff
Department of Medicine, Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 103:5308-13. 2006..SUMO-2-associated proteins identified in this study may contribute to SUMO-dependent regulation of transcription or other processes... - SUMO changes Sox for developmental diversityGrace Gill
Department of Pathology, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA
Mol Cell 20:495-6. 2005.... - SUMO-1 modification represses Sp3 transcriptional activation and modulates its subnuclear localizationSarah Ross
Department of Pathology, Harvard Medical School, Children s Hospital, Boston, MA 02115, USA
Mol Cell 10:831-42. 2002..These studies reveal a direct effect of SUMO-1 modification on activity of a dual function transcription factor and provide a mechanism for functional specificity within the Sp transcription factor family... - GC box-binding transcription factors control the neuronal specific transcription of the cyclin-dependent kinase 5 regulator p35Sarah Ross
Department of Pathology and Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
J Biol Chem 277:4455-64. 2002.... - Specific and covalent targeting of conjugating and deconjugating enzymes of ubiquitin-like proteinsJoris Hemelaar
Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
Mol Cell Biol 24:84-95. 2004..The UBL probes described here will be valuable tools for the further characterization of the enzymatic pathways that govern modification by UBLs...