S N Ghaemi

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi Antidepressant discontinuation in bipolar depression: a Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD) randomized clinical trial of long-term effectiveness and safety
    S Nassir Ghaemi
    Mood Disorders Program, Department of Psychiatry, Tufts Medical Center, 800 Washington St, Box 1007, Boston, MA 02111, USA
    J Clin Psychiatry 71:372-80. 2010
  2. ncbi Oxcarbazepine treatment of bipolar disorder
    S Nassir Ghaemi
    Bipolar Disorder Research Program, Cambridge Hospital, Cambridge, Mass, USA
    J Clin Psychiatry 64:943-5. 2003
  3. ncbi Topiramate treatment of bipolar spectrum disorders: a retrospective chart review
    S N Ghaemi
    Bipolar Disorder Research Program, Cambridge Hospital, Massachusetts 02139, USA
    Ann Clin Psychiatry 13:185-9. 2001
  4. ncbi Oxcarbazepine treatment of refractory bipolar disorder: a retrospective chart review
    S Nassir Ghaemi
    Bipolar Disorder Research Program, Cambridge Hospital, Cambridge, MA 02139, USA
    Bipolar Disord 4:70-4. 2002
  5. ncbi Evidence-based pharmacotherapy of bipolar disorder
    S Nassir Ghaemi
    Cambridge Health Alliance, Department of Psychiatry, Cambridge, MA 02139, USA
    Int J Neuropsychopharmacol 6:303-8. 2003
  6. ncbi Antidepressants in bipolar disorder: the case for caution
    S Nassir Ghaemi
    Bipolar Disorder Research Program, Cambridge Hospital, Cambridge, MA and Harvard Medical School, Boston, MA 02139, USA
    Bipolar Disord 5:421-33. 2003
  7. ncbi Antidepressant treatment in bipolar versus unipolar depression
    S Nassir Ghaemi
    Department of Psychiatry, Cambridge Hospital, MA 02139, USA
    Am J Psychiatry 161:163-5. 2004
  8. ncbi Strategies for preventing the recurrence of bipolar disorder
    S Nassir Ghaemi
    Bipolar Disorder Research Program, Department of Psychiatry, Cambridge Health Alliance, Cambridge, Mass 02139, USA
    J Clin Psychiatry 65:16-23. 2004
  9. ncbi Long-term observational comparison of risperidone and olanzapine in bipolar disorder
    S Nassir Ghaemi
    Bipolar Disorder Research Program, Cambridge Health Alliance, Cambridge, Massachusetts, USA
    Ann Clin Psychiatry 16:69-73. 2004
  10. ncbi Sensitivity and specificity of a new bipolar spectrum diagnostic scale
    S Nassir Ghaemi
    Bipolar Disorder Research Program, Department of Psychiatry, Cambridge Hospital, 1493 Cambridge Street, Cambridge, MA 02139, USA
    J Affect Disord 84:273-7. 2005

Collaborators

Detail Information

Publications78

  1. ncbi Antidepressant discontinuation in bipolar depression: a Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD) randomized clinical trial of long-term effectiveness and safety
    S Nassir Ghaemi
    Mood Disorders Program, Department of Psychiatry, Tufts Medical Center, 800 Washington St, Box 1007, Boston, MA 02111, USA
    J Clin Psychiatry 71:372-80. 2010
    ..To assess long-term effectiveness and safety of randomized antidepressant discontinuation after acute recovery from bipolar depression...
  2. ncbi Oxcarbazepine treatment of bipolar disorder
    S Nassir Ghaemi
    Bipolar Disorder Research Program, Cambridge Hospital, Cambridge, Mass, USA
    J Clin Psychiatry 64:943-5. 2003
    ..To assess the effectiveness and safety of oxcarbazepine in bipolar disorder...
  3. ncbi Topiramate treatment of bipolar spectrum disorders: a retrospective chart review
    S N Ghaemi
    Bipolar Disorder Research Program, Cambridge Hospital, Massachusetts 02139, USA
    Ann Clin Psychiatry 13:185-9. 2001
    ..Topiramate response and weight loss were both dose-related, with efficacy, in particular, associated with higher doses (mean = 180 mg/day) than frequently used in current clinical practice...
  4. ncbi Oxcarbazepine treatment of refractory bipolar disorder: a retrospective chart review
    S Nassir Ghaemi
    Bipolar Disorder Research Program, Cambridge Hospital, Cambridge, MA 02139, USA
    Bipolar Disord 4:70-4. 2002
    ..To determine if oxcarbazepine is effective as treatment for refractory bipolar illness in a naturalistic setting...
  5. ncbi Evidence-based pharmacotherapy of bipolar disorder
    S Nassir Ghaemi
    Cambridge Health Alliance, Department of Psychiatry, Cambridge, MA 02139, USA
    Int J Neuropsychopharmacol 6:303-8. 2003
    ..Further, RCTs only establish a categorical response to a research question, i.e. whether or not something happens. The frequency of an event (treatment response, side-effects) is often more accurately assessed with observational studies...
  6. ncbi Antidepressants in bipolar disorder: the case for caution
    S Nassir Ghaemi
    Bipolar Disorder Research Program, Cambridge Hospital, Cambridge, MA and Harvard Medical School, Boston, MA 02139, USA
    Bipolar Disord 5:421-33. 2003
    ....
  7. ncbi Antidepressant treatment in bipolar versus unipolar depression
    S Nassir Ghaemi
    Department of Psychiatry, Cambridge Hospital, MA 02139, USA
    Am J Psychiatry 161:163-5. 2004
    ..Antidepressant responses were compared in DSM-IV bipolar and unipolar depression...
  8. ncbi Strategies for preventing the recurrence of bipolar disorder
    S Nassir Ghaemi
    Bipolar Disorder Research Program, Department of Psychiatry, Cambridge Health Alliance, Cambridge, Mass 02139, USA
    J Clin Psychiatry 65:16-23. 2004
    ..Some psychotherapies also may possess adjunctive maintenance efficacy...
  9. ncbi Long-term observational comparison of risperidone and olanzapine in bipolar disorder
    S Nassir Ghaemi
    Bipolar Disorder Research Program, Cambridge Health Alliance, Cambridge, Massachusetts, USA
    Ann Clin Psychiatry 16:69-73. 2004
    ..EPS was similar, and tardive dyskinesia did not occur. Risperidone and olanzapine appeared to have similar real-world maintenance effectiveness for bipolar disorder, but differed somewhat in side effects...
  10. ncbi Sensitivity and specificity of a new bipolar spectrum diagnostic scale
    S Nassir Ghaemi
    Bipolar Disorder Research Program, Department of Psychiatry, Cambridge Hospital, 1493 Cambridge Street, Cambridge, MA 02139, USA
    J Affect Disord 84:273-7. 2005
    ..To assess the sensitivity and specificity of a self-report questionnaire for bipolar disorder, the Bipolar Spectrum Diagnostic Scale (BSDS)...
  11. ncbi "Cade's disease" and beyond: misdiagnosis, antidepressant use, and a proposed definition for bipolar spectrum disorder
    S Nassir Ghaemi
    Department of Psychiatry, Cambridge Hospital, 1493 Cambridge Street, Cambridge, MA 02139, USA
    Can J Psychiatry 47:125-34. 2002
    ..The role of antidepressants is also controversial. Our review of the evidence leads us to conclude that there should be less emphasis on using antidepressants to treat persons with this illness...
  12. ncbi Gabapentin treatment of the non-refractory bipolar spectrum: an open case series
    S N Ghaemi
    Psychopharmacology Program, Cambridge Hospital, Consolidated Department of Psychiatry, Harvard Medical School, Cambridge, MA, USA
    J Affect Disord 65:167-71. 2001
    ..To determine if gabapentin is effective in monotherapy or add-on treatment of non-refractory bipolar disorder in open prospective treatment...
  13. ncbi Long-term naturalistic treatment of depressive symptoms in bipolar illness with divalproex vs. lithium in the setting of minimal antidepressant use
    S N Ghaemi
    Psychopharmacology Program, Cambridge Hospital, Consolidated Department of Psychiatry, Harvard Medical School, Cambridge, MA, USA
    J Affect Disord 65:281-7. 2001
    ..Both agents, but particularly divalproex, demonstrated long-term antidepressant effects, with limited adjunctive standard antidepressant use...
  14. ncbi A prospective, open-label study of Aripiprazole mono- and adjunctive treatment in acute bipolar depression
    Robert T Dunn
    Psychopharmacology Research Program, Cambridge Health Alliance, Cambridge, MA, USA
    J Affect Disord 110:70-4. 2008
    ..To examine the efficacy and tolerability of aripiprazole treatment for acute bipolar depression...
  15. ncbi Depressive illness burden associated with complex polypharmacy in patients with bipolar disorder: findings from the STEP-BD
    Joseph F Goldberg
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA
    J Clin Psychiatry 70:155-62. 2009
    ..Many patients with bipolar disorder receive multi-drug treatment regimens, but the distinguishing profiles of patients who receive complex pharmacologies have not been established...
  16. ncbi Combination of a mood stabilizer with risperidone or haloperidol for treatment of acute mania: a double-blind, placebo-controlled comparison of efficacy and safety
    Gary S Sachs
    Bipolar Research Program, Department of Psychiatry, Massachusetts General Hospital, 50 Staniford Street, Suite 580, Boston, MA 02114, USA
    Am J Psychiatry 159:1146-54. 2002
    ..The study assessed the efficacy and safety of risperidone as an adjunctive agent to mood stabilizers in the treatment of acute mania...
  17. ncbi Long-term antidepressant treatment in bipolar disorder: meta-analyses of benefits and risks
    S N Ghaemi
    Mood Disorders Program, Department of Psychiatry, Tufts Medical Center, Boston, MA 02111, USA
    Acta Psychiatr Scand 118:347-56. 2008
    ..Long-term antidepressant (AD) treatment for depression in bipolar disorder (BPD) patients is highly prevalent, but its benefits and risks remain uncertain, encouraging this meta-analysis of available research...
  18. ncbi Does olanzapine have antidepressant properties? A retrospective preliminary study
    S N Ghaemi
    Harvard Bipolar Research Program, Massachusetts General Hospital, Consolidated Department of Psychiatry, Boston 02114, USA
    Bipolar Disord 2:196-9. 2000
    ..We sought to determine if olanzapine is effective in the add-on treatment of major affective disorders, particularly depressive symptoms, in a naturalistic setting...
  19. ncbi The impact of the discovery of lithium on psychiatric thought and practice in the USA and Europe
    F K Goodwin
    Department of Psychiatry, George Washington University, Washington, DC 20037, USA
    Aust N Z J Psychiatry 33:S54-64. 1999
    ..In addition, the development of lithium has demonstrated the closely intertwined purposes of clinical and basic research, and the continued importance of research in the clinical setting...
  20. ncbi The treatment of bipolar depression
    G S Sachs
    Massachusetts General Hospital, Consolidated Department of Psychiatry, Harvard Medical School, Boston 02114, USA
    Bipolar Disord 2:256-60. 2000
    ..This paper reviews the available literature on the treatment of bipolar depression and offers recommendations for clinical management...
  21. ncbi Why antidepressants are not antidepressants: STEP-BD, STAR*D, and the return of neurotic depression
    S Nassir Ghaemi
    Mood Disorders Program, Department of Psychiatry, Tufts Medical Center, 800 Washington Street, 1007, Boston, MA 02111, USA
    Bipolar Disord 10:957-68. 2008
    ..Diagnostic criteria for a revival of the concept of neurotic depression are proposed...
  22. ncbi Use of atypical antipsychotic agents in bipolar and schizoaffective disorders: review of the empirical literature
    S N Ghaemi
    Center on Neuroscience, Medical Progress, and Society, Department of Psychiatry, George Washington University, Washington, DC, USA
    J Clin Psychopharmacol 19:354-61. 1999
    ..If randomized or double-blind data support the open-label data reviewed here, atypical antipsychotic agents may possess an important role in the adjunctive treatment of bipolar disorder...
  23. ncbi Effectiveness and safety of long-term antidepressant treatment in bipolar disorder
    S N Ghaemi
    Consolidated Department of Psychiatry, Harvard Medical School, Boston, Mass, USA
    J Clin Psychiatry 62:565-9. 2001
    ..We sought to review research on use of antidepressants for long-term treatment of bipolar depression...
  24. ncbi Long-term outcome with divalproex in children and adolescents with bipolar disorder
    Charles A Henry
    Department of Psychiatry, Harvard Medical School, Cambridge, Massachusetts, USA
    J Child Adolesc Psychopharmacol 13:523-9. 2003
    ..One third of the patients discontinued treatment secondary to side effects, including a case of reversible liver enzyme elevation...
  25. ncbi Substance use disorder and other predictors of antidepressant-induced mania: a retrospective chart review
    Sumita G Manwani
    Bipolar Disorder Research Program, Department of Psychiatry, Cambridge Health Alliance, Cambridge, MA, USA
    J Clin Psychiatry 67:1341-5. 2006
    ..Type II illness, female gender, and TCA use also appeared to be predictors of ADM, while bupropion use appeared to predict lower likelihood of ADM...
  26. ncbi Predictors of response to ziprasidone: results from a 6-week randomized double-blind, placebo-controlled trial for acute depressive mixed state
    C U Pae
    Department of Psychiatry, Duke University Medical Center, Durham, NC, USA
    Pharmacopsychiatry 45:152-5. 2012
    ..The present study is aimed at investigating possible predictors of response to ziprasidone in a sample of patients with mixed depressive state...
  27. ncbi The emergency treatment of depression complicated by psychosis or agitation
    R L Glick
    Department of Psychiatry, University of Michigan Health System, Ann Arbor, USA
    J Clin Psychiatry 61:43-8. 2000
    ..This article will review relevant data and make recommendations for the emergency management of psychotic and agitated depressive syndromes...
  28. ncbi Pramipexole augmentation in the treatment of unipolar and bipolar depression: a retrospective chart review
    J Sporn
    Department of Psychiatry, Massachusetts General Hospital, USA
    Ann Clin Psychiatry 12:137-40. 2000
    ..To assess the effectiveness and safety of pramipexole as an adjunctive medication in refractory bipolar and unipolar depression in a naturalistic setting...
  29. ncbi Insight in psychosis: a systematic review of treatment interventions
    Charles Henry
    Bipolar Disorder Research Program, Cambridge Hospital, Cambridge, MA, USA
    Psychopathology 37:194-9. 2004
    ..We conclude that this literature suggests potentially useful options for clinicians, but further research is needed with better validated insight scales...
  30. ncbi Is adjunctive open-label zonisamide effective for bipolar disorder?
    S Nassir Ghaemi
    Bipolar Disorder Research Program, Department of Psychiatry, Emory University, Atlanta, GA 30322, United States
    J Affect Disord 105:311-4. 2008
    ..To assess the effectiveness and safety of zonisamide in bipolar disorder...
  31. ncbi Long-term lamotrigine plus lithium for bipolar disorder: One year outcome
    S Nassir Ghaemi
    Department of Psychiatry, School of Medicine, Emory University, GA, USA
    J Psychiatr Pract 12:300-5. 2006
    ..To obtain pilot data in an observational setting on the use of lamotrigine plus lithium in the long-term treatment of patients with bipolar disorder, 87% of whom had failed to respond to at least one previous mood stabilizer...
  32. ncbi Cholesterol levels in mood disorders: high or low?
    S N Ghaemi
    Harvard Bipolar Research Program, Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Bipolar Disord 2:60-4. 2000
    ..To assess cholesterol levels in patients with mood disorders...
  33. ncbi An open prospective study of zonisamide in acute bipolar depression
    S Nassir Ghaemi
    Bipolar Disorder Research Program, Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 1365 Clifton Road, Atlanta, GA 30322, USA
    J Clin Psychopharmacol 26:385-8. 2006
    ..To examine the effectiveness and safety of zonisamide in the treatment of acute bipolar depression...
  34. ncbi Divalproex in the treatment of acute bipolar depression: a preliminary double-blind, randomized, placebo-controlled pilot study
    S Nassir Ghaemi
    Bipolar Disorder Research Program, Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, GA, USA
    J Clin Psychiatry 68:1840-4. 2007
    ..To determine the efficacy of divalproex (extended release) in the treatment of acute nonrefractory bipolar depression...
  35. ncbi The prescription of psychotropic medications for patients discharged from a psychiatric emergency service
    Carrie L Ernst
    Department of Psychiatry, Massachusetts General Hospital, Boston, USA
    J Clin Psychiatry 67:720-6. 2006
    ....
  36. ncbi Side effects of atypical antipsychotics: extrapyramidal symptoms and the metabolic syndrome
    Arshia A Shirzadi
    Harvard South Shore Psychiatry Program, Brockton, MA, USA
    Harv Rev Psychiatry 14:152-64. 2006
    ..Future prospective observational cohort studies must target side effects and be designed to collect and analyze data on confounding factors...
  37. ncbi Persistent posttraumatic stress disorder following September 11 in patients with bipolar disorder
    Mark H Pollack
    Department of Psychiatry, Massachusetts General Hospital, Boston, Mass, USA
    J Clin Psychiatry 67:394-9. 2006
    ....
  38. ncbi Bipolar spectrum disorder: a pilot study
    S Nassir Ghaemi
    Bipolar Disorder Research Program, Department of Psychiatry, Cambridge Health Alliance, Cambridge, MA 02139, USA
    Psychopathology 37:222-6. 2004
    ..Further prospective study needs to be conducted comparing BSD with unipolar depression...
  39. ncbi Existential despair and bipolar disorder: the therapeutic alliance as a mood stabilizer
    Leston L Havens
    Harvard Medical School, Boston, MA, USA
    Am J Psychother 59:137-47. 2005
    ..It is a tall order, and one not infrequently avoided. Yet the times seem to call for a return to actually talking with manic patients, and maybe curing them with such talk. Or perhaps that is grandiose...
  40. ncbi Affective temperaments in clinical practice: a validation study in mood disorders
    P A Vöhringer
    Mood Disorders Program, Department of Psychiatry, Tufts Medical Center, Tufts University School of Medicine, Boston, MA 02111, United States
    J Affect Disord 136:577-80. 2012
    ..We sought to examine correlations between clinical validators and temperaments in clinical practice...
  41. ncbi Rediscovering existential psychotherapy: the contribution of Ludwig Binswanger
    S N Ghaemi
    Department of Psychiatry, Harvard Medical School, Cambridge Hospital, Cambridge, MA, USA
    Am J Psychother 55:51-64. 2001
    ..I discuss concrete clinical cases from Binswanger's work, along with a contemporary example of how to use these existential methods in psychiatric practice...
  42. ncbi Research reports on treatments for bipolar disorder: preliminary assessment of methodological quality
    F Soldani
    Department of Psychiatry, Harvard Medical School, Boston, MA 02478, USA
    Acta Psychiatr Scand 112:72-4. 2005
    ..To assess frequencies of types of publications about bipolar disorder (BD) and evaluate methodological quality of treatment studies...
  43. ncbi A double-blind, placebo-controlled pilot study of galantamine to improve cognitive dysfunction in minimally symptomatic bipolar disorder
    S Nassir Ghaemi
    Department of Psychiatry, Mood Disorders Program, Tufts Medical Center, Boston, MA, USA
    J Clin Psychopharmacol 29:291-5. 2009
    ..In addition, the effect of galantamine on clinical measures of functioning and psychopathology was assessed...
  44. ncbi Toward a Hippocratic psychopharmacology
    S Nassir Ghaemi
    Bipolar Disorder Research Program, Emory University, Atlanta, Georgia, USA
    Can J Psychiatry 53:189-96. 2008
    ..To provide a conceptual basis for psychopharmacology...
  45. ncbi Diagnostic guidelines for bipolar disorder: a summary of the International Society for Bipolar Disorders Diagnostic Guidelines Task Force Report
    S Nassir Ghaemi
    Bipolar Disorder Research Program, Department of Psychiatry, Emory University, Atlanta, GA 30322, USA
    Bipolar Disord 10:117-28. 2008
    ....
  46. ncbi Sensitivity and specificity of the Mood Disorder Questionnaire for detecting bipolar disorder
    Christopher J Miller
    Bipolar Disorder Research Program, Cambridge Hospital, Cambridge, MA 02139, USA
    J Affect Disord 81:167-71. 2004
    ..Specificity was 0.67. CONCLUSIONS: The MDQ demonstrates good sensitivity in insightful patients with bipolar I disorder, but may be less useful in patients with impaired insight or milder bipolar spectrum conditions...
  47. ncbi A systematic review of rates and diagnostic validity of comorbid adult attention-deficit/hyperactivity disorder and bipolar disorder
    Aliza P Wingo
    Bipolar Disorder Research Program, Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, GA 30322, USA
    J Clin Psychiatry 68:1776-84. 2007
    ..Concurrent diagnosis of adult ADHD and bipolar disorder remains controversial. In this study, we conducted a systematic review to examine the rates and diagnostic validity of the concept of comorbid adult ADHD and bipolar disorder...
  48. ncbi Extrapyramidal side effects with atypical neuroleptics in bipolar disorder
    S Nassir Ghaemi
    Bipolar Disorder Research Program, Department of Psychiatry, Emory University, 1365 Clifton Road, Building B, Suite 6100, Atlanta, GA 30322, USA
    Prog Neuropsychopharmacol Biol Psychiatry 30:209-13. 2006
    ..This rate is much higher than the 5-15% range reported in clinical trials, suggesting potential problems with clinical trial generalizability...
  49. ncbi Gender differences in bipolar disorder: retrospective data from the first 500 STEP-BD participants
    Claudia F Baldassano
    Bipolar Disorders Program, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA
    Bipolar Disord 7:465-70. 2005
    ..To examine gender differences in a large sample of patients with bipolar illness...
  50. ncbi Is insight in mania state-dependent?: A meta-analysis
    S Nassir Ghaemi
    Bipolar Disorder Research Program, Department of Psychiatry, Cambridge Health Alliance, Cambridge, Massachusetts 02139, USA
    J Nerv Ment Dis 192:771-5. 2004
    ..We suggest that impaired insight be considered as part of the diagnostic picture of acute mania...
  51. ncbi The International Society for Bipolar Disorders (ISBD) Task Force report on the nomenclature of course and outcome in bipolar disorders
    Mauricio Tohen
    Department of Psychiatry, Division of Mood and Anxiety Disorders, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, MC 7792, San Antonio, TX 78229, USA
    Bipolar Disord 11:453-73. 2009
    ....
  52. ncbi Existence and pluralism: the rediscovery of Karl Jaspers
    S Nassir Ghaemi
    Department of Psychiatry, Emory University, Atlanta, GA, USA
    Psychopathology 40:75-82. 2007
    ..Contemporary psychiatry has only a limited appreciation of Jaspers' work. In this paper, I attempt to describe these important concepts that can help us understand what we do in psychiatry, what we should be doing and why...
  53. ncbi Nosologomania: DSM & Karl Jaspers' critique of Kraepelin
    S Nassir Ghaemi
    Mood Disorders Program, Mood Disorders Clinic, Department of Psychiatry, Tufts Medical Center, 800 Washington Street, Box 1007, Boston, MA 02111, USA
    Philos Ethics Humanit Med 4:10. 2009
    ..Jaspers' critique of Kraepelin may help us reformulate our current neo-Kraepelinian nosology for the better...
  54. ncbi Galantamine treatment of cognitive impairment in bipolar disorder: four cases
    Eric Schrauwen
    Bipolar Disorder Research Program, Department of Psychiatry, Cambridge Health Alliance, Cambridge, MA, USA
    Bipolar Disord 8:196-9. 2006
    ..CONCLUSIONS: This pilot case series suggests that galantamine may have some utility in improving chronic cognitive impairment in bipolar disorder. Larger studies are required to clarify these initial pilot data...
  55. ncbi Tolerance in antidepressant treatment
    Ross J Baldessarini
    Psychother Psychosom 71:177-9. 2002
  56. ncbi All mixed up: on the absence of diagnostic guidelines for mixed states in the ISBD Diagnostic Guidelines Task Force Report
    S Nassir Ghaemi
    Bipolar Disord 10:129-30. 2008
  57. ncbi Issues for DSM-V: DSM-V should include a conceptual issues work group
    Kenneth S Kendler
    Am J Psychiatry 165:174-5. 2008
  58. ncbi The course of bipolar disorder and the nature of agitated depression
    Frederick K Goodwin
    Am J Psychiatry 160:2077-9. 2003
  59. ncbi Treatment of rapid-cycling bipolar disorder: are antidepressants mood destabilizers?
    S Nassir Ghaemi
    Am J Psychiatry 165:300-2. 2008
  60. ncbi Is aripiprazole an efficacious adjunct for unipolar depression?
    Jeffrey J Rakofsky
    J Clin Psychiatry 69:1021; author reply 1021-2. 2008
  61. ncbi Tardive dyskinesia and ziprasidone
    Klara J Rosenquist
    Am J Psychiatry 159:1436. 2002
  62. ncbi Clinical variables associated with early administration of antipsychotics in bipolar mania
    Chi Un Pae
    Department of Psychiatry, Kangnam St Mary s Hospital, The Catholic University of Korea College of Medicine, 505 Banpo Dong, Seocho Gu, Seoul 137 701, Republic of Korea
    Prog Neuropsychopharmacol Biol Psychiatry 30:151-4. 2006
    ..0 and 13.1, respectively). This study suggests that some clinical factors in bipolar mania might be linked to the earlier antipsychotic treatment. However, more studies will be needed to confirm this finding...
  63. ncbi Relapse prevention in bipolar I disorder: 18-month comparison of olanzapine plus mood stabiliser v. mood stabiliser alone
    Mauricio Tohen
    Lilly Research Laboratories, Indianapolis, Indiana 46285, USA
    Br J Psychiatry 184:337-45. 2004
    ..Aims To evaluate whether olanzapine plus either lithium or valproate reduces the rate of relapse, compared with lithium or valproate alone...
  64. ncbi Pharmacological Treatment Patterns at Study Entry for the First 500 STEP-BD Participants
    S Nassir Ghaemi
    Department of Psychiatry at Emory University in Atlanta, Georgia 30322, USA
    Psychiatr Serv 57:660-5. 2006
    ..This study assessed patterns of psychopharmacological treatment for bipolar disorder...
  65. ncbi Antidepressants for bipolar depression
    S Nassir Ghaemi
    Am J Psychiatry 162:1545-6; author reply 1547-8. 2005
  66. ncbi Acute treatment of bipolar depression with adjunctive zonisamide: a retrospective chart review
    Claudia F Baldassano
    Bipolar Outpatient Program, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 3309, USA
    Bipolar Disord 6:432-4. 2004
    ..This retrospective chart review evaluated the use of zonisamide as adjunctive treatment in patients with bipolar depression...
  67. ncbi Feeling and time: the phenomenology of mood disorders, depressive realism, and existential psychotherapy
    S Nassir Ghaemi
    Emory Clinic, 1365 Clifton Road, Atlanta, GA 30322, USA
    Schizophr Bull 33:122-30. 2007
    ....
  68. ncbi The manic-depressive spectrum and mood stabilization: Kraepelin's ghost
    S Nassir Ghaemi
    Psychother Psychosom 76:65-9. 2007
  69. ncbi Defining the boundaries of childhood bipolar disorder
    S Nassir Ghaemi
    Am J Psychiatry 164:185-8. 2007
  70. ncbi Relapse after antidepressant discontinuation
    Federico Soldani
    Am J Psychiatry 161:1312-3; author reply 1313. 2004
  71. ncbi Self-reported history of manic/hypomanic switch associated with antidepressant use: data from the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD)
    Christine J Truman
    Finney Psychotherapy Associates, Norfolk, VA, USA
    J Clin Psychiatry 68:1472-9. 2007
    ....
  72. ncbi Adjunctive antidepressant use and symptomatic recovery among bipolar depressed patients with concomitant manic symptoms: findings from the STEP-BD
    Joseph F Goldberg
    Affective Disorders Program, Silver Hill Hospital, New Canaan, Connecticut, USA
    Am J Psychiatry 164:1348-55. 2007
    ..However, few studies have examined the outcomes of patients with co-occurring manic and depressive symptoms who are treated with antidepressants plus mood stabilizing drugs...
  73. ncbi STAR*D level IV methodology
    Aliza P Wingo
    Am J Psychiatry 164:681; author reply 681. 2007
  74. ncbi The newest mania: seeing disease mongering everywhere
    S Nassir Ghaemi
    PLoS Med 3:e319; author reply e320. 2006
  75. ncbi Underdiagnosis of bipolar disorder in men with substance use disorder
    Mark J Albanese
    Harvard Medical School and Cambridge Health Alliance, MA 02143, USA
    J Psychiatr Pract 12:124-7. 2006
    ....
  76. ncbi Meta-analysis of observational studies: the case of rapid-cycling bipolar disorder
    S Nassir Ghaemi
    Acta Psychiatr Scand 108:1-3. 2003
  77. ncbi Improving the diagnosis of bipolar disorder: predictive value of screening tests
    James R Phelps
    Co-Psych.com and PsychEducation.org, Corvallis, OR, USA
    J Affect Disord 92:141-8. 2006
    ..To improve the performance of screening tools, the primary emphasis needs to be placed on improving clinicians' skill at recognizing clinical and historical features of bipolar diagnosis...
  78. ncbi The ethics of clinical innovation in psychopharmacology: Challenging traditional bioethics
    S Nassir Ghaemi
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA USA
    Philos Ethics Humanit Med 2:26. 2007
    ..To assess the scientific and ethical basis for clinical innovation in psychopharmacology...