Affiliation: Harvard University
- Aging renders the brain vulnerable to amyloid beta-protein neurotoxicityC Geula
Beth Israel Deaconess Medical Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts 02215, USA
Nat Med 4:827-31. 1998..Thus, longevity may contribute to the unique susceptibility of humans to Alzheimer's disease by rendering the brain vulnerable to Abeta neurotoxicity...
- Focal pathology in the Edinger-Westphal nucleus explains pupillary hypersensitivity in Alzheimer's diseaseL F Scinto
Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02138, USA
Acta Neuropathol 97:557-64. 1999..In contrast, the adjacent somatic portion of the oculomotor complex was virtually spared of pathology. Early pathology in the EW is likely to initiate a cascade of events that may give rise to pupillary hypersensitivity...
- Selective cell loss in Edinger-Westphal in asymptomatic elders and Alzheimer's patientsL F Scinto
Department of Neurology, Laboratory of Higher Cortical Functions, Brigham and Women s Hospital, Boston, MA 02115, USA
Neurobiol Aging 22:729-36. 2001....
- Special properties of cholinesterases in the cerebral cortex of Alzheimer's diseaseC Geula
Bullard and Denny Brown Laboratories, Department of Neurology, Harvard Medical School, Beth Israel Hospital, Boston, MA 02215
Brain Res 498:185-9. 1989..In comparison to the cholinesterases of the normal brain, the plaque and tangle-bound cholinesterases in Alzheimer's disease display major shifts in optimum pH and inhibitor sensitivity...
- Increased susceptibility to generalized seizures after immunolesions of the basal forebrain cholinergic neurons in ratsD C Silveira
Department of Neurology, Children s Hospital and Harvard Medical School, 300 Longwood Avenue, Enders 320, Boston, MA 02115, USA
Brain Res 878:223-7. 2000..Lesioned rats had significantly shorter latencies to onset of generalized tonic-clonic seizures than controls. Our findings suggest that basal forebrain cholinergic neurons may participate in the modulation of generalized seizures...
- Selective age-related loss of calbindin-D28k from basal forebrain cholinergic neurons in the common marmoset (Callithrix jacchus)C-K Wu
Laboratory for Neurodegenerative and Aging Research, Department of Medicine, Harvard Medical School and Division of Gerontology, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Burlington Research Facility, Boston, MA 02215, USA
Neuroscience 120:249-59. 2003..The vulnerability of the CB-negative BFCN in the aged marmoset to various insults which disturb calcium homeostasis remains to be investigated...