P Gerner

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Spinal tonicaine: potency and differential blockade of sensory and motor functions
    P Gerner
    Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Anesthesiology 92:1350-60. 2000
  2. ncbi request reprint Amitriptyline versus bupivacaine in rat sciatic nerve blockade
    P Gerner
    Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Anesthesiology 94:661-7. 2001
  3. ncbi request reprint N-phenylethyl amitriptyline in rat sciatic nerve blockade
    Peter Gerner
    Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Anesthesiology 96:1435-42. 2002
  4. ncbi request reprint Local anesthetic properties of prenylamine
    M G Mujtaba
    Department of Anesthesia Research Laboratories, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Anesthesiology 95:1198-204. 2001
  5. pmc Capsaicin combined with local anesthetics preferentially prolongs sensory/nociceptive block in rat sciatic nerve
    Peter Gerner
    Department of Anesthesiology, Perioperative, and Pain Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Anesthesiology 109:872-8. 2008
  6. ncbi request reprint Efficacy of lidocaine or bupivacaine combined with ephedrine in rat sciatic nerve block
    Yi Chuan Kau
    Department of Anesthesiology, Chang Gung Memorial Hospital, Taoyuan, Taiwan
    Reg Anesth Pain Med 31:14-8. 2006
  7. ncbi request reprint The role of sodium channels in chronic inflammatory and neuropathic pain
    Ron Amir
    Department of Cell and Animal Biology, Institute of Life Sciences, Hebrew University of Jerusalem, Jerusalem, Israel
    J Pain 7:S1-29. 2006
  8. ncbi request reprint Mitigation of direct neurotoxic effects of lidocaine and amitriptyline by inhibition of p38 mitogen-activated protein kinase in vitro and in vivo
    Philipp Lirk
    Department of Anesthesiology and Critical Care Medicine, Medical University of Innsbruck, Austria
    Anesthesiology 104:1266-73. 2006
  9. ncbi request reprint Inhibition of Nav1.7 and Nav1.4 sodium channels by trifluoperazine involves the local anesthetic receptor
    Patrick L Sheets
    Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    J Neurophysiol 96:1848-59. 2006
  10. pmc Bulleyaconitine A isolated from aconitum plant displays long-acting local anesthetic properties in vitro and in vivo
    Chi Fei Wang
    Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Anesthesiology 107:82-90. 2007

Collaborators

Detail Information

Publications33

  1. ncbi request reprint Spinal tonicaine: potency and differential blockade of sensory and motor functions
    P Gerner
    Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Anesthesiology 92:1350-60. 2000
    ..The purposes of this study were to measure directly the potency of this charged drug by internal perfusion of cultured neuronal cells, and to evaluate the differential blockade of sensory versus motor function via spinal route in rats...
  2. ncbi request reprint Amitriptyline versus bupivacaine in rat sciatic nerve blockade
    P Gerner
    Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Anesthesiology 94:661-7. 2001
    ..To date there is no report of amitriptyline producing peripheral nerve blockade. The authors therefore investigated the local anesthetic properties of amitriptyline in rats and in vitro...
  3. ncbi request reprint N-phenylethyl amitriptyline in rat sciatic nerve blockade
    Peter Gerner
    Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Anesthesiology 96:1435-42. 2002
    ..As with other drug modifications, adding a phenylethyl group to obtain a permanently charged quaternary ammonium derivative may improve these advantageous properties...
  4. ncbi request reprint Local anesthetic properties of prenylamine
    M G Mujtaba
    Department of Anesthesia Research Laboratories, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Anesthesiology 95:1198-204. 2001
    ..Prenylamine is a known calcium channel blocker, but its local anesthetic blocking effects on voltage-gated sodium channels have not been studied thus far...
  5. pmc Capsaicin combined with local anesthetics preferentially prolongs sensory/nociceptive block in rat sciatic nerve
    Peter Gerner
    Department of Anesthesiology, Perioperative, and Pain Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Anesthesiology 109:872-8. 2008
    ..05% capsaicin, in a rat sciatic nerve block model...
  6. ncbi request reprint Efficacy of lidocaine or bupivacaine combined with ephedrine in rat sciatic nerve block
    Yi Chuan Kau
    Department of Anesthesiology, Chang Gung Memorial Hospital, Taoyuan, Taiwan
    Reg Anesth Pain Med 31:14-8. 2006
    ..We therefore hypothesized that either lidocaine or bupivacaine would show synergy with ephedrine in a rat sciatic nerve block model, allowing a dose reduction and limiting side effects while improving efficacy...
  7. ncbi request reprint The role of sodium channels in chronic inflammatory and neuropathic pain
    Ron Amir
    Department of Cell and Animal Biology, Institute of Life Sciences, Hebrew University of Jerusalem, Jerusalem, Israel
    J Pain 7:S1-29. 2006
    ..This restricted expression raises the possibility that isoform-specific drugs might be analgesic and lacking the cardiotoxicity and neurotoxicity that limit the use of current sodium-channel blockers...
  8. ncbi request reprint Mitigation of direct neurotoxic effects of lidocaine and amitriptyline by inhibition of p38 mitogen-activated protein kinase in vitro and in vivo
    Philipp Lirk
    Department of Anesthesiology and Critical Care Medicine, Medical University of Innsbruck, Austria
    Anesthesiology 104:1266-73. 2006
    ....
  9. ncbi request reprint Inhibition of Nav1.7 and Nav1.4 sodium channels by trifluoperazine involves the local anesthetic receptor
    Patrick L Sheets
    Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    J Neurophysiol 96:1848-59. 2006
    ..7 channels with nanomolar concentrations of TFP raises the possibility that TFP, or TFP analogues, might be useful for regional anesthesia and pain management and could be more potent than traditional local anesthetics...
  10. pmc Bulleyaconitine A isolated from aconitum plant displays long-acting local anesthetic properties in vitro and in vivo
    Chi Fei Wang
    Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Anesthesiology 107:82-90. 2007
    ..Bulleyaconitine A (BLA) is an active ingredient of Aconitum bulleyanum plants. BLA has been approved for the treatment of chronic pain and rheumatoid arthritis in China, but its underlying mechanism remains unclear...
  11. pmc Magnesium sulfate diminishes the effects of amide local anesthetics in rat sciatic-nerve block
    Yu Chun Hung
    Department of Anesthesiology, Mackay Memorial Hospital, Taipei, Taiwan
    Reg Anesth Pain Med 32:288-95. 2007
    ..Further, the mechanism of possible synergy between LAs and MgSO(4) was investigated in whole-cell mode patch-clamp experiments...
  12. ncbi request reprint Safety evaluation of topically applied amitriptyline in porcine full-thickness wounds
    Bohdan Pomahac
    Division of Plastic Surgery, Brigham and Women s Hospital, Boston, MA 02115, USA
    Reg Anesth Pain Med 32:377-81. 2007
    ..We assessed if daily topical application of amitriptyline into the wound chambers for 10 days impedes wound healing as measured by (1) wound contraction and (2) histopathological findings...
  13. doi request reprint In vitro, inhibition of mitogen-activated protein kinase pathways protects against bupivacaine- and ropivacaine-induced neurotoxicity
    Philipp Lirk
    Department of Anesthesiology and Critical Care Medicine, Innsbruck Medical University, Anichstr 35, 6020 Innsbruck, Austria
    Anesth Analg 106:1456-64, table of contents. 2008
    ....
  14. pmc Use of bulleyaconitine A as an adjuvant for prolonged cutaneous analgesia in the rat
    Chi Fei Wang
    Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, 75 Francis St, Boston, MA 02115, USA
    Anesth Analg 107:1397-405. 2008
    ..BLA has several potential targets, including voltage-gated Na+ channels. We tested whether BLA elicited long-lasting cutaneous analgesia, when co-injected with lidocaine and epinephrine, as a model for prolonged infiltration anesthesia...
  15. ncbi request reprint Ephedrine blocks rat sciatic nerve in vivo and sodium channels in vitro
    Yu Chun Hung
    Department of Anesthesiology, Mackay Memorial Hospital, Taipei, Taiwan
    Anesthesiology 103:1246-52. 2005
    ....
  16. ncbi request reprint Differential block of N-propyl derivatives of amitriptyline and doxepin for sciatic nerve block in rats
    Peter Gerner
    Pain Research Center, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Reg Anesth Pain Med 30:344-50. 2005
    ..In addition, tetrodotoxin (TTX), a naturally occuring Na + channel blocker, was coinjected to investigate whether it increased block duration...
  17. ncbi request reprint Amitriptyline for prolonged cutaneous analgesia in the rat
    Mohammed A Khan
    Department of Anesthesiology, Perioperative and Pain Medicne, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Anesthesiology 96:109-16. 2002
    ..In keeping with the objective of identifying drugs for prolonged cutaneous analgesia, the authors compared the cutaneous analgesic effectiveness of amitriptyline and bupivacaine in rats...
  18. ncbi request reprint Tricyclic antidepressants as long-acting local anesthetics
    Yukari Sudoh
    Department of Anesthesia, Harvard Medical School and Brigham and Women s Hospital, Boston, MA 02115 USA
    Pain 103:49-55. 2003
    ..TCAs with a tertiary amine appear more effective in penetrating these membrane barriers than TCAs with a secondary amine...
  19. ncbi request reprint Cutaneous analgesia after transdermal application of amitriptyline versus lidocaine in rats
    Anna Haderer
    Department of Anesthesiology, Ried General Hospital, Ried, Austria
    Anesth Analg 96:1707-10, table of contents. 2003
    ..The development of amitriptyline as a longer-lasting topical analgesic may improve our ability to treat chronic pain, such as neuropathic pain and neuralgia, and to prevent pain in procedures such as venipuncture...
  20. ncbi request reprint Assessment of differential blockade by amitriptyline and its N-methyl derivative in different species by different routes
    Peter Gerner
    Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Anesthesiology 98:1484-90. 2003
    ..Most drugs show a different profile depending on the model or species studied. This study was designed to investigate the differential nerve-blocking properties of amitriptyline and its quaternary ammonium derivative in rats and sheep...
  21. ncbi request reprint The relative toxicity of amitriptyline, bupivacaine, and levobupivacaine administered as rapid infusions in rats
    Venkatesh Srinivasa
    Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Anesth Analg 97:91-5, table of contents. 2003
    ..5 +/- 7 mg/kg and 22.7 +/- 7 mg/kg, respectively) (P < 0.05). A significantly larger dose of amitriptyline, given by rapid infusion, is required to cause CV and CNS toxicity in rats, when compared with bupivacaine and levobupivacaine...
  22. ncbi request reprint Neurologic and histopathologic evaluation after high-volume intrathecal amitriptyline
    Yukari Sudoh
    Department of Anesthesiology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Reg Anesth Pain Med 29:434-40. 2004
    ..We evaluated spinal block after various concentrations of amitriptyline administered intrathecally in a fixed high volume...
  23. ncbi request reprint Phase Ia and Ib study of amitriptyline for ulnar nerve block in humans: side effects and efficacy
    Peter Fridrich
    Trauma Hospital Lorenz Boehler, Vienna, Austria
    Anesthesiology 100:1511-8. 2004
    ..Therefore, the authors investigated the adverse effects and effectiveness of this drug when given for ulnar nerve blockade in human volunteers...
  24. ncbi request reprint Topical amitriptyline in healthy volunteers
    Peter Gerner
    Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Reg Anesth Pain Med 28:289-93. 2003
    ..In a randomized, double-blinded, and placebo-controlled trial, we investigated whether amitriptyline also is capable of providing cutaneous analgesia when applied topically in 14 healthy volunteers...
  25. doi request reprint Low-dose systemic bupivacaine prevents the development of allodynia after thoracotomy in rats
    Jin Woo Shin
    Department of Anesthesiology, Brigham and Women s Hospital, Harvard Medical School, 75 Francis St, Boston, MA 02115, USA
    Anesth Analg 107:1587-91. 2008
    ..Our purpose was to test whether intercostal and systemic injection of bupivacaine prevented the development of allodynia in an animal model of chronic intercostal neuropathic pain...
  26. ncbi request reprint Use of a charged lidocaine derivative, tonicaine, for prolonged infiltration anesthesia
    Mohammed A Khan
    Department of Anesthesiology, Tufts University School of Medicine and New England Medical Center, Boston, Massachusetts
    Reg Anesth Pain Med 27:173-9. 2002
    ....
  27. doi request reprint Sensory and motor complications of local anesthetics
    Peter Gerner
    Muscle Nerve 37:421-5. 2008
  28. ncbi request reprint In vitro, lidocaine-induced axonal injury is prevented by peripheral inhibition of the p38 mitogen-activated protein kinase, but not by inhibiting caspase activity
    Philipp Lirk
    Department of Anesthesiology and Critical Care Medicine, Innsbruck Medical University, Innsbruck, Austria
    Anesth Analg 105:1657-64, table of contents. 2007
    ..This approach, however, does not accurately reflect the in vivo situation for peripheral nerve blockade, where LA is applied to the axon alone...
  29. ncbi request reprint Tricyclic antidepressants and their local anesthetic properties: from bench to bedside and back again
    Peter Gerner
    Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Reg Anesth Pain Med 29:286-9. 2004
  30. ncbi request reprint The neurotoxic effects of amitriptyline are mediated by apoptosis and are effectively blocked by inhibition of caspase activity
    Philipp Lirk
    Department of Anesthesiology and Critical Care Medicine, Innsbruck Medical University, Austria
    Anesth Analg 102:1728-33. 2006
    ..In vivo studies will have to corroborate whether the co-injection of anti-apoptotic drugs with local anesthetics decreases neurotoxic side effects...
  31. pmc Phase 1A safety assessment of intravenous amitriptyline
    Peter Fridrich
    Trauma Hospital, Lorenz Boehler, Vienna, and Department of Anesthesiology and Critical Care Medicine, Medical University Innsbruck, Austria
    J Pain 8:549-55. 2007
    ..As this occurs at very low plasma concentrations, a single preoperative intravenous infusion of amitriptyline could provide long-lasting pain relief and decrease the incidence of chronic pain...
  32. ncbi request reprint Neurotoxicity of lidocaine involves specific activation of the p38 mitogen-activated protein kinase, but not extracellular signal-regulated or c-jun N-terminal kinases, and is mediated by arachidonic acid metabolites
    Ingrid Haller
    Department of Anesthesiology and Critical Care Medicine, Medical University of Innsbruck, Innsbruck, Austria
    Anesthesiology 105:1024-33. 2006
    ....
  33. ncbi request reprint Doxepin by topical application and intrathecal route in rats
    Peter Gerner
    Pain Research Center, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Anesth Analg 102:283-7. 2006
    ..Intrathecally, 20 mM of doxepin was not significantly different for motor and proprioceptive function from 23 mM (0.75%) bupivacaine; however, neurotoxicity (defined as persistent neurological deficit) commenced at 50 mM...