Katia Georgopoulos

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Harnessing of the nucleosome-remodeling-deacetylase complex controls lymphocyte development and prevents leukemogenesis
    Jiangwen Zhang
    Faculty of Arts and Sciences Research Computing, Harvard University, Cambridge, Massachusetts, USA
    Nat Immunol 13:86-94. 2012
  2. pmc Pre-T cell receptor (TCR) and TCR-controlled checkpoints in T cell differentiation are set by Ikaros
    S Winandy
    Cutaneous Biology Research Center, Harvard Medical School, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    J Exp Med 190:1039-48. 1999
  3. doi request reprint From immunity to tolerance through HDAC
    Katia Georgopoulos
    Cutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Nat Immunol 10:13-4. 2009
  4. ncbi request reprint Haematopoietic cell-fate decisions, chromatin regulation and ikaros
    Katia Georgopoulos
    CBRC, MGH East, 13th St, Charlestown, Massachusetts 02129, USA
    Nat Rev Immunol 2:162-74. 2002
  5. pmc The role of the chromatin remodeler Mi-2beta in hematopoietic stem cell self-renewal and multilineage differentiation
    Toshimi Yoshida
    Cutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Genes Dev 22:1174-89. 2008
  6. pmc Transcriptional regulation of the Ikzf1 locus
    Toshimi Yoshida
    Cutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA
    Blood 122:3149-59. 2013
  7. ncbi request reprint The chromatin remodeler Mi-2beta is required for CD4 expression and T cell development
    Christine J Williams
    Cutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Immunity 20:719-33. 2004
  8. ncbi request reprint Antagonistic interactions between Ikaros and the chromatin remodeler Mi-2beta determine silencer activity and Cd4 gene expression
    Taku Naito
    Cutaneous Biology Research Center, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Immunity 27:723-34. 2007
  9. pmc Genome-wide lineage-specific transcriptional networks underscore Ikaros-dependent lymphoid priming in hematopoietic stem cells
    Samuel Yao Ming Ng
    Cutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Immunity 30:493-507. 2009
  10. pmc Ikaros SUMOylation: switching out of repression
    Pablo Gómez-del Arco
    Cutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Mol Cell Biol 25:2688-97. 2005

Research Grants

  1. Ikaros regulation: study on hemo-lymphopoiesis
    Katia Georgopoulos; Fiscal Year: 2007
  2. The chromatin remodeler Mi2 in T cell development
    Katia Georgopoulos; Fiscal Year: 2005
  3. The chromatin remodeler Mi2 in T cell development
    Katia Georgopoulos; Fiscal Year: 2006
  4. Ikaros, Aiolos, Mi-2b complex B cell development
    Katia Georgopoulos; Fiscal Year: 2006
  5. Ikaros, Aiolos, Mi-2b complex B cell development
    Katia Georgopoulos; Fiscal Year: 2007
  6. The chromatin remodeler Mi2 in T cell development
    Katia Georgopoulos; Fiscal Year: 2007
  7. Ikaros and Mi-2 beta interactions in early lymphoid development
    Katia Georgopoulos; Fiscal Year: 2009
  8. The chromatin remodeler Mi2 in T cell development
    Katia Georgopoulos; Fiscal Year: 2009
  9. Ikaros and Mi-2 beta interactions in early lymphoid development
    Katia Georgopoulos; Fiscal Year: 2010
  10. Ikaros and Mi-2 beta interactions in early lymphoid development
    Katia Georgopoulos; Fiscal Year: 2009

Collaborators

Detail Information

Publications31

  1. pmc Harnessing of the nucleosome-remodeling-deacetylase complex controls lymphocyte development and prevents leukemogenesis
    Jiangwen Zhang
    Faculty of Arts and Sciences Research Computing, Harvard University, Cambridge, Massachusetts, USA
    Nat Immunol 13:86-94. 2012
    ..Thus, release of NuRD from Ikaros regulation blocks lymphocyte maturation and mediates progression to a leukemic state by engaging functionally opposing epigenetic and genetic networks...
  2. pmc Pre-T cell receptor (TCR) and TCR-controlled checkpoints in T cell differentiation are set by Ikaros
    S Winandy
    Cutaneous Biology Research Center, Harvard Medical School, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    J Exp Med 190:1039-48. 1999
    ..We conclude that Ikaros regulates T cell differentiation, selection, and homeostasis by providing signaling thresholds for pre-TCR and TCR...
  3. doi request reprint From immunity to tolerance through HDAC
    Katia Georgopoulos
    Cutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Nat Immunol 10:13-4. 2009
    ..Regulation of expression of the gene encoding interleukin 10 by the histone deacetylase HDAC11 emphasizes the ability of an antigen-presenting cell to induce immunity or tolerance in CD4+ T cells...
  4. ncbi request reprint Haematopoietic cell-fate decisions, chromatin regulation and ikaros
    Katia Georgopoulos
    CBRC, MGH East, 13th St, Charlestown, Massachusetts 02129, USA
    Nat Rev Immunol 2:162-74. 2002
    ....
  5. pmc The role of the chromatin remodeler Mi-2beta in hematopoietic stem cell self-renewal and multilineage differentiation
    Toshimi Yoshida
    Cutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Genes Dev 22:1174-89. 2008
    ..Thus, Mi-2beta provides the hematopoietic system with immune cell capabilities as well as with an extensive regenerative capacity...
  6. pmc Transcriptional regulation of the Ikzf1 locus
    Toshimi Yoshida
    Cutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA
    Blood 122:3149-59. 2013
    ..Mutations in the Ikzf1 regulatory elements and their interacting factors are likely to have adverse effects on lymphopoiesis and contribute to leukemogenesis. ..
  7. ncbi request reprint The chromatin remodeler Mi-2beta is required for CD4 expression and T cell development
    Christine J Williams
    Cutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Immunity 20:719-33. 2004
    ..These findings provide important insights into the regulation of CD4 expression during T cell development and define a role for Mi-2beta in gene activation...
  8. ncbi request reprint Antagonistic interactions between Ikaros and the chromatin remodeler Mi-2beta determine silencer activity and Cd4 gene expression
    Taku Naito
    Cutaneous Biology Research Center, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Immunity 27:723-34. 2007
    ..Thus, concomitant interactions between functionally opposing chromatin-regulating machineries are an important mode of gene regulation during lineage determination...
  9. pmc Genome-wide lineage-specific transcriptional networks underscore Ikaros-dependent lymphoid priming in hematopoietic stem cells
    Samuel Yao Ming Ng
    Cutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Immunity 30:493-507. 2009
    ..Taken together, our studies provide new insight into the priming and restriction of lineage potentials during early hematopoiesis and identify Ikaros as a key bivalent regulator of this process...
  10. pmc Ikaros SUMOylation: switching out of repression
    Pablo Gómez-del Arco
    Cutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Mol Cell Biol 25:2688-97. 2005
    ..These studies reveal a new dynamic way by which Ikaros-mediated gene repression is controlled by SUMOylation...
  11. pmc Early hematopoietic lineage restrictions directed by Ikaros
    Toshimi Yoshida
    Cutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Nat Immunol 7:382-91. 2006
    ..Using this approach, we identify previously unknown pivotal functions for Ikaros in distinct fate 'decisions' in the early hematopoietic hierarchy...
  12. ncbi request reprint A molecular dissection of the repression circuitry of Ikaros
    Joseph Koipally
    Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Biol Chem 277:27697-705. 2002
    ..Finally, we show that, barring CtBP, the Ikaros family members Aiolos, Helios, and Eos can associate with all of the identified corepressors of Ikaros including its newly identified interactors, Class II HDACs...
  13. pmc A complex network of regulatory elements in Ikaros and their activity during hemo-lymphopoiesis
    Christoph Kaufmann
    Cutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    EMBO J 22:2211-23. 2003
    ....
  14. doi request reprint Loss of Ikaros DNA-binding function confers integrin-dependent survival on pre-B cells and progression to acute lymphoblastic leukemia
    Ila Joshi
    Cutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA
    Nat Immunol 15:294-304. 2014
    ....
  15. ncbi request reprint Ikaros and chromatin regulation in early hematopoiesis
    Samuel Yao Ming Ng
    Cutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Curr Opin Immunol 19:116-22. 2007
    ..Genetic studies of this family of nuclear factors are now providing unique insight into the functional molecular signatures that bestow plasticity to the hematopoietic stem cell and its early progeny...
  16. ncbi request reprint The chromatin remodeler Mi-2beta is required for establishment of the basal epidermis and normal differentiation of its progeny
    Mariko Kashiwagi
    Cutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Development 134:1571-82. 2007
    ..Mi-2beta is however essential for the reprogramming of basal cells to the follicular and, subsequently, hair matrix fates...
  17. ncbi request reprint Ikaros-CtIP interactions do not require C-terminal binding protein and participate in a deacetylase-independent mode of repression
    Joseph Koipally
    Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Biol Chem 277:23143-9. 2002
    ..Finally, we show that CtIP and CtBP can interact with the general transcription factors, TATA binding protein and transcription factor IIB, which suggests a possible mechanism for their deacetylase-independent mode of repression...
  18. ncbi request reprint Roles for Dnmt3b in mammalian development: a mouse model for the ICF syndrome
    Yoshihide Ueda
    Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, Charlestown, MA 02129, USA
    Development 133:1183-92. 2006
    ..These mutant mice will be useful for further elucidation of the pathogenic and molecular mechanisms underlying ICF syndrome...
  19. ncbi request reprint Unconventional potentiation of gene expression by Ikaros
    Joseph Koipally
    Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
    J Biol Chem 277:13007-15. 2002
    ..Thus, potentiation of gene expression by Ikaros correlates strongly with its ability to localize to PC-HC in combination with the chromatin remodeler Mi-2beta...
  20. pmc Targeted deletion of integrin-linked kinase reveals a role in T-cell chemotaxis and survival
    Emerson Liu
    Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Charlestown, 02129, USA
    Mol Cell Biol 25:11145-55. 2005
    ..These data extend the role of ILK to immune-cell trafficking and survival via modulation of Akt- and Rac-dependent substrates, and have implications for cell recruitment in both homeostatic and pathological processes...
  21. pmc Awakening lineage potential by Ikaros-mediated transcriptional priming
    Toshimi Yoshida
    Cutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Curr Opin Immunol 22:154-60. 2010
    ..Loss of Ikaros removes the lymphoid leg of the immune system and may confer aberrant self-renewing properties to myeloid progenitors...
  22. pmc Phosphorylation controls Ikaros's ability to negatively regulate the G(1)-S transition
    Pablo Gómez-del Arco
    Cutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Mol Cell Biol 24:2797-807. 2004
    ..We thus propose that Ikaros's activity as a regulator of the G(1)-S transition is controlled by phosphorylation in response to signaling events that down-modulate its DNA binding activity...
  23. pmc Aiolos promotes TH17 differentiation by directly silencing Il2 expression
    Francisco J Quintana
    Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Nat Immunol 13:770-7. 2012
    ..Thus, we have identified a module in the transcriptional program of T(H)17 cells that actively limits IL-2 production and promotes their differentiation...
  24. pmc Aiolos is required for the generation of high affinity bone marrow plasma cells responsible for long-term immunity
    Marta Cortes
    Cutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    J Exp Med 199:209-19. 2004
    ..These studies support a model by which the high affinity plasma cell population in the BM undergoes a unique differentiation program that is dependent on Aiolos...
  25. ncbi request reprint Promoter Decommissioning by the NuRD Chromatin Remodeling Complex Triggers Synaptic Connectivity in the Mammalian Brain
    Tomoko Yamada
    Department of Anatomy and Neurobiology, Washington University in St Louis School of Medicine, St Louis, MO 63110, USA Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA
    Neuron 83:122-34. 2014
    ..Our findings define NuRD-dependent promoter decommissioning as a developmentally regulated programming mechanism that drives synaptic connectivity in the mammalian brain. ..
  26. ncbi request reprint The CD8alpha gene locus is regulated by the Ikaros family of proteins
    Nicola Harker
    Division of Molecular Immunology, National Institute for Medical Research, Medical Research Council, NW7 1AA, London, United Kingdom
    Mol Cell 10:1403-15. 2002
    ....
  27. ncbi request reprint Epigenetic flexibility underlying lineage choices in the adaptive immune system
    Dimitris Kioussis
    Molecular Immunology, Medical Research Council MRC National Institute for Medical Research, The Ridgeway, London NW7 1AA, UK
    Science 317:620-2. 2007
    ....
  28. ncbi request reprint Ikaros is expressed in developing striatal neurons and involved in enkephalinergic differentiation
    Denes V Agoston
    Department of Anatomy, Physiology and Genetics, USUHS, Bethesda, Maryland 20814, USA
    J Neurochem 102:1805-16. 2007
    ..These results demonstrate that Ik-1 and Ik-2 proteins through their DNA binding act as positive regulators of ENK gene expression in the developing striatum and participate in regulating enkephalinergic differentiation...
  29. ncbi request reprint Lack of the transcriptional coactivator OBF-1 prevents the development of systemic lupus erythematosus-like phenotypes in Aiolos mutant mice
    Jian Sun
    Friedrich Miescher Institute for Biomedical Research, Novartis Research Foundation, Basel, Switzerland
    J Immunol 170:1699-706. 2003
    ..Our results indicate that B cells play a crucial role in the development of SLE in Aiolos mutant mice and might be useful for the strategy of SLE treatment...
  30. pmc Ikaros, a lymphoid-cell-specific transcription factor, contributes to the leukemogenic phenotype of a mink cell focus-inducing murine leukemia virus
    Nancy L DiFronzo
    Center for Virology, Immunology, and Infectious Disease Research, Children s National Medical Center, George Washington University School of Medicine and Health Sciences, Washington, DC 20010, USA
    J Virol 76:78-87. 2002
    ..These data are consistent with the hypothesis that the Ikaros-binding sites in the U3 region of MCF 247 are functional and cooperate with other DNA elements for optimal enhancer function in vivo...
  31. ncbi request reprint Ikaros DNA-binding proteins as integral components of B cell developmental-stage-specific regulatory circuits
    Elizabeth C Thompson
    Lymphocyte Development Group, MRC Clinical Sciences Centre, Imperial College London, Du Cane Road, London W12 0NN, UK
    Immunity 26:335-44. 2007
    ..Aiolos expression was controlled by pre-BCR signals via the adaptor protein SLP-65. Thus, pre-BCR signaling regulates Aiolos and the silencing of Igll1 via a developmental-stage-specific feedback loop...

Research Grants33

  1. Ikaros regulation: study on hemo-lymphopoiesis
    Katia Georgopoulos; Fiscal Year: 2007
    ..We hypothesize that achieving some of these goals would dramatically increase our ability to analyze and manipulate development of the hemopoietic stem cell in vivo and in vitro with important therapeutic implications. ..
  2. The chromatin remodeler Mi2 in T cell development
    Katia Georgopoulos; Fiscal Year: 2005
    ..This investigation may also identify molecular targets for intervention in immune disease, characterized by inappropriate lymphocyte proliferation such as autoimmunity, leukemia and lymphoma. ..
  3. The chromatin remodeler Mi2 in T cell development
    Katia Georgopoulos; Fiscal Year: 2006
    ..This investigation may also identify molecular targets for intervention in immune disease, characterized by inappropriate lymphocyte proliferation such as autoimmunity, leukemia and lymphoma. ..
  4. Ikaros, Aiolos, Mi-2b complex B cell development
    Katia Georgopoulos; Fiscal Year: 2006
    ..abstract_text> ..
  5. Ikaros, Aiolos, Mi-2b complex B cell development
    Katia Georgopoulos; Fiscal Year: 2007
    ..abstract_text> ..
  6. The chromatin remodeler Mi2 in T cell development
    Katia Georgopoulos; Fiscal Year: 2007
    ..This investigation may also identify molecular targets for intervention in immune disease, characterized by inappropriate lymphocyte proliferation such as autoimmunity, leukemia and lymphoma. ..
  7. Ikaros and Mi-2 beta interactions in early lymphoid development
    Katia Georgopoulos; Fiscal Year: 2009
    ..These studies will provide us with new important and far-reaching paradigms that will impact our understanding of normal development and cancer. ..
  8. The chromatin remodeler Mi2 in T cell development
    Katia Georgopoulos; Fiscal Year: 2009
    ..This investigation may also identify molecular targets for intervention in immune disease, characterized by inappropriate lymphocyte proliferation such as autoimmunity, leukemia and lymphoma. ..
  9. Ikaros and Mi-2 beta interactions in early lymphoid development
    Katia Georgopoulos; Fiscal Year: 2010
    ..These studies will provide us with new important and far-reaching paradigms that will impact our understanding of normal development and cancer. ..
  10. Ikaros and Mi-2 beta interactions in early lymphoid development
    Katia Georgopoulos; Fiscal Year: 2009
    ..These studies will provide us with new important and far-reaching paradigms that will impact our understanding of normal development and cancer. ..
  11. Ikaros, Aiolos, Mi-2b complex B cell development
    Katia Georgopoulos; Fiscal Year: 2005
    ..abstract_text> ..
  12. MECHANISM OF ACTION IKAROS-NURD COMPLEX IN T CELLS
    Katia Georgopoulos; Fiscal Year: 2004
    ..e immuno-deficiency, autoimmunity and neoplastic transformation. An important outcome of these studies will be an increase in our ability to apply molecular intervention to these differentiation processes. ..
  13. Ikaros, Aiolos, Mi-2b complex B cell development
    Katia Georgopoulos; Fiscal Year: 2004
    ..abstract_text> ..
  14. LYMPHOCYTE DEVELOPMENT IN IKAROS C-/- MUTANT MICE
    Katia Georgopoulos; Fiscal Year: 1999
    ..Finally, target genes for the Ikaros proteins, important in the development and maturation of lymphoid progenitors, will be investigated by studying differential mRNA expression in the Ikaros C-/mutant lymphoid and HSC populations. ..
  15. AIOLOS GENE IN B LYMPHOCYTE DEVELOPMENT AND FUNCTION
    Katia Georgopoulos; Fiscal Year: 1999
    ..In the long run, these studies on the role of Aiolos in B-cell differentiation and function, we will have a great impact on our ability to apply molecular intervention to our immune system. ..
  16. AIOLOS GENE IN B LYMPHOCYTE DEVELOPMENT AND FUNCTION
    Katia Georgopoulos; Fiscal Year: 2000
    ..In the long run, these studies on the role of Aiolos in B-cell differentiation and function, we will have a great impact on our ability to apply molecular intervention to our immune system. ..
  17. MECHANISM OF ACTION IKAROS-NURD COMPLEX IN T CELLS
    Katia Georgopoulos; Fiscal Year: 2000
    ..e immuno-deficiency, autoimmunity and neoplastic transformation. An important outcome of these studies will be an increase in our ability to apply molecular intervention to these differentiation processes. ..
  18. MECHANISM OF ACTION IKAROS-NURD COMPLEX IN T CELLS
    Katia Georgopoulos; Fiscal Year: 2001
    ..e immuno-deficiency, autoimmunity and neoplastic transformation. An important outcome of these studies will be an increase in our ability to apply molecular intervention to these differentiation processes. ..
  19. AIOLOS GENE IN B LYMPHOCYTE DEVELOPMENT AND FUNCTION
    Katia Georgopoulos; Fiscal Year: 2001
    ..In the long run, these studies on the role of Aiolos in B-cell differentiation and function, we will have a great impact on our ability to apply molecular intervention to our immune system. ..
  20. AIOLOS GENE IN B LYMPHOCYTE DEVELOPMENT AND FUNCTION
    Katia Georgopoulos; Fiscal Year: 2002
    ..In the long run, these studies on the role of Aiolos in B-cell differentiation and function, we will have a great impact on our ability to apply molecular intervention to our immune system. ..
  21. MECHANISM OF ACTION IKAROS-NURD COMPLEX IN T CELLS
    Katia Georgopoulos; Fiscal Year: 2002
    ..e immuno-deficiency, autoimmunity and neoplastic transformation. An important outcome of these studies will be an increase in our ability to apply molecular intervention to these differentiation processes. ..
  22. Ikaros, Aiolos, Mi-2b complex B cell development
    Katia Georgopoulos; Fiscal Year: 2003
    ..abstract_text> ..
  23. DE NOVO METHYLTRANSFERASES AND CANCER
    Katia Georgopoulos; Fiscal Year: 2003
    ..The molecular and genetic approaches described in this proposal will unravel the biological function of de novo methylation in development and cancer. ..
  24. MECHANISM OF ACTION IKAROS-NURD COMPLEX IN T CELLS
    Katia Georgopoulos; Fiscal Year: 2003
    ..e immuno-deficiency, autoimmunity and neoplastic transformation. An important outcome of these studies will be an increase in our ability to apply molecular intervention to these differentiation processes. ..
  25. Ikaros and Mi-2 beta interactions in early lymphoid development
    Katia Georgopoulos; Fiscal Year: 2011
    ..These studies will provide us with new important and far-reaching paradigms that will impact our understanding of normal development and cancer. ..