Niels Geijsen

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi gPS navigates germ cells to pluripotency
    Niels Geijsen
    Massachusetts General Hospital Center for Regenerative Medicine and Cancer Center, Harvard Stem Cell Institute, Boston, MA 02114, USA
    Cell Stem Cell 5:3-4. 2009
  2. ncbi Seminal discoveries in regenerative medicine: contributions of the male germ line to understanding pluripotency
    Niels Geijsen
    Harvard Medical School, Massachusetts General Hospital, Center for Regenerative Medicine and Technology, Boston, MA 02114, USA
    Hum Mol Genet 17:R16-22. 2008
  3. ncbi In vitro generation of germ cells from murine embryonic stem cells
    Jason A West
    Graduate Program of Biological and Biomedical Sciences, Harvard Medical School, Boston, Massachusetts, USA
    Nat Protoc 1:2026-36. 2006
  4. ncbi The growth factor environment defines distinct pluripotent ground states in novel blastocyst-derived stem cells
    Yu Fen Chou
    Harvard Stem Cell Institute, Massachusetts General Hospital, Center for Regenerative Medicine, CPZN 4256, 185 Cambridge Street, Boston, MA 02114, USA
    Cell 135:449-61. 2008
  5. ncbi In vitro generation of germ cells: new techniques to solve current issues
    Joshua M Baughman
    Graduate Program of Biological and Biomedical Sciences, Harvard Medical School, Boston, MA 02115, USA
    Ann N Y Acad Sci 1061:33-40. 2005
  6. ncbi Male germ cells
    Niels Geijsen
    Harvard Stem Cell Institute, Center for Regenerative Medicine and Technology, Boston, Massachusetts, USA
    Methods Enzymol 418:307-14. 2006
  7. ncbi A murine ESC-like state facilitates transgenesis and homologous recombination in human pluripotent stem cells
    Christa Buecker
    Center for Regenerative Medicine, Harvard Medical School, Massachusetts General Hospital, Boston, MA 02114, USA
    Cell Stem Cell 6:535-46. 2010
  8. ncbi Different flavors of pluripotency, molecular mechanisms, and practical implications
    Christa Buecker
    Center for Regenerative Medicine, Harvard Medical School, Massachusetts General Hospital, CPZN 4256, 185 Cambridge Street, Boston, MA 02114, USA
    Cell Stem Cell 7:559-64. 2010

Collaborators

Detail Information

Publications8

  1. ncbi gPS navigates germ cells to pluripotency
    Niels Geijsen
    Massachusetts General Hospital Center for Regenerative Medicine and Cancer Center, Harvard Stem Cell Institute, Boston, MA 02114, USA
    Cell Stem Cell 5:3-4. 2009
    ..In this issue of Cell Stem Cell, Ko et al. (2009) reproducibly generate pluripotent cell lines from murine testes and unequivocally demonstrate their origin from spermatogonial stem cells...
  2. ncbi Seminal discoveries in regenerative medicine: contributions of the male germ line to understanding pluripotency
    Niels Geijsen
    Harvard Medical School, Massachusetts General Hospital, Center for Regenerative Medicine and Technology, Boston, MA 02114, USA
    Hum Mol Genet 17:R16-22. 2008
    ....
  3. ncbi In vitro generation of germ cells from murine embryonic stem cells
    Jason A West
    Graduate Program of Biological and Biomedical Sciences, Harvard Medical School, Boston, Massachusetts, USA
    Nat Protoc 1:2026-36. 2006
    ..It serves as a platform for studying the poorly understood process of germ cell allocation, imprint erasure and gamete formation, with 4-6 weeks being required to isolate PGCs as well as haploid cells...
  4. ncbi The growth factor environment defines distinct pluripotent ground states in novel blastocyst-derived stem cells
    Yu Fen Chou
    Harvard Stem Cell Institute, Massachusetts General Hospital, Center for Regenerative Medicine, CPZN 4256, 185 Cambridge Street, Boston, MA 02114, USA
    Cell 135:449-61. 2008
    ..We demonstrate that the culture growth factor environment and cell-cell interaction play a critical role in defining several unique and stable stem cell ground states...
  5. ncbi In vitro generation of germ cells: new techniques to solve current issues
    Joshua M Baughman
    Graduate Program of Biological and Biomedical Sciences, Harvard Medical School, Boston, MA 02115, USA
    Ann N Y Acad Sci 1061:33-40. 2005
    ..In this review the different methods used for the in vitro generation of germ cells and how these techniques may be improved and applied to further advance our knowledge of germ-cell biology are discussed...
  6. ncbi Male germ cells
    Niels Geijsen
    Harvard Stem Cell Institute, Center for Regenerative Medicine and Technology, Boston, Massachusetts, USA
    Methods Enzymol 418:307-14. 2006
    ..This chapter details methods for in vitro derivation of germ lineage elements and discusses potential applications of these techniques in germ cell research...
  7. ncbi A murine ESC-like state facilitates transgenesis and homologous recombination in human pluripotent stem cells
    Christa Buecker
    Center for Regenerative Medicine, Harvard Medical School, Massachusetts General Hospital, Boston, MA 02114, USA
    Cell Stem Cell 6:535-46. 2010
    ..Finally, we demonstrate that the hLR5 state facilitates gene targeting, and as such provides a powerful tool for the generation of recombinant human pluripotent stem cell lines...
  8. ncbi Different flavors of pluripotency, molecular mechanisms, and practical implications
    Christa Buecker
    Center for Regenerative Medicine, Harvard Medical School, Massachusetts General Hospital, CPZN 4256, 185 Cambridge Street, Boston, MA 02114, USA
    Cell Stem Cell 7:559-64. 2010
    ..Recent findings demonstrate that the naive and primed pluripotent states are interconvertible, even in human cells, and hint that growth factor-mediated Nanog expression may be an important factor regulating the balance between them...