Vivek Gautam

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. doi request reprint Synaptotagmins interact with APP and promote Aβ generation
    Vivek Gautam
    Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, 02129, USA
    Mol Neurodegener 10:31. 2015
  2. pmc Nedd4 is a specific E3 ubiquitin ligase for the NMDA receptor subunit GluN2D
    Vivek Gautam
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, 985800 Nebraska Medical Center, Omaha, NE 68198 5800, USA
    Neuropharmacology 74:96-107. 2013
  3. pmc The E280A presenilin mutation reduces voltage-gated sodium channel levels in neuronal cells
    Doo Yeon Kim
    Neurobiology of Disease Laboratory, Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School, Charlestown, Mass, USA
    Neurodegener Dis 13:64-8. 2014
  4. doi request reprint GluN2D N-Methyl-d-Aspartate Receptor Subunit Contribution to the Stimulation of Brain Activity and Gamma Oscillations by Ketamine: Implications for Schizophrenia
    Kiran Sapkota
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, Nebraska K S, Z M, P S, D L, M L, D T M Departments of Pharmacology and Experimental Therapeutics and Neurology, School of Medicine, Boston University, Boston, Massachusetts T I Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts V G
    J Pharmacol Exp Ther 356:702-11. 2016
  5. pmc BACE1 activity regulates cell surface contactin-2 levels
    Vivek Gautam
    Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Mol Neurodegener 9:4. 2014

Collaborators

Detail Information

Publications5

  1. doi request reprint Synaptotagmins interact with APP and promote Aβ generation
    Vivek Gautam
    Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, 02129, USA
    Mol Neurodegener 10:31. 2015
    ..However, proteins regulating Aβ generation at the synapse have not been characterized. Here, we sought to identify synaptic proteins that interact with the extracellular domain of APP and regulate Aβ generation...
  2. pmc Nedd4 is a specific E3 ubiquitin ligase for the NMDA receptor subunit GluN2D
    Vivek Gautam
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, 985800 Nebraska Medical Center, Omaha, NE 68198 5800, USA
    Neuropharmacology 74:96-107. 2013
    ..This article is part of the Special Issue entitled 'Glutamate Receptor-Dependent Synaptic Plasticity'. ..
  3. pmc The E280A presenilin mutation reduces voltage-gated sodium channel levels in neuronal cells
    Doo Yeon Kim
    Neurobiology of Disease Laboratory, Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School, Charlestown, Mass, USA
    Neurodegener Dis 13:64-8. 2014
    ..1 levels. Here, we tested whether FAD-linked PS1 mutations modulate Navβ2 cleavages and Nav1.1 levels...
  4. doi request reprint GluN2D N-Methyl-d-Aspartate Receptor Subunit Contribution to the Stimulation of Brain Activity and Gamma Oscillations by Ketamine: Implications for Schizophrenia
    Kiran Sapkota
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, Nebraska K S, Z M, P S, D L, M L, D T M Departments of Pharmacology and Experimental Therapeutics and Neurology, School of Medicine, Boston University, Boston, Massachusetts T I Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts V G
    J Pharmacol Exp Ther 356:702-11. 2016
    ..These results suggest a critical role of GluN2D-containing NMDARs in neuronal oscillations and ketamine's psychotomimetic, dissociative effects and hence suggests a critical role for GluN2D subunits in cognition and perception. ..
  5. pmc BACE1 activity regulates cell surface contactin-2 levels
    Vivek Gautam
    Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Mol Neurodegener 9:4. 2014
    ..BACE1 cleaves over 60 putative substrates, however the majority of these cleavages have not been characterized. Here we investigated BACE1-mediated cleavage of human contactin-2, a GPI-anchored cell adhesion molecule...