Wendy S Garrett

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Enterobacteriaceae act in concert with the gut microbiota to induce spontaneous and maternally transmitted colitis
    Wendy S Garrett
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA
    Cell Host Microbe 8:292-300. 2010
  2. pmc The gut microbiota and mucosal T cells
    Patrick M Smith
    Department of Immunology and Infectious Diseases, Harvard School of Public Health Boston, MA, USA
    Front Microbiol 2:111. 2011
  3. pmc Homeostasis and inflammation in the intestine
    Wendy S Garrett
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA
    Cell 140:859-70. 2010
  4. pmc Colitis-associated colorectal cancer driven by T-bet deficiency in dendritic cells
    Wendy S Garrett
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA
    Cancer Cell 16:208-19. 2009
  5. pmc The microbial metabolites, short-chain fatty acids, regulate colonic Treg cell homeostasis
    Patrick M Smith
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA, USA
    Science 341:569-73. 2013
  6. pmc Bifidobacterium animalis subsp. lactis fermented milk product reduces inflammation by altering a niche for colitogenic microbes
    Patrick Veiga
    Harvard School of Public Health, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 107:18132-7. 2010
  7. pmc T-bet-/- RAG2-/- ulcerative colitis: the role of T-bet as a peacekeeper of host-commensal relationships
    Wendy S Garrett
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA
    Cytokine 48:144-7. 2009
  8. pmc Severity of innate immune-mediated colitis is controlled by the cytokine deficiency-induced colitis susceptibility-1 (Cdcs1) locus
    Joerg Ermann
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 108:7137-41. 2011
  9. pmc Gut microbiome composition and function in experimental colitis during active disease and treatment-induced remission
    Michelle G Rooks
    Harvard School of Public Health, Boston, MA, USA
    ISME J 8:1403-17. 2014
  10. pmc Fusobacterium nucleatum potentiates intestinal tumorigenesis and modulates the tumor-immune microenvironment
    Aleksandar D Kostic
    Department of Medicine, Harvard Medical School, Boston, MA 02115, USA
    Cell Host Microbe 14:207-15. 2013

Collaborators

Detail Information

Publications18

  1. pmc Enterobacteriaceae act in concert with the gut microbiota to induce spontaneous and maternally transmitted colitis
    Wendy S Garrett
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA
    Cell Host Microbe 8:292-300. 2010
    ..Cross-fostering experiments indicated a role for these organisms in maternal transmission of disease. Our findings illustrate how gut microbial communities work in concert with specific culturable colitogenic agents to cause IBD...
  2. pmc The gut microbiota and mucosal T cells
    Patrick M Smith
    Department of Immunology and Infectious Diseases, Harvard School of Public Health Boston, MA, USA
    Front Microbiol 2:111. 2011
    ..In this review, we focus on the gut microbiota's influence on the development and function of mucosal T cells subsets, specifically intraepithelial lymphocytes and lamina propria CD4 T cells...
  3. pmc Homeostasis and inflammation in the intestine
    Wendy S Garrett
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA
    Cell 140:859-70. 2010
    ..In this Review, we consider the many cellular and molecular methods by which inflammatory responses are regulated to maintain intestinal homeostasis and the disease states that can ensue when this balance is lost...
  4. pmc Colitis-associated colorectal cancer driven by T-bet deficiency in dendritic cells
    Wendy S Garrett
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA
    Cancer Cell 16:208-19. 2009
    ..TRUC colitis-associated colorectal cancer resembles the human disease and provides ample opportunity to probe how inflammation drives colorectal cancer development and to test preventative and therapeutic strategies preclinically...
  5. pmc The microbial metabolites, short-chain fatty acids, regulate colonic Treg cell homeostasis
    Patrick M Smith
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA, USA
    Science 341:569-73. 2013
    ..Our study reveals that a class of abundant microbial metabolites underlies adaptive immune microbiota coadaptation and promotes colonic homeostasis and health. ..
  6. pmc Bifidobacterium animalis subsp. lactis fermented milk product reduces inflammation by altering a niche for colitogenic microbes
    Patrick Veiga
    Harvard School of Public Health, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 107:18132-7. 2010
    ..lactis-containing fermented milk product, and therefore this model provides a framework for evaluating and optimizing probiotic-based functional foods...
  7. pmc T-bet-/- RAG2-/- ulcerative colitis: the role of T-bet as a peacekeeper of host-commensal relationships
    Wendy S Garrett
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA
    Cytokine 48:144-7. 2009
    ..1]. The TRUC (T-bet-/- RAG2-/- ulcerative colitis) model is discussed in the broader context of the adaptive and innate immune mechanisms that regulate host-commensal relationships within the intestine...
  8. pmc Severity of innate immune-mediated colitis is controlled by the cytokine deficiency-induced colitis susceptibility-1 (Cdcs1) locus
    Joerg Ermann
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 108:7137-41. 2011
    ..We conclude that the Cdcs1 locus controls colitis severity in T-bet(-/-).Rag2(-/-) mice through innate immune cells...
  9. pmc Gut microbiome composition and function in experimental colitis during active disease and treatment-induced remission
    Michelle G Rooks
    Harvard School of Public Health, Boston, MA, USA
    ISME J 8:1403-17. 2014
    ..Thus, our study provides insight into specific microbial clades and pathways associated with health, active disease and treatment interventions in a mouse model of colitis. ..
  10. pmc Fusobacterium nucleatum potentiates intestinal tumorigenesis and modulates the tumor-immune microenvironment
    Aleksandar D Kostic
    Department of Medicine, Harvard Medical School, Boston, MA 02115, USA
    Cell Host Microbe 14:207-15. 2013
    ..Collectively, these data suggest that, through recruitment of tumor-infiltrating immune cells, fusobacteria generate a proinflammatory microenvironment that is conducive for colorectal neoplasia progression. ..
  11. pmc Sequence-based discovery of Bradyrhizobium enterica in cord colitis syndrome
    Ami S Bhatt
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA, USA
    N Engl J Med 369:517-28. 2013
    ..It has been hypothesized that the cord colitis syndrome, a complication of umbilical-cord hematopoietic stem-cell transplantation, is infectious in origin...
  12. pmc Computational meta'omics for microbial community studies
    Nicola Segata
    Biostatistics Department, Harvard School of Public Health, Boston, MA, USA
    Mol Syst Biol 9:666. 2013
    ..We thus review here the technological and computational meta'omics approaches that are already available, those that are under active development, their success in biological discovery, and several outstanding challenges...
  13. pmc Current concepts of the intestinal microbiota and the pathogenesis of infection
    Leslie H Wardwell
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, 665 Huntington Avenue, SPH 1 909, Boston, MA, 02115, USA
    Curr Infect Dis Rep 13:28-34. 2011
    ..Key concepts of colonization resistance, host-commensal microbe interaction in immunity, antibiotics and gut bacterial communities, viral-gut bacterial interactions, and evolving methods for studying commensal microbes are explored...
  14. pmc Metagenomic biomarker discovery and explanation
    Nicola Segata
    Department of Biostatistics, 677 Huntington Avenue, Harvard School of Public Health, Boston, MA 02115, USA
    Genome Biol 12:R60. 2011
    ..We extensively validate our method on several microbiomes and a convenient online interface for the method is provided at http://huttenhower.sph.harvard.edu/lefse/...
  15. pmc Exploring host-microbiota interactions in animal models and humans
    Aleksandar D Kostic
    Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Genes Dev 27:701-18. 2013
    ..Here we consider how model systems are influencing current understanding of host-microbiota interactions and explore recent human microbiome studies...
  16. doi request reprint Host and gut microbiota symbiotic factors: lessons from inflammatory bowel disease and successful symbionts
    Sonia A Ballal
    Harvard School of Public Health, Boston, MA, USA
    Cell Microbiol 13:508-17. 2011
    ..While model symbionts have provided perspective into host-microbial homeostasis, high-throughput approaches are becoming increasingly practical for functionally characterizing the gut microbiota as a community...
  17. pmc Communicable ulcerative colitis induced by T-bet deficiency in the innate immune system
    Wendy S Garrett
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA
    Cell 131:33-45. 2007
    ..These findings reveal a novel function for T-bet as a peacekeeper of host-commensal relationships and provide new perspectives on the pathophysiology of IBD...