Igor Garkavtsev

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Dehydro-alpha-lapachone, a plant product with antivascular activity
    Igor Garkavtsev
    Edwin L Steele Laboratory, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 108:11596-601. 2011
  2. ncbi The candidate tumour suppressor protein ING4 regulates brain tumour growth and angiogenesis
    Igor Garkavtsev
    Edwin L Steele Laboratory for Tumour Biology, Department of Radiation Oncology Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Nature 428:328-32. 2004
  3. ncbi An intact ING1-P53 pathway can potentiate the cytotoxic effects of taxol
    Igor Garkavtsev
    Department of Radiation Oncology, Steele Laboratory, Massachusetts General Hospital, Charlestown, Massachussetts 02129, USA
    Cancer Biol Ther 4:48-9. 2005
  4. ncbi Human tumor xenografts recurring after radiotherapy are more sensitive to anti-vascular endothelial growth factor receptor-2 treatment than treatment-naive tumors
    Sergey V Kozin
    Edwin L Steele Laboratory for Tumor Biology, Department of Radiation Oncology, Massachusetts General Hospital, and Harvard Medical School, Boston, Massachusetts 02114, USA
    Cancer Res 67:5076-82. 2007
  5. ncbi Kinetics of vascular normalization by VEGFR2 blockade governs brain tumor response to radiation: role of oxygenation, angiopoietin-1, and matrix metalloproteinases
    Frank Winkler
    E L Steele Laboratory for Tumor Biology, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, 100 Blossom Street, Boston, MA 02114, USA
    Cancer Cell 6:553-63. 2004
  6. pmc Merlin/NF2 regulates angiogenesis in schwannomas through a Rac1/semaphorin 3F-dependent mechanism
    Hon Kit Wong
    The Steele Lab of Tumor Biology, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA Center for Neurologic Diseases, Brigham and Women s Hospital and Harvard Medical School, Harvard Institutes of Medicine, Boston, MA 02115, USA
    Neoplasia 14:84-94. 2012
  7. doi Cancer cell-associated MT1-MMP promotes blood vessel invasion and distant metastasis in triple-negative mammary tumors
    Jean Y Perentes
    Edwin L Steele Laboratory for Tumor Biology, Department of Radiation Oncology, Molecular Pathology Unit, MGH Cancer Center, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Cancer Res 71:4527-38. 2011
  8. pmc Differential gene expression of primary cultured lymphatic and blood vascular endothelial cells
    Gregory M Nelson
    Edwin L Steele Laboratory, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Neoplasia 9:1038-45. 2007
  9. pmc Paracrine regulation of angiogenesis and adipocyte differentiation during in vivo adipogenesis
    Dai Fukumura
    Edwin L Steele Laboratory, Massachusetts General Hospital and Harvard Medical School, Boston, Mass 02114, USA
    Circ Res 93:e88-97. 2003
  10. ncbi A novel p53-inducible apoptogenic gene, PRG3, encodes a homologue of the apoptosis-inducing factor (AIF)
    Yoichi Ohiro
    Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    FEBS Lett 524:163-71. 2002

Collaborators

Detail Information

Publications10

  1. pmc Dehydro-alpha-lapachone, a plant product with antivascular activity
    Igor Garkavtsev
    Edwin L Steele Laboratory, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 108:11596-601. 2011
    ..We show that DAL targets cell adhesion by promoting ubiquitination of the Rho-GTPase Rac1, which is frequently up-regulated in many different cancers...
  2. ncbi The candidate tumour suppressor protein ING4 regulates brain tumour growth and angiogenesis
    Igor Garkavtsev
    Edwin L Steele Laboratory for Tumour Biology, Department of Radiation Oncology Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Nature 428:328-32. 2004
    ..These results indicate that ING4 has an important role in brain tumour pathogenesis...
  3. ncbi An intact ING1-P53 pathway can potentiate the cytotoxic effects of taxol
    Igor Garkavtsev
    Department of Radiation Oncology, Steele Laboratory, Massachusetts General Hospital, Charlestown, Massachussetts 02129, USA
    Cancer Biol Ther 4:48-9. 2005
  4. ncbi Human tumor xenografts recurring after radiotherapy are more sensitive to anti-vascular endothelial growth factor receptor-2 treatment than treatment-naive tumors
    Sergey V Kozin
    Edwin L Steele Laboratory for Tumor Biology, Department of Radiation Oncology, Massachusetts General Hospital, and Harvard Medical School, Boston, Massachusetts 02114, USA
    Cancer Res 67:5076-82. 2007
    ..Our findings suggest that antiangiogenic agents could be effective in the treatment of patients with relapses after radiotherapy...
  5. ncbi Kinetics of vascular normalization by VEGFR2 blockade governs brain tumor response to radiation: role of oxygenation, angiopoietin-1, and matrix metalloproteinases
    Frank Winkler
    E L Steele Laboratory for Tumor Biology, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, 100 Blossom Street, Boston, MA 02114, USA
    Cancer Cell 6:553-63. 2004
    ..During the normalization window, but not before or after it, VEGFR2 blockade increases pericyte coverage of brain tumor vessels via upregulation of Ang1 and degrades their pathologically thick basement membrane via MMP activation...
  6. pmc Merlin/NF2 regulates angiogenesis in schwannomas through a Rac1/semaphorin 3F-dependent mechanism
    Hon Kit Wong
    The Steele Lab of Tumor Biology, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA Center for Neurologic Diseases, Brigham and Women s Hospital and Harvard Medical School, Harvard Institutes of Medicine, Boston, MA 02115, USA
    Neoplasia 14:84-94. 2012
    ..Restoring the relative balance of proangiogenic and antiangiogenic factors, such as increases in SEMA3F, in schwannoma microenvironment may represent a novel strategy to alleviate the clinical symptoms of NF2-related schwannomas...
  7. doi Cancer cell-associated MT1-MMP promotes blood vessel invasion and distant metastasis in triple-negative mammary tumors
    Jean Y Perentes
    Edwin L Steele Laboratory for Tumor Biology, Department of Radiation Oncology, Molecular Pathology Unit, MGH Cancer Center, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Cancer Res 71:4527-38. 2011
    ..Together, our findings established that MT1-MMP activity in breast tumors is essential for BVI, but not LVI, and that MT1-MMP should be further explored as a predictor and therapeutic target of hematogenous metastasis in TNBC patients...
  8. pmc Differential gene expression of primary cultured lymphatic and blood vascular endothelial cells
    Gregory M Nelson
    Edwin L Steele Laboratory, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Neoplasia 9:1038-45. 2007
    ....
  9. pmc Paracrine regulation of angiogenesis and adipocyte differentiation during in vivo adipogenesis
    Dai Fukumura
    Edwin L Steele Laboratory, Massachusetts General Hospital and Harvard Medical School, Boston, Mass 02114, USA
    Circ Res 93:e88-97. 2003
    ..The full text of this article is available online at http://www.circresaha.org...
  10. ncbi A novel p53-inducible apoptogenic gene, PRG3, encodes a homologue of the apoptosis-inducing factor (AIF)
    Yoichi Ohiro
    Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    FEBS Lett 524:163-71. 2002
    ..The PRG3 gene is thus a novel p53 target gene in a p53-dependent apoptosis pathway...