Research Topics
Species | Xiang GaoSummaryAffiliation: Harvard University Country: USA Publications
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Publications
Variations in exon 7 of the MSH2 gene and susceptibility to gastrointestinal cancer in a Chinese populationYimei Fan
Department of Medical Genetics, Medical School, Nanjing University, Nanjing, China
Cancer Genet Cytogenet 170:121-8. 2006..1221C>G (p.Leu407Leu) and c.1223A>G (p.Tyr408Cys) in MSH2 and c.655 A>G (p.Ile219 Val) and c.927C>T (p.Pro309Pro) in MLH1 might be merely polymorphisms. Consequences of the variant c.2101C>A (p.Gln701Lys) in MLH1 remain to be elucidated...
Erectile function and risk of Parkinson's diseaseXiang Gao
Department of Nutrition, Harvard University School of Public Health, Boston, MA 02115, USA
Am J Epidemiol 166:1446-50. 2007..In conclusion, in this retrospective analysis in a large cohort of men, the authors observed that erectile dysfunction was associated with a higher risk of developing Parkinson's disease...- Prospective study of dietary pattern and risk of Parkinson diseaseXiang Gao
Department of Nutrition, Harvard School of Public Health, Cambridge, MA 02115, USA
Am J Clin Nutr 86:1486-94. 2007..Several studies have shown associations between Parkinson Disease (PD) risk and individual foods and nutrients with inconsistent results... - Perceived imbalance and risk of Parkinson's diseaseXiang Gao
Department of Nutrition, Harvard University School of Public Health, Boston, Massachusetts 02115, USA
Mov Disord 23:613-6. 2008..This result suggests that the imbalance may in some cases be an early sign of PD, and may represent the onset of motor symptoms although they have not been clinically recognized... - Diet, urate, and Parkinson's disease risk in menXiang Gao
Department of Nutrition, School of Public Health, Harvard University, Boston, MA 02115, USA
Am J Epidemiol 167:831-8. 2008..These potential benefits, however, should be weighed against expected adverse effects on risk of gout and other chronic diseases... - Vitamin C intake and serum uric acid concentration in menXiang Gao
Department of Nutrition, Harvard University School of Public Health, Boston, Massachusetts 02115, USA
J Rheumatol 35:1853-8. 2008..We examined associations between vitamin C intake and serum uric acid in men in a population-based study... - Intake of added sugar and sugar-sweetened drink and serum uric acid concentration in US men and womenXiang Gao
Department of Nutrition, Harvard University School of Public Health, Boston, MA 02115, USA
Hypertension 50:306-12. 2007..2; P for interaction <0.01). Further research is needed to confirm causality of these associations and the observed difference by gender... - Genetic determinants of hair color and Parkinson's disease riskXiang Gao
Department of Nutrition, Harvard University School of Public Health, Boston, MA, USA
Ann Neurol 65:76-82. 2009.... - Caffeine and risk of Parkinson's disease in a large cohort of men and womenNatalia Palacios
Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
Mov Disord 27:1276-82. 2012..Findings from this large, prospective study of men and women are consistent with a protective effect of caffeine intake on PD incidence, with an attenuating influence of HRT in women. © 2012 Movement Disorder Society... - Alcohol and risk of Parkinson's disease in a large, prospective cohort of men and womenNatalia Palacios
Department of Nutrition, Harvard School of Public Health, 655 Huntington Avenue, Boston, MA 02115, USA
Mov Disord 27:980-7. 2012..77 (95% CI: 0.41, 1.45; P trend: 0.87). Consumption of beer, wine, or liquor was also not associated with PD risk. The results of this large, prospective study do not support an association between alcohol intake and risk of PD... - Plasma urate and Parkinson's disease in womenEilis J O'Reilly
Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA
Am J Epidemiol 172:666-70. 2010..Unlike in men, these findings do not support the hypothesis that urate is strongly associated with lower rates of Parkinson's disease among women... - Prospective study of restless legs syndrome and risk of depression in womenYanping Li
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Am J Epidemiol 176:279-88. 2012..Further prospective studies using refined approaches to ascertainment of RLS and depression are warranted... 
Association of depression, psycho-social stress and acculturation with respiratory disease among Puerto Rican adults in MassachusettsStanislav Henkin
School of Medicine, Boston University, Boston, MA, USA
J Immigr Minor Health 13:214-23. 2011..Longitudinal research is needed to determine if there is a causal pathway for these associations...- Restless legs syndrome and Parkinson's disease in menXiang Gao
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, and Harvard Medical School, Boston, Massachusetts, USA
Mov Disord 25:2654-7. 2010..In conclusion, men with RLS are more likely to have concurrent PD. Prospective studies are warranted to clarify the temporal relationship between RLS and PD... - The maximal amount of dietary alpha-tocopherol intake in U.S. adults (NHANES 2001-2002)Xiang Gao
The Jean Mayer U.S. Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA
J Nutr 136:1021-6. 2006..Careful selection of the highest vitamin E source foods within these groups could further increase the likelihood of meeting the current recommended daily allowance... - Prospective study of statin use and risk of Parkinson diseaseXiang Gao
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
Arch Neurol 69:380-4. 2012..To prospectively examine whether use of statins is associated with altered risk of Parkinson disease (PD)... - Obesity, diabetes, and risk of Parkinson's diseaseNatalia Palacios
Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA
Mov Disord 26:2253-9. 2011..The results did not differ significantly by gender. Our results do not provide evidence for a relationship between body mass index, weight change, waist circumference, or baseline diabetes and risk of Parkinson's disease... - alpha-Tocopherol intake and plasma concentration of Hispanic and non-Hispanic white elders is associated with dietary intake patternXiang Gao
The Jean Mayer U.S. Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
J Nutr 136:2574-9. 2006..05 for all), although they had similar intakes. A large proportion of these elders (>90%) have inadequate intake of alpha-tocopherol, and plasma concentrations were associated with intake patterns... - Habitual sugar intake and cognitive function among middle-aged and older Puerto Ricans without diabetesXingwang Ye
Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
Br J Nutr 106:1423-32. 2011..In conclusion, higher sugar intake appears to be associated with lower cognitive function, but longitudinal studies are needed to clarify the direction of causality... - Prenatal and early life factors and risk of Parkinson's diseaseHannah Gardener
Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
Mov Disord 25:1560-7. 2010..Left-handedness was associated with a 62% increased risk of PD in women but not in men. Further investigation of the relation between prenatal, perinatal, or neonatal factors and PD in other study populations is suggested... - Meeting adequate intake for dietary calcium without dairy foods in adolescents aged 9 to 18 years (National Health and Nutrition Examination Survey 2001-2002)Xiang Gao
Department of Nutrition, Harvard University School of Public Health, Boston, MA 02111, USA
J Am Diet Assoc 106:1759-65. 2006..In addition, greater physical activity and responsible sunlight exposure should be encouraged to promote vitamin D adequacy... - The 2005 USDA Food Guide Pyramid is associated with more adequate nutrient intakes within energy constraints than the 1992 PyramidXiang Gao
Harvard School of Public Health, Boston, MA, USA
J Nutr 136:1341-6. 2006..Our analysis suggests that following the 2005 FGP may be associated with lower energy and optimal nutrient intake. Careful restriction of discretionary calories appears necessary for appropriate energy intakes to be maintained... - A study of dietary patterns in the Mexican-American population and their association with obesityPatricia M Carrera
Department of Nutrition, University of Maryland, College Park, USA
J Am Diet Assoc 107:1735-42. 2007..We hypothesized that Mexican-American adults following a traditional diet would have a lower prevalence of obesity than those following a more typical American diet... - Obesity and restless legs syndrome in men and womenXiang Gao
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, and Harvard Medical School, Boston, MA 02115, USA
Neurology 72:1255-61. 2009..We therefore examined whether individuals who are obese have an increased risk of RLS in two ongoing US cohorts, the Nurses' Health Study II and the Health Professional Follow-up Study... - Greater consumption of sweetened beverages and added sugars is associated with obesity among US young adultsOdilia I Bermudez
Tufts University School of Medicine, Boston, MA, USA
Ann Nutr Metab 57:211-8. 2010..s... - Restless legs syndrome and hypertension in middle-aged womenSalma Batool-Anwar
Harvard Medical School, Brigham and Women s Hospital, Division of Sleep Medicine, 221 Longwood Ave, BL1044, Boston, MA 02115, USA
Hypertension 58:791-6. 2011..0001 for both). Women with restless legs syndrome have a higher prevalence of hypertension, and this prevalence increases with more frequent restless legs symptoms... - Calcium channel blocker use and risk of Parkinson's diseaseKelly Claire Simon
Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA
Mov Disord 25:1818-22. 2010..18, 95% CI: 0.73-1.92), frequency of use or duration of use of CCBs and PD risk was observed (P > 0.2 for all). These findings do not support a role for CCBs in providing neuroprotection against development of PD... - Restless legs syndrome and erectile dysfunctionXiang Gao
Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
Sleep 33:75-9. 2010..Dopaminergic hypofunction in the central nervous system may contribute to restless legs syndrome (RLS) and erectile dysfunction (ED). We therefore examined whether men with RLS have higher prevalences of ED... - Urinary 8-hydroxy-2-deoxyguanosine and cognitive function in Puerto Rican adultsXiang Gao
Department of Nutrition, Harvard University School of Public Health, Boston, Massachusetts 02115, USA
Am J Epidemiol 172:271-8. 2010..Prospective studies are needed to elucidate whether elevated urinary 8-OHdG concentrations can predict the rate of cognitive decline and incident dementia... - Smoking and Parkinson's disease: using parental smoking as a proxy to explore causalityEilis J O'Reilly
Department of Epidemiology and Nutrition, Harvard School of Public Health, Boston, MA 02215, USA
Am J Epidemiol 169:678-82. 2009..If the inverse association between smoking and Parkinson's disease were due to confounding by an environmental factor or were the result of reverse causation, it is unlikely that parental smoking would predict Parkinson's disease... - Television viewing is associated with prevalence of metabolic syndrome in Hispanic eldersXiang Gao
Jean Mayer USDA HNRCA at Tufts University, 711 Washington St, Boston, MA 02111 1524, USA
Diabetes Care 30:694-700. 2007..We examined associations between television viewing and prevalence of the metabolic syndrome among a representative sample of Caribbean-origin Hispanic elders living in Massachusetts... - Reproductive factors, exogenous estrogen use, and risk of Parkinson's diseaseKelly Claire Simon
Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA
Mov Disord 24:1359-65. 2009..The use of postmenopausal hormone use may interact with other risk factors, but findings are preliminary and need confirmation in other populations... - Prospective study of restless legs syndrome and coronary heart disease among womenYanping Li
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 181 Longwood Ave, Boston, MA 02115, USA
Circulation 126:1689-94. 2012..Therefore, we prospectively examined whether RLS was associated with an increased risk of CHD in women who participated in the Nurses' Health Study, taking into account the duration of RLS symptoms... - Telomere length and risk of Parkinson's diseaseHao Wang
Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA
Mov Disord 23:302-5. 2008..the highest quartile 0.33; 95% confidence interval: 0.12-0.90). Our results suggest that, contrary to telomere attrition observed in several aging-related diseases, shorter telomeres are not associated with an increased risk of PD... - Use of ibuprofen and risk of Parkinson diseaseXiang Gao
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, and Harvard Medical School, 181 Longwood Ave, Boston, MA 02115, USA
Neurology 76:863-9. 2011..Use of nonsteroidal anti-inflammatory drugs (NSAID) in general, and possibly ibuprofen in particular, has been shown to be related to lower PD risk in previous epidemiologic studies... - RLS in middle aged women and attention deficit/hyperactivity disorder in their offspringXiang Gao
Department of Nutrition, Harvard University School of Public Health, Boston, MA 02115, USA
Sleep Med 12:89-91. 2011..To test this hypothesis, we conducted a large-scaled cross-sectional study to examine whether women with a child with ADHD had a higher risk of having RLS than women of unaffected children... - Prospective studies of dairy product and calcium intakes and prostate cancer risk: a meta-analysisXiang Gao
Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
J Natl Cancer Inst 97:1768-77. 2005..65 to 3.25; P > .2) for the highest versus lowest intake categories of calcium. CONCLUSIONS: High intake of dairy products and calcium may be associated with an increased risk of prostate cancer, although the increase appears to be small... - A prospective study of sleep duration and pneumonia risk in womenSanjay R Patel
Division of Sleep Medicine, Brigham and Women s Hospital, 221 Longwood Avenue, Boston, MA 02115, USA
Sleep 35:97-101. 2012..Experimental data suggest sleep deprivation may impair host immunity. We sought to assess the effect of poor sleep on pneumonia risk... - A prospective study of bowel movement frequency and risk of Parkinson's diseaseXiang Gao
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
Am J Epidemiol 174:546-51. 2011..In conclusion, infrequent bowel movements may antedate the onset of cardinal motor symptoms of Parkinson's disease and may contribute to the identification of populations with higher than average Parkinson's disease risk... - A case-control study of body mass index and asthma in Asian childrenStanislav Henkin
Department of Public Health and Family Medicine, Tufts University School of Medicine, Boston, Massachusetts 21111, USA
Ann Allergy Asthma Immunol 100:447-51. 2008..Numerous studies have focused on the relationship between the 2 factors. However, to our knowledge, this association in Asian Americans has not been extensively studied... - Food insecurity and cognitive function in Puerto Rican adultsXiang Gao
Department of Nutrition, Harvard University School of Public Health, Boston, MA 02115, USA
Am J Clin Nutr 89:1197-203. 2009..Food insecurity is associated with nutrient inadequacy and a variety of unfavorable health outcomes. However, little is known about whether food security is associated with lower cognitive function in the elderly... - Dietary pattern is associated with homocysteine and B vitamin status in an urban Chinese populationXiang Gao
The Jean Mayer U.S. Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
J Nutr 133:3636-42. 2003..Dietary patterns appear to play an important role in the micronutrient and homocysteine status of these Chinese adults... - The maximal amount of alpha-tocopherol intake from foods alone in U.S. adults (1994-1996 CSFII): an analysis by linear programmingXiang Gao
The Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
Ann N Y Acad Sci 1031:385-6. 2004 - Smoking and risk of skin cancer: a prospective analysis and a meta-analysisFengju Song
Department of Epidemiology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China
Int J Epidemiol 41:1694-705. 2012..The association between smoking and the risk of skin cancer has not been well established... - No association between Parkinson disease alleles and the risk of melanomaShasha Meng
Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
Cancer Epidemiol Biomarkers Prev 21:243-5. 2012..It has been hypothesized that these two diseases may share common genetic and environmental risk factors... - Plasma C-reactive protein and homocysteine concentrations are related to frequent fruit and vegetable intake in Hispanic and non-Hispanic white eldersXiang Gao
The Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
J Nutr 134:913-8. 2004..Because both of these metabolites are known risk factors for CVD, these findings contribute to the evidence that a higher intake of fruit and vegetables may reduce the risk of CVD... - Sugar-sweetened soft drinks, diet soft drinks, and serum uric acid level: the Third National Health and Nutrition Examination SurveyJee Woong J Choi
Arthritis Research Centre of Canada, Vancouver, British Columbia, Canada
Arthritis Rheum 59:109-16. 2008..Our objective was to evaluate the relationship between sugar-sweetened soft drink intake, diet soft drink intake, and serum uric acid levels in a nationally representative sample of men and women... - Risk of second primary cancer in the contralateral breast in women treated for early-stage breast cancer: a population-based studyXiang Gao
Central Arkansas Radiation Therapy Institute, Little Rock, AR 72215, USA
Int J Radiat Oncol Biol Phys 56:1038-45. 2003..To study the potential risk factors, including radiotherapy (RT) for contralateral breast cancer (CBC), in patients treated for early-stage breast cancer... - Second primary cancers in patients with laryngeal cancer: a population-based studyXiang Gao
Central Arkansas Radiation Therapy Institute, Little Rock, AR 72215, USA
Int J Radiat Oncol Biol Phys 56:427-35. 2003..Literature regarding incidence of site-specific second cancers after laryngeal cancer is limited. Risk factors associated with second primaries are unknown... - Clinical cellular cardiomyoplasty: technical considerationsFumin Zhang
The First Affiliated Hospital of Nanjing Medical University, Nanjing, P.R. China
J Card Surg 18:268-73. 2003..Our experience indicated the safety and early benefit of cellular cardiomyoplasty using autologous satellite cells... - OCTN and CARD15 gene polymorphism in Chinese patients with inflammatory bowel diseaseMei Li
Department of Gastroenterology, the First Affiliated Hospital of Zhongshan University, Guangzhou 510089, Guangdong Province, China
World J Gastroenterol 14:4923-7. 2008..To investigate the single nucleotide polymorphism (SNPs) distribution of NOD2/CARD15 (R702W, G908R), OCTN1 1672C/T and OCTN2-207G/C in Chinese patients with inflammatory bowel disease (IBD)... - [Study on relationship between ambient PM10, PM2.5 pollution and daily mortality in a district in Shanghai]Haixia Dai
School of Public Health, Fudan University, Shanghai 200032, China
Wei Sheng Yan Jiu 33:293-7. 2004..5 were associated with 0.53% (0.22%-0.85%), 0.85% (0.32%-1.39%) increase in total daily mortality respectively. CONCLUSION: Ambient particulate pollution has potential acute adverse health effects on human... - Efficacy and safety of a potent and selective peroxisome proliferator activated receptor alpha agonist in subjects with dyslipidemia and type 2 diabetes mellitusSteven G Terra
Pfizer Global Research and Development, Groton, Connecticut, USA
Am J Cardiol 102:434-9. 2008..In conclusion, CP-778,875 2 mg/day significantly increased HDL cholesterol, significantly lowered fasting triglycerides, and increased apoA-I and HDL subfractions. The clinical relevance of the increase in homocysteine levels is unknown... - [Diagnostic role of anti-saccharomyces cerevisiae and antineutrophil cytoplasmic autoantibodies in inflammatory bowel disease.]Xiang Gao
Department of Gastroenterology, First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China
Zhonghua Nei Ke Za Zhi 44:428-30. 2005..3% respectively. CONCLUSIONS: The positive of either ASCA or pANCA are not enough sensible to screen the IBD, but useful to diagnosis IBD. The combination pANCA and ASCA can not be as a serum differential diagnosis marker for IBD... - Blockade of MyD88 attenuates cardiac hypertrophy and decreases cardiac myocyte apoptosis in pressure overload-induced cardiac hypertrophy in vivoTuanzhu Ha
Department of Surgery, East Tennessee State University, Campus Box 70575, Johnson City, Tennessee 37614 0575, USA
Am J Physiol Heart Circ Physiol 290:H985-94. 2006..Blockade of MyD88 significantly reduced cardiac hypertrophy, cardiac myocyte apoptosis, and improved cardiac function in vivo... - Observational studies on the effect of dietary antioxidants on asthma: a meta-analysisJinming Gao
Department of Respiratory Diseases, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China
Respirology 13:528-36. 2008..A meta-analysis was undertaken to examine the association between dietary antioxidant intake and the risk of asthma... - Premarital sexual activities among students in a university in Beijing, ChinaLiying Zhang
Center of Social Research, National Research Institute for Family Planning, No 12, Dahuisi, Haidian District, Beijing 100081, China
Sex Transm Dis 29:212-5. 2002..Sexually transmitted diseases are becoming a serious public health problem in China. College students are recognized as one of the age groups most affected... - Conditional knock-out of beta-catenin in postnatal-born dentate gyrus granule neurons results in dendritic malformationXiang Gao
Spinal Cord and Brain Injury Research Center, University of Kentucky, Lexington, Kentucky 40536, USA
J Neurosci 27:14317-25. 2007..Our results indicate that beta-catenin plays an important role in dendritic development of postnatal-born neurons in vivo, and is therefore essential for the neurogenesis in the postnatal brain... - Histopathological study of five cases with sporadic meningioangiomatosisYin Wang
Department of Neuropathology, Institute of Neurology, Huashan Hospital, Fudan University, 12 Wu Lu Mu Qi Zhong Road, Shanghai 200040, China
Neuropathology 26:249-56. 2006..Since this lesion is a distinct clinicopathological entity and hamartomatous in nature, it is important to make a correct diagnosis in order to avoid further aggressive treatment...